GB1126214A - Antiamoebin, a new antiprotozoal and anthelmintic antibiotic, and a method of producing the same - Google Patents
Antiamoebin, a new antiprotozoal and anthelmintic antibiotic, and a method of producing the sameInfo
- Publication number
- GB1126214A GB1126214A GB42265/65A GB4226565A GB1126214A GB 1126214 A GB1126214 A GB 1126214A GB 42265/65 A GB42265/65 A GB 42265/65A GB 4226565 A GB4226565 A GB 4226565A GB 1126214 A GB1126214 A GB 1126214A
- Authority
- GB
- United Kingdom
- Prior art keywords
- antiamoebin
- antibiotic
- ethylene glycol
- antiprotozoal
- anthelmintic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000000059 antiamebic agent Substances 0.000 title abstract 5
- 108010057789 antiamoebin Proteins 0.000 title abstract 5
- 230000003115 biocidal effect Effects 0.000 title abstract 5
- 230000000507 anthelmentic effect Effects 0.000 title abstract 3
- 230000000842 anti-protozoal effect Effects 0.000 title abstract 3
- 239000003904 antiprotozoal agent Substances 0.000 title abstract 3
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 abstract 9
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 abstract 4
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 abstract 3
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 abstract 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 abstract 3
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 abstract 3
- FUOOLUPWFVMBKG-UHFFFAOYSA-N 2-Aminoisobutyric acid Chemical compound CC(C)(N)C(O)=O FUOOLUPWFVMBKG-UHFFFAOYSA-N 0.000 abstract 2
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 abstract 2
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 abstract 2
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 abstract 2
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 abstract 2
- -1 aliphatic alcohols Chemical class 0.000 abstract 2
- 239000002904 solvent Substances 0.000 abstract 2
- 238000001179 sorption measurement Methods 0.000 abstract 2
- 239000005995 Aluminium silicate Substances 0.000 abstract 1
- DKPFZGUDAPQIHT-UHFFFAOYSA-N Butyl acetate Natural products CCCCOC(C)=O DKPFZGUDAPQIHT-UHFFFAOYSA-N 0.000 abstract 1
- 241001619326 Cephalosporium Species 0.000 abstract 1
- LCGLNKUTAGEVQW-UHFFFAOYSA-N Dimethyl ether Chemical compound COC LCGLNKUTAGEVQW-UHFFFAOYSA-N 0.000 abstract 1
- 241000771233 Emericellopsis humicola Species 0.000 abstract 1
- 241000190560 Emericellopsis minima Species 0.000 abstract 1
- 241000771146 Emericellopsis synnematicola Species 0.000 abstract 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 1
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 abstract 1
- 208000006968 Helminthiasis Diseases 0.000 abstract 1
- PMMYEEVYMWASQN-DMTCNVIQSA-N Hydroxyproline Chemical compound O[C@H]1CN[C@H](C(O)=O)C1 PMMYEEVYMWASQN-DMTCNVIQSA-N 0.000 abstract 1
- ONIBWKKTOPOVIA-BYPYZUCNSA-N L-Proline Chemical compound OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 abstract 1
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 abstract 1
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 abstract 1
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 abstract 1
- COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 abstract 1
- KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 abstract 1
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 abstract 1
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 abstract 1
- 239000004472 Lysine Substances 0.000 abstract 1
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 abstract 1
- 241001465754 Metazoa Species 0.000 abstract 1
- ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 abstract 1
- 206010037075 Protozoal infections Diseases 0.000 abstract 1
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical group CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 abstract 1
- KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 abstract 1
- 229960000583 acetic acid Drugs 0.000 abstract 1
- 238000005903 acid hydrolysis reaction Methods 0.000 abstract 1
- PZZYQPZGQPZBDN-UHFFFAOYSA-N aluminium silicate Chemical compound O=[Al]O[Si](=O)O[Al]=O PZZYQPZGQPZBDN-UHFFFAOYSA-N 0.000 abstract 1
- 229910000323 aluminium silicate Inorganic materials 0.000 abstract 1
- 235000012211 aluminium silicate Nutrition 0.000 abstract 1
- 235000001014 amino acid Nutrition 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- NEHMKBQYUWJMIP-UHFFFAOYSA-N anhydrous methyl chloride Natural products ClC NEHMKBQYUWJMIP-UHFFFAOYSA-N 0.000 abstract 1
- 239000003242 anti bacterial agent Substances 0.000 abstract 1
- 229940088710 antibiotic agent Drugs 0.000 abstract 1
- 238000002425 crystallisation Methods 0.000 abstract 1
- 230000008025 crystallization Effects 0.000 abstract 1
- PMMYEEVYMWASQN-UHFFFAOYSA-N dl-hydroxyproline Natural products OC1C[NH2+]C(C([O-])=O)C1 PMMYEEVYMWASQN-UHFFFAOYSA-N 0.000 abstract 1
- 238000010828 elution Methods 0.000 abstract 1
- 238000000605 extraction Methods 0.000 abstract 1
- 238000000855 fermentation Methods 0.000 abstract 1
- 230000004151 fermentation Effects 0.000 abstract 1
- 239000012362 glacial acetic acid Substances 0.000 abstract 1
- 235000013922 glutamic acid Nutrition 0.000 abstract 1
- 239000004220 glutamic acid Substances 0.000 abstract 1
- 239000001963 growth medium Substances 0.000 abstract 1
- FUZZWVXGSFPDMH-UHFFFAOYSA-N hexanoic acid Chemical compound CCCCCC(O)=O FUZZWVXGSFPDMH-UHFFFAOYSA-N 0.000 abstract 1
- 229960002591 hydroxyproline Drugs 0.000 abstract 1
- 150000002576 ketones Chemical class 0.000 abstract 1
- 229910052749 magnesium Inorganic materials 0.000 abstract 1
- 239000011777 magnesium Substances 0.000 abstract 1
- 230000008018 melting Effects 0.000 abstract 1
- 238000002844 melting Methods 0.000 abstract 1
- 229940050176 methyl chloride Drugs 0.000 abstract 1
- 230000007935 neutral effect Effects 0.000 abstract 1
- 208000014837 parasitic helminthiasis infectious disease Diseases 0.000 abstract 1
- 239000003208 petroleum Substances 0.000 abstract 1
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 abstract 1
- 239000002798 polar solvent Substances 0.000 abstract 1
- 229920001184 polypeptide Polymers 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 238000000746 purification Methods 0.000 abstract 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 abstract 1
- 238000000638 solvent extraction Methods 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- FGMPLJWBKKVCDB-UHFFFAOYSA-N trans-L-hydroxy-proline Natural products ON1CCCC1C(O)=O FGMPLJWBKKVCDB-UHFFFAOYSA-N 0.000 abstract 1
- 239000004474 valine Substances 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- D—TEXTILES; PAPER
- D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
- D01H—SPINNING OR TWISTING
- D01H9/00—Arrangements for replacing or removing bobbins, cores, receptacles, or completed packages at paying-out or take-up stations ; Combination of spinning-winding machine
- D01H9/02—Arrangements for replacing or removing bobbins, cores, receptacles, or completed packages at paying-out or take-up stations ; Combination of spinning-winding machine for removing completed take-up packages and replacing by bobbins, cores, or receptacles at take-up stations; Transferring material between adjacent full and empty take-up elements
- D01H9/08—Doffing arrangements independent of spinning or twisting machines
- D01H9/10—Doffing carriages ; Loading carriages with cores
Landscapes
- Engineering & Computer Science (AREA)
- Mechanical Engineering (AREA)
- Textile Engineering (AREA)
- Spinning Or Twisting Of Yarns (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Manufacture, Treatment Of Glass Fibers (AREA)
Abstract
1,126,214. Antiprotozoal and anthelmintic antibiotic. HINDUSTAN ANTIBIOTICS Ltd. 5 Oct., 1965, No. 42265/65. Heading C2A. An antiprotozoal and anthelmintic antibiotic, antiamoebin, is prepared by cultivating an antiamoebin-producing strain of Emericellopsis synnematicola, e.g. ATCC 16540, E. poonensis, e.g. ATCC 16411, E. minima, E. humicola or Cephalosporium pimprina, in a culture medium under submerged or surface aerobic cultivation. Antiamoeba is isolated from a fermentation broth by (a) solvent extraction, (b) adsorption. Adsorption is on activated C or magnesium aluminium silicate, followed by elution with an alcohol, e.g. methanol. Extraction may be of the clarified broth or mycelium at e.g. pH 5À0 using waterimmiscible, polar solvents for the broth e.g. n-butanol, and aliphatic alcohols, ketones, and aliphatic mono-alkyl ethers of ethylene glycol for the mycelium. The antibiotic is precipitated from the extract by the addition of a non- solvent. Further purification is by crystallization from solvents. Antiamoebin is a neutral polypeptide, forming white needles, melting point 219-220 C., [α]D<SP>D5</SP> + 10 (C = 1À02% CH 3 OH); soluble in CH 3 OH, C 2 H 5 OH, C 3 H 7 OH, pyridine, glacial acetic acid, dimethyl formamide, methyl ether of ethylene glycol; insoluble in water, chloroform, ether, petroleum ether, ethyl acetate, butyl acetate, acetone, benzene, methyl chloride and ethylene glycol; acid hydrolysis produces the amino acids proline, α-amino isobutyric acid, phenylalanine, valine, leucine, hydroxyproline, lysine and glutamic acid; elementary analysis C = 56À11%, H = 7À56% and N = 13À56%; U.V. (Fig. 1, not shown); I.R. Figs. 2 and 3. A therapeutic oral preparation for the treatment of protozoal and helminth infections in man and animals comprises the antibiotic antiamoebin.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DESC040931 | 1967-06-24 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1126214A true GB1126214A (en) | 1968-09-05 |
Family
ID=7435947
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB42265/65A Expired GB1126214A (en) | 1967-06-24 | 1965-10-05 | Antiamoebin, a new antiprotozoal and anthelmintic antibiotic, and a method of producing the same |
| GB29645/68A Expired GB1216214A (en) | 1967-06-24 | 1968-06-21 | Improvements relating to cop-tube changing apparatus |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB29645/68A Expired GB1216214A (en) | 1967-06-24 | 1968-06-21 | Improvements relating to cop-tube changing apparatus |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US3503198A (en) |
| CH (1) | CH465460A (en) |
| DE (1) | DE1685996A1 (en) |
| ES (1) | ES355308A1 (en) |
| FR (1) | FR1570951A (en) |
| GB (2) | GB1126214A (en) |
| NL (1) | NL6808769A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0302214A1 (en) | 1983-05-24 | 1989-02-08 | Maschinenfabrik Rieter Ag | Automat location system |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH508745A (en) * | 1969-02-25 | 1971-06-15 | Toyoda Automatic Loom Works | Process for the automatic piecing of a thread after a thread break at a spinning station of a ringless spinning machine and spinning machine for its implementation |
| US3854275A (en) * | 1971-05-28 | 1974-12-17 | Celanese Corp | Mechanized bobbin handler |
| DE2809001C2 (en) * | 1978-03-02 | 1983-11-03 | Schubert & Salzer Maschinenfabrik Ag, 8070 Ingolstadt | Maintenance system on an open-end spinning machine |
| DE3600980A1 (en) * | 1986-01-15 | 1987-07-16 | Zinser Textilmaschinen Gmbh | METHOD AND DEVICE FOR POSITIONING HANGING WAGONES FITTED WITH ROVER REELS ON AT LEAST ONE RAIL AGAINST PROCESSING POINTS OF A FINISHED YARN SPINDING MACHINE |
| GB2199342A (en) * | 1987-02-18 | 1988-07-06 | Hollingsworth Uk Ltd | Servicing robot for spinning machine |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3300959A (en) * | 1963-04-05 | 1967-01-31 | Toyoda Automatic Loom Works | Control for automated spinning machine |
| CH417425A (en) * | 1965-05-08 | 1966-07-15 | Gillono Matteo | Automatic machine for piecing the broken threads on spinning machines |
| US3360914A (en) * | 1965-12-16 | 1968-01-02 | Parks Cramer Co | Travelling tending system for textile machines |
| US3411281A (en) * | 1966-01-17 | 1968-11-19 | Guido Carlo | Device for indicating broken threads in spinning machines |
| US3374617A (en) * | 1966-03-04 | 1968-03-26 | Jefferson Mills | Vehicle for doffing and collecting bobbins from a spinning frame |
-
1965
- 1965-10-05 GB GB42265/65A patent/GB1126214A/en not_active Expired
-
1967
- 1967-06-24 DE DE19671685996 patent/DE1685996A1/en active Pending
-
1968
- 1968-06-20 FR FR1570951D patent/FR1570951A/fr not_active Expired
- 1968-06-21 GB GB29645/68A patent/GB1216214A/en not_active Expired
- 1968-06-21 ES ES355308A patent/ES355308A1/en not_active Expired
- 1968-06-21 CH CH936468A patent/CH465460A/en unknown
- 1968-06-21 NL NL6808769A patent/NL6808769A/xx unknown
- 1968-06-24 US US741156A patent/US3503198A/en not_active Expired - Lifetime
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0302214A1 (en) | 1983-05-24 | 1989-02-08 | Maschinenfabrik Rieter Ag | Automat location system |
Also Published As
| Publication number | Publication date |
|---|---|
| CH465460A (en) | 1968-11-15 |
| NL6808769A (en) | 1968-12-27 |
| ES355308A1 (en) | 1969-11-16 |
| GB1216214A (en) | 1970-12-16 |
| DE1685996A1 (en) | 1971-10-14 |
| US3503198A (en) | 1970-03-31 |
| FR1570951A (en) | 1969-06-13 |
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