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GB1111871A - Cofactor u and a process for its production - Google Patents

Cofactor u and a process for its production

Info

Publication number
GB1111871A
GB1111871A GB28985/64A GB2898564A GB1111871A GB 1111871 A GB1111871 A GB 1111871A GB 28985/64 A GB28985/64 A GB 28985/64A GB 2898564 A GB2898564 A GB 2898564A GB 1111871 A GB1111871 A GB 1111871A
Authority
GB
United Kingdom
Prior art keywords
ginsenga
zymosan
roots
hydrolysis
adsorption
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB28985/64A
Inventor
Alexander James Brown Wardrope
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nyegaard and Co AS
Original Assignee
Nyegaard and Co AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nyegaard and Co AS filed Critical Nyegaard and Co AS
Priority to GB28985/64A priority Critical patent/GB1111871A/en
Priority to FR24436A priority patent/FR4689M/fr
Priority to NL6509044A priority patent/NL6509044A/xx
Priority to FR24445A priority patent/FR1476552A/en
Priority to BE666877D priority patent/BE666877A/xx
Priority to BR171274/65A priority patent/BR6571274D0/en
Priority to DE19651492058 priority patent/DE1492058A1/en
Publication of GB1111871A publication Critical patent/GB1111871A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/99—Enzyme inactivation by chemical treatment
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2/00—Peptides of undefined number of amino acids; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/14—Fungi; Culture media therefor
    • C12N1/145—Fungal isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P1/00—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes
    • C12P1/02—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes by using fungi
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/645—Fungi ; Processes using fungi

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Botany (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Analytical Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

A crystalline substance "Cofactor U", having the structure: <FORM:1111871/C2/1> and showing anti-kininase and non-specific resistance activity in vivo, is obtained by hydrolysis (e.g. with acid at 80-120 DEG C.) and subsequent working up steps of fluorescent polypeptides having the same physiological properties which are derived from animal glands, zymosan and ginsenga roots by the processes disclosed in Specifications 104,184 and 104,185. The pure substance may be produced from the crude hydrolysate by adsorption on charcoal and elution therefrom with 90% aqueous phenol followed by a working up process involving chromatography and adsorption and elution on ion-exchange materials.ALSO:Pharmaceutical compositions e.g. for injection and which have anti-kinnase and non-specific resistance activity comprise a carrier and "Co-factor-U" of the formula: <FORM:1111871/A5-A6/1> which is obtained by hydrolysis of fluorescent polypeptides having the same physiological activity and derived from animal glands, zymosan and ginsenga roots (see Div. C2).
GB28985/64A 1964-07-14 1964-07-14 Cofactor u and a process for its production Expired GB1111871A (en)

Priority Applications (7)

Application Number Priority Date Filing Date Title
GB28985/64A GB1111871A (en) 1964-07-14 1964-07-14 Cofactor u and a process for its production
FR24436A FR4689M (en) 1964-07-14 1965-07-13
NL6509044A NL6509044A (en) 1964-07-14 1965-07-13
FR24445A FR1476552A (en) 1964-07-14 1965-07-13 Process for the preparation of a novel derivative of polypeptides
BE666877D BE666877A (en) 1964-07-14 1965-07-14
BR171274/65A BR6571274D0 (en) 1964-07-14 1965-07-14 PROCESS FOR THE PREPARATION OF THE CO-FACTOR
DE19651492058 DE1492058A1 (en) 1964-07-14 1965-07-14 Process for the production of cofactor U

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB28985/64A GB1111871A (en) 1964-07-14 1964-07-14 Cofactor u and a process for its production

Publications (1)

Publication Number Publication Date
GB1111871A true GB1111871A (en) 1968-05-01

Family

ID=10284408

Family Applications (1)

Application Number Title Priority Date Filing Date
GB28985/64A Expired GB1111871A (en) 1964-07-14 1964-07-14 Cofactor u and a process for its production

Country Status (6)

Country Link
BE (1) BE666877A (en)
BR (1) BR6571274D0 (en)
DE (1) DE1492058A1 (en)
FR (1) FR4689M (en)
GB (1) GB1111871A (en)
NL (1) NL6509044A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6954882B2 (en) * 2001-06-15 2005-10-11 International Business Machines Corporation Method and apparatus for fault location in a loop network

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6954882B2 (en) * 2001-06-15 2005-10-11 International Business Machines Corporation Method and apparatus for fault location in a loop network

Also Published As

Publication number Publication date
FR4689M (en) 1966-12-19
BE666877A (en) 1965-11-03
BR6571274D0 (en) 1973-08-02
NL6509044A (en) 1966-01-17
DE1492058A1 (en) 1969-02-20

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