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GB1190054A - Process for the production of N,N'-Bis-Halogenoalkyl Phosphoric and Thiophosphoric Acid Ester Amides - Google Patents

Process for the production of N,N'-Bis-Halogenoalkyl Phosphoric and Thiophosphoric Acid Ester Amides

Info

Publication number
GB1190054A
GB1190054A GB3184867A GB3184867A GB1190054A GB 1190054 A GB1190054 A GB 1190054A GB 3184867 A GB3184867 A GB 3184867A GB 3184867 A GB3184867 A GB 3184867A GB 1190054 A GB1190054 A GB 1190054A
Authority
GB
United Kingdom
Prior art keywords
bis
phosphoric
halogenoalkyl
production
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB3184867A
Inventor
Herbert Arnold
Norbert Brock
Friedrich Bourseaux
Heinz Bekel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ASTA - WERKE AG CHEMISCHE FABRIK
Asta Medica GmbH
Original Assignee
ASTA - WERKE AG CHEMISCHE FABRIK
Asta Werke AG Chemische Fabrik
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ASTA - WERKE AG CHEMISCHE FABRIK, Asta Werke AG Chemische Fabrik filed Critical ASTA - WERKE AG CHEMISCHE FABRIK
Publication of GB1190054A publication Critical patent/GB1190054A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
    • C07F9/6581—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms
    • C07F9/6584—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms having one phosphorus atom as ring hetero atom
    • C07F9/65848—Cyclic amide derivatives of acids of phosphorus, in which two nitrogen atoms belong to the ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/564—Three-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
    • C07F9/6581—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms
    • C07F9/6584—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms having one phosphorus atom as ring hetero atom
    • C07F9/65842—Cyclic amide derivatives of acids of phosphorus, in which one nitrogen atom belongs to the ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)

Abstract

1,190,054. Preparing N,N<SP>1</SP>-bis(halogenoalkyl) phosphorus ester amides. ASTA-WERKE A.G. CHEMISCHE FABRIK. 11 July, 1967 [11 July, 1966], No. 31848/67. Heading C2C. N,N<SP>1</SP>-bishalogenoalkyl phosphoric and thiophosphoric acid esters amides of the formula wherein X is halogen, X 1 is an O or S atom, and R 1 is C 1 -C 4 alkyl substituted by one or more halogen atoms are obtained by reacting a hydrohalic acid with a compound of the formula wherein R 1 and X 1 are as defined above and recovering the compound of Formula I. The hydrohalic acid may be HF, HCl, HBr or HI and is preferably HCl. The reaction may be carried out in the presence of an inert solvent, e.g. a hydrocarbon or halogenated hydrocarbon. Traces of water may be present but water is preferably absent. An example is given for the production of N,N<SP>1</SP>-bis-(2- chloroethyl)-N<SP>1</SP>,O-propylene phosphoric acid ester diamide. The products are cytostatically active.
GB3184867A 1966-07-11 1967-07-11 Process for the production of N,N'-Bis-Halogenoalkyl Phosphoric and Thiophosphoric Acid Ester Amides Expired GB1190054A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DEA0052990 1966-07-11

Publications (1)

Publication Number Publication Date
GB1190054A true GB1190054A (en) 1970-04-29

Family

ID=6938756

Family Applications (1)

Application Number Title Priority Date Filing Date
GB3184867A Expired GB1190054A (en) 1966-07-11 1967-07-11 Process for the production of N,N'-Bis-Halogenoalkyl Phosphoric and Thiophosphoric Acid Ester Amides

Country Status (9)

Country Link
AT (1) AT265313B (en)
BE (1) BE700713A (en)
CH (1) CH484200A (en)
DE (1) DE1645922A1 (en)
DK (1) DK121232B (en)
GB (1) GB1190054A (en)
IL (1) IL28262A (en)
NL (1) NL158182B (en)
SE (1) SE327203B (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4684742A (en) * 1984-07-31 1987-08-04 Polska Akademia Nauk-Centrum Baden Molekularnych i Makromolekularnych Process for the production of 2-(2-halogenoethylamino)-2-oxo-3-(2-halogenoethyl)-1.3.2.-oxazaphosphorinanes

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4684742A (en) * 1984-07-31 1987-08-04 Polska Akademia Nauk-Centrum Baden Molekularnych i Makromolekularnych Process for the production of 2-(2-halogenoethylamino)-2-oxo-3-(2-halogenoethyl)-1.3.2.-oxazaphosphorinanes

Also Published As

Publication number Publication date
IL28262A (en) 1971-05-26
NL6709607A (en) 1968-01-12
AT265313B (en) 1968-10-10
DK121232B (en) 1971-09-27
NL158182B (en) 1978-10-16
CH484200A (en) 1970-01-15
SE327203B (en) 1970-08-17
BE700713A (en) 1967-12-01
DE1645922A1 (en) 1971-01-28

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Legal Events

Date Code Title Description
PS Patent sealed
PLNP Patent lapsed through nonpayment of renewal fees