GB1168307A - Novel Esters of 5-Nitro-Quinoline - Google Patents
Novel Esters of 5-Nitro-QuinolineInfo
- Publication number
- GB1168307A GB1168307A GB37268/67A GB3726867A GB1168307A GB 1168307 A GB1168307 A GB 1168307A GB 37268/67 A GB37268/67 A GB 37268/67A GB 3726867 A GB3726867 A GB 3726867A GB 1168307 A GB1168307 A GB 1168307A
- Authority
- GB
- United Kingdom
- Prior art keywords
- nitro
- quinoline
- esters
- novel esters
- aug
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000002148 esters Chemical class 0.000 title abstract 5
- NDDZXHOCOKCNBM-UHFFFAOYSA-N 5-nitroquinoline Chemical compound C1=CC=C2C([N+](=O)[O-])=CC=CC2=N1 NDDZXHOCOKCNBM-UHFFFAOYSA-N 0.000 title abstract 3
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 abstract 2
- OFTKFKYVSBNYEC-UHFFFAOYSA-N 2-furoyl chloride Chemical compound ClC(=O)C1=CC=CO1 OFTKFKYVSBNYEC-UHFFFAOYSA-N 0.000 abstract 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 abstract 1
- 229940124323 amoebicide Drugs 0.000 abstract 1
- -1 amoebicides Substances 0.000 abstract 1
- 230000000507 anthelmentic effect Effects 0.000 abstract 1
- 230000000844 anti-bacterial effect Effects 0.000 abstract 1
- 239000003716 antitrichomonal agent Substances 0.000 abstract 1
- 239000003899 bactericide agent Substances 0.000 abstract 1
- 239000003085 diluting agent Substances 0.000 abstract 1
- 239000000417 fungicide Substances 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 239000008101 lactose Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- RJIWZDNTCBHXAL-UHFFFAOYSA-N nitroxoline Chemical compound C1=CN=C2C(O)=CC=C([N+]([O-])=O)C2=C1 RJIWZDNTCBHXAL-UHFFFAOYSA-N 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Quinoline Compounds (AREA)
Abstract
1,168,307. Novel esters of 5-nitro-quinoline. SOC. D'ETUDES DE PRODUITS CHEMIQUES. 7 Aug., 1968 [14 Aug., 1967], No. 37268/67. Heading C2C. Novel esters of 5-nitro-quinoline having the general Formula I wherein R represents a furyl radical which may be substituted by a nitro group or a halogen atom may be prepared by esterifying 5-nitro-8- hydroxy quinoline with the appropriate furoyl chloride, usually in a slight excess. The reaction may be carried out in the presence of a solvent, such as pyridine. Pharmaceutical compositions contain the above esters in the presence of a diluent or carrier, such as lactose. The esters are usable as bacteriostats, bactericides, fungicides, amoebicides, trichomonacides and anthelminthics. The compositions may be administered orally or topically.
Priority Applications (10)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB37268/67A GB1168307A (en) | 1967-08-14 | 1967-08-14 | Novel Esters of 5-Nitro-Quinoline |
| FR1589095D FR1589095A (en) | 1967-08-14 | 1968-07-24 | |
| BE718997D BE718997A (en) | 1967-08-14 | 1968-08-02 | |
| CH1166568A CH481137A (en) | 1967-08-14 | 1968-08-02 | Process for the preparation of furoic esters of 5-Nitro-8-hydroxyquinoline |
| OA53345A OA02872A (en) | 1967-08-14 | 1968-08-05 | Nitro-5 oxine esters and processes for their preparation. |
| AT792168A AT281828B (en) | 1967-08-14 | 1968-08-13 | Process for the preparation of new furan-2-carboxylic acid esters of 5-nitro-8-hydroxyquinoline |
| ES357235A ES357235A1 (en) | 1967-08-14 | 1968-08-13 | Novel Esters of 5-Nitro-Quinoline |
| NL6811481A NL6811481A (en) | 1967-08-14 | 1968-08-13 | |
| DE19681795125 DE1795125C (en) | 1967-08-14 | 1968-08-14 | Quinoline derivatives, a process for their preparation and pharmaceuticals |
| FR170764A FR8230M (en) | 1967-08-14 | 1968-10-22 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB37268/67A GB1168307A (en) | 1967-08-14 | 1967-08-14 | Novel Esters of 5-Nitro-Quinoline |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1168307A true GB1168307A (en) | 1969-10-22 |
Family
ID=10395086
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB37268/67A Expired GB1168307A (en) | 1967-08-14 | 1967-08-14 | Novel Esters of 5-Nitro-Quinoline |
Country Status (8)
| Country | Link |
|---|---|
| AT (1) | AT281828B (en) |
| BE (1) | BE718997A (en) |
| CH (1) | CH481137A (en) |
| ES (1) | ES357235A1 (en) |
| FR (2) | FR1589095A (en) |
| GB (1) | GB1168307A (en) |
| NL (1) | NL6811481A (en) |
| OA (1) | OA02872A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111295372A (en) * | 2018-09-29 | 2020-06-16 | 江苏亚虹医药科技有限公司 | Nitroxoline prodrugs and uses thereof |
-
1967
- 1967-08-14 GB GB37268/67A patent/GB1168307A/en not_active Expired
-
1968
- 1968-07-24 FR FR1589095D patent/FR1589095A/fr not_active Expired
- 1968-08-02 CH CH1166568A patent/CH481137A/en not_active IP Right Cessation
- 1968-08-02 BE BE718997D patent/BE718997A/xx unknown
- 1968-08-05 OA OA53345A patent/OA02872A/en unknown
- 1968-08-13 AT AT792168A patent/AT281828B/en not_active IP Right Cessation
- 1968-08-13 ES ES357235A patent/ES357235A1/en not_active Expired
- 1968-08-13 NL NL6811481A patent/NL6811481A/xx unknown
- 1968-10-22 FR FR170764A patent/FR8230M/fr not_active Expired
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111295372A (en) * | 2018-09-29 | 2020-06-16 | 江苏亚虹医药科技有限公司 | Nitroxoline prodrugs and uses thereof |
| CN111295372B (en) * | 2018-09-29 | 2021-03-09 | 江苏亚虹医药科技股份有限公司 | Nitroquinoline prodrug and use thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| DE1795125B1 (en) | 1972-09-21 |
| OA02872A (en) | 1970-12-15 |
| NL6811481A (en) | 1969-02-18 |
| CH481137A (en) | 1969-11-15 |
| BE718997A (en) | 1969-01-16 |
| FR1589095A (en) | 1970-03-23 |
| AT281828B (en) | 1970-06-10 |
| ES357235A1 (en) | 1970-03-16 |
| FR8230M (en) | 1970-09-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed | ||
| PCNP | Patent ceased through non-payment of renewal fee |