GB1167688A - Dealkylation of Cyclic N-alkyl Derivatives - Google Patents
Dealkylation of Cyclic N-alkyl DerivativesInfo
- Publication number
- GB1167688A GB1167688A GB3718268A GB3718268A GB1167688A GB 1167688 A GB1167688 A GB 1167688A GB 3718268 A GB3718268 A GB 3718268A GB 3718268 A GB3718268 A GB 3718268A GB 1167688 A GB1167688 A GB 1167688A
- Authority
- GB
- United Kingdom
- Prior art keywords
- dealkylation
- cyclic
- alkyl derivatives
- aug
- spasmolytic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 125000004122 cyclic group Chemical group 0.000 title 1
- 230000020335 dealkylation Effects 0.000 title 1
- 238000006900 dealkylation reaction Methods 0.000 title 1
- 230000002048 spasmolytic effect Effects 0.000 abstract 2
- ATKYNAZQGVYHIB-UHFFFAOYSA-N tropaic acid nortropanyl ester Natural products C1C(N2)CCC2CC1OC(=O)C(CO)C1=CC=CC=C1 ATKYNAZQGVYHIB-UHFFFAOYSA-N 0.000 abstract 2
- CVDLBKMNONQOHJ-OLQVQODUSA-N (1r,5s)-8-azabicyclo[3.2.1]octan-3-one Chemical compound C1C(=O)C[C@@]2([H])CC[C@]1([H])N2 CVDLBKMNONQOHJ-OLQVQODUSA-N 0.000 abstract 1
- JIYPUEZSSJAXBO-KNVOCYPGSA-N (1r,5s)-9-azabicyclo[3.3.1]nonan-3-one Chemical compound C1CC[C@@H]2CC(=O)C[C@H]1N2 JIYPUEZSSJAXBO-KNVOCYPGSA-N 0.000 abstract 1
- ATKYNAZQGVYHIB-IXXDHKBRSA-N Norhyoscyamine Natural products C1([C@@H](C(=O)OC2C[C@H]3CC[C@H](N3)C2)CO)=CC=CC=C1 ATKYNAZQGVYHIB-IXXDHKBRSA-N 0.000 abstract 1
- ATKYNAZQGVYHIB-IZGVIRRGSA-N [(1r,5s)-8-azabicyclo[3.2.1]octan-3-yl] (2s)-3-hydroxy-2-phenylpropanoate Chemical compound C1([C@H](C(=O)OC2C[C@H]3CC[C@H](N3)C2)CO)=CC=CC=C1 ATKYNAZQGVYHIB-IZGVIRRGSA-N 0.000 abstract 1
- ATKYNAZQGVYHIB-DGKWVBSXSA-N [(1r,5s)-8-azabicyclo[3.2.1]octan-3-yl] 3-hydroxy-2-phenylpropanoate Chemical compound C([C@]1(CC[C@@](C2)(N1)[H])[H])C2OC(=O)C(CO)C1=CC=CC=C1 ATKYNAZQGVYHIB-DGKWVBSXSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 239000000812 cholinergic antagonist Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- MOYZEMOPQDTDHA-YQYZCKNZSA-N norhyoscine Chemical compound C1([C@H](C(=O)OC2C[C@@H]3N[C@@H]([C@H]4O[C@H]43)C2)CO)=CC=CC=C1 MOYZEMOPQDTDHA-YQYZCKNZSA-N 0.000 abstract 1
- MOYZEMOPQDTDHA-UHFFFAOYSA-N norscopolamine Natural products C1C(C2OC22)NC2CC1OC(=O)C(CO)C1=CC=CC=C1 MOYZEMOPQDTDHA-UHFFFAOYSA-N 0.000 abstract 1
- -1 norscopoline Chemical compound 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
1,167,688. Spasmolytic medicines. BOEHRINGER INGELHEIM G.m.b.H. 5 Aug., 1968 [4 Aug., 1967], No. 37182/68. Addition to 1,166,798. Heading ASB. [Also in Division C2] Pharmaceutical compositions comprise norscopolamine, noratropine, nortropinone, norhyoscyamine, norscopoline, norpseudopelletierine or their pharmaceutically acceptable acid addition salts in conjunction with a suitable excipient, are administered orally or parenterally and exhibit spasmolytic activity.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE1670258A DE1670258C3 (en) | 1967-08-04 | 1967-08-04 | Process for the preparation of norscopolamine by dealkylation of tertiary, cyclic amines |
| DE19671670257 DE1670257A1 (en) | 1967-08-04 | 1967-08-04 | Cyclic amino compounds and processes for their preparation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1167688A true GB1167688A (en) | 1969-10-22 |
Family
ID=25754378
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB3718268A Expired GB1167688A (en) | 1967-08-04 | 1968-08-05 | Dealkylation of Cyclic N-alkyl Derivatives |
Country Status (4)
| Country | Link |
|---|---|
| BE (1) | BE719020A (en) |
| CH (1) | CH507246A (en) |
| FR (1) | FR95289E (en) |
| GB (1) | GB1167688A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2092049A1 (en) * | 1970-04-16 | 1972-01-21 | Egyt Gyogyszervegyeszeti Gyar |
-
1968
- 1968-08-02 BE BE719020D patent/BE719020A/xx unknown
- 1968-08-02 CH CH1160268A patent/CH507246A/en not_active IP Right Cessation
- 1968-08-05 GB GB3718268A patent/GB1167688A/en not_active Expired
- 1968-08-05 FR FR161933A patent/FR95289E/en not_active Expired
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2092049A1 (en) * | 1970-04-16 | 1972-01-21 | Egyt Gyogyszervegyeszeti Gyar |
Also Published As
| Publication number | Publication date |
|---|---|
| BE719020A (en) | 1969-02-03 |
| FR95289E (en) | 1970-08-14 |
| CH507246A (en) | 1971-05-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed | ||
| PE20 | Patent expired after termination of 20 years |