GB1150245A - New Piperazine Derivatives and a Process for the Preparation thereof. - Google Patents
New Piperazine Derivatives and a Process for the Preparation thereof.Info
- Publication number
- GB1150245A GB1150245A GB955367A GB955367A GB1150245A GB 1150245 A GB1150245 A GB 1150245A GB 955367 A GB955367 A GB 955367A GB 955367 A GB955367 A GB 955367A GB 1150245 A GB1150245 A GB 1150245A
- Authority
- GB
- United Kingdom
- Prior art keywords
- formula
- radical
- reacting
- hydrogen
- acid addition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000004885 piperazines Chemical class 0.000 title abstract 3
- 229940066771 systemic antihistamines piperazine derivative Drugs 0.000 title 1
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 abstract 6
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical compound C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 150000002576 ketones Chemical class 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 229910052757 nitrogen Inorganic materials 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 125000001424 substituent group Chemical group 0.000 abstract 2
- 239000003826 tablet Substances 0.000 abstract 2
- 239000004480 active ingredient Substances 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 229940035676 analgesics Drugs 0.000 abstract 1
- 239000000730 antalgic agent Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000000839 emulsion Substances 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- DDBREPKUVSBGFI-UHFFFAOYSA-N phenobarbital Chemical compound C=1C=CC=CC=1C1(CC)C(=O)NC(=O)NC1=O DDBREPKUVSBGFI-UHFFFAOYSA-N 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 229940125723 sedative agent Drugs 0.000 abstract 1
- 239000000932 sedative agent Substances 0.000 abstract 1
- 239000000243 solution Substances 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- 239000000725 suspension Substances 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
- C07D295/205—Radicals derived from carbonic acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
Abstract
1,150,245. N,N<SP>1</SP>-substituted piperazines. CHINOIN GYOGYSZER ES VEGYESZETI TERMEKEK GYARART. 28 Feb., 1967 [4 March, 1966; 30 Dec., 1966 (2)], No. 9553/67. Heading C2C. Novel substituted piperazines of Formula I wherein R<SP>1</SP> is a 5- or 6-membered heterooyclic radical containing at least one nitrogen atom or a phenyl group unsubstituted or substituted by one or two substituents, which may be the same or different, and are halogen, alkyl, or alkoxy, with the proviso that when n is 1 and R<SP>2</SP> is hydrogen at least one of the above-mentioned substituents is present, R<SP>2</SP> is hydrogen or an alkyl radical, R<SP>3</SP> is an alkyl radical and n is 0 to 3, and their acid addition salts, are prepared by either reacting the corresponding ketone of formula R<SP>1.</SP>CO.CHR<SP>2</SP>.(CH 2 ).(CH 2 ) n -X, where X represents an active radical, with an N-unsubstituted N<SP>1</SP>-carboalkoxy piperazine or when n is 1 in the above Formula I by reacting the corresponding ketone of formula R<SP>1</SP>.CO.CH 2 R<SP>2</SP> with the piparazine derivative in the presence of formaldehyde or substances capable of producing formaldehyde. Therapeutic composition, in the form of tablets, coated tablets, emulsions, suspensions or solutions, contain the above novel compounds or their pharmacologically acceptable acid addition salts as the active ingredient. The compositions, which can be administered orally or parenterally, can be used as sedatives, analgesics or hypotensers.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HUCI000615 | 1966-03-04 | ||
| HUCI000689 | 1966-12-30 | ||
| HUCI000688 | 1966-12-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1150245A true GB1150245A (en) | 1969-04-30 |
Family
ID=27270142
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB955367A Expired GB1150245A (en) | 1966-03-04 | 1967-02-28 | New Piperazine Derivatives and a Process for the Preparation thereof. |
Country Status (4)
| Country | Link |
|---|---|
| CH (2) | CH507261A (en) |
| DE (1) | DE1670431A1 (en) |
| FR (1) | FR6437M (en) |
| GB (1) | GB1150245A (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE8304361D0 (en) * | 1983-08-10 | 1983-08-10 | Ferrosan Ab | NOVEL 1-ACYLPIPERAZINE DERIVATIVES NOVEL 1-ACYLPIPERAZINE DERIVATIVES |
-
1967
- 1967-02-28 GB GB955367A patent/GB1150245A/en not_active Expired
- 1967-02-28 DE DE19671670431 patent/DE1670431A1/en active Pending
- 1967-03-02 CH CH619970A patent/CH507261A/en not_active IP Right Cessation
- 1967-03-02 CH CH307367A patent/CH496004A/en not_active IP Right Cessation
- 1967-06-02 FR FR97445A patent/FR6437M/fr not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| DE1670431A1 (en) | 1971-02-11 |
| CH507261A (en) | 1971-05-15 |
| FR6437M (en) | 1968-11-04 |
| CH496004A (en) | 1970-09-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed | ||
| 435 | Patent endorsed 'licences of right' on the date specified (sect. 35/1949) | ||
| PCNP | Patent ceased through non-payment of renewal fee |