GB1006728A - Amine salts of pyrrolidone carboxylic acid - Google Patents
Amine salts of pyrrolidone carboxylic acidInfo
- Publication number
- GB1006728A GB1006728A GB4880862A GB4880862A GB1006728A GB 1006728 A GB1006728 A GB 1006728A GB 4880862 A GB4880862 A GB 4880862A GB 4880862 A GB4880862 A GB 4880862A GB 1006728 A GB1006728 A GB 1006728A
- Authority
- GB
- United Kingdom
- Prior art keywords
- carboxylic acid
- pyrrolidone carboxylic
- acid
- amine
- salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- ODHCTXKNWHHXJC-VKHMYHEASA-N 5-oxo-L-proline Chemical class OC(=O)[C@@H]1CCC(=O)N1 ODHCTXKNWHHXJC-VKHMYHEASA-N 0.000 title abstract 5
- -1 Amine salts Chemical class 0.000 title abstract 5
- 229940079889 pyrrolidonecarboxylic acid Drugs 0.000 title abstract 5
- YNAVUWVOSKDBBP-UHFFFAOYSA-N Morpholine Chemical compound C1COCCN1 YNAVUWVOSKDBBP-UHFFFAOYSA-N 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 210000002966 serum Anatomy 0.000 abstract 2
- 239000000243 solution Substances 0.000 abstract 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 2
- KWIUHFFTVRNATP-UHFFFAOYSA-N Betaine Natural products C[N+](C)(C)CC([O-])=O KWIUHFFTVRNATP-UHFFFAOYSA-N 0.000 abstract 1
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 abstract 1
- KWIUHFFTVRNATP-UHFFFAOYSA-O N,N,N-trimethylglycinium Chemical compound C[N+](C)(C)CC(O)=O KWIUHFFTVRNATP-UHFFFAOYSA-O 0.000 abstract 1
- 150000001412 amines Chemical class 0.000 abstract 1
- 229960003237 betaine Drugs 0.000 abstract 1
- 230000036765 blood level Effects 0.000 abstract 1
- 239000002775 capsule Substances 0.000 abstract 1
- 150000001732 carboxylic acid derivatives Chemical class 0.000 abstract 1
- OEYIOHPDSNJKLS-UHFFFAOYSA-N choline Chemical compound C[N+](C)(C)CCO OEYIOHPDSNJKLS-UHFFFAOYSA-N 0.000 abstract 1
- 229960001231 choline Drugs 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- 108010074605 gamma-Globulins Proteins 0.000 abstract 1
- 235000013922 glutamic acid Nutrition 0.000 abstract 1
- 239000004220 glutamic acid Substances 0.000 abstract 1
- 239000008187 granular material Substances 0.000 abstract 1
- 235000010299 hexamethylene tetramine Nutrition 0.000 abstract 1
- VKYKSIONXSXAKP-UHFFFAOYSA-N hexamethylenetetramine Chemical compound C1N(C2)CN3CN1CN2C3 VKYKSIONXSXAKP-UHFFFAOYSA-N 0.000 abstract 1
- 239000012442 inert solvent Substances 0.000 abstract 1
- 239000007788 liquid Substances 0.000 abstract 1
- 229960004011 methenamine Drugs 0.000 abstract 1
- 229940113083 morpholine Drugs 0.000 abstract 1
- 238000007911 parenteral administration Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000004885 piperazines Chemical class 0.000 abstract 1
- 239000000843 powder Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000003826 tablet Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
- C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
- C07D207/277—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D207/28—2-Pyrrolidone-5- carboxylic acids; Functional derivatives thereof, e.g. esters, nitriles
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrrole Compounds (AREA)
Abstract
The invention comprises amine salts, especially betaine, choline, methenamine, morpholine and piperazine salts, of pyrrolidone carboxylic acid, and this preparation thereof by reacting the acid with the amine or a salt of the acid with an amine salt in an inert solvent consisting of water, a liquid C1-6-alkanol or a mixture of these, and recovering the amine salt of the carboxylic acid. Pyrrolidone carboxylic acid is prepared by autoclaving glutamic acid and water. Pharmaceutical compositions, used to increase the blood serum level of pyrrolidone carboxylic acid to produce a psychotonic effect or to produce a reduction in the blood level of serum gamma-globulin, comprise an amine salt of pyrrolidone carboxylic acid and a pharmaceutically acceptable carrier. The compositions may be formulated as tablets, capsules, powders, granules or solutions for oral administration or as solutions for parenteral administration.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DEM0055280 | 1962-12-31 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1006728A true GB1006728A (en) | 1965-10-06 |
Family
ID=7308255
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB4880862A Expired GB1006728A (en) | 1962-12-31 | 1962-12-28 | Amine salts of pyrrolidone carboxylic acid |
Country Status (2)
| Country | Link |
|---|---|
| DE (1) | DE1470033A1 (en) |
| GB (1) | GB1006728A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2827598A1 (en) * | 2001-07-19 | 2003-01-24 | Ajinomoto Kk | Method for producing pyrrolidone carboxylic acid or its salt for use in cosmetics or toiletry goods, comprises bringing glutamic acid or its salt into contact with high-temperature high-pressure water |
| WO2016180870A1 (en) * | 2015-05-13 | 2016-11-17 | H. Lundbeck A/S | Vortioxetine pyroglutamate |
-
1962
- 1962-12-28 GB GB4880862A patent/GB1006728A/en not_active Expired
- 1962-12-31 DE DE19621470033 patent/DE1470033A1/en active Pending
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2827598A1 (en) * | 2001-07-19 | 2003-01-24 | Ajinomoto Kk | Method for producing pyrrolidone carboxylic acid or its salt for use in cosmetics or toiletry goods, comprises bringing glutamic acid or its salt into contact with high-temperature high-pressure water |
| US7022863B2 (en) | 2001-07-19 | 2006-04-04 | Ajinomoto Co., Inc. | Production method of pyrrolidone carboxylic acid and salt thereof |
| WO2016180870A1 (en) * | 2015-05-13 | 2016-11-17 | H. Lundbeck A/S | Vortioxetine pyroglutamate |
| CN107567440A (en) * | 2015-05-13 | 2018-01-09 | H.隆德贝克有限公司 | pyroglutamic acid vortioxetine |
| US10287261B2 (en) | 2015-05-13 | 2019-05-14 | H. Lundbeck A/S | Vortioxetine pyroglutamate |
| EA032363B1 (en) * | 2015-05-13 | 2019-05-31 | Х. Лундбекк А/С | Vortioxetine pyroglutamate |
| CN107567440B (en) * | 2015-05-13 | 2021-06-22 | H.隆德贝克有限公司 | Vortioxetine Pyroglutamate |
| US11279682B2 (en) | 2015-05-13 | 2022-03-22 | H. Lundbeck A/S | Vortioxetine pyroglutamate |
Also Published As
| Publication number | Publication date |
|---|---|
| DE1470033A1 (en) | 1969-05-14 |
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