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GB1095670A - A novel 9ª‰,10ª‡-steroid - Google Patents

A novel 9ª‰,10ª‡-steroid

Info

Publication number
GB1095670A
GB1095670A GB3275967A GB3275967A GB1095670A GB 1095670 A GB1095670 A GB 1095670A GB 3275967 A GB3275967 A GB 3275967A GB 3275967 A GB3275967 A GB 3275967A GB 1095670 A GB1095670 A GB 1095670A
Authority
GB
United Kingdom
Prior art keywords
novel
steroid
androsta
methyl
diacetoxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB3275967A
Inventor
Engbert Harmen Ree Rink
Hendrik Frederik Louisschoeler
Pieter Westerhof
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of GB1095670A publication Critical patent/GB1095670A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A61K31/568—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A61K31/568—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone
    • A61K31/5685—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone having an oxo group in position 17, e.g. androsterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A61K31/568—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone
    • A61K31/569—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone substituted in position 17 alpha, e.g. ethisterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • C—CHEMISTRY; METALLURGY
    • C02—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
    • C02F—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
    • C02F5/00—Softening water; Preventing scale; Adding scale preventatives or scale removers to water, e.g. adding sequestering agents
    • C02F5/08—Treatment of water with complexing chemicals or other solubilising agents for softening, scale prevention or scale removal, e.g. adding sequestering agents
    • C02F5/10—Treatment of water with complexing chemicals or other solubilising agents for softening, scale prevention or scale removal, e.g. adding sequestering agents using organic substances
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J75/00—Processes for the preparation of steroids in general

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hydrology & Water Resources (AREA)
  • Engineering & Computer Science (AREA)
  • Environmental & Geological Engineering (AREA)
  • Water Supply & Treatment (AREA)
  • Steroid Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

The novel 3,17b - diacetoxy - 17a - methyl-9b ,10a - androsta - 2,4,6 - triene is prepared by reacting 17a - methyl - 17b - acetoxy - 9b ,10a -androsta - 4,6 - dien - 3 - one with isopropenyl acetate in presence of p-toluenesulphonic acid.
GB3275967A 1965-07-19 1965-07-19 A novel 9ª‰,10ª‡-steroid Expired GB1095670A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB3054865A GB1095665A (en) 1965-07-19 1965-07-19 Novel 9ª‰, 10ª‡-steroids and a process for the manufacture thereof

Publications (1)

Publication Number Publication Date
GB1095670A true GB1095670A (en) 1967-12-20

Family

ID=10309369

Family Applications (7)

Application Number Title Priority Date Filing Date
GB3275765A Expired GB1095668A (en) 1965-07-19 1965-07-19 A novel 9ª‰, 10ª‡-steroid derivative
GB3275667A Expired GB1095667A (en) 1965-07-19 1965-07-19 A novel 9ª‰, 10-ª‡steroid
GB30546/65A Expired GB1078499A (en) 1965-07-19 1965-07-19 Novel 10ª‡-methyl-9ª‰-steroids and a process for the manufacture thereof
GB3054865A Expired GB1095665A (en) 1965-07-19 1965-07-19 Novel 9ª‰, 10ª‡-steroids and a process for the manufacture thereof
GB3275967A Expired GB1095670A (en) 1965-07-19 1965-07-19 A novel 9ª‰,10ª‡-steroid
GB3275867A Expired GB1095669A (en) 1965-07-19 1965-07-19 Novel 9ª‰,10ª‡-steroids
GB3275567A Expired GB1095666A (en) 1965-07-19 1965-07-19 A novel 9ª‰, 10ª‡-steroid derivative

Family Applications Before (4)

Application Number Title Priority Date Filing Date
GB3275765A Expired GB1095668A (en) 1965-07-19 1965-07-19 A novel 9ª‰, 10ª‡-steroid derivative
GB3275667A Expired GB1095667A (en) 1965-07-19 1965-07-19 A novel 9ª‰, 10-ª‡steroid
GB30546/65A Expired GB1078499A (en) 1965-07-19 1965-07-19 Novel 10ª‡-methyl-9ª‰-steroids and a process for the manufacture thereof
GB3054865A Expired GB1095665A (en) 1965-07-19 1965-07-19 Novel 9ª‰, 10ª‡-steroids and a process for the manufacture thereof

Family Applications After (2)

Application Number Title Priority Date Filing Date
GB3275867A Expired GB1095669A (en) 1965-07-19 1965-07-19 Novel 9ª‰,10ª‡-steroids
GB3275567A Expired GB1095666A (en) 1965-07-19 1965-07-19 A novel 9ª‰, 10ª‡-steroid derivative

Country Status (3)

Country Link
BE (1) BE667072A (en)
FR (1) FR4759M (en)
GB (7) GB1095668A (en)

Also Published As

Publication number Publication date
GB1095667A (en) 1967-12-20
GB1078499A (en) 1967-08-09
FR4759M (en) 1967-01-16
GB1095665A (en) 1967-12-20
BE667072A (en)
GB1095668A (en) 1967-12-20
GB1095669A (en) 1967-12-20
GB1095666A (en) 1967-12-20

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