GB1060558A - Benzimidazole derivatives - Google Patents
Benzimidazole derivativesInfo
- Publication number
- GB1060558A GB1060558A GB253466A GB253466A GB1060558A GB 1060558 A GB1060558 A GB 1060558A GB 253466 A GB253466 A GB 253466A GB 253466 A GB253466 A GB 253466A GB 1060558 A GB1060558 A GB 1060558A
- Authority
- GB
- United Kingdom
- Prior art keywords
- formula
- group
- piperidino
- dimethylamino
- phenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 229940058303 antinematodal benzimidazole derivative Drugs 0.000 title abstract 2
- 125000003785 benzimidazolyl group Chemical class N1=C(NC2=C1C=CC=C2)* 0.000 title 1
- -1 methoxyphenyl Chemical group 0.000 abstract 5
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- HYZJCKYKOHLVJF-UHFFFAOYSA-N 1H-benzimidazole Chemical compound C1=CC=C2NC=NC2=C1 HYZJCKYKOHLVJF-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 150000001556 benzimidazoles Chemical class 0.000 abstract 1
- 210000003169 central nervous system Anatomy 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000002147 dimethylamino group Chemical group [H]C([H])([H])N(*)C([H])([H])[H] 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- 125000002541 furyl group Chemical group 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 238000007911 parenteral administration Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 125000000587 piperidin-1-yl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 abstract 1
- 125000004076 pyridyl group Chemical group 0.000 abstract 1
- 125000002112 pyrrolidino group Chemical group [*]N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 abstract 1
- 125000001453 quaternary ammonium group Chemical group 0.000 abstract 1
- 230000029058 respiratory gaseous exchange Effects 0.000 abstract 1
- 230000004936 stimulating effect Effects 0.000 abstract 1
- 125000001680 trimethoxyphenyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/18—Benzimidazoles; Hydrogenated benzimidazoles with aryl radicals directly attached in position 2
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
The invention comprises benzimidazole derivatives of the formula <FORM:1060558/C2/1> wherein R1 represents a hydrogen atom or a phenyl, methoxyphenyl, trimethoxyphenyl, furyl, pyridyl or ethylpyridyl group, and R2 represents a dimethylamino, diethylamino, morpholino, piperidino or pyrrolidino group, with the proviso that if R1 is a phenyl or methoxyphenyl group, R2 is other than dimethylamino or piperidino; pharmaceutically acceptable acid addition and quaternary ammonium derivatives threof; and a process for their preparation comprising reacting a benzimidazole of the formula <FORM:1060558/C2/2> with an aminoalkyl halide of the formula <FORM:1060558/C2/3> wherein X represents a halogen atom. Pharmaceutical compositions, having a stimulant effect on the respiration and central nervous system, for oral or parenteral administration, comprise a compound of the invention together with pharmaceutical carrier.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DEE0030557 | 1965-11-29 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1060558A true GB1060558A (en) | 1967-03-08 |
Family
ID=7074581
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB253466A Expired GB1060558A (en) | 1965-11-29 | 1966-01-19 | Benzimidazole derivatives |
Country Status (2)
| Country | Link |
|---|---|
| DE (1) | DE1545780A1 (en) |
| GB (1) | GB1060558A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2212154A1 (en) * | 1973-01-02 | 1974-07-26 | Knoll Ag | |
| CN102206204A (en) * | 2011-04-08 | 2011-10-05 | 奇方(天津)医药科技有限公司 | Benzimidazole compound and medicinal application thereof |
-
1965
- 1965-11-29 DE DE19651545780 patent/DE1545780A1/en active Pending
-
1966
- 1966-01-19 GB GB253466A patent/GB1060558A/en not_active Expired
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2212154A1 (en) * | 1973-01-02 | 1974-07-26 | Knoll Ag | |
| CN102206204A (en) * | 2011-04-08 | 2011-10-05 | 奇方(天津)医药科技有限公司 | Benzimidazole compound and medicinal application thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| DE1545780A1 (en) | 1970-04-16 |
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