GB1054523A - - Google Patents
Info
- Publication number
- GB1054523A GB1054523A GB1054523DA GB1054523A GB 1054523 A GB1054523 A GB 1054523A GB 1054523D A GB1054523D A GB 1054523DA GB 1054523 A GB1054523 A GB 1054523A
- Authority
- GB
- United Kingdom
- Prior art keywords
- insulin
- aqueous
- crystalline
- experimentalnoi
- endokrinologii
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 abstract 10
- 102000004877 Insulin Human genes 0.000 abstract 5
- 108090001061 Insulin Proteins 0.000 abstract 5
- 229940125396 insulin Drugs 0.000 abstract 5
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 abstract 2
- NWUYHJFMYQTDRP-UHFFFAOYSA-N 1,2-bis(ethenyl)benzene;1-ethenyl-2-ethylbenzene;styrene Chemical class C=CC1=CC=CC=C1.CCC1=CC=CC=C1C=C.C=CC1=CC=CC=C1C=C NWUYHJFMYQTDRP-UHFFFAOYSA-N 0.000 abstract 1
- 238000001640 fractional crystallisation Methods 0.000 abstract 1
- 210000000496 pancreas Anatomy 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
- C07K14/625—Extraction from natural sources
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Endocrinology (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Diabetes (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pyrrole Compounds (AREA)
Abstract
1,054,523. Obtaining insulin. VSESOJUZNY NAUCHNO - ISSLEDOVATELSKY INSTITUT EXPERIMENTALNOI ENDOKRINOLOGII. Oct. 25, 1965, No. 45009/65. Heading A5B. Crystalline insulin is obtained by adsorbing the insulin contained in an aqueous aqueousalcoholic or aqueous-actetone extract of pancreas at a pH above 7.4 or below 3.5 on a sulphonated cation exchange resin, selectively eluting the insulin with an alkaline aqueous/ acetone solution and treating the eluate in conventional manner to obtain crystalline insulin by fractional crystallization.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DEV0029751 | 1965-11-17 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1054523A true GB1054523A (en) | 1900-01-01 |
Family
ID=7585121
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB1054523D Expired GB1054523A (en) | 1965-11-17 |
Country Status (3)
| Country | Link |
|---|---|
| DE (1) | DE1492229A1 (en) |
| GB (1) | GB1054523A (en) |
| MY (1) | MY6800099A (en) |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3715345A (en) * | 1970-08-03 | 1973-02-06 | Lilly Co Eli | Glucagon separation process |
| US3907676A (en) * | 1970-07-28 | 1975-09-23 | Novo Terapeutisk Labor As | Process for purifying insulin |
| FR2375193A1 (en) * | 1976-12-27 | 1978-07-21 | Univ Minnesota | PROCESS FOR STABILIZATION, CONCENTRATION AND PURIFICATION OF INSULIN |
| US4459226A (en) * | 1982-02-26 | 1984-07-10 | Eli Lilly And Company | Process for recovering insulin |
| GB2173503A (en) * | 1985-04-12 | 1986-10-15 | Berlin Chemie Veb | Purification of insulin |
| EP1758540A4 (en) * | 2004-05-24 | 2007-06-20 | Wockhardt Ltd | Purification of insulin-like material by reverse phase chromatography |
| WO2013048330A1 (en) * | 2011-09-30 | 2013-04-04 | Ge Healthcare Bio-Sciences Ab | Method for purification of cleaved pro-insulin |
-
0
- GB GB1054523D patent/GB1054523A/en not_active Expired
-
1965
- 1965-11-17 DE DE19651492229 patent/DE1492229A1/en active Pending
-
1968
- 1968-12-31 MY MY6800099A patent/MY6800099A/en unknown
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3907676A (en) * | 1970-07-28 | 1975-09-23 | Novo Terapeutisk Labor As | Process for purifying insulin |
| US3715345A (en) * | 1970-08-03 | 1973-02-06 | Lilly Co Eli | Glucagon separation process |
| FR2375193A1 (en) * | 1976-12-27 | 1978-07-21 | Univ Minnesota | PROCESS FOR STABILIZATION, CONCENTRATION AND PURIFICATION OF INSULIN |
| US4459226A (en) * | 1982-02-26 | 1984-07-10 | Eli Lilly And Company | Process for recovering insulin |
| GB2173503A (en) * | 1985-04-12 | 1986-10-15 | Berlin Chemie Veb | Purification of insulin |
| EP1758540A4 (en) * | 2004-05-24 | 2007-06-20 | Wockhardt Ltd | Purification of insulin-like material by reverse phase chromatography |
| WO2013048330A1 (en) * | 2011-09-30 | 2013-04-04 | Ge Healthcare Bio-Sciences Ab | Method for purification of cleaved pro-insulin |
| CN103827136A (en) * | 2011-09-30 | 2014-05-28 | 通用电气健康护理生物科学股份公司 | Method for purification of cleaved pro-insulin |
| CN103827136B (en) * | 2011-09-30 | 2016-07-06 | 通用电气健康护理生物科学股份公司 | Purify the insulinogenic method of cracking |
| US9409967B2 (en) | 2011-09-30 | 2016-08-09 | Ge Healthcare Bioprocess R&D Ab | Method for purification of cleaved pro-insulin |
Also Published As
| Publication number | Publication date |
|---|---|
| MY6800099A (en) | 1968-12-31 |
| DE1492229A1 (en) | 1969-12-11 |
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