BRPI0821921A2 - Derivados de piripiropeno tendo uma atividade inibidora da acat2 - Google Patents
Derivados de piripiropeno tendo uma atividade inibidora da acat2Info
- Publication number
- BRPI0821921A2 BRPI0821921A2 BRPI0821921-4A BRPI0821921A BRPI0821921A2 BR PI0821921 A2 BRPI0821921 A2 BR PI0821921A2 BR PI0821921 A BRPI0821921 A BR PI0821921A BR PI0821921 A2 BRPI0821921 A2 BR PI0821921A2
- Authority
- BR
- Brazil
- Prior art keywords
- inhibitory activity
- pyripyropene derivatives
- acat2
- acat2 inhibitory
- pyripyropene
- Prior art date
Links
- 230000002401 inhibitory effect Effects 0.000 title 1
- 229930188995 pyripyropene Natural products 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/12—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains three hetero rings
- C07D493/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2007331444 | 2007-12-25 | ||
| PCT/JP2008/073501 WO2009081957A1 (ja) | 2007-12-25 | 2008-12-17 | Acat 2 阻害活性を有するピリピロペン誘導体 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0821921A2 true BRPI0821921A2 (pt) | 2015-06-16 |
Family
ID=40801257
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0821921-4A BRPI0821921A2 (pt) | 2007-12-25 | 2008-12-17 | Derivados de piripiropeno tendo uma atividade inibidora da acat2 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US8519128B2 (pt) |
| EP (1) | EP2228376B1 (pt) |
| JP (1) | JP5479110B2 (pt) |
| CN (1) | CN101965352A (pt) |
| BR (1) | BRPI0821921A2 (pt) |
| CA (1) | CA2710791A1 (pt) |
| WO (1) | WO2009081957A1 (pt) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010150739A1 (ja) * | 2009-06-23 | 2010-12-29 | 学校法人北里研究所 | Ａｃａｔ２阻害活性を示す水酸基含有ピリピロペン誘導体 |
| CA2795064A1 (en) | 2010-03-31 | 2011-10-06 | School Juridical Person Kitasato Institute | Pyripyropene derivative having acat2 inhibiting activity and stable to metabolizing enzymes |
| US20130131091A1 (en) | 2010-05-24 | 2013-05-23 | Kimihiko Goto | Harmful organism control agent |
| EP2567959B1 (en) | 2011-09-12 | 2014-04-16 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| CN103536922B (zh) * | 2012-07-13 | 2017-05-03 | 中国科学院上海生命科学研究院 | 酰基辅酶a:胆固醇酰基转移酶‑2抑制剂在抑制肝癌生长中的应用 |
| JP2014144922A (ja) * | 2013-01-28 | 2014-08-14 | Kitasato Institute | Ａｃａｔ２阻害活性を示すピリピロペンａ構造簡略型誘導体 |
| WO2015065595A1 (en) | 2013-10-30 | 2015-05-07 | Trustees Of Dartmouth College | Method for selectively inhibiting acat1 in the treatment of obesity, metabolic syndrome, and atherosclerosis |
| JP5946100B2 (ja) * | 2014-06-24 | 2016-07-05 | 学校法人北里研究所 | コレステロールアシル転移酵素アイソザイム２（ａｃａｔ２）阻害活性を有する新規医薬化合物 |
| KR102502031B1 (ko) | 2016-11-16 | 2023-02-20 | 퍼듀 리서치 파운데이션 | 체중 및 대사 증후군을 조절하기 위한 조성물 및 방법 |
| CN110950881A (zh) * | 2018-09-27 | 2020-04-03 | 中国科学院上海药物研究所 | 一类三环类似物、其制备方法和用途 |
| CN115052598A (zh) * | 2020-01-27 | 2022-09-13 | 学校法人北里研究所 | 前蛋白转化酶枯草溶菌素/Kexin 9型（PCSK9）抑制剂及其药物用途 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3233476B2 (ja) * | 1992-10-22 | 2001-11-26 | 社団法人北里研究所 | Ｆｏ−１２８９物質およびその製造法 |
| JP3725198B2 (ja) | 1995-03-27 | 2005-12-07 | 社団法人北里研究所 | ピリピロペン誘導体 |
| JPH08269065A (ja) * | 1995-04-03 | 1996-10-15 | Kitasato Inst:The | ピリピロペン誘導体 |
| DE102004036689A1 (de) | 2004-07-28 | 2006-03-23 | Henkel Kgaa | Rückstandsarmer Deodorant- oder Antitranspirant-Stift auf Basis einer Öl-in-Wasser-Dispersion |
| TWI388282B (zh) * | 2005-06-01 | 2013-03-11 | Meiji Seika Pharma Co Ltd | 害蟲控制劑 |
-
2008
- 2008-12-17 JP JP2009547119A patent/JP5479110B2/ja active Active
- 2008-12-17 US US12/810,545 patent/US8519128B2/en active Active
- 2008-12-17 CA CA2710791A patent/CA2710791A1/en not_active Abandoned
- 2008-12-17 BR BRPI0821921-4A patent/BRPI0821921A2/pt not_active IP Right Cessation
- 2008-12-17 WO PCT/JP2008/073501 patent/WO2009081957A1/ja not_active Ceased
- 2008-12-17 EP EP08864334.1A patent/EP2228376B1/en active Active
- 2008-12-17 CN CN2008801274459A patent/CN101965352A/zh active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| US8519128B2 (en) | 2013-08-27 |
| WO2009081957A1 (ja) | 2009-07-02 |
| EP2228376B1 (en) | 2015-06-03 |
| EP2228376A1 (en) | 2010-09-15 |
| JPWO2009081957A1 (ja) | 2011-05-06 |
| JP5479110B2 (ja) | 2014-04-23 |
| EP2228376A4 (en) | 2011-10-19 |
| US20110184173A1 (en) | 2011-07-28 |
| CN101965352A (zh) | 2011-02-02 |
| CA2710791A1 (en) | 2009-07-02 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| BRPI0821921A2 (pt) | Derivados de piripiropeno tendo uma atividade inibidora da acat2 | |
| DOP2007000084A (es) | Derivados de dihidropirazolopirimidinona | |
| DK2134708T3 (da) | 3-Cyano-4-(4-tetrahydropyranphenyl)-pyridin-2-on-derivater | |
| BRPI0813707A2 (pt) | Derivados de pirimidinil-piridazinona | |
| BRPI0820112A2 (pt) | Derivados de isoxazol-piridina | |
| BRPI0809992A2 (pt) | Derivados de pirrolopirimidina | |
| BRPI0820113A2 (pt) | Derivados de isoxazolo-piridazina | |
| BRPI0906495A2 (pt) | Derivados de indolol-piridona tendo atividade inibidora de quinase de ponto de checagem 1 | |
| BRPI0812155A2 (pt) | derivados de espiroindolinona | |
| BRPI0817935A2 (pt) | Derivados de biarila | |
| BRPI0821947A2 (pt) | derivados de antibiótico de glicopetídeo glicosilatado | |
| BRPI0720220A2 (pt) | Derivados de quinolinas antibacterianos | |
| ATE483711T1 (de) | Spiroindolinonderivate | |
| ATE469905T1 (de) | Pyridopyrimidinonderivate | |
| BRPI0814236A2 (pt) | Derivados de quinazolinamida | |
| ATE512135T1 (de) | Spiroindolinonderivate | |
| FR20C1027I2 (fr) | Derives de tiglien-3-one | |
| BRPI0807087A2 (pt) | Inibidores de hcv macrocíclicos substituídos de pirimidina | |
| BRPI0812518A2 (pt) | Derivados de indazolamida | |
| DK2035394T3 (da) | 2-pyrazincarboxamidderivater | |
| BRPI0820649A2 (pt) | Derivados de isoxazalo-pirazina | |
| CR10562A (es) | Nuevos derivados de piridazina | |
| BRPI0920183A2 (pt) | derivados de fenetilamida e seus analogos heterociclicos | |
| BRPI0719879A2 (pt) | Derivados de hidrobenzamida como inibidores de hsp90 | |
| CR10809A (es) | Derivados de heteroaril-pirrolidinil-y-piperidinil-cetona |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE AS 6A E 7A ANUIDADES. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2343 DE 01-12-2015 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |