FR2672037A1 - DEVICE FOR DISTRIBUTING A COSMETIC OR PHARMACEUTICAL COMPOSITION TO ACTIVE VARIABLE ACTIVE DOSES DURING USE. - Google Patents

Abstract

A device is described for dispensing a stable cosmetic or pharmaceutic composition comprising two non-mixable viscous phases (A) and (B), phase (A) being constituted of at least one inclusion in phase (B) and incorporating at least one active principle. Phase (A) is ordered in phase (B) so that there is a concentration gradient of the active principle(s) when the composition is dispensed from the said device. In particular, phases (A) and (B) have viscosities eta A et eta B respectively, at 25 DEG C, of: 0.5 < eta A/ eta B < 1.5.

Description

DEVICE FOR DISPENSING A COMPOSITION
COSMETIC OR PHARMACEUTICAL IN DOSES OF
ACTIVE VARIABLE PRINCIPLE DURING THE UTILI
SATION.

 The present invention relates to a device for dispensing a cosmetic or pharmaceutical composition at varying doses of active ingredient during use.

 Many cosmetic or pharmaceutical applications require that the corresponding compositions be used at varying doses of active ingredient during use. Shock treatment is generally begun with compositions with a high concentration of active ingredient, followed by a maintenance treatment with compositions with a lower concentration of active ingredient, in order to maintain the results obtained at the same time. first stage. By way of examples, mention may be made of anti-dandruff, anti-hair loss, anti-inflammatory and antipsoriatic treatments.

It may also be mentioned the protection of keratin and, in particular, of the skin against ultraviolet radiation, by solar compositions which, for the beginning of exposure to the sun, have high protection indices and then decreasing protection indices. as the tan appears.

 To carry out these treatments, it has hitherto been resorted either to successive applications of compositions whose active ingredient levels are decreasing, each of them having a fixed concentration of active ingredient, or by multiplying the applications of compositions of which the level of active ingredient is identical to obtain the total dose required for treatment.

 Thus, devices, such as that described in the European patent application EP-A-243 321, are known for conditioning compositions different from each other, either in nature or in concentrations of active principle (s), so that to allow their successive delivery and a progressive treatment.

 Another device, such as that described in French Patent No. 2 233 036, comprises several compartments or containers containing a bronzing composition whose percentage of active ingredient increases from one compartment or container to another, which allows apply the bronzing cream in the form of gradual concentration doses.

 The Applicant Company has now discovered that, without the use of a specifically adapted packaging, it is possible to proceed to a progressive or decreasing treatment in active ingredient through the use of a dispenser containing a composition in which one or more inclusion (s) containing at least one active ingredient is (or are) distributed so as to allow a concentration gradient of active principle during the distribution.

 The present invention therefore firstly relates to a device for dispensing a stable composition for cosmetic or pharmaceutical use, comprising, in a dispenser, two viscous phases (A) and (B), immiscible, the phase ( A), said internal, being disposed in the form of at least one inclusion within the phase (B), said external, and containing at least one active principle, characterized in that the internal phase (A) is ordered within the external phase (B) so that a concentration gradient of the active principle (s) is established during the delivery of the composition at the outlet of said dispensing device.

 By "gradient", we do not necessarily mean a linear gradient. The overall objective is, in fact, to allow for example an application at high doses of active ingredient with the first applications and lower doses of active ingredient, once the shock treatment performed.

According to the invention, the organization of the internal phase (A) within the external phase (B) allows an application at increasing or decreasing concentration of the active principle (s) contained in the internal phase (A).

The two viscous phases (A) and (B) are, according to the invention, non-miscible with each other, the internal phase (A) having to have a viscosity sufficient to maintain its initial shape, and the external phase (B) to present a sufficient viscosity for the splint does not dissolve the internal phase and keep it in suspension. Meets these requirements a composition whose phases (A) and (B) have viscosities respectively, iA and #B, measured at the temperature of 25 C at Contraves module 4, whose report verifies the next inequality? 7A
0.5 <# <1.5 #B
The phases (A) and (B) of the composition contained in the dispenser according to the invention can respectively represent from 0.1 to 50% by weight and from 50 to 99.9% by weight of the total composition, the PA and PB of the two phases A and B satisfying the following weight ratio
PA
0.001 <<1
PB
In an advantageous embodiment, the phases (A) and (B) of the composition contained in the dispenser according to the invention represent, respectively, from 1 to 30% by weight and from 70 to 99% by weight of the total composition, in a weight ratio of
PA
0.01 <<0.42
PB
The concentration gradient can be obtained in two ways - the concentration in active principle (s) of the phase
(A) is constant, and the concentration gradient in
principle (s) active during the distribution is
obtained by variation of inclusion or inclusions
phase (A) in its form and / or, in the case of
where inclusions are multiple, their distribution
and / or their number, within phase (B); the phase inclusions (A) are uniformly
distributed within phase (B), and the gradient of
concentration in active principle (s) during the
distribution is obtained by variation of the concentration
in active principle (s) of phase (A).

 Inclusions can be arranged continuously or discontinuously. They may be in the form of beads, pearls, rods or cones, the dimensions and / or surface of which may be varied within the external phase, or in the form of cords that may represent helices or spirals. of which the pitch and / or the shape and / or the size of the turns can be varied, or in the form of arrangements of straight lines, or of planes and / or they can be formed by combinations of these various forms.

In a particular embodiment, the dispenser is constituted by a pot filled with the composition, which is distributed by successive samples using the fingers or a spatula, and the (or) inclusion (s) is presented ( nt) in the form of at least one spiral winding or variable pitch helix depending on the desired active concentration concentration gradient (s), of axis substantially parallel to the axis of the pot, or of at least one cone of axis substantially parallel to the mean axis of the pot, or in the form of rods arranged perpendicularly to the axis of the pot, the distance between the rods of successive planes varying according to the concentration gradient in principle (s) ) active (s) sought, or in the form of beads or beads whose density and / or dimensions vary in successive planes or in successive slices perpendicular to the average axis of the pot according to the concentration gradient in principle (s) ) active (s) search
According to another embodiment, the dispenser is constituted by a flexible tube or a piston distributor.

 Figures 1 to 5 of the accompanying drawing are schematic views illustrating a number of possibilities of shapes and arrangements of phase inclusions (A) in a composition contained in a distributor shown schematically in vertical section.

FIG. 1 is intended to illustrate the fact that, in the case of inclusion (s) in a helix, the pitch a, the diameter b and the section c of the cord which constitutes the helix can be varied; Figures 2 to 5 show inclusions respectively spiral, beads, horizontal rods and adjacent cones.

 The internal phase (A) may contain at least one active principle chosen, by way of non-limiting examples, from ultraviolet radiation filtering agents, natural or synthetic dyes, self-tanning agents, melanin pigments or precursors. melanin, slimming, antibacterial, antiperspirant, antifungal, antipsoriatic, anti-acneic, anti-inflammatory, soothing, anti-seborrhoeic agents, agents promoting regrowth and / or diminishing hair loss, vasodilating or rubbing agents, anti-dandruff agents, moisturizing agents and hair conditioning agents.

 Furthermore, each of the phases (A) and (B) of the composition may be in the form of an aqueous formulation, thickened or gelled, a water-in-oil or water-in-oil emulsion or a dispersion aqueous vesicles consisting of ionic or nonionic lipid layers encapsulating an aqueous phase. Such vesicles are well known and prepared from a lipid phase comprising at least one ionic and / or nonionic amphiphilic lipid optionally associated with at least one stabilizing additive, and they contain an encapsulated aqueous phase, which may contain products cosmetically active agents such as those described above. The lipid phase of the vesicles may also contain active agents such as those described above.

fI n est une valeur statistique moyenne comprise
entre 2 et 6 " R représents
(a) une chaîne aliphatique, linéaire ou
ramifiée, saturée ou insaturée, contenant de
12 à 18 atomes de carbone
(b) un reste R1CO, où R1 est un radical
aliphatique, linéaire ou ramifié, en
C11-C17;
(c) un reste R-[-OC2H3(R3)-]-, où
. R peut prendre la signification (a) ou
(b) donnée pour R ;
.OC2H3(R3)- est représenté par les
structures suivantes, prises en mélange
ou séparément

Among the nonionic lipids that may be used, mention may be made
(1) polyglycerol ethers, linear or branched, of
formula
R 0 - [- C3H5 (OHO -] - H
in which
-C3H5 (OH) O is represented by the structures
following taken as a mixture or separately

fI n is a mean statistical value included
between 2 and 6 "R represent
(a) an aliphatic chain, linear or
branched, saturated or unsaturated, containing
12 to 18 carbon atoms
(b) a radical R1CO, where R1 is a radical
aliphatic, linear or branched, in
C11-C17;
(c) a remainder R - [- OC2H3 (R3) -] -, where
. R can take the meaning (a) or
(b) given for R;
.OC2H3 (R3) - is represented by the
following structures, mixed
or separately

where R3 takes the meaning (a) given
for RO (2) the polyoxyethylenated fatty alcohols; (3) optionally polyoxyethylenated polyol esters (4) cerebrosides; and (5) oxyethylenated polyglycerol stearate.

Among the ionic amphiphilic lipids that may be used, mention may be made
phosphoaminolipids;
glycolipids;
natural phospholipids, such as lecithin
egg or soya, sphingomyêline, phosphati
dylserine, dipalmitoylphosphatidylcholine and
hydrogenated lecithins.

 The stabilizing additive is intended, in a known manner, to modify the permeability and / or the surface charge of the vesicles. It is preferably selected from the group consisting of sterols and anionic stabilizers. The sterol is advantageously cholesterol. The anionic stabilizer is advantageously chosen, on the one hand, from the monosodium or disodium salts of (C 14 -C 22) acyl-glutamates, such as the monosodium salt of N-stearoyl-glutamic acid, the disodium salts with acyl radicals of cocoyl and tallow or the cocoyl and stearoyl radicals, and, secondly, among the phosphoric esters of C12-C22 fatty alcohols. In a known manner, it is possible to add to the amphiphilic lipid (s) both a sterol and an anionic stabilizer.

 According to a particular embodiment of the present invention, the internal phase (A) is an oil-in-water emulsion or an aqueous dispersion, if appropriate thickened, of vesicles consisting of ionic or nonionic lipid layers, and the outer phase (B) is a gelled aqueous composition.

 In the case where one of the phases (A) or (B) is thickened, the (or) thickening agent (s) used for this purpose is (or are) chosen (s) in the crosslinked polyacrylic acids, for example those sold under the name "CARBOPOL", cellulose derivatives, for example hydroxypropylcellulose, carboxymethylcellulose, hydroxyethylcellulose, hydroxypropylmethylcellulose, gums such as gum carbohydrate, xanthan, sclo.'rogiucans and the like, mixtures of cetylstearyl alcohol and oxyethylenated cetylstearyl alcohol (for example, with 33 moles of ethylene oxide), the acrylamide copolymers; sodium acrylate and vinylpyrrolidone / vinyl acetate copolymers or their mixture. This (where) thickening agent (s) is (or is) present generally at a level of from 0.1 to 10% by weight and preferably from 0.2 to 5% by weight relative to to the total weight of phase (A) and / or phase (B), which is thickened.

 Moreover, the phase (A) and / or the phase (B) may contain at least one usual additive, chosen in particular from the group formed by surfactants, cosmetically or pharmaceutically acceptable solvents, emollients, perfumes. , pH modifiers, preservatives and sequestering agents.

 The present invention also relates to a topical treatment method, according to which a concentration composition is applied in active principle (s) variable during use in a crescent or increasing direction, characterized by the fact that takes the composition from a dispensing device as defined above.

 To manufacture the device according to the invention, it is possible to use any machine known for injecting into a gel, for example transparent, inclusions of another substance, for example a colored product. It is possible, among other things, to use the machine as described in French Pat. No. 2,634,686, comprising a turntable intended to receive a jar for containing a gel and the inclusion product, and means for injecting the jelly product. inclusion in the pot, with the possibility of relative movement, between the tray and said means for injecting the product, in a direction substantially orthogonal to the tray.

 To better understand the object of the invention will now be described, as purely illustrative and non-limiting examples, several modes of implementation.

EXAMPLE 1
A cylindrical distributor containing a sun cream whose protection index will vary in a decreasing manner as samples and applications are prepared is prepared. For this purpose, the cream comprises an internal phase (A) arranged along a cord of constant section helically shaped, the diameter of the helix being decreasing from the top to the bottom of the dispenser, as shown in FIG. external phase 6B). The weight ratio of the phases (A) and (B) is 15/85. Each of the phases is formulated as follows:
Internal phase (A)
A mixture of cetylstearyl alcohol and cetylstearyl alcohol oxyethylenated with 33 moles of ethylene oxide sold by HENKEL under the name "SINNOtAX AO" .................. .. 10 g
Mineral oil ......................... 12 g
Stearyl alcohol .................... 2 g of 2-ethylhexyl dimethylaminobenzoate sold by the company VAN DYK under the name "ESCALOL 507" 2,5 2-ethylhexyl-p-methoxycinnamate, sold by GIVAUDAN under the name "PARSOL MCX" ............ 1.5 g
Conservative ............................ qs

Water ................................. q, sp 100 g
Viscosity at 250C measured with the device "Conlfraves module 4": 50 Pascal-s spontaneous pH 6.7
External phase (B)
Crosslinked polyacrylic acid sold by GOODRICH under the name "CARBOPOL 940" ........................ 1.8 g
2-hydroxy-4-methoxybenzophenone sulfonic acid-5 sold by the company BASF under the name "UVINUL MS 40" .......... 5 g
Triethanolamine .................... qs ........ pH = 7
Conservative ..................................... qs

Water ........................................ qs 100 g
Viscosity 25 C measured on the device "Contraves module 4": 70 Pascal-s
The inner dimensions of the dispenser are as follows: height: 100mm, diameter: 36mm.The blade has a constant diameter of 35mm and a pitch that varies from 10 mm to 2 mm. The proof index, for a 1 mm thick check, varies from 10 to 4 of the upper part at the bottom of the dispenser.

 There was no redness or sunburn on the treated skin throughout the treatment period.

EXAMPLE 2
A dispenser containing an antidandruff cream is prepared, the concentration of active agent decreases as samples and applications. For this purpose, the cream comprises pearl inclusions, arranged as shown in FIG. 3, with an internal phase (A) consisting of an aqueous dispersion of nonionic lipid layer vesicles containing the active agent, in a single phase. external (B). The weight ratio of phase (A) to phase (B) is 10/90.

dans laquelle
o -C3HS(OH)O- est constitué par un mélange
de radicaux :

-O-C2H3(R) = est constitué par un mélange
de radicaux

Each phase is formulated as follows:
Internal phase (A)
Nonionic lipid of formula

in which
o -C3HS (OH) O- is constituted by a mixture
of radicals:

-O-C2H3 (R) = is constituted by a mixture
of radicals

n is a mean statistical value equal to 6
R is a mixture of radicals C14H29 and C16H33
6 g
Cholesterol ............... l, 6 g
Crosslinked polyacrylic acid sold by the company GOODRICH under the name "CARBOPOL 940" ................. 1 g
Ethanolamine salt of 1-hydroxy-methyl-4 (2,4,4-trimethyl-pentyl) -6 (1H) -pyridinone-2 sold by HOECHST under the name "OCTOPIROX" ........ ................ 1 g
Amino-2-methyl-2-propanol-1 ...... qs ... pH = 8
Water .......................... qsp ... 100 g
Viscosity 250C measured with the device "Contraves module 4": 50 Pascal-s
External phase (B)
Crosslinked polyacrylic acid sold by GOODRICH under the name "CARBOPOL 940t" ........................ 1.2 g
Vinylpyrrolidone / vinyl acetate copolymer (65/35 by weight) sold by BASF under the name "LUVISKOL VA 64" ........................ .... 2.5 g
Hydroxypropylcellulose .......................... 0.5 g
2-Hydroxy-4-methoxybenzophenone-5-sulfonic acid sold by the BASF Company under the name "Uvinul MS 40" ......................... .. 0.05 g
Triethanolamine ................... qs ....... pH = 7.5
Dye, sequestering .......... qs

Water g qsp .......... 100 g
Viscosity 25 C measured on the device "Contraves module 4": 75 Pascal-s
The internal dimensions of the dispenser are as follows: height: 100 mm; ; diameter: 36, mm. The distribution of the phase A beads is made on lines parallel to the axis of the distributor, regularly distributed over the entire section of the dispenser. On each line, the distance of two successive beads varies from 2 mm to 10 mm when going from the top to the bottom of the dispenser.

 This cream was applied to the scalp daily after shampooing, with a total of 40 applications; each application corresponds to the removal of a 2.5 mm layer over the entire surface of the straight section of the dispenser. A gradual disappearance of dandruff has been observed.

EXAMPLE 3
A dispenser is prepared containing a slimming cream, the concentration of active agent decreases as sampling and applications. For this purpose, the cream comprises spiral inclusions arranged as shown in FIG. 2, of an internal phase (A) constituted by an aqueous dispersion of nonionic lipid-layer vesicles containing the active agent, in an external phase. (B). The weight ratio of phase (A) to phase (B) is 10/90.

dans laquelle
o -C3H5(OH)O- est constitué par un melange
de radicaux

o -O-C2H3(R)- est constitué par un mélange
de radicaux

fI n est une valeur statistique moyenne égale à 6
# R est un mélange de radicaux C14H29 et Cl6H33
6 g
Cholestérol ........................... 1,6 g
Acide polyacrylique réticule, vendu par la Société GOODRICH sous la dénomination "CARBOPOL 940" ................ 1 g
Nicotinate de méthyle ................... 1 g
Amino-2 méthyl-2 propanol-l ....... q.s. .. pH = 7,5
Eau ....................... q.s.p 100 g
Viscosité 25 C mesurée à l'appareil "Contraves module 4" : 50 Pascal-s
Phase externe (B)
Acide polyacrylique réticulé, vendu par la Société GOODRICH sous la dénomination "CARBOPOL 940" ................ 1,2 g
Copolymère vinylpyrrolidone/acétate de vinyle (65/35 en poids), vendu par la Société BASF sous la dénomination "LUVISKOL VA 64" ................................. 2.5 g
Hydroxypropylcellulose ........................... 0.5 g
Acide hydroxy-2 methoxy-4 benzophénone-sulfonique-5, vendu par la Société BASF sous la dénomination "UVIMUL MS 40" ................................... 0.05 g
Triéthanolamine ............... q.s. ........... pH = 7.5
Colorant, séquestrant ........... q.s.Each phase is formulated as follows:
Internal phase (A)
Nonionic lipid of formula

in which
o -C3H5 (OH) O- is constituted by a mixture
of radicals

o -O-C2H3 (R) - is a mixture
of radicals

fI n is a mean statistical value equal to 6
# R is a mixture of radicals C14H29 and Cl6H33
6 g
Cholesterol ........................... 1.6 g
Reticular polyacrylic acid, sold by the company GOODRICH under the name "CARBOPOL 940" ................ 1 g
Methyl Nicotinate ................... 1 g
Amino-2-methyl-2-propanol-1 ....... qs .. pH = 7.5
Water ....................... qs 100 g
Viscosity 25 C measured on the device "Contraves module 4": 50 Pascal-s
External phase (B)
Crosslinked polyacrylic acid sold by GOODRICH under the name "CARBOPOL 940" ............ 1.2 g
Vinylpyrrolidone / vinyl acetate copolymer (65/35 by weight), sold by BASF under the name "LUVISKOL VA 64" ....................... .......... 2.5 g
Hydroxypropylcellulose ........................... 0.5 g
2-hydroxy-4-methoxybenzophenone-sulfonic acid-5, sold by BASF under the name "UVIMUL MS 40" ........................ ........... 0.05 g
Triethanolamine ............... qs ........... pH = 7.5
Dye, sequestering ........... qs

Water ....................... qs ............... 100 g
Viscosity 25 C measured on the device "Contraves module 4": 75 Pascal-s
The internal dimensions of the dispenser are the same as for example 2. The diameter of the spiral decreases from 35 mm to 10 mm when going from the top to the bottom of the dispenser.

 This cream was applied to areas of skin to be treated once a day, with a total of 20 applications, each application corresponding to the removal of a 5 mm thick layer over the entire cross section of the dispenser. A decrease in excess fat and / or cellulite has been observed.

EXAMPLE 4
A dispenser containing an anti-inflammatory cream is prepared, the concentration of active agent decreases as samples and applications. For this purpose, the cream comprises a helical inclusion, arranged as shown in FIG. 2, of an internal phase (A) consisting of an aqueous dispersion of nonionic lipid layer vesicles containing the active agent, in a single phase. external (B). The weight ratio of phase (A) to phase (B) is 15/85.

formule où n est une valeur statistique moyenne égale à 3 et où -C3H5(OH)O- est représenté par les structures suivantes prises en mélange ou séparément

Each phase is formulated as follows:
Internal phase (A)
Nonionic lipid of formula

formula where n is a mean statistical value equal to 3 and where -C3H5 (OH) O- is represented by the following structures taken as a mixture or separately

....... 7.6 g
Cholesterol ................................ 7.6 g
Dicetylphosphate .............................. 0.8 g
Betamethasone Valerate-17 ................................. 1 g
Water ....................... qs ............... 100 g
Viscosity 25 C measured on the device "Contraves module 4": 40 Pascal-s spontaneous pH .............................. ......... 5.5
External phase (B)
Crosslinked polyacrylic acid sold by GOODRICH under the name "CARBOPOL 940" ............. 1.2 g
Vinylpyrrolidone / vinyl acetate copolymer (65/35 by weight), sold by BASF under the name "LUVISKOL VA 64" ....................... ............. 2.5 g
Hydroxypropylcellulose .............................. 0.5 g
Triethanolamine ................ qs ........... pH = 7.5
Conservative, sequestering ....... qs

Water .................... qsp ........ 100 g
Viscosity 25 C measured on the device "Contraves module 4": 75 Pascal-s
The internal dimensions of the dispenser are the same as for example 2. The propeller has a diameter, which varies from 35mm at the top of the dispenser to 10mm at the bottom of the dispenser; the pitch of the propeller varies from 2mm at the top of the dispenser to 10mm at the bottom of the dispenser; all these variations are linear.

 This cream was applied to irritated skin daily, with a total of 4U applications; each application corresponds to a sampling of a 2.5mm layer over the entire cross section of the dispenser. There has been a gradual disappearance of redness.

formule où est une valeur statistique moyenne égale à 3 et ou -C3H5(0H)F est représenté par les structures suivantes prises en mélange ou séparément

EXAMPLE 5
A dispenser containing an anti-inflammatory cream is prepared, the concentration of active agent decreases as samples and applications. For this purpose, the cream comprises pearl inclusions, arranged as shown in FIG. 3, of an internal phase (A) constituted by an aqueous dispersion of nonionic lipid layer vesicles containing the active agent, in a single phase. external (B) .The weight ratio of phase (A) to phase (B) is 15/85
Each phase is formulated as follows:
Internal phase (A)
Nonionic lipid of formula

where is a mean statistical value equal to 3 and or -C3H5 (0H) F is represented by the following structures taken as a mixture or separately

7.6 g
Cholesterol; 7.6 g
Dicetylphosphate ............................ 0.8 g
Niflumic acid ................................ 0.5 g
Crosslinked polyacrylic acid sold by GOODRICH under the name "CARBOPOL 940" .................... 0.5 g
Amino-2-methyl-2-propanol-1 .. qs ............ pH = 7.5
Water ..................... qsp ............. 100 g
Viscosity 25 C measured on the device "Contraves module 4": 60 Pascal-s
External phase (B)
Crosslinked polyacrylic acid sold by GOODRICH under the name "CARBOPOL 940" ........................ 1.2 g
Vinylpyrrolidone / vinyl acetate copolymer (65/35 by weight), sold by BASF under the name "LWISKOL VA 64" ................... 2.5 g
Hydroxypropylcellulose ....................... 0.5 g
Conservative, sequestering ......................... qs

Triethanolamine .................... qs ............... pH = 7.5
Water ........................ qsp ..................... 100 g
Viscosity 25 C measured on the device "Contraves module 4": 75 Pascal-s
The internal dimensions of the dispenser are the same as for example 2. The distribution of the beads is the same as in example 2.

This cream was applied to irritated skin once a day, with a total of 40 applications; each application corresponds to the removal of a layer of 2.5 mm over the entire surface of the right section of the distributor;
There has been a gradual disappearance of redness.

EXAMPLE 6
A catena'nt = a soothing cream, the concentration of active agent will be decreasing as the samples and applications. For this purpose, the cream comprises inclusions, arranged as shown in FIG. 5, of an internal phase (A) consisting of an aqueous dispersion of nonionic lipid-sheet vesicles containing the active agent, in an external phase ( B). The weight ratio of phase (A) to phase (B) is 15/85.

dans laquelle
-C3H5(OH)O- est constitué par un
mélange de radicaux

-O-C2H3 (R) - est constitué par un
mélange de radicaux

Each phase is formulated as follows
Internal phase (A)
Nonionic lipid of formula

in which
-C3H5 (OH) O- is constituted by a
mixture of radicals

-O-C2H3 (R) - is constituted by a
mixture of radicals

o is a mean statistical value equal to 6
R is a mixture of radicals C14H29 and C16H33
... 12 g
Cholesterol ... 3.2 g
Crosslinked polyacrylic acid sold by GOODRICH under the name "CARBOPOL 940" ... 1 g a-Bisabolol ... 1 g
Amino-2-methyl-2-propanol-1 ... qs ... pH = 7
Water ... qsp ... 100 g
Viscosity 25 C measured on the device "Contraves Module 4": 50 Pascal-s
External phase (B)
Vinylpyrrolidone / vinyl acetate copolymer (65/35 wt.wt.), sold by BASF under the name "LUVISKOL VA 64" ... 2.5 g
Acrylamide / sodium acrylate copolymer sold by HOECHST under the name "HOSTACERIN PN 73" ... 0.75 g
2-Hydroxy-4-methoxybenzophenone-sulfonic acid-5 ... 0.05 g
Polydimethylsiloxane oxyethylenated with 66 moles of ethylene oxide, sold by the company TSCHIMMER & SCHWARZ under the name "SKINOTAN S10" ... 0.5 g
Dye, preservative ... qs

Water ... qsp ... 100 g
Viscosity 25 C measured on the device "Contraves module 4": 50 Pascal-s
spontaneous pH ... 6.5
The internal dimensions of the dispenser are as follows: height 66mm, diameter 4Omm; the diameter of the cones varies from 5mm to 0, imm.

 This cream has been applied to sun-erythema-treated skin 2 times a day, with a total of 20 applications. Each application corresponds to the removal of a 2.5mm layer over the entire cross-sectional area of the dispenser. There was a gradual disappearance of redness and a soothing effect.

EXAMPLE 7
A dispenser containing an anti-inflammatory cream is prepared, the concentration of active agent decreases as samples and applications. For this purpose, the cream comprises a spiral inclusion, arranged as shown in FIG. 2, of an internal phase (A) consisting of an aqueous dispersion of nonionic lipid layer vesicles containing the active agent, in a phase external (B). The weight ratio of phase (A) to phase (B) is 15/85.

dans laquelle
-C3H5(OH)O- est constitué par un mélange
de radicaux

-O-C2H3(R)- est constitué par un mélange de radicaux

n est une valeur statistique moyenne égale à 6 .R est un mélange de radicaux C14H29 et C16H33
12 g
Sel monosodique du glutamate de formule

dans laquelle R' est un mélange de radicaux alkényle et/ou alkyle en C13-C21 dérivé des acides gras du suif, vendu par la Société AJINOMOTO sous la dénomination commerciale "ACYLGLUTAMATE HS 11" ... 1,2 g
Sel d'ammonium de l'acide
B-glycyrrhétinique, glycoside ... 0,5 g
Eau ... q.s.p.... 100 g
Viscosité 250C mesurée à l'appareil "Contraves module" : 40 Pascal-s pH spontané ... 8
Phase externe (B)
Copolymère vinylpyrrolidone/acétate de vinyle (65/35 en poids), vendu par la Société BASF sous la dénomination "LUVISKOL VA 64" ... 2,5 g
Copolymère acrylamide/acrylate de sodium, vendu par la Société HOECHST sous la dénomination "HOSTACERIN PN 73" .... 0,75 g
Acide hydroxy-2 méthoxy-4 benzophénone-sulfonique-5 ... 0,05 g
Polydiméthylsiloxane oxyethyléné à 66 moles d'oxyde d'éthylène, vendu par la Société TSCHIMMER & SCHWARZ sous la dénomination "SKINOTAN S10" ... 0,5 g
Colorant, conservateur v q.s.Each phase is formulated as follows:
Internal phase (A):
Nonionic lipid of formula

in which
-C3H5 (OH) O- is constituted by a mixture
of radicals

-O-C2H3 (R) - consists of a mixture of radicals

n is a mean statistical value equal to 6 .R is a mixture of radicals C14H29 and C16H33
12 g
Monosodium salt of formula glutamate

in which R 'is a mixture of alkenyl and / or C13-C21 alkyl radicals derived from tallow fatty acids, sold by the company AJINOMOTO under the trade name "ACYLGLUTAMATE HS 11" ... 1.2 g
Ammonium salt of the acid
B-glycyrrhetinic, glycoside ... 0.5 g
Water ... qsp ... 100 g
Viscosity 250C measured with the device "Contraves module": 40 Pascal-s spontaneous pH ... 8
External phase (B)
Vinylpyrrolidone / vinyl acetate copolymer (65/35 by weight), sold by the company BASF under the name "LUVISKOL VA 64" ... 2.5 g
Acrylamide / sodium acrylate copolymer, sold by HOECHST under the name "HOSTACERIN PN 73" .... 0.75 g
2-Hydroxy-4-methoxybenzophenone-sulfonic acid-5 ... 0.05 g
Polydimethylsiloxane oxyethylenated with 66 moles of ethylene oxide, sold by the company TSCHIMMER & SCHWARZ under the name "SKINOTAN S10" ... 0.5 g
Dye, preservative v qs

Water ... qsp ... 100 g
Viscosity 250C measured with the device "Contraves module 4": 50 spontaneous Pascal-s 6.5
The internal dimensions of the distributor are the same as for example 1. The propeller arrangement and its dimensioning are the same as for example 1.

 This cream was applied to irritated skin 2 times a day, with a total of 10 applications; each application corresponds to the removal of a 5mm layer over the entire surface of the right section of the dispenser. There has been a gradual disappearance of redness.

Claims (14)

 1 - Device for dispensing a stable composition for cosmetic or pharmaceutical use  comprising, in a distributor, two viscous phases (A) and (B), immiscible, the so-called internal phase (A) being arranged in the form of at least one inclusion within the phase (B) ), said external, and containing at least one active principle, characterized in that the internal phase (A) is ordered within the external phase (B) so that a concentration gradient of (or ) principle (s) active (s) during the delivery of the composition at the output of said distribution device.  2 - Device according to claim 1, characterized in that the phases (A) and (B) have respectively 25 C viscosities T'A and t7B, such that  0.5 <#A <1.5 T'B  3 - Device according to one of claims 1 or 2, characterized in that the phases (A) and (B) of the composition respectively represent from 0.1 to 50% by weight and from 50 to 99.9% by weight. weight of the total composition, the weights PA and PB of the two phases being such that  PA  0.001 <<1  PB  4 - Device according to claim 3, characterized in that the phases (A) and (B) of the composition respectively represent 1 to 30% by weight and -70 to 99% by weight of the total composition, the PA weight and PB of the two phases being such that  PA  0.01 <- <0.42  PB  5 - Device according to one of claims 1 to 4, characterized in that the concentration of active principle (s) of (A) phase is constant, and that, to obtain the variation of the concentration gradient in active principle (s) during the distribution, the phase inclusions (A) are diversified in their form and / or size and / or distribution and / or number per unit volume within the phase. (B).  6 - Device according to one of claims 1 to 5, characterized in that the phase inclusions (A) are uniformly distributed within the phase (B), and that, to obtain the variation of the concentration gradient in principle (s) active during the distribution, the concentration in active principle (s) of phase (A) varies according to the inclusions.  7 - Device according to one of claims 1 to 6, characterized in that the phase inclusions (A) are arranged continuously or discontinuously in phase (B).  8 - Device according to one of claims 1 to 7, characterized in that the internal phase inclusions (A) are in the form of beads, beads, rods or cones whose dimensions and / or orientation within of the external phase (B), may be variable and which may be interconnected, or in the form of at least one continuous bead which may represent a helix or a spiral, the pitch and / or shape and / or the size of the turns can be variable, or in the form of arrangement (s) of straight or curved lines, or in the form of combinations of these various embodiments.  9 - Device according to claim 8, characterized in that the dispenser is constituted by a pot, a tube or a piston distributor, filled with the composition to be dispensed, which is distributed by successive samples, the inclusions being in the form of at least one spiral winding or variable pitch helix depending on the concentration gradient in principle (s) active (s) sought, of axis substantially parallel to the mean axis of the distributor or at least one cone d axis substantially parallel to the mean axis of the distributor, or in the form of rods arranged perpendicularly to the axis of the distributor, the distance between the rods successive planes varying according to the concentration gradient principle (s) active (s) desired, or in the form of beads or beads whose density and / or dimensions vary in successive planes or successive slices perpendicular to the mean axis of the distributor according to the gra the concentration in active principle (s) sought.  10 - Device according to one of claims 1 to 9, characterized in that the internal phase (A) rnfer-me - the-hands-a - pre-active-active selected from the group formed by the agents filtering ultraviolet radiation, natural or synthetic dyes, self-tanning agents, melanin pigments or melanin precursors, slimming, antibacterial, antiperspirant, antifungal, antipsoriatic, anti-acne, anti-inflammatory, soothing, anti-seborrhoeic, promoting agents regrowing and / or decreasing hair loss, vasodilating or rubbing agents, anti-dandruff agents, moisturizing agents and hair conditioning agents.  1 - Device according to one of claims 1 to 10, characterized in that at least one of the phases (A) and (B) of the composition is in the form of an aqueous formulation, thick or gelled, d an oil-in-water or water-in-oil emulsion or an aqueous dispersion of vesicles consisting of ionic or nonionic lipid layers encapsulating an aqueous phase.  12 - Device according to claim 11, characterized in that the internal phase (A) is an oil-in-water emulsion or an aqueous dispersion, thickened if appropriate, of vesicles consisting of lipidic or nonionic lipid sheets, and the outer phase (B) is a gelled aqueous composition.  13 - Device according to one of claims 11 or 12, wherein at least one of the phases (A) or (B) is thickened, characterized in that the (or) agent (s) thickener (s) used for this purpose is (or are) chosen from the group consisting of crosslinked polyacrylic acids, cellulose derivatives, gums, mixtures of cetylstearyl alcohol and of oxyethylenated cetylstearyl alcohol, acrylamide copolymers; sodium acrylate, vinylpyrrolidone / vinyl acetate copolymers and mixtures thereof.  14 - Device according to claim 13, characterized in that the (or) agent (s) thickener (s) is (or are) present (s) at a rate of 0.1 to 10% by weight relative to the weight total of phase (A) and / or (B), which is thickened.  15 - Device according to one of claims la 14, characterized in that the phase (A) and / or phase (B) contains (s) at least one additive selected from the group consisting of surfactants, cosmetically acceptable solvents, emollients, fragrances, pH modifiers, preservatives and sequestering agents.