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FI972185L - Aminoguanidiinikarboksylaatit insuliinista riippumaton diabeteksen hoitoon - Google Patents

Aminoguanidiinikarboksylaatit insuliinista riippumaton diabeteksen hoitoon Download PDF

Info

Publication number
FI972185L
FI972185L FI972185A FI972185A FI972185L FI 972185 L FI972185 L FI 972185L FI 972185 A FI972185 A FI 972185A FI 972185 A FI972185 A FI 972185A FI 972185 L FI972185 L FI 972185L
Authority
FI
Finland
Prior art keywords
insulin
treatment
diabetes mellitus
dependent diabetes
aminoguanidine
Prior art date
Application number
FI972185A
Other languages
English (en)
Swedish (sv)
Other versions
FI972185A7 (fi
FI972185A0 (fi
Inventor
Scott D Larsen
Valerie A Vaillancourt
Paul D May
Steven P Tanis
John A Tucker
Martin D Meglasson
Heinrich J Schostarez
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/484,547 external-priority patent/US5994577A/en
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of FI972185A7 publication Critical patent/FI972185A7/fi
Publication of FI972185A0 publication Critical patent/FI972185A0/fi
Publication of FI972185L publication Critical patent/FI972185L/fi

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C281/00—Derivatives of carbonic acid containing functional groups covered by groups C07C269/00 - C07C279/00 in which at least one nitrogen atom of these functional groups is further bound to another nitrogen atom not being part of a nitro or nitroso group
    • C07C281/16—Compounds containing any of the groups, e.g. aminoguanidine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C281/00—Derivatives of carbonic acid containing functional groups covered by groups C07C269/00 - C07C279/00 in which at least one nitrogen atom of these functional groups is further bound to another nitrogen atom not being part of a nitro or nitroso group
    • C07C281/16—Compounds containing any of the groups, e.g. aminoguanidine
    • C07C281/18—Compounds containing any of the groups, e.g. aminoguanidine the other nitrogen atom being further doubly-bound to a carbon atom, e.g. guanylhydrazones

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Obesity (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
FI972185A 1994-11-23 1995-11-13 Aminoguanidiinikarboksylaatit insuliinista riippumaton diabeteksen hoitoon FI972185L (fi)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US34427494A 1994-11-23 1994-11-23
US08/484,547 US5994577A (en) 1994-11-23 1995-06-07 Aminoguanidine carboxylates for the treatment of non-insulin-dependent diabetes mellitus
PCT/US1995/014126 WO1996016031A1 (en) 1994-11-23 1995-11-13 Aminoguanidine carboxylates for the treatment of non-insulin-dependent diabetes mellitus

Publications (3)

Publication Number Publication Date
FI972185A7 FI972185A7 (fi) 1997-05-22
FI972185A0 FI972185A0 (fi) 1997-05-22
FI972185L true FI972185L (fi) 1997-05-22

Family

ID=26993832

Family Applications (1)

Application Number Title Priority Date Filing Date
FI972185A FI972185L (fi) 1994-11-23 1995-11-13 Aminoguanidiinikarboksylaatit insuliinista riippumaton diabeteksen hoitoon

Country Status (24)

Country Link
US (2) US6166080A (fi)
EP (1) EP0793646B1 (fi)
JP (1) JPH10509455A (fi)
CN (2) CN1097580C (fi)
AT (1) ATE205188T1 (fi)
AU (1) AU705893B2 (fi)
BR (1) BR9509741A (fi)
CA (1) CA2202265A1 (fi)
CZ (1) CZ288597B6 (fi)
DE (2) DE793646T1 (fi)
DK (1) DK0793646T3 (fi)
EE (1) EE03392B1 (fi)
ES (1) ES2163531T3 (fi)
FI (1) FI972185L (fi)
GE (1) GEP20002026B (fi)
HU (1) HUT77133A (fi)
MX (1) MX9703807A (fi)
NO (1) NO308992B1 (fi)
NZ (1) NZ297604A (fi)
PL (1) PL184614B1 (fi)
PT (1) PT793646E (fi)
RU (1) RU2162462C2 (fi)
SK (1) SK282357B6 (fi)
WO (1) WO1996016031A1 (fi)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9526331D0 (en) * 1995-12-22 1996-02-21 Smithkline Beecham Plc Novel method
AU3117497A (en) 1996-05-21 1997-12-09 Pharmacia & Upjohn Company Aminoguanidine carboxylate lactams for the treatment of non-insulin-dependent diabetes mellitus
CA2280871A1 (en) * 1997-02-13 1998-08-20 Valerie Piercy Use of nitric oxide synthase inhibitors for the treatment of diabetes
US6001578A (en) * 1997-06-26 1999-12-14 Pharmacia & Upjohn Ab Methods of screening for modulators of uncoupling protein-2 (UCP-2) as potential treatments for obesity
SE9702457D0 (sv) * 1997-06-26 1997-06-26 Pharmacia & Upjohn Ab Screening
US6288124B1 (en) 1998-05-22 2001-09-11 Rima Kaddurah-Daouk Methods of inhibiting undesirable cell growth using an aminoguanidine compound
US6169115B1 (en) 1998-05-22 2001-01-02 Rima Kaddurah-Daouk Use of aminoguanidine analogs for the treatment of diseases of the nervous system
US6815421B1 (en) * 2001-03-22 2004-11-09 Osteopharm Inc. Polypeptides for use in ameliorating effects of aging in mammals
US8871527B2 (en) * 2008-04-29 2014-10-28 Becton, Dickinson And Company Method and system for measuring a sample to determine the presence of and optionally treat a pathologic condition
EP2303838B1 (en) * 2008-06-26 2013-12-04 Laboratorios Silanes, S.A. de C.V. A new metformin glycinate salt for blood glucose control
GB201300435D0 (en) * 2013-01-10 2013-02-27 Medical Res Council Benzylideneguanidine Derivatives and Therapeutic Use for the Treatment of Protein Misfolding Diseases
JP6121638B2 (ja) * 2015-04-23 2017-04-26 三菱瓦斯化学株式会社 ガス発生剤、及びそれを用いた発泡体の製造方法
US20170056352A1 (en) * 2015-08-25 2017-03-02 Rgenix, Inc. PHARMACEUTICALLY ACCEPTABLE SALTS OF beta-GUANIDINOPROPIONIC ACID WITH IMPROVED PROPERTIES AND USES THEREOF
WO2018160178A1 (en) 2017-03-01 2018-09-07 Rgenix, Inc. Pharmaceutically acceptable salts of b-guanidinopropionic acid with improved properties and uses thereof
IL293721A (en) 2019-12-11 2022-08-01 Inspirna Inc Methods of treating cancer

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3412105A (en) 1966-01-05 1968-11-19 American Home Prod beta-aryl-n-guanidino-beta-alanines
US3943253A (en) * 1974-06-27 1976-03-09 Barer Sol J Guanido acids as fungicides
JPS54128523A (en) 1978-03-29 1979-10-05 Nippon Carbide Ind Co Ltd 3-guanidinoamino propionic acid and its preparation
US5272165A (en) * 1984-03-19 1993-12-21 The Rockefeller University 2-alkylidene-aminoguanidines and methods of use therefor
US4758583A (en) * 1984-03-19 1988-07-19 The Rockefeller University Method and agents for inhibiting protein aging
US5130324A (en) * 1984-03-19 1992-07-14 The Rockefeller University 2-alkylidene-aminoguanidines and methods of use therefor
IT1201511B (it) 1985-12-23 1989-02-02 Italfarmaco Spa Derivati citoprotettivi in patologie a base ischemica,loro preparazione e composizioni che li cntengono
US5059712A (en) 1989-09-13 1991-10-22 Cornell Research Foundation, Inc. Isolating aminoarginine and use to block nitric oxide formation in body
GB9200114D0 (en) * 1992-01-04 1992-02-26 Scras Dual inhibitors of no synthase and cyclooxygenase

Also Published As

Publication number Publication date
ATE205188T1 (de) 2001-09-15
AU705893B2 (en) 1999-06-03
AU4279696A (en) 1996-06-17
EE9700094A (et) 1997-10-15
GEP20002026B (en) 2000-04-10
US6329545B1 (en) 2001-12-11
CN1377642A (zh) 2002-11-06
JPH10509455A (ja) 1998-09-14
SK282357B6 (sk) 2002-01-07
HUT77133A (hu) 1998-03-02
MX9703807A (es) 1997-08-30
WO1996016031A1 (en) 1996-05-30
CA2202265A1 (en) 1996-05-30
FI972185A7 (fi) 1997-05-22
FI972185A0 (fi) 1997-05-22
DE69522580D1 (de) 2001-10-11
CZ136997A3 (cs) 1998-02-18
NO308992B1 (no) 2000-11-27
CZ288597B6 (cs) 2001-07-11
CN1164226A (zh) 1997-11-05
PL184614B1 (pl) 2002-11-29
BR9509741A (pt) 1997-10-21
RU2162462C2 (ru) 2001-01-27
CN1097580C (zh) 2003-01-01
EP0793646B1 (en) 2001-09-05
PT793646E (pt) 2002-03-28
NO972346D0 (no) 1997-05-22
NZ297604A (en) 2000-07-28
DE793646T1 (de) 1999-12-30
EE03392B1 (et) 2001-04-16
SK64097A3 (en) 1997-11-05
NO972346L (no) 1997-07-23
EP0793646A1 (en) 1997-09-10
DK0793646T3 (da) 2001-12-17
PL320361A1 (en) 1997-09-29
ES2163531T3 (es) 2002-02-01
US6166080A (en) 2000-12-26
DE69522580T2 (de) 2002-10-10

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