[go: up one dir, main page]

IT1201511B - Derivati citoprotettivi in patologie a base ischemica,loro preparazione e composizioni che li cntengono - Google Patents

Derivati citoprotettivi in patologie a base ischemica,loro preparazione e composizioni che li cntengono

Info

Publication number
IT1201511B
IT1201511B IT23373/85A IT2337385A IT1201511B IT 1201511 B IT1201511 B IT 1201511B IT 23373/85 A IT23373/85 A IT 23373/85A IT 2337385 A IT2337385 A IT 2337385A IT 1201511 B IT1201511 B IT 1201511B
Authority
IT
Italy
Prior art keywords
methyl
hydrogen
group
formula
citoprotective
Prior art date
Application number
IT23373/85A
Other languages
English (en)
Other versions
IT8523373A0 (it
Inventor
Giancarlo Sporletti
Pietro Cremonesi
Monique Sarret
Original Assignee
Italfarmaco Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Italfarmaco Spa filed Critical Italfarmaco Spa
Publication of IT8523373A0 publication Critical patent/IT8523373A0/it
Priority to IT23373/85A priority Critical patent/IT1201511B/it
Priority to JP61306184A priority patent/JPS62158249A/ja
Priority to US06/944,949 priority patent/US4789681A/en
Priority to DE8686117895T priority patent/DE3677943D1/de
Priority to AT86117895T priority patent/ATE61347T1/de
Priority to EP86117895A priority patent/EP0230037B1/en
Priority to ES86117895T priority patent/ES2020508B3/es
Priority to CA000526235A priority patent/CA1284646C/en
Application granted granted Critical
Publication of IT1201511B publication Critical patent/IT1201511B/it
Priority to GR91400552T priority patent/GR3001879T3/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/88—Nitrogen atoms, e.g. allantoin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
IT23373/85A 1985-12-23 1985-12-23 Derivati citoprotettivi in patologie a base ischemica,loro preparazione e composizioni che li cntengono IT1201511B (it)

Priority Applications (9)

Application Number Priority Date Filing Date Title
IT23373/85A IT1201511B (it) 1985-12-23 1985-12-23 Derivati citoprotettivi in patologie a base ischemica,loro preparazione e composizioni che li cntengono
AT86117895T ATE61347T1 (de) 1985-12-23 1986-12-22 Zytoprotektive derivate zur anwendung bei ischaemischen erkrankungen, ihre herstellung und sie enthaltende zusammensetzungen.
US06/944,949 US4789681A (en) 1985-12-23 1986-12-22 Cytoprotective guanidine derivatives useful in ischemic diseases
DE8686117895T DE3677943D1 (de) 1985-12-23 1986-12-22 Zytoprotektive derivate zur anwendung bei ischaemischen erkrankungen, ihre herstellung und sie enthaltende zusammensetzungen.
JP61306184A JPS62158249A (ja) 1985-12-23 1986-12-22 抗虚血剤およびその製法
EP86117895A EP0230037B1 (en) 1985-12-23 1986-12-22 Cytoprotective derivatives useful in ischemic diseases, their preparation and compositions containing them
ES86117895T ES2020508B3 (es) 1985-12-23 1986-12-22 Derivados citoprotectores utiles para enfermedades isquemicas, su preparacion y composiciones que los contienen.
CA000526235A CA1284646C (en) 1985-12-23 1986-12-23 Cytoprotective derivatives useful in ischemic diseases, their preparation and compositions containing them
GR91400552T GR3001879T3 (en) 1985-12-23 1991-04-29 Cytoprotective derivatives useful in ischemic diseases, their preparation and compositions containing them

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT23373/85A IT1201511B (it) 1985-12-23 1985-12-23 Derivati citoprotettivi in patologie a base ischemica,loro preparazione e composizioni che li cntengono

Publications (2)

Publication Number Publication Date
IT8523373A0 IT8523373A0 (it) 1985-12-23
IT1201511B true IT1201511B (it) 1989-02-02

Family

ID=11206518

Family Applications (1)

Application Number Title Priority Date Filing Date
IT23373/85A IT1201511B (it) 1985-12-23 1985-12-23 Derivati citoprotettivi in patologie a base ischemica,loro preparazione e composizioni che li cntengono

Country Status (9)

Country Link
US (1) US4789681A (it)
EP (1) EP0230037B1 (it)
JP (1) JPS62158249A (it)
AT (1) ATE61347T1 (it)
CA (1) CA1284646C (it)
DE (1) DE3677943D1 (it)
ES (1) ES2020508B3 (it)
GR (1) GR3001879T3 (it)
IT (1) IT1201511B (it)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5770623A (en) * 1989-09-13 1998-06-23 Board Of Regents, The University Of Texas System Argine antagonists for inhibition of systemic hypotension associated with nitric oxide production or endothelial derived relaxing factor
US5028627A (en) * 1989-09-13 1991-07-02 Cornell Research Foundation, Inc. Method of using arginine derivatives to inhibit systemic hypotension associated with nitric oxide production or endothelial derived relaxing factor
GB8929076D0 (en) * 1989-12-22 1990-02-28 Scras Treatment of shock by blocking agents of edrf effect or formation
US5710324A (en) * 1990-02-26 1998-01-20 Merrell Pharmaceuticals Inc. Inhibitors of nitric oxide biosynthesis
CA2036770C (en) * 1990-02-26 2003-09-09 Jeffrey P. Whitten Inhibitors of nitric oxide biosynthesis
US5318992A (en) * 1990-02-26 1994-06-07 Merrell Dow Pharmaceuticals Inc. Inhibitors of nitric oxide biosynthesis
US5585402A (en) * 1992-12-23 1996-12-17 Glaxo Wellcome Inc. Nitric oxide synthase inhibitors
WO1994026261A1 (en) * 1993-05-14 1994-11-24 Amira, Inc. Treating body parts susceptible to ischemia using creatine analogs
GB9312761D0 (en) * 1993-06-21 1993-08-04 Wellcome Found Amino acid derivatives
PT793646E (pt) 1994-11-23 2002-03-28 Biovitrum Ab Carboxilatos de aminoguanidina destinados ao tratamento de diabetes mellitus nao-insulinodependente
WO1996018607A1 (en) * 1994-12-12 1996-06-20 Chugai Seiyaku Kabushiki Kaisha Aniline derivative having the effect of inhibiting nitrogen monoxide synthase
DE19544686A1 (de) * 1995-11-30 1997-06-05 Thomae Gmbh Dr K Aminosäurederivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
DE19544685A1 (de) * 1995-11-30 1997-06-05 Thomae Gmbh Dr K Aminosäurederivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
AU3117497A (en) 1996-05-21 1997-12-09 Pharmacia & Upjohn Company Aminoguanidine carboxylate lactams for the treatment of non-insulin-dependent diabetes mellitus
WO2000010546A2 (en) * 1998-08-25 2000-03-02 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. D-arginine for the treatment of neorodegenerative diseases
CA2587444C (en) * 2004-11-12 2013-09-10 Ucl Business Plc Guanidine derivatives as inhibitors of ddah
CN109593052B (zh) * 2018-11-20 2021-04-20 首都医科大学 用于诊断和治疗的放射性精氨酸衍生物及其制备方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1195303B (de) * 1964-04-16 1965-06-24 Bayer Ag Verfahren zur Herstellung von tetracyclischen und pentacyclischen Triterpenamidino-hydrazonen
US3576844A (en) * 1966-10-13 1971-04-27 Sumitomo Chemical Co N-alkoxycarbonyl-aminoalkyl guanidines
FR2390954A1 (fr) * 1976-10-13 1978-12-15 Choay Sa Nouvelles guanylhydrazones, leurs procedes de preparation et medicaments les contenant
IT1127321B (it) * 1979-12-28 1986-05-21 Italfarmaco Spa Composizione farmaceutiche aventi specifiche proprieta' terapeutiche nei confronti dell'edema polmonare acuto,di alcuni stati di shock e dell'iperfibrinolisi
IT1127322B (it) * 1979-12-28 1986-05-21 Italfarmaco Spa Composizioni farmaceutiche con esaltazione dell'attivita' terapeutica di cortisonici
US4477429A (en) * 1982-08-26 1984-10-16 Johnson & Johnson Products, Inc. Oral compositions comprising N.sup.α -alkyl derivatives of arginine
US4499068A (en) * 1982-08-26 1985-02-12 Johnson & Johnson Products, Inc. Oral compositions comprising NG -alkyl derivatives of arginine

Also Published As

Publication number Publication date
IT8523373A0 (it) 1985-12-23
ATE61347T1 (de) 1991-03-15
EP0230037B1 (en) 1991-03-06
JPS62158249A (ja) 1987-07-14
CA1284646C (en) 1991-06-04
US4789681A (en) 1988-12-06
GR3001879T3 (en) 1992-11-23
EP0230037A1 (en) 1987-07-29
ES2020508B3 (es) 1991-08-16
DE3677943D1 (de) 1991-04-11

Similar Documents

Publication Publication Date Title
IT1201511B (it) Derivati citoprotettivi in patologie a base ischemica,loro preparazione e composizioni che li cntengono
ATE175958T1 (de) Farnesyl-transferase-inhibitoren, ihre herstellung und sie enthaltende pharmazeutische zusammensetzungen
LU91196I2 (fr) Picoxystrobin et ses dérivlés pharmaceutiquement acceptables(ACANTO).
MX9203165A (es) Derivados de succinimida y composicion farmaceutica que los contiene .
DE3781716D1 (de) Mittel zur ortsspezifischen alkylierung.
YU164791A (sh) Nezasićene hidroksialkilhinolin kiseline
AU2910600A (en) Phenyl urea and phenyl thiourea derivatives
ES2082780T3 (es) Derivados de acido bisfosfonico heterociclicos.
SE8302694L (sv) Immunomudulerande medel
KR860005794A (ko) 이미다졸 유도체의 제조방법
ATE109770T1 (de) Derivate der coffeinsäure und pharmazeutische zusammensetzungen, die sie enthalten.
ES2163617T3 (es) Derivados antiinflamatorios de acido benzoico.
ES8601897A1 (es) Un metodo de preparar derivados de 4-quinolona
ATE202103T1 (de) 6-azaindole-hemmer der tromboxan-synthetase
ATE38675T1 (de) Phosphatesterderivate und ihre verwendung als anti-krebsmittel.
BG102429A (en) Derivatives of 5-naphthalen-1-yl-1,3-dioxan, their preparation and usage as therapeutical means
ES2067601T3 (es) Derivados de arilpirazoles como inhibidores de la agregacion de plaquetas.
ES2082971T3 (es) Esteres de fosfato de acilo y modificacion de proteinas con los mismos.
ES8207543A1 (es) Un procedimiento para la preparacion de nuevos derivados heterotriciclicos jaula.
KR860004040A (ko) 3,4-디아졸 유도체의 제조방법
ES2058182T3 (es) Analogos de mitomicina. un procedimiento para su preparacion y composiciones farmaceuticas.
IT1276161B1 (it) Derivati dell'acido fosfonico ad attivita' inibitrice delle metallopeptidasi
IT1205114B (it) 2-selenometil-1,4-diidropiridine,procedimento per la loro preparazione e composizioni farmaceutiche che le contengono
ES406298A1 (es) Un procedimiento para la preparacion de un compuesto acilo-xialquilheterociclico.
MY104048A (en) New allylaminoethylazoles.