FI971037L - Multivesikulääristen liposomien valmistus aktiivisten aineiden vapauttamiseksi kontrolloidusti - Google Patents
Multivesikulääristen liposomien valmistus aktiivisten aineiden vapauttamiseksi kontrolloidusti Download PDFInfo
- Publication number
- FI971037L FI971037L FI971037A FI971037A FI971037L FI 971037 L FI971037 L FI 971037L FI 971037 A FI971037 A FI 971037A FI 971037 A FI971037 A FI 971037A FI 971037 L FI971037 L FI 971037L
- Authority
- FI
- Finland
- Prior art keywords
- preparation
- active ingredients
- controlled release
- multivesicular liposomes
- multivesicular
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
- A61K9/1277—Preparation processes; Proliposomes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/829—Liposomes, e.g. encapsulation
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Dispersion Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Manufacturing Of Micro-Capsules (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US30515894 | 1994-09-13 | ||
| US08/305,158 US5993850A (en) | 1994-09-13 | 1994-09-13 | Preparation of multivesicular liposomes for controlled release of encapsulated biologically active substances |
| PCT/US1995/011609 WO1996008235A1 (en) | 1994-09-13 | 1995-09-13 | Preparation of multivesicular liposomes for controlled release of active agents |
| US9511609 | 1995-09-13 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| FI971037A0 FI971037A0 (fi) | 1997-03-12 |
| FI971037L true FI971037L (fi) | 1997-05-12 |
| FI119621B FI119621B (fi) | 2009-01-30 |
Family
ID=23179585
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI971037A FI119621B (fi) | 1994-09-13 | 1997-03-12 | Multivesikulääristen liposomien valmistus aktiivisten aineiden vapauttamiseksi kontrolloidusti |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US5993850A (fi) |
| EP (1) | EP0781123B1 (fi) |
| JP (1) | JP3026271B2 (fi) |
| KR (1) | KR100387561B1 (fi) |
| CN (1) | CN1096850C (fi) |
| AU (1) | AU697484B2 (fi) |
| BR (1) | BR9508913A (fi) |
| CA (1) | CA2199004C (fi) |
| DE (1) | DE69535297T2 (fi) |
| FI (1) | FI119621B (fi) |
| MX (1) | MX9701856A (fi) |
| NO (1) | NO323581B1 (fi) |
| NZ (2) | NZ292830A (fi) |
| WO (1) | WO1996008235A1 (fi) |
Families Citing this family (82)
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|---|---|---|---|---|
| US6558952B1 (en) * | 1992-12-14 | 2003-05-06 | Waratah Pharmaceuticals, Inc. | Treatment for diabetes |
| US5931809A (en) * | 1995-07-14 | 1999-08-03 | Depotech Corporation | Epidural administration of therapeutic compounds with sustained rate of release |
| US5997899A (en) * | 1996-10-01 | 1999-12-07 | Skyepharma Inc. | Method for producing liposomes with increased percent of compound encapsulated |
| KR19980067138A (ko) * | 1997-01-31 | 1998-10-15 | 박원훈 | 유전자 또는 생물학적 활성 약물을 세포내로 효과적으로 전달하는 지방 유제 및 그것의 제조방법 |
| US5891467A (en) * | 1997-01-31 | 1999-04-06 | Depotech Corporation | Method for utilizing neutral lipids to modify in vivo release from multivesicular liposomes |
| US6106858A (en) * | 1997-09-08 | 2000-08-22 | Skyepharma, Inc. | Modulation of drug loading in multivescular liposomes |
| US6306432B1 (en) * | 1997-09-08 | 2001-10-23 | Chiron Corporation | High and low load formulations of IGF-I in multivesicular liposomes |
| EP2308470A1 (en) | 1997-09-18 | 2011-04-13 | Pacira Pharmaceuticals, Inc. | Sustained-release liposomal anesthetic compositions |
| NZ504188A (en) * | 1997-11-14 | 2001-10-26 | Skyepharma Inc | Emulsification process for preparing multivesicular liposomes |
| EP1098610B1 (en) * | 1998-07-17 | 2009-04-15 | Pacira Pharmaceuticals, Inc. | Biodegradable compositions for the controlled release of encapsulated substances |
| US20040037818A1 (en) * | 1998-07-30 | 2004-02-26 | Brand Stephen J. | Treatment for diabetes |
| IL141095A0 (en) | 1998-08-19 | 2002-02-10 | Rtp Pharma Inc | Injectable aqueous dispersions of propofol |
| US20030059440A1 (en) * | 1998-09-01 | 2003-03-27 | Tim Clarot | Composition and method for moisturizing nasal tissue |
| US6740643B2 (en) * | 1999-01-21 | 2004-05-25 | Mirus Corporation | Compositions and methods for drug delivery using amphiphile binding molecules |
| CA2365847A1 (en) * | 1999-04-06 | 2000-10-12 | Gregg M. Duthaler | Methods for producing droplets for use in capsule-based electrophoretic displays |
| AUPQ259399A0 (en) | 1999-09-01 | 1999-09-23 | Lustre Investments Pte Ltd | Therapeutic agents |
| US6812217B2 (en) | 2000-12-04 | 2004-11-02 | Medtronic, Inc. | Medical device and methods of use |
| US6897196B1 (en) * | 2001-02-07 | 2005-05-24 | The Regents Of The University Of California | pH sensitive lipids based on ortho ester linkers, composition and method |
| DE10109897A1 (de) * | 2001-02-21 | 2002-11-07 | Novosom Ag | Fakultativ kationische Liposomen und Verwendung dieser |
| US20050156340A1 (en) | 2004-01-20 | 2005-07-21 | E Ink Corporation | Preparation of capsules |
| ATE373466T1 (de) * | 2001-11-13 | 2007-10-15 | Celator Pharmaceuticals Inc | Lipidträgerzusammensetzungen und verfahren zur verbesserten wirkstoffzurückhaltung |
| US20040082521A1 (en) * | 2002-03-29 | 2004-04-29 | Azaya Therapeutics Inc. | Novel formulations of digitalis glycosides for treating cell-proliferative and other diseases |
| KR20050037508A (ko) * | 2002-05-24 | 2005-04-22 | 와라타 파마수티컬즈, 인크. | 당뇨병의 치료 |
| US6998051B2 (en) * | 2002-07-03 | 2006-02-14 | Ferro Corporation | Particles from supercritical fluid extraction of emulsion |
| US6966990B2 (en) | 2002-10-11 | 2005-11-22 | Ferro Corporation | Composite particles and method for preparing |
| BR0315523A (pt) * | 2002-10-22 | 2005-08-30 | Waratah Pharmaceuticals Inc | Tratamento de diabetes |
| US20040229810A1 (en) * | 2002-10-22 | 2004-11-18 | Antonio Cruz | Gastrin compositions and formulations, and methods of use and preparation |
| US7718189B2 (en) | 2002-10-29 | 2010-05-18 | Transave, Inc. | Sustained release of antiinfectives |
| HUE025491T2 (en) * | 2002-10-29 | 2016-04-28 | Insmed Inc | Delayed release of anti-infective agents |
| US7179484B2 (en) * | 2002-11-06 | 2007-02-20 | Azaya Therapeutics, Inc. | Protein-stabilized liposomal formulations of pharmaceutical agents |
| US7083748B2 (en) * | 2003-02-07 | 2006-08-01 | Ferro Corporation | Method and apparatus for continuous particle production using supercritical fluid |
| US20060008531A1 (en) * | 2003-05-08 | 2006-01-12 | Ferro Corporation | Method for producing solid-lipid composite drug particles |
| US7416756B2 (en) | 2003-09-10 | 2008-08-26 | Eastman Chemical Company | Process for the recovery of a phytolipid composition |
| CN1315530C (zh) * | 2005-07-04 | 2007-05-16 | 重庆大学 | 蛋白质类药物控制释放系统制备方法 |
| US20070110674A1 (en) * | 2005-07-29 | 2007-05-17 | Yuhong Xu | Sono-active liposomes and lipid particles and use thereof as contrast agents and active-agent delivery systems |
| HUE029994T2 (en) | 2005-12-08 | 2017-04-28 | Insmed Inc | Lipid-based compositions of antiinfectives for treating pulmonary infections |
| CN101190183B (zh) * | 2006-11-29 | 2010-05-12 | 上海医药工业研究院 | 一种盐酸可乐定多泡脂质体及其制备方法 |
| WO2008137717A1 (en) * | 2007-05-04 | 2008-11-13 | Transave, Inc. | Compositions of multicationic drugs for reducing interactions with polyanionic biomolecules and methods and uses thereof |
| US9114081B2 (en) | 2007-05-07 | 2015-08-25 | Insmed Incorporated | Methods of treating pulmonary disorders with liposomal amikacin formulations |
| US9333214B2 (en) | 2007-05-07 | 2016-05-10 | Insmed Incorporated | Method for treating pulmonary disorders with liposomal amikacin formulations |
| US9119783B2 (en) | 2007-05-07 | 2015-09-01 | Insmed Incorporated | Method of treating pulmonary disorders with liposomal amikacin formulations |
| US20100102142A1 (en) * | 2008-10-28 | 2010-04-29 | Daria Tagliareni | Scent dispenser assembly |
| CN101756902B (zh) * | 2008-12-23 | 2011-10-05 | 上海医药工业研究院 | 一种可乐定多囊脂质体及其制备方法 |
| CN104959052B (zh) | 2010-04-09 | 2018-07-13 | 帕西拉制药有限公司 | 用于配制大直径合成膜囊泡的方法 |
| EP2394640A1 (en) * | 2010-05-21 | 2011-12-14 | MediGene AG | Improved liposomal formulations of lipophilic compounds |
| LT3243526T (lt) | 2010-07-06 | 2020-02-10 | Glaxosmithkline Biologicals S.A. | Rnr pristatymas, skirtas keleto imuninio atsako paleidimui |
| BR112013000244A2 (pt) | 2010-07-06 | 2016-05-17 | Novartis Ag | lipossomas com lipídeos apresentando pka vantajoso para administração de rna |
| PT2591114T (pt) | 2010-07-06 | 2016-08-02 | Glaxosmithkline Biologicals Sa | Imunização de mamíferos de grande porte com doses baixas de arn |
| EP4066857B1 (en) | 2010-08-31 | 2022-12-21 | GlaxoSmithKline Biologicals SA | Pegylated liposomes for delivery of immunogen-encoding rna |
| EP3520813B1 (en) | 2010-10-11 | 2023-04-19 | GlaxoSmithKline Biologicals S.A. | Antigen delivery platforms |
| ES2770575T3 (es) | 2010-10-28 | 2020-07-02 | Pacira Pharmaceuticals Inc | Formulación de liberación sostenida de un fármaco antiinflamatorio no esteroideo |
| JP2014510045A (ja) * | 2011-02-08 | 2014-04-24 | ハロザイム インコーポレイテッド | ヒアルロナン分解酵素の組成物および脂質製剤ならびに良性前立腺肥大症の治療のためのその使用 |
| JP6320912B2 (ja) * | 2011-03-25 | 2018-05-09 | セレクタ バイオサイエンシーズ インコーポレーテッドSelecta Biosciences,Inc. | 浸透圧媒介性放出合成ナノ担体 |
| US11896636B2 (en) | 2011-07-06 | 2024-02-13 | Glaxosmithkline Biologicals Sa | Immunogenic combination compositions and uses thereof |
| US10722458B2 (en) | 2011-12-02 | 2020-07-28 | Pegasus Laboratories, Inc. | Amphipathic lipid-based sustained release compositions |
| WO2013082470A1 (en) * | 2011-12-02 | 2013-06-06 | Pegasus Laboratories, Inc. | Amphipathic lipid-based sustained release compositions |
| RU2678433C2 (ru) | 2012-05-10 | 2019-01-29 | Пейнреформ Лтд. | Депо-составы гидрофобного активного ингредиента и способы их получения |
| SI2852391T1 (sl) | 2012-05-21 | 2022-04-29 | Insmed Incorporated | Sistemi za obravnavo pljučnih infekcij |
| CN102764456B (zh) * | 2012-07-24 | 2014-10-15 | 上海交通大学 | 血管栓塞剂及其用途、制备方法 |
| RU2675859C2 (ru) | 2012-11-29 | 2018-12-25 | Инсмед Инкорпорейтед | Стабилизированные составы ванкомицина |
| FR3008900B1 (fr) * | 2013-07-25 | 2018-03-30 | Centre Nat Rech Scient | Nanoparticules lipidiques multicompartimentees |
| AU2015258947B2 (en) | 2014-05-15 | 2020-04-09 | Insmed Incorporated | Methods for treating pulmonary non-tuberculous mycobacterial infections |
| JP6316182B2 (ja) | 2014-12-19 | 2018-04-25 | 富士フイルム株式会社 | リポソームの製造方法及びリポソーム製造装置 |
| EP3372223B1 (en) | 2015-11-02 | 2024-04-17 | FUJIFILM Corporation | Liposome composition and method for producing same |
| CN109983013A (zh) | 2016-11-18 | 2019-07-05 | 帕西拉制药有限公司 | 美洛昔康锌复合物微粒多囊脂质体制剂及其制备方法 |
| KR102069670B1 (ko) * | 2017-03-02 | 2020-01-23 | 단디바이오사이언스 주식회사 | 면역활성물질을 포함하는 다중도메인캡슐, 이의 제조방법, 및 이를 포함하는 면역조절 조성물 |
| CN106924185B (zh) * | 2017-03-29 | 2019-11-26 | 烟台大学 | 一种载有囊泡的多囊脂质体的制备方法 |
| EP3773505A4 (en) | 2018-03-30 | 2021-12-22 | Insmed Incorporated | PROCESS FOR THE CONTINUOUS MANUFACTURING OF LIPOSOMAL MEDICINAL PRODUCTS |
| CA3098573A1 (en) | 2018-05-02 | 2019-11-07 | Insmed Incorporated | Methods for the manufacture of liposomal drug formulations |
| KR102186704B1 (ko) | 2019-02-18 | 2020-12-04 | (주)아이엠디팜 | 서방성 지질 전구 제제 및 이를 포함하는 지질 용액 형태의 서방성 주사용 약학 조성물 |
| US12151024B2 (en) | 2021-01-22 | 2024-11-26 | Pacira Pharmaceuticals, Inc. | Manufacturing of bupivacaine multivesicular liposomes |
| US11357727B1 (en) | 2021-01-22 | 2022-06-14 | Pacira Pharmaceuticals, Inc. | Manufacturing of bupivacaine multivesicular liposomes |
| US11278494B1 (en) | 2021-01-22 | 2022-03-22 | Pacira Pharmaceuticals, Inc. | Manufacturing of bupivacaine multivesicular liposomes |
| US11033495B1 (en) | 2021-01-22 | 2021-06-15 | Pacira Pharmaceuticals, Inc. | Manufacturing of bupivacaine multivesicular liposomes |
| CN113509440B (zh) * | 2021-03-26 | 2022-08-30 | 中国药科大学 | 一种高包封率酮咯酸多囊脂质体制备及提高其稳定性方法 |
| CN113171343A (zh) * | 2021-05-14 | 2021-07-27 | 成都大学 | 一种局部注射用硫酸阿米卡星多囊脂质体及其制备方法 |
| US12285419B2 (en) | 2021-10-14 | 2025-04-29 | Pacira Pharmaceuticals, Inc. | Bupivacaine multivesicular liposome formulations and uses thereof |
| CN116983214B (zh) * | 2023-07-12 | 2026-02-03 | 广州暨大美塑生物科技有限公司 | 一种化妆品用脂质体及其制备方法和应用 |
| CN117205156A (zh) * | 2023-10-26 | 2023-12-12 | 徐州医科大学 | 一种用于干预高原肺水肿的压力敏感的多囊泡脂质体及其制备方法和应用 |
| US12246092B1 (en) | 2024-05-20 | 2025-03-11 | Pacira Pharmaceuticals, Inc. | Manufacturing of bupivacaine multivesicular liposomes |
| US12280149B1 (en) | 2024-05-20 | 2025-04-22 | Pacira Pharmaceuticals, Inc. | Manufacturing of bupivacaine multivesicular liposomes |
| US12251472B1 (en) | 2024-05-20 | 2025-03-18 | Pacira Pharmaceuticals, Inc. | Manufacturing of bupivacaine multivesicular liposomes |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH588887A5 (fi) * | 1974-07-19 | 1977-06-15 | Battelle Memorial Institute | |
| US4897308A (en) * | 1975-06-30 | 1990-01-30 | L'oreal | Compositions comprising aqueous dispersions of lipid spheres |
| US4078052A (en) * | 1976-06-30 | 1978-03-07 | The United States Of America As Represented By The Secretary Of Health, Education And Welfare | Large unilamellar vesicles (LUV) and method of preparing same |
| US4086257A (en) * | 1976-10-12 | 1978-04-25 | Sears Barry D | Phosphatidyl quaternary ammonium compounds |
| CH624011A5 (fi) * | 1977-08-05 | 1981-07-15 | Battelle Memorial Institute | |
| US4235871A (en) * | 1978-02-24 | 1980-11-25 | Papahadjopoulos Demetrios P | Method of encapsulating biologically active materials in lipid vesicles |
| US4310506A (en) * | 1979-02-22 | 1982-01-12 | California Institute Of Technology | Means of preparation and applications of liposomes containing high concentrations of entrapped ionic species |
| JPS55153713A (en) * | 1979-05-02 | 1980-11-29 | Kureha Chem Ind Co Ltd | Pharmaceutical preparation of ribosome containing active substance |
| US4394372A (en) * | 1980-12-22 | 1983-07-19 | The Procter & Gamble Company | Process for making lipid membrane structures |
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| US4588578A (en) * | 1983-08-08 | 1986-05-13 | The Liposome Company, Inc. | Lipid vesicles prepared in a monophase |
| US4599227A (en) * | 1983-11-07 | 1986-07-08 | Wisconsin Alumni Research Foundation | Injectable pharmaceutical preparation for the induction of multiple follicular growth |
| JPS60118666A (ja) * | 1983-11-30 | 1985-06-26 | 太陽誘電株式会社 | 誘電体磁器組成物 |
| US5077056A (en) * | 1984-08-08 | 1991-12-31 | The Liposome Company, Inc. | Encapsulation of antineoplastic agents in liposomes |
| IE58981B1 (en) * | 1985-10-15 | 1993-12-15 | Vestar Inc | Anthracycline antineoplastic agents encapsulated in phospholipid micellular particles |
| US5204112A (en) * | 1986-06-16 | 1993-04-20 | The Liposome Company, Inc. | Induction of asymmetry in vesicles |
| US4781871A (en) * | 1986-09-18 | 1988-11-01 | Liposome Technology, Inc. | High-concentration liposome processing method |
| US4752425A (en) * | 1986-09-18 | 1988-06-21 | Liposome Technology, Inc. | High-encapsulation liposome processing method |
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| GB8704171D0 (en) * | 1987-02-23 | 1987-04-01 | Clayton Found Res | Multivesicular liposomes |
| JP2666345B2 (ja) * | 1987-04-16 | 1997-10-22 | 武田薬品工業株式会社 | リポソーム製剤およびその製造法 |
| CA1335348C (en) * | 1988-03-04 | 1995-04-25 | Yasuaki Ogawa | Liposome composition |
| US5576017A (en) * | 1988-05-30 | 1996-11-19 | Depotech Corporation | Heterovesicular liposomes |
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| BE1001869A3 (fr) * | 1988-10-12 | 1990-04-03 | Franz Legros | Procede d'encapsulation liposomiale d'antibiotiques aminoglucosidiques, en particulier de la gentamycine. |
| US5766627A (en) * | 1993-11-16 | 1998-06-16 | Depotech | Multivescular liposomes with controlled release of encapsulated biologically active substances |
| RO116341B1 (ro) * | 1993-11-16 | 2001-01-30 | Depotech Corp La Jolia | Lipozom multivezicular si procedeu de obtinere a acestuia |
-
1994
- 1994-09-13 US US08/305,158 patent/US5993850A/en not_active Expired - Lifetime
-
1995
- 1995-09-13 EP EP95931820A patent/EP0781123B1/en not_active Expired - Lifetime
- 1995-09-13 BR BR9508913A patent/BR9508913A/pt not_active IP Right Cessation
- 1995-09-13 NZ NZ292830A patent/NZ292830A/en not_active IP Right Cessation
- 1995-09-13 DE DE69535297T patent/DE69535297T2/de not_active Expired - Lifetime
- 1995-09-13 AU AU35115/95A patent/AU697484B2/en not_active Ceased
- 1995-09-13 CA CA002199004A patent/CA2199004C/en not_active Expired - Lifetime
- 1995-09-13 KR KR1019970701650A patent/KR100387561B1/ko not_active Expired - Fee Related
- 1995-09-13 JP JP8510312A patent/JP3026271B2/ja not_active Expired - Fee Related
- 1995-09-13 NZ NZ334561A patent/NZ334561A/xx not_active IP Right Cessation
- 1995-09-13 WO PCT/US1995/011609 patent/WO1996008235A1/en not_active Ceased
- 1995-09-13 CN CN95196186A patent/CN1096850C/zh not_active Expired - Fee Related
-
1997
- 1997-03-12 FI FI971037A patent/FI119621B/fi active
- 1997-03-12 NO NO19971149A patent/NO323581B1/no not_active IP Right Cessation
- 1997-03-12 MX MX9701856A patent/MX9701856A/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US5993850A (en) | 1999-11-30 |
| KR100387561B1 (ko) | 2003-10-08 |
| JPH10502667A (ja) | 1998-03-10 |
| BR9508913A (pt) | 1997-12-30 |
| WO1996008235A1 (en) | 1996-03-21 |
| EP0781123B1 (en) | 2006-11-15 |
| CA2199004A1 (en) | 1996-03-21 |
| CN1166136A (zh) | 1997-11-26 |
| EP0781123A4 (en) | 2000-12-20 |
| NZ292830A (en) | 1999-04-29 |
| JP3026271B2 (ja) | 2000-03-27 |
| NO323581B1 (no) | 2007-06-11 |
| NO971149D0 (no) | 1997-03-12 |
| CA2199004C (en) | 2008-02-19 |
| AU3511595A (en) | 1996-03-29 |
| FI119621B (fi) | 2009-01-30 |
| EP0781123A1 (en) | 1997-07-02 |
| NZ334561A (en) | 2000-01-28 |
| FI971037A0 (fi) | 1997-03-12 |
| DE69535297T2 (de) | 2007-05-16 |
| CN1096850C (zh) | 2002-12-25 |
| AU697484B2 (en) | 1998-10-08 |
| NO971149L (no) | 1997-05-13 |
| MX9701856A (es) | 1998-07-31 |
| DE69535297D1 (de) | 2006-12-28 |
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