FI974001L - Nya metylenbisfosfonsyraderivat - Google Patents

Nya metylenbisfosfonsyraderivat Download PDF

Info

Publication number: FI974001L
Authority: FI; Finland
Prior art keywords: new; acid derivatives; methylenebisphosphonic acid; methylenebisphosphonic; derivatives
Prior art date: 1997-10-20

Application number

FI974001A

Other languages

English (en)

Finnish (fi)

Other versions

FI104901B (sv

FI974001A0 (fi

Inventor

Esko Kalervo Pohjala

Jouko Juhani Vepsaelaeinen

Heikki Nupponen

Jouni Pekka Kaehkoenen

Leena Lauren

Ritva Hannuniemi

Tomi Lauri Jaervinen

Marko Juhani Ahlmark

Original Assignee

Leiras Oy

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-10-20

Filing date

1997-10-20

Publication date

1999-04-21

1997-10-20 Application filed by Leiras Oy filed Critical Leiras Oy

1997-10-20 Publication of FI974001A0 publication Critical patent/FI974001A0/fi

1997-10-20 Priority to FI974001A priority Critical patent/FI104901B/sv

1998-10-20 Priority to RU2000112534/04A priority patent/RU2205833C2/ru

1998-10-20 Priority to NZ504390A priority patent/NZ504390A/en

1998-10-20 Priority to BR9813102-8A priority patent/BR9813102A/pt

1998-10-20 Priority to EP98949022A priority patent/EP1032578A1/en

1998-10-20 Priority to PL98340055A priority patent/PL340055A1/xx

1998-10-20 Priority to IL13563998A priority patent/IL135639A0/xx

1998-10-20 Priority to KR1020007004256A priority patent/KR20010031269A/ko

1998-10-20 Priority to US09/529,826 priority patent/US6326363B1/en

1998-10-20 Priority to HU0004386A priority patent/HUP0004386A3/hu

1998-10-20 Priority to CNB988103710A priority patent/CN1147497C/zh

1998-10-20 Priority to AU95437/98A priority patent/AU740355B2/en

1998-10-20 Priority to CA002306080A priority patent/CA2306080A1/en

1998-10-20 Priority to TR2000/01055T priority patent/TR200001055T2/xx

1998-10-20 Priority to JP2000516975A priority patent/JP2001520232A/ja

1998-10-20 Priority to PCT/FI1998/000814 priority patent/WO1999020634A1/en

1998-10-20 Priority to EEP200000239A priority patent/EE04061B1/xx

1999-04-21 Publication of FI974001L publication Critical patent/FI974001L/sv

2000-04-17 Priority to NO20002006A priority patent/NO20002006L/no

2000-04-28 Application granted granted Critical

2000-04-28 Publication of FI104901B publication Critical patent/FI104901B/sv

2000-05-17 Priority to BG104452A priority patent/BG104452A/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/40—Esters thereof
- C07F9/4071—Esters thereof the ester moiety containing a substituent or a structure which is considered as characteristic
- C07F9/409—Compounds containing the structure P(=X)-X-acyl, P(=X) -X-heteroatom, P(=X)-X-CN (X = O, S, Se)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/40—Esters thereof
- C07F9/4071—Esters thereof the ester moiety containing a substituent or a structure which is considered as characteristic
- C07F9/409—Compounds containing the structure P(=X)-X-acyl, P(=X) -X-heteroatom, P(=X)-X-CN (X = O, S, Se)
- C07F9/4093—Compounds containing the structure P(=X)-X-C(=X)- (X = O, S, Se)

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Physical Education & Sports Medicine (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Rheumatology (AREA)
Animal Behavior & Ethology (AREA)
Crystallography & Structural Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
Orthopedic Medicine & Surgery (AREA)
Obesity (AREA)
Diabetes (AREA)
Hematology (AREA)
Endocrinology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

FI974001A 1997-10-20 1997-10-20 Nya metylenbisfosfonsyraderivat FI104901B (sv)

Priority Applications (19)

Application Number	Priority Date	Filing Date	Title
FI974001A FI104901B (sv)	1997-10-20	1997-10-20	Nya metylenbisfosfonsyraderivat
CNB988103710A CN1147497C (zh)	1997-10-20	1998-10-20	亚甲基双膦酸类衍生物
CA002306080A CA2306080A1 (en)	1997-10-20	1998-10-20	Novel methylenebisphosphonic acid derivatives
BR9813102-8A BR9813102A (pt)	1997-10-20	1998-10-20	Derivados de ácido metilenobisfosfÈnico novos
EP98949022A EP1032578A1 (en)	1997-10-20	1998-10-20	Novel methylenebisphosphonic acid derivatives
PL98340055A PL340055A1 (en)	1997-10-20	1998-10-20	Novel derivatives of methylene biphosphonic acid
IL13563998A IL135639A0 (en)	1997-10-20	1998-10-20	Novel methylenebisphosphonic acid derivatives
KR1020007004256A KR20010031269A (ko)	1997-10-20	1998-10-20	신규한 메틸렌비스포스폰산 유도체
US09/529,826 US6326363B1 (en)	1997-10-20	1998-10-20	Methylenebisphosphonic acid derivatives
HU0004386A HUP0004386A3 (en)	1997-10-20	1998-10-20	Methylenebisphosphonic acid derivatives, process for producing them and medicaments containing the same as active agent
RU2000112534/04A RU2205833C2 (ru)	1997-10-20	1998-10-20	Производные ангидрида метиленбисфосфоновой кислоты, способы их получения, фармацевтическая композиция
AU95437/98A AU740355B2 (en)	1997-10-20	1998-10-20	Novel Methylenebisphosphonic Acid Derivatives
NZ504390A NZ504390A (en)	1997-10-20	1998-10-20	Methylenebisphosphonic acid anhydride derivatives and pharmaceuticals thereof
TR2000/01055T TR200001055T2 (tr)	1997-10-20	1998-10-20	Yeni metilenbifosfonik asit türevleri
JP2000516975A JP2001520232A (ja)	1997-10-20	1998-10-20	新規なメチレンビスホスホン酸誘導体
PCT/FI1998/000814 WO1999020634A1 (en)	1997-10-20	1998-10-20	Novel methylenebisphosphonic acid derivatives
EEP200000239A EE04061B1 (et)	1997-10-20	1998-10-20	Metüleenbisfosfoonhappe derivaadid
NO20002006A NO20002006L (no)	1997-10-20	2000-04-17	Nye metylenbisfosfonsyrederivater
BG104452A BG104452A (en)	1997-10-20	2000-05-17	New derivatives of the methylenebisphosphonic acid

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
FI974001		1997-10-20
FI974001A FI104901B (sv)	1997-10-20	1997-10-20	Nya metylenbisfosfonsyraderivat

Publications (3)

Publication Number	Publication Date
FI974001A0 FI974001A0 (fi)	1997-10-20
FI974001L true FI974001L (sv)	1999-04-21
FI104901B FI104901B (sv)	2000-04-28

Family

ID=8549759

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
FI974001A FI104901B (sv)	1997-10-20	1997-10-20	Nya metylenbisfosfonsyraderivat

Country Status (19)

Country	Link
US (1)	US6326363B1 (sv)
EP (1)	EP1032578A1 (sv)
JP (1)	JP2001520232A (sv)
KR (1)	KR20010031269A (sv)
CN (1)	CN1147497C (sv)
AU (1)	AU740355B2 (sv)
BG (1)	BG104452A (sv)
BR (1)	BR9813102A (sv)
CA (1)	CA2306080A1 (sv)
EE (1)	EE04061B1 (sv)
FI (1)	FI104901B (sv)
HU (1)	HUP0004386A3 (sv)
IL (1)	IL135639A0 (sv)
NO (1)	NO20002006L (sv)
NZ (1)	NZ504390A (sv)
PL (1)	PL340055A1 (sv)
RU (1)	RU2205833C2 (sv)
TR (1)	TR200001055T2 (sv)
WO (1)	WO1999020634A1 (sv)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NO313180B1 (no) *	2000-07-04	2002-08-26	Anticancer Therapeutic Inv Sa	Bensökende alfapartikkel emitterende radiofarmasöytika
US7862552B2 (en)	2005-05-09	2011-01-04	Boston Scientific Scimed, Inc.	Medical devices for treating urological and uterine conditions
US8288545B2 (en) *	2006-07-21	2012-10-16	Glsynthesis Inc.	Reactive pyrophosphoric and bisphosphonic acid derivatives and methods of their use
WO2010059215A1 (en)	2008-11-20	2010-05-27	Glsynthesis Inc.	Novel antithrombotic diadenosine tetraphosphates and related analogs
CN107011380A (zh) *	2016-01-28	2017-08-04	臧伟	一种二膦酸衍生物及含二膦酸衍生物的组合物治疗骨折的应用

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4447256A (en)	1977-07-20	1984-05-08	Nissan Chemical Industries, Ltd.	N-(Unsubstituted or substituted pyridyl)aminomethylene-diphosphonic acids, herbicidal compositions containing same, their use for herbicides, and process for preparing same
DE2758580A1 (de)	1977-12-29	1979-07-05	Hoechst Ag	Verfahren zur herstellung von phosphin- und phosphonsaeure-anhydriden
DK126888A (da)	1987-03-10	1988-09-11	Yamanouchi Pharma Co Ltd	Bisphosphonsyrederivater og terapeutiske praeparater indeholdende disse forbindelser
US4933472A (en)	1988-04-08	1990-06-12	Yamanouchi Pharmaceutical Co., Ltd.	Substituted aminomethylenebis(phosphonic acid) derivatives
EP0356866A3 (en)	1988-08-29	1991-03-27	E.R. SQUIBB & SONS, INC.	Phosphorus-containing squalene synthetase inhibitors and method
FI83421C (sv) *	1989-06-21	1991-07-10	Huhtamaeki Oy	Förfarande för framställning av farmakologiskt användbara metylenbisfo sfonsyraderivat
EP0416689B1 (en) *	1989-09-06	1995-11-29	Merck & Co. Inc.	Acyloxymethyl esters of bisphosphonic acids as bone resorption inhibitors
FI89366C (sv)	1990-12-20	1993-09-27	Leiras Oy	Förfarande för framställning av nya farmakologiskt användbara metylenb isfosfonsyraderivat
FI89365C (sv) *	1990-12-20	1993-09-27	Leiras Oy	Förfarande för framställning av nya farmakologiskt användbara metylenb isfosfonsyraderivat
FI89364C (sv) *	1990-12-20	1993-09-27	Leiras Oy	Förfarande för framställning av nya, farmakologiskt användbara metylen bisfosfonsyraderivat
HUT64967A (en)	1991-04-06	1994-03-28	Fisons Plc	Atp analogues and pharmaceutical compositions containing them
TW237386B (sv)	1992-04-15	1995-01-01	Ciba Geigy
SK281309B6 (sk) *	1993-02-10	2001-02-12	Astra Pharmaceuticals Limited	N-alkyl-2-substituované adenozíntrifosfátové deriváty, spôsob ich prípravy, farmaceutické prostriedky obsahujúce tieto deriváty a použitie týchto derivátov
US5462932A (en)	1994-05-17	1995-10-31	Merck & Co., Inc.	Oral liquid alendronate formulations

1997
- 1997-10-20 FI FI974001A patent/FI104901B/sv not_active IP Right Cessation
1998
- 1998-10-20 PL PL98340055A patent/PL340055A1/xx unknown
- 1998-10-20 TR TR2000/01055T patent/TR200001055T2/xx unknown
- 1998-10-20 CA CA002306080A patent/CA2306080A1/en not_active Abandoned
- 1998-10-20 AU AU95437/98A patent/AU740355B2/en not_active Ceased
- 1998-10-20 EE EEP200000239A patent/EE04061B1/xx not_active IP Right Cessation
- 1998-10-20 CN CNB988103710A patent/CN1147497C/zh not_active Expired - Fee Related
- 1998-10-20 JP JP2000516975A patent/JP2001520232A/ja not_active Withdrawn
- 1998-10-20 IL IL13563998A patent/IL135639A0/xx unknown
- 1998-10-20 EP EP98949022A patent/EP1032578A1/en not_active Withdrawn
- 1998-10-20 NZ NZ504390A patent/NZ504390A/en unknown
- 1998-10-20 BR BR9813102-8A patent/BR9813102A/pt not_active IP Right Cessation
- 1998-10-20 WO PCT/FI1998/000814 patent/WO1999020634A1/en not_active Ceased
- 1998-10-20 HU HU0004386A patent/HUP0004386A3/hu unknown
- 1998-10-20 KR KR1020007004256A patent/KR20010031269A/ko not_active Ceased
- 1998-10-20 US US09/529,826 patent/US6326363B1/en not_active Expired - Lifetime
- 1998-10-20 RU RU2000112534/04A patent/RU2205833C2/ru not_active IP Right Cessation
2000
- 2000-04-17 NO NO20002006A patent/NO20002006L/no not_active Application Discontinuation
- 2000-05-17 BG BG104452A patent/BG104452A/xx unknown

Also Published As

Publication number	Publication date
TR200001055T2 (tr)	2000-09-21
NO20002006L (no)	2000-06-15
HUP0004386A2 (hu)	2001-04-28
AU9543798A (en)	1999-05-10
NO20002006D0 (no)	2000-04-17
PL340055A1 (en)	2001-01-15
FI104901B (sv)	2000-04-28
EE04061B1 (et)	2003-06-16
IL135639A0 (en)	2001-05-20
CN1147497C (zh)	2004-04-28
RU2205833C2 (ru)	2003-06-10
BG104452A (en)	2000-12-29
JP2001520232A (ja)	2001-10-30
FI974001A0 (fi)	1997-10-20
CN1276793A (zh)	2000-12-13
EE200000239A (et)	2001-08-15
EP1032578A1 (en)	2000-09-06
KR20010031269A (ko)	2001-04-16
CA2306080A1 (en)	1999-04-29
HUP0004386A3 (en)	2002-08-28
US6326363B1 (en)	2001-12-04
WO1999020634A1 (en)	1999-04-29
NZ504390A (en)	2001-10-26
BR9813102A (pt)	2000-08-22
AU740355B2 (en)	2001-11-01

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Legal Events

Date	Code	Title	Description
2005-04-30	MA	Patent expired