FI965040L - Uusia substituoituja purinyylijohdannaisia joilla on immunomoduloiva aktiivisuus - Google Patents

Uusia substituoituja purinyylijohdannaisia joilla on immunomoduloiva aktiivisuus Download PDF

Info

Publication number: FI965040L
Authority: FI; Finland
Prior art keywords: immunomodulatory activity; new substituted; substituted purinyl; purinyl derivatives; derivatives
Prior art date: 1994-06-22

Application number

FI965040A

Other languages

English (en)

Swedish (sv)

Other versions

FI965040A7 (fi

FI965040A0 (fi

Inventor

Christopher Penney

Boulos Zacharie

Lyne Gagnon

Giorgio Attardo

Timothy Connolly

Yves St-Denis

Salam Kadhim

Guy Ely

Original Assignee

Iaf Biochem Int

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-06-22

Filing date

1995-06-21

Publication date

1997-02-21

1995-06-21 Application filed by Iaf Biochem Int filed Critical Iaf Biochem Int

1996-12-16 Publication of FI965040A0 publication Critical patent/FI965040A0/fi

1997-02-21 Publication of FI965040L publication Critical patent/FI965040L/fi

1997-02-21 Publication of FI965040A7 publication Critical patent/FI965040A7/fi

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
- C07D473/32—Nitrogen atom
- C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
- C07K5/0808—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Immunology (AREA)
Epidemiology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Molecular Biology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

FI965040A 1994-06-22 1995-06-21 Uusia substituoituja purinyylijohdannaisia joilla on immunomoduloiva aktiivisuus FI965040A7 (fi)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US26402894A	1994-06-22	1994-06-22
PCT/CA1995/000356 WO1995035297A1 (en)	1994-06-22	1995-06-21	Novel substituted purinyl derivatives with immunomodulating activity

Publications (3)

Publication Number	Publication Date
FI965040A0 FI965040A0 (fi)	1996-12-16
FI965040L true FI965040L (fi)	1997-02-21
FI965040A7 FI965040A7 (fi)	1997-02-21

Family

ID=23004250

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
FI965040A FI965040A7 (fi)	1994-06-22	1995-06-21	Uusia substituoituja purinyylijohdannaisia joilla on immunomoduloiva aktiivisuus

Country Status (16)

Country	Link
US (2)	US6110923A (fi)
EP (1)	EP0766683A1 (fi)
JP (1)	JP4151765B2 (fi)
CN (1)	CN1051083C (fi)
AU (1)	AU2666795A (fi)
BR (1)	BR9508115A (fi)
FI (1)	FI965040A7 (fi)
HU (1)	HUT77780A (fi)
IL (1)	IL114266A0 (fi)
MX (1)	MX9700211A (fi)
NO (1)	NO317552B1 (fi)
NZ (1)	NZ287827A (fi)
PL (1)	PL184342B1 (fi)
RU (1)	RU2191189C2 (fi)
WO (1)	WO1995035297A1 (fi)
ZA (1)	ZA955131B (fi)

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JPWO2007034917A1 (ja) *	2005-09-22	2009-03-26	大日本住友製薬株式会社	新規なアデニン化合物
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US8138172B2 (en) *	2006-07-05	2012-03-20	Astrazeneca Ab	8-oxoadenine derivatives acting as modulators of TLR7
TW200831105A (en) *	2006-12-14	2008-08-01	Astrazeneca Ab	Novel compounds
JP5480637B2 (ja) *	2007-03-19	2014-04-23	アストラゼネカ・アクチエボラーグ	Ｔｏｌｌ様受容体（ｔｌｒ７）モジュレーターとしての９−置換−８−オキソ−アデニン化合物
US8063051B2 (en) *	2007-03-19	2011-11-22	Astrazeneca Ab	9-substituted-8-oxo-adenine compounds as toll-like receptor (TLR7) modulators
JPWO2008114819A1 (ja) *	2007-03-20	2010-07-08	大日本住友製薬株式会社	新規アデニン化合物
PE20081887A1 (es) *	2007-03-20	2009-01-16	Dainippon Sumitomo Pharma Co	Nuevo compuesto de adenina
CA2686163A1 (en) *	2007-05-08	2008-11-13	Astrazenca Ab	Imidazoquinolines with immuno-modulating properties
US8247410B2 (en) *	2007-10-05	2012-08-21	Verastem	Pyrimidine substituted purine derivatives
PE20091236A1 (es)	2007-11-22	2009-09-16	Astrazeneca Ab	Derivados de pirimidina como immunomoduladores de tlr7
PE20091156A1 (es)	2007-12-17	2009-09-03	Astrazeneca Ab	Sales de (3-{[[3-(6-amino-2-butoxi-8-oxo-7,8-dihidro-9h-purin-9-il)propil](3-morfolin-4-ilpropil)amino]metil}fenil)acetato de metilo
JP5577099B2 (ja) *	2008-01-17	2014-08-20	大日本住友製薬株式会社	アデニン化合物の製造方法
WO2009091031A1 (ja) *	2008-01-17	2009-07-23	Dainippon Sumitomo Pharma Co., Ltd.	アデニン化合物の製造方法
RU2424241C2 (ru) *	2008-12-29	2011-07-20	Сергей Павлович Сяткин	Производные ксантина, обладающие антипролиферативной активностью, модуляторы клеточной дифференцировки, способ замедления скорости пролиферации опухолевых клеток, способ индукции дифференциации в клетках
GB0908772D0 (en) *	2009-05-21	2009-07-01	Astrazeneca Ab	New salts 756
MX2011012337A (es)	2009-05-21	2011-12-08	Dainippon Sumitomo Pharma Co	Nuevos derivados de pirimidina y su uso en el tratamiento de cancer y de otras enfermedades.
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RU2492825C2 (ru) *	2010-10-18	2013-09-20	Федеральное государственное учреждение "Ростовский научно-исследовательский онкологический институт Федерального агентства по высокотехнологичной медицинской помощи"	Способ лечения рака сигмовидной кишки у женщин по сидоренко ю.с.
ES2575688T3 (es)	2010-12-16	2016-06-30	Sumitomo Dainippon Pharma Co., Ltd.	Derivado de imidazo[4,5-c]quinolin-1-ilo útil en terapia
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1995
- 1995-06-07 US US08/487,329 patent/US6110923A/en not_active Expired - Fee Related
- 1995-06-07 US US08/474,073 patent/US5994361A/en not_active Expired - Fee Related
- 1995-06-21 AU AU26667/95A patent/AU2666795A/en not_active Abandoned
- 1995-06-21 BR BR9508115A patent/BR9508115A/pt not_active IP Right Cessation
- 1995-06-21 NZ NZ287827A patent/NZ287827A/xx not_active IP Right Cessation
- 1995-06-21 PL PL95317902A patent/PL184342B1/pl not_active IP Right Cessation
- 1995-06-21 FI FI965040A patent/FI965040A7/fi not_active Application Discontinuation
- 1995-06-21 MX MX9700211A patent/MX9700211A/es not_active IP Right Cessation
- 1995-06-21 CN CN95194679A patent/CN1051083C/zh not_active Expired - Fee Related
- 1995-06-21 JP JP50142996A patent/JP4151765B2/ja not_active Expired - Fee Related
- 1995-06-21 ZA ZA955131A patent/ZA955131B/xx unknown
- 1995-06-21 WO PCT/CA1995/000356 patent/WO1995035297A1/en not_active Ceased
- 1995-06-21 HU HU9603492A patent/HUT77780A/hu unknown
- 1995-06-21 EP EP95921669A patent/EP0766683A1/en not_active Withdrawn
- 1995-06-21 RU RU97100789/04A patent/RU2191189C2/ru not_active IP Right Cessation
- 1995-06-22 IL IL11426695A patent/IL114266A0/xx unknown
1996
- 1996-12-13 NO NO19965394A patent/NO317552B1/no unknown

Also Published As

Publication number	Publication date
HUT77780A (hu)	1998-08-28
US6110923A (en)	2000-08-29
NZ287827A (en)	1999-02-25
WO1995035297A1 (en)	1995-12-28
MX9700211A (es)	1998-01-31
US5994361A (en)	1999-11-30
FI965040A7 (fi)	1997-02-21
CN1157618A (zh)	1997-08-20
NO317552B1 (no)	2004-11-15
BR9508115A (pt)	1998-11-03
JP4151765B2 (ja)	2008-09-17
JPH10501533A (ja)	1998-02-10
PL317902A1 (en)	1997-04-28
AU2666795A (en)	1996-01-15
CN1051083C (zh)	2000-04-05
EP0766683A1 (en)	1997-04-09
HU9603492D0 (en)	1997-02-28
FI965040A0 (fi)	1996-12-16
IL114266A0 (en)	1995-10-31
PL184342B1 (pl)	2002-10-31
RU2191189C2 (ru)	2002-10-20
NO965394L (no)	1997-02-21
ZA955131B (en)	1997-03-24
NO965394D0 (no)	1996-12-13

Publication	Publication Date	Title
FI965040L (fi)	1997-02-21	Uusia substituoituja purinyylijohdannaisia joilla on immunomoduloiva aktiivisuus
FI954829L (fi)	1996-04-15	Aroyylipiperidiinijohdannaiset
NO952854D0 (no)	1995-07-18	1-arylpyrimidin-derivater
DE59508427D1 (de)	2000-07-06	3-aryl-4-hydroxy-delta 3 -dihydrothiophenon-derivate
ATA75293A (de)	1997-11-15	Indolderivate
FI933037A7 (fi)	1994-01-03	Tiazolylvinylfenylderivat
FI943976A7 (fi)	1995-03-01	5-aryyli-indolijohdannaiset
EP0708091A3 (en)	1996-07-17	Indoloyl-guanidines derivatives
DE69330497D1 (de)	2001-08-30	Chinazolin-derivate
FI952722A7 (fi)	1995-06-02	Allergian vastaisia triatsolobentsatsepiinijohdannaisia
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DE69430587D1 (de)	2002-06-13	Pyrimidin-acyclonukleosid-derivate
BR9509793A (pt)	1997-09-30	Derivados de tiofeneno
DE59308714D1 (de)	1998-07-30	Cyclobutan-benzol-derivate
FI971227L (fi)	1997-05-23	Pyramidinyylipyratsolijohdannaisia
IS4321A (is)	1996-01-17	Nýjar díalkoxý-pýridínýl-bensimidasólafleiður
DE69527786D1 (de)	2002-09-19	Diaminomethyliden-derivate
FI964853A7 (fi)	1997-02-07	Deasetoksitaksolijohdannaiset
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DE69510792D1 (de)	1999-08-19	Naphtochinonderivate
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FI955026A7 (fi)	1996-04-23	Alkyyli-5-metyylisulfonyylibentsoyyliguanidiinijohdannaisia
BR9509877A (pt)	1997-09-30	Novos derivados de pirimidinilóxi-e piridimidinilamino- etilfenil-dioxolano
FI930934L (fi)	1993-09-05	Tetrahydropyrimidinderivat
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