FI964815L - Piperazinderivat som 5-HT1A antagonister - Google Patents

Piperazinderivat som 5-HT1A antagonister Download PDF

Info

Publication number: FI964815L
Authority: FI; Finland
Prior art keywords: piperazine derivatives; ht1a antagonists; ht1a; antagonists; piperazine
Prior art date: 1994-06-03

Application number

FI964815A

Other languages

English (en)

Finnish (fi)

Other versions

FI114985B (sv

FI964815A0 (sv

Inventor

Christopher Ian Brightwell

Michael Gerard Kelly

Original Assignee

Wyeth John & Brother Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-06-03

Filing date

1996-12-02

Publication date

1996-12-02

1996-12-02 Application filed by Wyeth John & Brother Ltd filed Critical Wyeth John & Brother Ltd

1996-12-02 Publication of FI964815L publication Critical patent/FI964815L/sv

1996-12-02 Publication of FI964815A0 publication Critical patent/FI964815A0/sv

2005-02-15 Application granted granted Critical

2005-02-15 Publication of FI114985B publication Critical patent/FI114985B/sv

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Engineering & Computer Science (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Psychiatry (AREA)
Anesthesiology (AREA)
Pain & Pain Management (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Pyridine Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
Hydrogenated Pyridines (AREA)

FI964815A 1994-06-03 1996-12-02 Piperazinderivat som 5-HT1A antagonister FI114985B (sv)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
GB9411099A GB9411099D0 (en)	1994-06-03	1994-06-03	Piperazine derivatives
GB9411099		1994-06-03
GB9501263		1995-01-23
PCT/GB1995/001263 WO1995033743A1 (en)	1994-06-03	1995-06-01	Piperazine derivatives as 5ht1a antagonists

Publications (3)

Publication Number	Publication Date
FI964815L true FI964815L (sv)	1996-12-02
FI964815A0 FI964815A0 (sv)	1996-12-02
FI114985B FI114985B (sv)	2005-02-15

Family

ID=10756114

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
FI964815A FI114985B (sv)	1994-06-03	1996-12-02	Piperazinderivat som 5-HT1A antagonister

Country Status (25)

Country	Link
US (1)	US5723464A (sv)
EP (1)	EP0763031B1 (sv)
JP (1)	JPH10500989A (sv)
KR (1)	KR100359393B1 (sv)
CN (2)	CN1048985C (sv)
AT (1)	ATE192744T1 (sv)
AU (1)	AU680147B2 (sv)
BR (1)	BR9507910A (sv)
CA (1)	CA2191871C (sv)
CZ (1)	CZ287381B6 (sv)
DE (1)	DE69516867T2 (sv)
DK (1)	DK0763031T3 (sv)
ES (1)	ES2145275T3 (sv)
FI (1)	FI114985B (sv)
GB (1)	GB9411099D0 (sv)
GR (1)	GR3033449T3 (sv)
HU (1)	HUT76466A (sv)
IL (1)	IL113967A (sv)
MX (1)	MX9605915A (sv)
NZ (2)	NZ331452A (sv)
PT (1)	PT763031E (sv)
RU (1)	RU2165933C2 (sv)
SK (1)	SK281418B6 (sv)
WO (1)	WO1995033743A1 (sv)
ZA (1)	ZA954525B (sv)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
MX9201991A (es) *	1991-05-02	1992-11-01	Jonh Wyeth & Brother Limited	Derivados de piperazina y procedimiento para su preparacion.
ATE222238T1 (de) *	1994-06-03	2002-08-15	Wyeth John & Brother Ltd	Verfahren und zwischenprodukte zur herstellung von piperazinderivaten
EP0773942A1 (en) *	1994-07-26	1997-05-21	Pfizer Inc.	4-indole derivatives as serotonin agonists and antagonists
US5519025A (en) *	1995-04-10	1996-05-21	American Home Products Corporation	4-indolylpiperazinyl derivatives
US5486518A (en) *	1995-04-10	1996-01-23	American Home Products Corporation	4-indolylpiperazinyl derivatives
US5990114A (en) *	1996-02-28	1999-11-23	Recordati, S.A., Chemical And Pharmaceutical Company	Use of 5-HT1A receptor antagonists for the treatment of urinary incontinence
IT1282705B1 (it) *	1996-02-28	1998-03-31	Recordati Chem Pharm	Uso di antagonisti del recettore serotoninergico 5-ht\|a per il trattamento dell'incontinenza urinaria
DE19615232A1 (de) *	1996-04-18	1997-10-23	Merck Patent Gmbh	Neue Carbamoylderivate und deren Verwendung als 5-HT ¶1¶¶A¶-Antagonisten
DE19725664A1 (de) *	1997-06-18	1998-12-24	Merck Patent Gmbh	3-Benzylpiperidine
IT1293807B1 (it) *	1997-08-01	1999-03-10	Recordati Chem Pharm	Derivati 1- (n-fenilaminoalchil) piperazinici sostituiti alla posizione 2 dell'anello fenilico
US6399614B1 (en)	1997-08-01	2002-06-04	Recordati S.A. Chemical And Pharmaceutical Company	1-(N-phenylaminoalkyl)piperazine derivatives substituted at position 2 of the phenyl ring
WO1999006382A1 (en) *	1997-08-01	1999-02-11	Recordati S.A., Chemical And Pharmaceutical Company	1,4-disubstituted piperazines
US6271234B1 (en)	1997-08-01	2001-08-07	Recordati S.A., Chemical And Pharmaceutical Company	1,4-disubstituted piperazines
IT1293804B1 (it)	1997-08-01	1999-03-10	Recordati Chem Pharm	Diarilalchilpiperazine attive sulle basse vie urinarie
US6376494B1 (en)	1998-06-15	2002-04-23	American Home Products Corporation	Cycloalkyl-substituted aryl-piperazines, piperidines and tetrahydropyridines as serotonergic agents
CA2334254A1 (en) *	1998-06-15	1999-12-23	American Home Products Corporation	Cycloalkyl-substituted aryl-piperazines, piperidines and tetrahydropyridines as serotonergic agents
US20060287335A1 (en)	2000-11-28	2006-12-21	Wyeth	Serotonergic agents for treating sexual dysfunction
US20060223824A1 (en) *	2000-11-28	2006-10-05	Wyeth	Serotonergic agents
EP1367053A4 (en) *	2001-02-27	2005-08-03	Kaneka Corp	PROCESS FOR THE PRODUCTION OF OPTICALLY ACTIVE N-ARYL-1-AMINO-2-PROPANOL DERIVATIVES
DE10123163A1 (de) *	2001-05-09	2003-01-16	Gruenenthal Gmbh	Substituierte Cyclohexan-1,4-diaminderivate
US7361773B2 (en)	2002-03-12	2008-04-22	Wyeth	Preparation of N1-(2'-pyridyl)-1,2-propanediamine sulfamic acid and its use in the synthesis of biologically active piperazines
JP4391241B2 (ja) *	2002-03-12	2009-12-24	ワイス	キラルｎ−アリールピペラジンの合成方法
ES2334836T3 (es)	2002-03-12	2010-03-16	Wyeth	Preparacion de 2-((2,3-dihidro-benzo(1,4)dioxin-5-il)-(2-hidroxietil)-amino)-etanol y productos intermedios correspondientes.
CN100451014C (zh)	2002-03-12	2009-01-14	惠氏公司	制备手性1,4-二取代哌嗪的方法
US7091349B2 (en)	2002-03-12	2006-08-15	Wyeth	Process for synthesizing N-aryl piperazines with chiral N′-1-[benzoyl(2-pyridyl)amino]-2-propane substitution
US7179813B2 (en)	2003-06-11	2007-02-20	Wyeth	Bicyclic indolyl derivatives and methods for their use as serotonergic agents
CN100436448C (zh) *	2003-06-11	2008-11-26	惠氏公司	二环吲哚基衍生物以及其作为5-羟色胺能活性剂的应用
TW200800959A (en)	2005-06-10	2008-01-01	Wyeth Corp	Piperazine-piperidine antagonists and agonists of the 5-HT1a receptor
CN101466365A (zh) *	2006-06-09	2009-06-24	惠氏公司	增强认知功能的方法
RU2016149812A (ru)	2014-06-06	2018-07-17	Флексус Байосайенсиз, Инк.	Иммунорегулирующие средства
UY36390A (es)	2014-11-05	2016-06-01	Flexus Biosciences Inc	Compuestos moduladores de la enzima indolamina 2,3-dioxigenasa (ido), sus métodos de síntesis y composiciones farmacéuticas que los contienen
US11242319B2 (en)	2014-11-05	2022-02-08	Flexus Biosciences, Inc.	Immunoregulatory agents
AR102537A1 (es)	2014-11-05	2017-03-08	Flexus Biosciences Inc	Agentes inmunomoduladores

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB8909209D0 (en) *	1989-04-22	1989-06-07	Wyeth John & Brother Ltd	Piperazine derivatives
DK0395312T3 (da) *	1989-04-22	1999-06-23	Wyeth John & Brother Ltd	Piperazinderivater
GB9021535D0 (en) *	1990-10-03	1990-11-14	Wyeth John & Brother Ltd	Piperazine derivatives
MX9201991A (es) *	1991-05-02	1992-11-01	Jonh Wyeth & Brother Limited	Derivados de piperazina y procedimiento para su preparacion.
SE9201138D0 (sv) *	1992-04-09	1992-04-09	Astra Ab	Novel phthalimidoalkylpiperazines
GB9300195D0 (en) *	1993-01-06	1993-03-03	Wyeth John & Brother Ltd	Piperazine derivatives

1994
- 1994-06-03 GB GB9411099A patent/GB9411099D0/en active Pending
1995
- 1995-06-01 JP JP8500531A patent/JPH10500989A/ja not_active Withdrawn
- 1995-06-01 AU AU26230/95A patent/AU680147B2/en not_active Ceased
- 1995-06-01 PT PT95921017T patent/PT763031E/pt unknown
- 1995-06-01 CA CA002191871A patent/CA2191871C/en not_active Expired - Fee Related
- 1995-06-01 EP EP95921017A patent/EP0763031B1/en not_active Expired - Lifetime
- 1995-06-01 DE DE69516867T patent/DE69516867T2/de not_active Expired - Fee Related
- 1995-06-01 CZ CZ19963507A patent/CZ287381B6/cs not_active IP Right Cessation
- 1995-06-01 IL IL11396795A patent/IL113967A/xx not_active IP Right Cessation
- 1995-06-01 RU RU97100151/04A patent/RU2165933C2/ru not_active IP Right Cessation
- 1995-06-01 BR BR9507910A patent/BR9507910A/pt not_active Application Discontinuation
- 1995-06-01 CN CN95193383A patent/CN1048985C/zh not_active Expired - Fee Related
- 1995-06-01 NZ NZ331452A patent/NZ331452A/xx unknown
- 1995-06-01 MX MX9605915A patent/MX9605915A/es not_active IP Right Cessation
- 1995-06-01 NZ NZ287498A patent/NZ287498A/xx unknown
- 1995-06-01 ZA ZA954525A patent/ZA954525B/xx unknown
- 1995-06-01 SK SK1541-96A patent/SK281418B6/sk unknown
- 1995-06-01 AT AT95921017T patent/ATE192744T1/de not_active IP Right Cessation
- 1995-06-01 ES ES95921017T patent/ES2145275T3/es not_active Expired - Lifetime
- 1995-06-01 DK DK95921017T patent/DK0763031T3/da active
- 1995-06-01 HU HU9603315A patent/HUT76466A/hu unknown
- 1995-06-01 WO PCT/GB1995/001263 patent/WO1995033743A1/en not_active Ceased
- 1995-06-01 KR KR1019960706880A patent/KR100359393B1/ko not_active Expired - Fee Related
- 1995-06-02 US US08/459,205 patent/US5723464A/en not_active Expired - Lifetime
1996
- 1996-12-02 FI FI964815A patent/FI114985B/sv active IP Right Grant
1998
- 1998-11-10 CN CN98122461A patent/CN1093122C/zh not_active Expired - Fee Related
2000
- 2000-05-19 GR GR20000401137T patent/GR3033449T3/el not_active IP Right Cessation

Also Published As

Publication number	Publication date
DK0763031T3 (da)	2000-08-14
CA2191871C (en)	2004-09-21
HU9603315D0 (en)	1997-01-28
HUT76466A (en)	1997-09-29
US5723464A (en)	1998-03-03
IL113967A0 (en)	1995-10-31
ZA954525B (en)	1996-12-02
EP0763031B1 (en)	2000-05-10
JPH10500989A (ja)	1998-01-27
MX9605915A (es)	1997-12-31
DE69516867T2 (de)	2000-11-02
CN1048985C (zh)	2000-02-02
CZ350796A3 (en)	1997-06-11
CN1227841A (zh)	1999-09-08
IL113967A (en)	1999-03-12
CN1149873A (zh)	1997-05-14
SK281418B6 (sk)	2001-03-12
GB9411099D0 (en)	1994-07-27
RU2165933C2 (ru)	2001-04-27
FI114985B (sv)	2005-02-15
SK154196A3 (en)	1997-08-06
DE69516867D1 (de)	2000-06-15
WO1995033743A1 (en)	1995-12-14
NZ331452A (en)	2000-01-28
KR970703333A (ko)	1997-07-03
ATE192744T1 (de)	2000-05-15
FI964815A0 (sv)	1996-12-02
PT763031E (pt)	2000-10-31
GR3033449T3 (en)	2000-09-29
KR100359393B1 (ko)	2003-01-24
AU680147B2 (en)	1997-07-17
ES2145275T3 (es)	2000-07-01
CA2191871A1 (en)	1995-12-14
EP0763031A1 (en)	1997-03-19
AU2623095A (en)	1996-01-04
NZ287498A (en)	1998-10-28
CZ287381B6 (en)	2000-11-15
BR9507910A (pt)	1997-08-12
CN1093122C (zh)	2002-10-23

Publication	Publication Date	Title
FI964815L (sv)	1996-12-02	Piperazinderivat som 5-HT1A antagonister
FI942252L (sv)	1994-11-15	Piperazinderivat
BR9712037A (pt)	1999-08-24	Derivados de piperazina
FI942635A7 (sv)	1994-06-03	Piperazinderivat som 5HT1A-antagonister
ATE353326T1 (de)	2007-02-15	Piperazin-derivate
TR199600438A2 (tr)	1996-12-21	Piperazin türevleri.
NO960371D0 (no)	1996-01-29	Piperazinderivater som ter
FI955184L (sv)	1996-05-01	Benzylpiperidinderivat
FI962749L (sv)	1996-09-04	Nya heterocykliska föreningar
FI930799L (fi)	1993-02-23	Piperazinylderivat
DK1131308T3 (da)	2004-06-28	Piperazin- og piperidinderivater
ATE321042T1 (de)	2006-04-15	Piperazin-derivate
NO972937D0 (no)	1997-06-23	Farmasöytiske piperazinforbindelser
BR9507666A (pt)	1997-09-23	Novos derivados de pirimidina
DK0839146T3 (da)	2000-11-20	Piperazinderivater og deres anvendelse som 5-HT1A-antagonister
FI945086L (sv)	1995-05-03	1-(2H-1-bensopyran-2-on-8-yl)piperazinderivat
FI970110A7 (sv)	1997-01-10	Anti-Helicobakteriska heterocykliska azolonderivat
DE69524611D1 (de)	2002-01-24	Pyrimidon-derivate
FI960367A7 (sv)	1996-01-26	Nya dialkoxipyridinylbenzimidazolderivat
NO992066D0 (no)	1999-04-29	Piperazinoderivater som neurokininantagonister
FI972795L (sv)	1997-06-27	Pyrimidinderivat
FI970745A7 (sv)	1997-02-21	Dihydropyridinderivat som bradykininantagonister
DK91890A (da)	1990-10-16	Piperazin-derivater
FI931610A7 (sv)	1993-10-14	Piperazinderivat
FI971177L (sv)	1997-05-20	Bicykliska karboxamider som 5HT1A-antagonister

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2005-02-15	FG	Patent granted	Ref document number: 114985 Country of ref document: FI

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