FI952422L - Menetelmä finasteridin valmistamiseksi - Google Patents

Menetelmä finasteridin valmistamiseksi Download PDF

Info

Publication number: FI952422L
Authority: FI; Finland
Prior art keywords: preparing finasteride; finasteride; preparing
Prior art date: 1992-11-19

Application number

FI952422A

Other languages

English (en)

Swedish (sv)

Other versions

FI107450B (fi

FI952422A0 (fi

Inventor

Ulf H Dolling

James A Mccauley

Richard J Varsolona

Original Assignee

Merck & Co Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-11-19

Filing date

1995-05-18

Publication date

1995-05-18

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26681536&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=FI952422(L) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1995-05-18 Application filed by Merck & Co Inc filed Critical Merck & Co Inc

1995-05-18 Publication of FI952422A0 publication Critical patent/FI952422A0/fi

1995-05-18 Publication of FI952422L publication Critical patent/FI952422L/fi

2001-08-15 Application granted granted Critical

2001-08-15 Publication of FI107450B publication Critical patent/FI107450B/fi

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F3/00—Compounds containing elements of Groups 2 or 12 of the Periodic Table
- C07F3/003—Compounds containing elements of Groups 2 or 12 of the Periodic Table without C-Metal linkages
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J73/00—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms
- C07J73/001—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom
- C07J73/005—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom by nitrogen as hetero atom
- H—ELECTRICITY
- H04—ELECTRIC COMMUNICATION TECHNIQUE
- H04N—PICTORIAL COMMUNICATION, e.g. TELEVISION
- H04N5/00—Details of television systems
- H04N5/74—Projection arrangements for image reproduction, e.g. using eidophor
- H04N5/7416—Projection arrangements for image reproduction, e.g. using eidophor involving the use of a spatial light modulator, e.g. a light valve, controlled by a video signal
- H04N5/7458—Projection arrangements for image reproduction, e.g. using eidophor involving the use of a spatial light modulator, e.g. a light valve, controlled by a video signal the modulator being an array of deformable mirrors, e.g. digital micromirror device [DMD]

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
Multimedia (AREA)
Signal Processing (AREA)
Diabetes (AREA)
Endocrinology (AREA)
Dermatology (AREA)
Urology & Nephrology (AREA)
Steroid Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Confectionery (AREA)
Dental Preparations (AREA)
Seasonings (AREA)

FI952422A 1992-11-19 1995-05-18 Menetelmä finasteridin valmistamiseksi FI107450B (fi)

Applications Claiming Priority (6)

Application Number	Priority Date	Filing Date	Title
US97853592A	1992-11-19	1992-11-19
US97853592		1992-11-19
US1073493		1993-01-29
US08/010,734 US5468860A (en)	1992-11-19	1993-01-29	New finasteride processes
US9310659		1993-11-05
PCT/US1993/010659 WO1994011387A2 (en)	1992-11-19	1993-11-05	A process for the production of finasteride

Publications (3)

Publication Number	Publication Date
FI952422A0 FI952422A0 (fi)	1995-05-18
FI952422L true FI952422L (fi)	1995-05-18
FI107450B FI107450B (fi)	2001-08-15

Family

ID=26681536

Family Applications (4)

Application Number	Title	Priority Date	Filing Date
FI952422A FI107450B (fi)	1992-11-19	1995-05-18	Menetelmä finasteridin valmistamiseksi
FI20010289A FI114800B (fi)	1992-11-19	2001-02-15	Menetelmä finasteridin polymorfisen muodon valmistamiseksi
FI20010290A FI114215B (fi)	1992-11-19	2001-02-15	Menetelmä finasteridin polymorfisen muodon valmistamiseksi
FI20040559A FI116941B (fi)	1992-11-19	2004-04-21	Menetelmä finasteridin polymorfisen muodon valmistamiseksi

Family Applications After (3)

Application Number	Title	Priority Date	Filing Date
FI20010289A FI114800B (fi)	1992-11-19	2001-02-15	Menetelmä finasteridin polymorfisen muodon valmistamiseksi
FI20010290A FI114215B (fi)	1992-11-19	2001-02-15	Menetelmä finasteridin polymorfisen muodon valmistamiseksi
FI20040559A FI116941B (fi)	1992-11-19	2004-04-21	Menetelmä finasteridin polymorfisen muodon valmistamiseksi

Country Status (32)

Country	Link
US (3)	US5468860A (fi)
EP (3)	EP0655458B1 (fi)
JP (2)	JPH07110875B2 (fi)
CN (1)	CN1058018C (fi)
AT (2)	ATE164850T1 (fi)
AU (1)	AU658774B2 (fi)
BG (2)	BG62362B1 (fi)
CA (1)	CA2103107C (fi)
CY (1)	CY2135B1 (fi)
CZ (3)	CZ301160B6 (fi)
DE (4)	DE69323754T2 (fi)
DK (2)	DK0655458T3 (fi)
DZ (1)	DZ1733A1 (fi)
ES (2)	ES2052476T5 (fi)
FI (4)	FI107450B (fi)
GR (4)	GR940300045T1 (fi)
HR (2)	HRP931410B1 (fi)
HU (2)	HU216195B (fi)
IL (1)	IL107574A (fi)
IS (2)	IS1692B (fi)
LV (2)	LV12212B (fi)
MX (1)	MX9307222A (fi)
MY (2)	MY110411A (fi)
NO (3)	NO305912B1 (fi)
PH (1)	PH31120A (fi)
RO (2)	RO115164B1 (fi)
RU (1)	RU2120445C1 (fi)
SI (1)	SI9300603B (fi)
SK (2)	SK286488B6 (fi)
TW (1)	TW257766B (fi)
UA (1)	UA41341C2 (fi)
WO (1)	WO1994011387A2 (fi)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5468860A (en) *	1992-11-19	1995-11-21	Merck & Co., Inc.	New finasteride processes
TW408127B (en) *	1993-09-17	2000-10-11	Glaxo Inc	Androstenones
IT1270660B (it) *	1994-10-13	1997-05-07	Poli Ind Chimica Spa	Procedimento microbiologico per la preparazione di 3-oxo-4-azasteroidi-17beta-carbossi sostituiti e uso dei prodotti come inibitori dell'enzima 5alfa-riduttasi
US5670643A (en) *	1995-03-16	1997-09-23	Glaxo Wellcome Inc.	Method for preparing finasteride
US5585383A (en) *	1995-05-03	1996-12-17	Merck & Co., Inc.	Process for crystallizing a 4-azasteroid 5alpha-reductase inhibitor
EP0859761A4 (en) *	1995-09-15	2000-01-26	Merck & Co Inc	4-AZASTEROIDS FOR TREATING HYPERANDROGEN STATES
GB2338234B (en) *	1998-06-10	2000-05-03	Torcan Chemical Ltd	Preparation of finasteride
ES2153789B1 (es) *	1999-07-05	2001-10-16	Raga Consultores S L	Procedimiento para la obtencion de 178-(n-terc-butlcarbamoil)-3-ona-4-aza-esteroides
AU773067B2 (en) *	1999-11-01	2004-05-13	Torcan Chemical Ltd.	Production of polymorphic forms I and II of finasteride by complexation with group I or II metal salts
MXPA03002031A (es) *	2000-09-07	2004-12-13	Reddys Lab Ltd Dr	Forma polimorfica novedosa de 17-beta-(n-tercbutil carbamoil)-4-aza-5-alfa-androst-1-en-3-ona y proceso para preparar la misma.
CZ2003679A3 (cs) *	2000-09-07	2004-02-18	Dr. Reddy´S Laboratories Ltd.	Nová polymorfní forma 17beta-(N-terc-butylkarbamoyl)-4-aza-5alfa-androst-1-en-3-on a způsob její přípravy
JP2004508380A (ja) *	2000-09-07	2004-03-18	ドクター・レディーズ・ラボラトリーズ・リミテッド	１７−β−（Ｎ−ｔｅｒ−ブチルカルバモイル）−４−アザ−５−α−アンドロスト−１−エン−３−オンの新規の多形体及びその調製方法
KR100415858B1 (ko) *	2001-09-22	2004-01-24	한미약품 주식회사	17베타-(엔-3차-부틸카바모일)-3-온 스테로이드 화합물의제조방법
CN100428897C (zh) *	2002-08-16	2008-10-29	浙江寿峰堂生物工程有限公司	抗疲劳改善亚健康的保健食品及其制备方法
ES2206065B1 (es) *	2002-10-31	2005-08-16	Ragactives, S.L.	Procedimiento para la obtencion de la forma polimorfica i de finasterida.
WO2004083230A1 (en) *	2003-03-19	2004-09-30	Hetero Drugs Limited	Novel crystalline forms of finasteride
WO2005003149A1 (en) *	2003-07-03	2005-01-13	Cipla Limited	Process for the preparation of finasteride form i
US20050136015A1 (en) *	2003-12-17	2005-06-23	McKie Derrick B.	Topical use of halosalicylic acid derivatives
US20070167477A1 (en) *	2006-01-13	2007-07-19	Mandava Venkata Naga Brahmeswa	Processes to prepare finasteride polymorphs
US7531658B2 (en) *	2006-01-20	2009-05-12	Apotex Pharmachem Inc.	Process for the preparation of 17-N-substituted-carbamoyl-4-aza-androst-1-en-3-ones
US7927614B2 (en)	2006-02-03	2011-04-19	Jr Chem, Llc	Anti-aging treatment using copper and zinc compositions
US7897800B2 (en)	2006-02-03	2011-03-01	Jr Chem, Llc	Chemical compositions and methods of making them
US7687650B2 (en)	2006-02-03	2010-03-30	Jr Chem, Llc	Chemical compositions and methods of making them
US7867522B2 (en)	2006-09-28	2011-01-11	Jr Chem, Llc	Method of wound/burn healing using copper-zinc compositions
US20090076058A1 (en) *	2007-09-17	2009-03-19	Protia, Llc	Deuterium-enriched finasteride
US8273791B2 (en)	2008-01-04	2012-09-25	Jr Chem, Llc	Compositions, kits and regimens for the treatment of skin, especially décolletage
US9004752B2 (en) *	2008-05-05	2015-04-14	Abbvie, Inc.	Method for evaluating the solubility of a crystalline substance in a polymer
WO2010085753A1 (en)	2009-01-23	2010-07-29	Jr Chem, Llc	Rosacea treatments and kits for performing them
US8952057B2 (en)	2011-01-11	2015-02-10	Jr Chem, Llc	Compositions for anorectal use and methods for treating anorectal disorders

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NZ211145A (en) *	1984-02-27	1988-10-28	Merck & Co Inc	4-aza-5-alpha-androst-1-en-3-ones and pharmaceutical compositions
US4760071A (en) *	1984-02-27	1988-07-26	Merck & Co., Inc.	17β-N-monosubstituted carbamoyl-4-aza-5α-androst-1-en-3-ones which are active as testosterone 5α-reductase inhibitors
EP0285383B1 (en) *	1987-04-03	1994-03-16	Merck & Co. Inc.	Treatment of prostatic carcinoma with 17beta-n-monosubstituted-carbamoyl-4-aza-5alpha-androst-1-en-3-ones
NZ225100A (en) *	1987-06-29	1991-09-25	Merck & Co Inc	Reaction of steroids (including 4-azasteroids) with a silylating agent in the presence of a quinone to introduce a delta' double bond and silylated intermediates
US5084574A (en) *	1988-04-18	1992-01-28	Merck & Co., Inc.	Dehydrogenation process
US5237061A (en) *	1988-10-31	1993-08-17	Merck & Co., Inc.	Methods of synthesizing benign prostatic hypertropic agents and their intermediates
US5021575A (en) *	1989-11-13	1991-06-04	Merck & Co., Inc.	Method for introducing a 1,2 double bond into azasteroids
ES2078447T3 (es) *	1990-06-15	1995-12-16	Merck & Co Inc	Un procedimiento de cristalizacion para mejorar la estructura y el tamaño de los cristales.
EP0462662A3 (en) *	1990-06-20	1992-08-19	Merck & Co. Inc.	17beta-n-monosubstituted adamantyl/norbornanyl carbamoyl-4-aza-5alpha-androst-1-en-3-ones and androstan-3-ones
US5120847A (en) †	1990-08-27	1992-06-09	Merck & Co., Inc.	Process for iodinating or brominating the α-methylenic carbon of a secondary amide
US5091534A (en)	1990-08-27	1992-02-25	Merck & Co., Inc.	Trialkylsilyl trifluoromethanesulfonate mediated α-methylenic carbon functionalization of 4-AZA-5α-androstan-3-one steroids
US5061801A (en) *	1990-09-24	1991-10-29	Merck & Co., Inc.	Intermediate for making 3-oxo-4-aza-androst-1-ene 17β-ketones
CA2050824A1 (en) *	1990-09-24	1992-03-25	John M. Williams	Process for making 3-oxo-4-aza-androst-1-ene 17-.beta.-ketones
US5468860A (en) *	1992-11-19	1995-11-21	Merck & Co., Inc.	New finasteride processes

1993
- 1993-01-29 US US08/010,734 patent/US5468860A/en not_active Expired - Fee Related
- 1993-11-05 CZ CZ20003685A patent/CZ301160B6/cs not_active IP Right Cessation
- 1993-11-05 RO RO95-00940A patent/RO115164B1/ro unknown
- 1993-11-05 CZ CZ20003686A patent/CZ301191B6/cs not_active IP Right Cessation
- 1993-11-05 UA UA95058438A patent/UA41341C2/uk unknown
- 1993-11-05 SK SK1897-2000A patent/SK286488B6/sk not_active IP Right Cessation
- 1993-11-05 RO RO99-00785A patent/RO115165B1/ro unknown
- 1993-11-05 SK SK659-95A patent/SK281765B6/sk unknown
- 1993-11-05 CZ CZ19951268A patent/CZ287842B6/cs not_active IP Right Cessation
- 1993-11-05 IS IS4286A patent/IS1692B/is unknown
- 1993-11-05 US US08/411,685 patent/US5652365A/en not_active Expired - Lifetime
- 1993-11-05 RU RU95112521A patent/RU2120445C1/ru active
- 1993-11-05 WO PCT/US1993/010659 patent/WO1994011387A2/en not_active Ceased
- 1993-11-11 TW TW082109464A patent/TW257766B/zh not_active IP Right Cessation
- 1993-11-11 MY MYPI96001019A patent/MY110411A/en unknown
- 1993-11-11 MY MYPI93002365A patent/MY110410A/en unknown
- 1993-11-11 IL IL10757493A patent/IL107574A/xx not_active IP Right Cessation
- 1993-11-12 ES ES93203163T patent/ES2052476T5/es not_active Expired - Lifetime
- 1993-11-12 ES ES95200270T patent/ES2072848T3/es not_active Expired - Lifetime
- 1993-11-12 DE DE69323754T patent/DE69323754T2/de not_active Expired - Fee Related
- 1993-11-12 EP EP95200270A patent/EP0655458B1/en not_active Expired - Lifetime
- 1993-11-12 AT AT93203163T patent/ATE164850T1/de active
- 1993-11-12 DK DK95200270T patent/DK0655458T3/da active
- 1993-11-12 EP EP93203163A patent/EP0599376B2/en not_active Expired - Lifetime
- 1993-11-12 EP EP97201712A patent/EP0823436A3/en not_active Withdrawn
- 1993-11-12 DE DE69317856T patent/DE69317856T2/de not_active Expired - Lifetime
- 1993-11-12 DE DE0599376T patent/DE599376T1/de active Pending
- 1993-11-12 DE DE0655458T patent/DE655458T1/de active Pending
- 1993-11-12 DK DK93203163T patent/DK0599376T4/da active
- 1993-11-12 AT AT95200270T patent/ATE177112T1/de not_active IP Right Cessation
- 1993-11-15 CA CA2103107A patent/CA2103107C/en not_active Expired - Lifetime
- 1993-11-16 IS IS4094A patent/IS1671B/is unknown
- 1993-11-17 DZ DZ930120A patent/DZ1733A1/fr active
- 1993-11-18 MX MX9307222A patent/MX9307222A/es not_active IP Right Cessation
- 1993-11-18 JP JP5289536A patent/JPH07110875B2/ja not_active Expired - Fee Related
- 1993-11-18 HU HU9303275A patent/HU216195B/hu unknown
- 1993-11-18 AU AU50787/93A patent/AU658774B2/en not_active Expired
- 1993-11-18 HR HR931410A patent/HRP931410B1/xx not_active IP Right Cessation
- 1993-11-19 CN CN93114530A patent/CN1058018C/zh not_active Expired - Lifetime
- 1993-11-19 PH PH47298A patent/PH31120A/en unknown
- 1993-11-19 SI SI9300603A patent/SI9300603B/sl unknown
1994
- 1994-07-29 GR GR940300045T patent/GR940300045T1/el unknown
- 1994-11-07 HU HU94P/P00041P patent/HU210535A9/hu unknown
1995
- 1995-05-16 BG BG99637A patent/BG62362B1/bg unknown
- 1995-05-18 FI FI952422A patent/FI107450B/fi not_active IP Right Cessation
- 1995-05-19 NO NO951986A patent/NO305912B1/no not_active IP Right Cessation
- 1995-07-31 GR GR950300043T patent/GR950300043T1/el unknown
1996
- 1996-09-30 JP JP8259373A patent/JP2742409B2/ja not_active Expired - Lifetime
1997
- 1997-03-26 US US08/824,426 patent/US5886184A/en not_active Expired - Lifetime
1998
- 1998-04-09 GR GR980400749T patent/GR3026577T3/el unknown
- 1998-10-26 LV LVP-98-236A patent/LV12212B/en unknown
1999
- 1999-02-01 NO NO990468A patent/NO307888B1/no not_active IP Right Cessation
- 1999-02-11 BG BG103170A patent/BG64464B1/bg unknown
- 1999-03-04 GR GR990400546T patent/GR3029554T3/el unknown
- 1999-05-28 NO NO992580A patent/NO307609B1/no not_active IP Right Cessation
- 1999-09-07 CY CY9900028A patent/CY2135B1/xx unknown
2000
- 2000-02-23 LV LVP-00-26A patent/LV12460B/en unknown
- 2000-05-12 HR HR20000295A patent/HRP20000295B1/xx not_active IP Right Cessation
2001
- 2001-02-15 FI FI20010289A patent/FI114800B/fi not_active IP Right Cessation
- 2001-02-15 FI FI20010290A patent/FI114215B/fi not_active IP Right Cessation
2004
- 2004-04-21 FI FI20040559A patent/FI116941B/fi not_active IP Right Cessation

Also Published As

Publication number	Publication date
LV12460A (lv)	2000-04-20
NO990468D0 (no)	1999-02-01
CN1058018C (zh)	2000-11-01
ES2072848T1 (es)	1995-08-01
DE599376T1 (de)	1994-12-08
CZ287842B6 (en)	2001-02-14
DE69323754D1 (de)	1999-04-08
NO992580D0 (no)	1999-05-28
GR3029554T3 (en)	1999-06-30
ES2052476T1 (es)	1994-07-16
NO992580L (no)	1995-05-19
DE655458T1 (de)	1995-11-30
RO115164B1 (ro)	1999-11-30
TW257766B (fi)	1995-09-21
AU658774B2 (en)	1995-04-27
FI107450B (fi)	2001-08-15
HRP931410A2 (en)	1996-06-30
NO990468L (no)	1995-05-19
FI20010290L (fi)	2001-02-15
LV12460B (en)	2000-09-20
FI952422A0 (fi)	1995-05-18
BG99637A (bg)	1996-04-30
HK1008338A1 (en)	1999-05-07
GR950300043T1 (en)	1995-07-31
EP0599376A2 (en)	1994-06-01
FI20010289L (fi)	2001-02-15
JP2742409B2 (ja)	1998-04-22
SK286488B6 (sk)	2008-11-06
SK281765B6 (sk)	2001-07-10
NO307609B1 (no)	2000-05-02
DE69323754T2 (de)	1999-10-07
HUT66973A (en)	1995-01-30
DZ1733A1 (fr)	2002-02-17
IS1671B (is)	1997-12-19
LV12212A (lv)	1999-01-20
EP0823436A3 (en)	1998-11-25
NO307888B3 (no)	2000-06-13
CY2135B1 (en)	2002-05-21
NO307888B1 (no)	2000-06-13
DE69317856T2 (de)	1998-11-05
EP0599376B2 (en)	2008-04-16
FI114800B (fi)	2004-12-31
FI116941B (fi)	2006-04-13
MY110410A (en)	1998-05-30
SI9300603B (sl)	2004-06-30
HRP20000295B1 (en)	2002-08-31
EP0599376A3 (en)	1994-09-28
ES2052476T5 (es)	2008-11-01
WO1994011387A2 (en)	1994-05-26
EP0823436A2 (en)	1998-02-11
SK65995A3 (en)	1995-10-11
DK0655458T3 (da)	1999-09-27
UA41341C2 (uk)	2001-09-17
HU9303275D0 (en)	1994-03-28
FI20040559A7 (fi)	2004-04-21
FI114215B (fi)	2004-09-15
NO951986L (no)	1995-05-19
US5652365A (en)	1997-07-29
CZ301191B6 (cs)	2009-12-02
GR940300045T1 (en)	1994-07-29
NO951986D0 (no)	1995-05-19
RU95112521A (ru)	1997-02-10
US5468860A (en)	1995-11-21
DE69317856D1 (de)	1998-05-14
IS4094A (is)	1994-05-20
US5886184A (en)	1999-03-23
IL107574A0 (en)	1994-02-27
NO305912B1 (no)	1999-08-16
ES2072848T3 (es)	1999-05-01
BG62362B1 (bg)	1999-09-30
CA2103107A1 (en)	1994-05-20
IS1692B (is)	1998-04-20
CN1090583A (zh)	1994-08-10
CZ301160B6 (cs)	2009-11-18
DK0599376T4 (da)	2008-07-28
HRP931410B1 (en)	2000-06-30
EP0655458A3 (en)	1996-07-10
GR3026577T3 (en)	1998-07-31
LV12212B (en)	1999-03-20
CZ126895A3 (en)	1995-12-13
HU210535A9 (en)	1995-04-28
ATE177112T1 (de)	1999-03-15
AU5078793A (en)	1994-06-16
WO1994011387A3 (en)	1994-09-29
ES2052476T3 (es)	1998-06-16
MY110411A (en)	1998-05-30
MX9307222A (es)	1994-07-29
RU2120445C1 (ru)	1998-10-20
SI9300603A (en)	1994-06-30
JPH09235294A (ja)	1997-09-09
IL107574A (en)	2000-07-16
JPH07110875B2 (ja)	1995-11-29
HU216195B (hu)	1999-05-28
RO115165B1 (ro)	1999-11-30
PH31120A (en)	1998-02-23
BG103170A (en)	1999-09-30
BG64464B1 (bg)	2005-03-31
JPH06199889A (ja)	1994-07-19
HRP20000295A2 (en)	2000-08-31
ATE164850T1 (de)	1998-04-15
EP0655458A2 (en)	1995-05-31
IS4286A (is)	1994-05-20
EP0599376B1 (en)	1998-04-08
EP0655458B1 (en)	1999-03-03
CA2103107C (en)	2010-09-28

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2010-04-20

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Owner name: MERCK SHARP & DOHME CORP.

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2012-08-15