FI20010290L - Menetelmä finasteridin polymorfisen muodon valmistamiseksi - Google Patents

Menetelmä finasteridin polymorfisen muodon valmistamiseksi Download PDF

Info

Publication number: FI20010290L
Authority: FI; Finland
Prior art keywords: finasteride; preparing; polymorphic form; polymorphic
Prior art date: 1992-11-19

Application number

FI20010290A

Other languages

English (en)

Swedish (sv)

Other versions

FI114215B (fi

Inventor

Ulf H Dolling

James A Mccauley

Richard J Varsolona

Original Assignee

Merck & Co Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-11-19

Filing date

2001-02-15

Publication date

2001-02-15

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26681536&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=FI20010290(L) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2001-02-15 Application filed by Merck & Co Inc filed Critical Merck & Co Inc

2001-02-15 Publication of FI20010290L publication Critical patent/FI20010290L/fi

2004-09-15 Application granted granted Critical

2004-09-15 Publication of FI114215B publication Critical patent/FI114215B/fi

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F3/00—Compounds containing elements of Groups 2 or 12 of the Periodic Table
- C07F3/003—Compounds containing elements of Groups 2 or 12 of the Periodic Table without C-Metal linkages
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J73/00—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms
- C07J73/001—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom
- C07J73/005—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom by nitrogen as hetero atom
- H—ELECTRICITY
- H04—ELECTRIC COMMUNICATION TECHNIQUE
- H04N—PICTORIAL COMMUNICATION, e.g. TELEVISION
- H04N5/00—Details of television systems
- H04N5/74—Projection arrangements for image reproduction, e.g. using eidophor
- H04N5/7416—Projection arrangements for image reproduction, e.g. using eidophor involving the use of a spatial light modulator, e.g. a light valve, controlled by a video signal
- H04N5/7458—Projection arrangements for image reproduction, e.g. using eidophor involving the use of a spatial light modulator, e.g. a light valve, controlled by a video signal the modulator being an array of deformable mirrors, e.g. digital micromirror device [DMD]

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
Multimedia (AREA)
Signal Processing (AREA)
Diabetes (AREA)
Endocrinology (AREA)
Urology & Nephrology (AREA)
Dermatology (AREA)
Steroid Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Confectionery (AREA)
Dental Preparations (AREA)
Seasonings (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)

FI20010290A 1992-11-19 2001-02-15 Menetelmä finasteridin polymorfisen muodon valmistamiseksi FI114215B (fi)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US97853592A	1992-11-19	1992-11-19
US08/010,734 US5468860A (en)	1992-11-19	1993-01-29	New finasteride processes
PCT/US1993/010659 WO1994011387A2 (en)	1992-11-19	1993-11-05	A process for the production of finasteride

Publications (2)

Publication Number	Publication Date
FI20010290L true FI20010290L (fi)	2001-02-15
FI114215B FI114215B (fi)	2004-09-15

Family

ID=26681536

Family Applications (4)

Application Number	Title	Priority Date	Filing Date
FI952422A FI107450B (fi)	1992-11-19	1995-05-18	Menetelmä finasteridin valmistamiseksi
FI20010290A FI114215B (fi)	1992-11-19	2001-02-15	Menetelmä finasteridin polymorfisen muodon valmistamiseksi
FI20010289A FI114800B (fi)	1992-11-19	2001-02-15	Menetelmä finasteridin polymorfisen muodon valmistamiseksi
FI20040559A FI116941B (fi)	1992-11-19	2004-04-21	Menetelmä finasteridin polymorfisen muodon valmistamiseksi

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
FI952422A FI107450B (fi)	1992-11-19	1995-05-18	Menetelmä finasteridin valmistamiseksi

Family Applications After (2)

Application Number	Title	Priority Date	Filing Date
FI20010289A FI114800B (fi)	1992-11-19	2001-02-15	Menetelmä finasteridin polymorfisen muodon valmistamiseksi
FI20040559A FI116941B (fi)	1992-11-19	2004-04-21	Menetelmä finasteridin polymorfisen muodon valmistamiseksi

Country Status (32)

Country	Link
US (3)	US5468860A (fi)
EP (3)	EP0599376B2 (fi)
JP (2)	JPH07110875B2 (fi)
CN (1)	CN1058018C (fi)
AT (2)	ATE164850T1 (fi)
AU (1)	AU658774B2 (fi)
BG (2)	BG62362B1 (fi)
CA (1)	CA2103107C (fi)
CY (1)	CY2135B1 (fi)
CZ (3)	CZ301160B6 (fi)
DE (4)	DE599376T1 (fi)
DK (2)	DK0655458T3 (fi)
DZ (1)	DZ1733A1 (fi)
ES (2)	ES2052476T5 (fi)
FI (4)	FI107450B (fi)
GR (4)	GR940300045T1 (fi)
HR (2)	HRP931410B1 (fi)
HU (2)	HU216195B (fi)
IL (1)	IL107574A (fi)
IS (2)	IS1692B (fi)
LV (2)	LV12212B (fi)
MX (1)	MX9307222A (fi)
MY (2)	MY110410A (fi)
NO (3)	NO305912B1 (fi)
PH (1)	PH31120A (fi)
RO (2)	RO115164B1 (fi)
RU (1)	RU2120445C1 (fi)
SI (1)	SI9300603B (fi)
SK (2)	SK281765B6 (fi)
TW (1)	TW257766B (fi)
UA (1)	UA41341C2 (fi)
WO (1)	WO1994011387A2 (fi)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5468860A (en) *	1992-11-19	1995-11-21	Merck & Co., Inc.	New finasteride processes
TW408127B (en) *	1993-09-17	2000-10-11	Glaxo Inc	Androstenones
IT1270660B (it) *	1994-10-13	1997-05-07	Poli Ind Chimica Spa	Procedimento microbiologico per la preparazione di 3-oxo-4-azasteroidi-17beta-carbossi sostituiti e uso dei prodotti come inibitori dell'enzima 5alfa-riduttasi
US5670643A (en) *	1995-03-16	1997-09-23	Glaxo Wellcome Inc.	Method for preparing finasteride
US5585383A (en) *	1995-05-03	1996-12-17	Merck & Co., Inc.	Process for crystallizing a 4-azasteroid 5alpha-reductase inhibitor
WO1997010217A1 (en) *	1995-09-15	1997-03-20	Merck & Co., Inc.	4-azasteroids for treatment of hyperandrogenic conditions
GB2338234B (en) *	1998-06-10	2000-05-03	Torcan Chemical Ltd	Preparation of finasteride
ES2153789B1 (es) *	1999-07-05	2001-10-16	Raga Consultores S L	Procedimiento para la obtencion de 178-(n-terc-butlcarbamoil)-3-ona-4-aza-esteroides
EA200200524A1 (ru) *	1999-11-01	2002-10-31	Торкан Кемикал Лтд.	Получение полиморфных форм i и ii финастерида путем образования комплексов с солями металлов группы i или ii
CZ2003679A3 (cs) *	2000-09-07	2004-02-18	Dr. Reddy´S Laboratories Ltd.	Nová polymorfní forma 17beta-(N-terc-butylkarbamoyl)-4-aza-5alfa-androst-1-en-3-on a způsob její přípravy
CN1468254A (zh) *	2000-09-07	2004-01-14	雷迪实验室有限公司	17-β-(N-叔丁基氨基甲酰基)-4-氮杂-5-α-雄甾-1-烯-3-酮的新颖多晶型物及其制备方法
NZ525116A (en) *	2000-09-07	2004-11-26	Dr	Novel polymorphic form of 17- beta -(N-ter.butyl carbamoyl)-4-AZA-5- alpha -androst-1-en-3-one and a process for preparing it
KR100415858B1 (ko) *	2001-09-22	2004-01-24	한미약품 주식회사	17베타-(엔-3차-부틸카바모일)-3-온 스테로이드 화합물의제조방법
CN100428897C (zh) *	2002-08-16	2008-10-29	浙江寿峰堂生物工程有限公司	抗疲劳改善亚健康的保健食品及其制备方法
ES2206065B1 (es) *	2002-10-31	2005-08-16	Ragactives, S.L.	Procedimiento para la obtencion de la forma polimorfica i de finasterida.
AU2003217439A1 (en) *	2003-03-19	2004-10-11	Hetero Drugs Limited	Novel crystalline forms of finasteride
ATE406376T1 (de) *	2003-07-03	2008-09-15	Cipla Ltd	Verfahren zur herstellung von finasterid form i
US20050136015A1 (en) *	2003-12-17	2005-06-23	McKie Derrick B.	Topical use of halosalicylic acid derivatives
US20070167477A1 (en) *	2006-01-13	2007-07-19	Mandava Venkata Naga Brahmeswa	Processes to prepare finasteride polymorphs
US7531658B2 (en) *	2006-01-20	2009-05-12	Apotex Pharmachem Inc.	Process for the preparation of 17-N-substituted-carbamoyl-4-aza-androst-1-en-3-ones
US7927614B2 (en)	2006-02-03	2011-04-19	Jr Chem, Llc	Anti-aging treatment using copper and zinc compositions
US7897800B2 (en)	2006-02-03	2011-03-01	Jr Chem, Llc	Chemical compositions and methods of making them
US7687650B2 (en)	2006-02-03	2010-03-30	Jr Chem, Llc	Chemical compositions and methods of making them
US7867522B2 (en)	2006-09-28	2011-01-11	Jr Chem, Llc	Method of wound/burn healing using copper-zinc compositions
US20090076058A1 (en) *	2007-09-17	2009-03-19	Protia, Llc	Deuterium-enriched finasteride
US8273791B2 (en)	2008-01-04	2012-09-25	Jr Chem, Llc	Compositions, kits and regimens for the treatment of skin, especially décolletage
CA2723398C (en) *	2008-05-05	2017-07-04	Abbott Gmbh & Co. Kg	Method for evaluating the solubility of a crystalline substance in a polymer
CA2750636C (en)	2009-01-23	2017-07-25	Jr Chem, Llc	Rosacea treatments and kits for performing them
US8952057B2 (en)	2011-01-11	2015-02-10	Jr Chem, Llc	Compositions for anorectal use and methods for treating anorectal disorders

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4760071A (en) *	1984-02-27	1988-07-26	Merck & Co., Inc.	17β-N-monosubstituted carbamoyl-4-aza-5α-androst-1-en-3-ones which are active as testosterone 5α-reductase inhibitors
NZ211145A (en)	1984-02-27	1988-10-28	Merck & Co Inc	4-aza-5-alpha-androst-1-en-3-ones and pharmaceutical compositions
DE3888378T2 (de) *	1987-04-03	1994-09-29	Merck & Co Inc	Behandlung von Prostatacarcinoma mit 17-beta-n-monosubstituierten-Carbamoyl-4-aza-5-alpha-Androst-1-en-3-onen.
NZ225100A (en)	1987-06-29	1991-09-25	Merck & Co Inc	Reaction of steroids (including 4-azasteroids) with a silylating agent in the presence of a quinone to introduce a delta' double bond and silylated intermediates
US5084574A (en) *	1988-04-18	1992-01-28	Merck & Co., Inc.	Dehydrogenation process
US5237061A (en) *	1988-10-31	1993-08-17	Merck & Co., Inc.	Methods of synthesizing benign prostatic hypertropic agents and their intermediates
US5021575A (en) *	1989-11-13	1991-06-04	Merck & Co., Inc.	Method for introducing a 1,2 double bond into azasteroids
JP3282731B2 (ja) *	1990-06-15	2002-05-20	メルクエンドカムパニーインコーポレーテッド	結晶の構造および大きさを改良する結晶化方法
EP0462662A3 (en) *	1990-06-20	1992-08-19	Merck & Co. Inc.	17beta-n-monosubstituted adamantyl/norbornanyl carbamoyl-4-aza-5alpha-androst-1-en-3-ones and androstan-3-ones
US5120847A (en) †	1990-08-27	1992-06-09	Merck & Co., Inc.	Process for iodinating or brominating the α-methylenic carbon of a secondary amide
US5091534A (en)	1990-08-27	1992-02-25	Merck & Co., Inc.	Trialkylsilyl trifluoromethanesulfonate mediated α-methylenic carbon functionalization of 4-AZA-5α-androstan-3-one steroids
CA2050824A1 (en) *	1990-09-24	1992-03-25	John M. Williams	Process for making 3-oxo-4-aza-androst-1-ene 17-.beta.-ketones
US5061801A (en) *	1990-09-24	1991-10-29	Merck & Co., Inc.	Intermediate for making 3-oxo-4-aza-androst-1-ene 17β-ketones
US5468860A (en) *	1992-11-19	1995-11-21	Merck & Co., Inc.	New finasteride processes

1993
- 1993-01-29 US US08/010,734 patent/US5468860A/en not_active Expired - Fee Related
- 1993-11-05 US US08/411,685 patent/US5652365A/en not_active Expired - Lifetime
- 1993-11-05 SK SK659-95A patent/SK281765B6/sk unknown
- 1993-11-05 UA UA95058438A patent/UA41341C2/uk unknown
- 1993-11-05 CZ CZ20003685A patent/CZ301160B6/cs not_active IP Right Cessation
- 1993-11-05 IS IS4286A patent/IS1692B/is unknown
- 1993-11-05 CZ CZ20003686A patent/CZ301191B6/cs not_active IP Right Cessation
- 1993-11-05 RO RO95-00940A patent/RO115164B1/ro unknown
- 1993-11-05 SK SK1897-2000A patent/SK286488B6/sk not_active IP Right Cessation
- 1993-11-05 RU RU95112521A patent/RU2120445C1/ru active
- 1993-11-05 RO RO99-00785A patent/RO115165B1/ro unknown
- 1993-11-05 CZ CZ19951268A patent/CZ287842B6/cs not_active IP Right Cessation
- 1993-11-05 WO PCT/US1993/010659 patent/WO1994011387A2/en not_active Ceased
- 1993-11-11 TW TW082109464A patent/TW257766B/zh not_active IP Right Cessation
- 1993-11-11 MY MYPI93002365A patent/MY110410A/en unknown
- 1993-11-11 MY MYPI96001019A patent/MY110411A/en unknown
- 1993-11-11 IL IL10757493A patent/IL107574A/xx not_active IP Right Cessation
- 1993-11-12 DE DE0599376T patent/DE599376T1/de active Pending
- 1993-11-12 ES ES93203163T patent/ES2052476T5/es not_active Expired - Lifetime
- 1993-11-12 DE DE69323754T patent/DE69323754T2/de not_active Expired - Fee Related
- 1993-11-12 EP EP93203163A patent/EP0599376B2/en not_active Expired - Lifetime
- 1993-11-12 ES ES95200270T patent/ES2072848T3/es not_active Expired - Lifetime
- 1993-11-12 DK DK95200270T patent/DK0655458T3/da active
- 1993-11-12 AT AT93203163T patent/ATE164850T1/de active
- 1993-11-12 DK DK93203163T patent/DK0599376T4/da active
- 1993-11-12 EP EP95200270A patent/EP0655458B1/en not_active Expired - Lifetime
- 1993-11-12 EP EP97201712A patent/EP0823436A3/en not_active Withdrawn
- 1993-11-12 DE DE0655458T patent/DE655458T1/de active Pending
- 1993-11-12 AT AT95200270T patent/ATE177112T1/de not_active IP Right Cessation
- 1993-11-12 DE DE69317856T patent/DE69317856T2/de not_active Expired - Lifetime
- 1993-11-15 CA CA2103107A patent/CA2103107C/en not_active Expired - Lifetime
- 1993-11-16 IS IS4094A patent/IS1671B/is unknown
- 1993-11-17 DZ DZ930120A patent/DZ1733A1/fr active
- 1993-11-18 HR HR931410A patent/HRP931410B1/xx not_active IP Right Cessation
- 1993-11-18 HU HU9303275A patent/HU216195B/hu unknown
- 1993-11-18 JP JP5289536A patent/JPH07110875B2/ja not_active Expired - Fee Related
- 1993-11-18 MX MX9307222A patent/MX9307222A/es not_active IP Right Cessation
- 1993-11-18 AU AU50787/93A patent/AU658774B2/en not_active Expired
- 1993-11-19 PH PH47298A patent/PH31120A/en unknown
- 1993-11-19 CN CN93114530A patent/CN1058018C/zh not_active Expired - Lifetime
- 1993-11-19 SI SI9300603A patent/SI9300603B/sl unknown
1994
- 1994-07-29 GR GR940300045T patent/GR940300045T1/el unknown
- 1994-11-07 HU HU94P/P00041P patent/HU210535A9/hu unknown
1995
- 1995-05-16 BG BG99637A patent/BG62362B1/bg unknown
- 1995-05-18 FI FI952422A patent/FI107450B/fi not_active IP Right Cessation
- 1995-05-19 NO NO951986A patent/NO305912B1/no not_active IP Right Cessation
- 1995-07-31 GR GR950300043T patent/GR950300043T1/el unknown
1996
- 1996-09-30 JP JP8259373A patent/JP2742409B2/ja not_active Expired - Lifetime
1997
- 1997-03-26 US US08/824,426 patent/US5886184A/en not_active Expired - Lifetime
1998
- 1998-04-09 GR GR980400749T patent/GR3026577T3/el unknown
- 1998-10-26 LV LVP-98-236A patent/LV12212B/en unknown
1999
- 1999-02-01 NO NO990468A patent/NO307888B1/no not_active IP Right Cessation
- 1999-02-11 BG BG103170A patent/BG64464B1/bg unknown
- 1999-03-04 GR GR990400546T patent/GR3029554T3/el unknown
- 1999-05-28 NO NO992580A patent/NO307609B1/no not_active IP Right Cessation
- 1999-09-07 CY CY9900028A patent/CY2135B1/xx unknown
2000
- 2000-02-23 LV LVP-00-26A patent/LV12460B/en unknown
- 2000-05-12 HR HR20000295A patent/HRP20000295B1/xx not_active IP Right Cessation
2001
- 2001-02-15 FI FI20010290A patent/FI114215B/fi not_active IP Right Cessation
- 2001-02-15 FI FI20010289A patent/FI114800B/fi not_active IP Right Cessation
2004
- 2004-04-21 FI FI20040559A patent/FI116941B/fi not_active IP Right Cessation

Also Published As

Publication number	Publication date
IS1692B (is)	1998-04-20
IS4286A (is)	1994-05-20
NO990468L (no)	1995-05-19
ATE177112T1 (de)	1999-03-15
NO305912B1 (no)	1999-08-16
NO307609B1 (no)	2000-05-02
BG62362B1 (bg)	1999-09-30
DE655458T1 (de)	1995-11-30
IS4094A (is)	1994-05-20
ES2052476T5 (es)	2008-11-01
GR940300045T1 (en)	1994-07-29
DE69317856D1 (de)	1998-05-14
ATE164850T1 (de)	1998-04-15
JPH07110875B2 (ja)	1995-11-29
NO992580D0 (no)	1999-05-28
IL107574A0 (en)	1994-02-27
CZ287842B6 (en)	2001-02-14
AU658774B2 (en)	1995-04-27
HU216195B (hu)	1999-05-28
EP0599376A3 (en)	1994-09-28
MX9307222A (es)	1994-07-29
HK1008338A1 (en)	1999-05-07
GR950300043T1 (en)	1995-07-31
RO115165B1 (ro)	1999-11-30
FI952422A0 (fi)	1995-05-18
LV12460A (lv)	2000-04-20
NO990468D0 (no)	1999-02-01
ES2072848T3 (es)	1999-05-01
FI952422L (fi)	1995-05-18
IS1671B (is)	1997-12-19
HU9303275D0 (en)	1994-03-28
JPH09235294A (ja)	1997-09-09
FI20010289L (fi)	2001-02-15
NO951986D0 (no)	1995-05-19
BG99637A (bg)	1996-04-30
RO115164B1 (ro)	1999-11-30
SK286488B6 (sk)	2008-11-06
TW257766B (fi)	1995-09-21
NO307888B3 (no)	2000-06-13
RU95112521A (ru)	1997-02-10
RU2120445C1 (ru)	1998-10-20
BG64464B1 (bg)	2005-03-31
CA2103107A1 (en)	1994-05-20
CY2135B1 (en)	2002-05-21
DK0599376T4 (da)	2008-07-28
EP0823436A3 (en)	1998-11-25
LV12212B (en)	1999-03-20
NO307888B1 (no)	2000-06-13
CZ301191B6 (cs)	2009-12-02
HRP20000295B1 (en)	2002-08-31
LV12460B (en)	2000-09-20
DE69323754D1 (de)	1999-04-08
EP0655458A3 (en)	1996-07-10
HRP931410B1 (en)	2000-06-30
MY110411A (en)	1998-05-30
HUT66973A (en)	1995-01-30
SI9300603A (en)	1994-06-30
SK65995A3 (en)	1995-10-11
PH31120A (en)	1998-02-23
JPH06199889A (ja)	1994-07-19
EP0599376A2 (en)	1994-06-01
DE69317856T2 (de)	1998-11-05
HRP931410A2 (en)	1996-06-30
DE69323754T2 (de)	1999-10-07
EP0655458A2 (en)	1995-05-31
EP0823436A2 (en)	1998-02-11
DE599376T1 (de)	1994-12-08
GR3029554T3 (en)	1999-06-30
CN1090583A (zh)	1994-08-10
SK281765B6 (sk)	2001-07-10
GR3026577T3 (en)	1998-07-31
FI20040559A7 (fi)	2004-04-21
AU5078793A (en)	1994-06-16
WO1994011387A3 (en)	1994-09-29
US5468860A (en)	1995-11-21
EP0655458B1 (en)	1999-03-03
US5652365A (en)	1997-07-29
SI9300603B (sl)	2004-06-30
FI114215B (fi)	2004-09-15
DK0655458T3 (da)	1999-09-27
DZ1733A1 (fr)	2002-02-17
NO992580L (no)	1995-05-19
CZ126895A3 (en)	1995-12-13
IL107574A (en)	2000-07-16
JP2742409B2 (ja)	1998-04-22
US5886184A (en)	1999-03-23
HU210535A9 (en)	1995-04-28
CA2103107C (en)	2010-09-28
FI107450B (fi)	2001-08-15
WO1994011387A2 (en)	1994-05-26
EP0599376B1 (en)	1998-04-08
BG103170A (en)	1999-09-30
MY110410A (en)	1998-05-30
HRP20000295A2 (en)	2000-08-31
UA41341C2 (uk)	2001-09-17
NO951986L (no)	1995-05-19
EP0599376B2 (en)	2008-04-16
FI114800B (fi)	2004-12-31
FI116941B (fi)	2006-04-13
ES2052476T3 (es)	1998-06-16
LV12212A (lv)	1999-01-20
CN1058018C (zh)	2000-11-01
CZ301160B6 (cs)	2009-11-18
ES2072848T1 (es)	1995-08-01
ES2052476T1 (es)	1994-07-16

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