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FI951541L - Suurimolekyylipainoinen desulfatohirudiini - Google Patents

Suurimolekyylipainoinen desulfatohirudiini Download PDF

Info

Publication number
FI951541L
FI951541L FI951541A FI951541A FI951541L FI 951541 L FI951541 L FI 951541L FI 951541 A FI951541 A FI 951541A FI 951541 A FI951541 A FI 951541A FI 951541 L FI951541 L FI 951541L
Authority
FI
Finland
Prior art keywords
desulphatohirudin
molecular weight
high molecular
weight
weight desulphatohirudin
Prior art date
Application number
FI951541A
Other languages
English (en)
Swedish (sv)
Other versions
FI951541A0 (fi
FI951541A7 (fi
Inventor
Hugo Grossenbacher
Jui Yoa Chang
Walter Maerki
Original Assignee
Ciba Geigy Ag
Upc Gen Pharma Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy Ag, Upc Gen Pharma Ag filed Critical Ciba Geigy Ag
Publication of FI951541L publication Critical patent/FI951541L/fi
Publication of FI951541A0 publication Critical patent/FI951541A0/fi
Publication of FI951541A7 publication Critical patent/FI951541A7/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55—Protease inhibitors
    • A61K38/57—Protease inhibitors from animals; from humans
    • A61K38/58—Protease inhibitors from animals; from humans from leeches, e.g. hirudin, eglin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/815—Protease inhibitors from leeches, e.g. hirudin, eglin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
FI951541A 1993-08-04 1994-07-23 Suurimolekyylipainoinen desulfatohirudiini FI951541A7 (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP93810552 1993-08-04
PCT/EP1994/002438 WO1995004823A1 (en) 1993-08-04 1994-07-23 High molecular weight desulphatohirudin

Publications (3)

Publication Number Publication Date
FI951541L true FI951541L (fi) 1995-03-31
FI951541A0 FI951541A0 (fi) 1995-03-31
FI951541A7 FI951541A7 (fi) 1995-03-31

Family

ID=8215008

Family Applications (1)

Application Number Title Priority Date Filing Date
FI951541A FI951541A7 (fi) 1993-08-04 1994-07-23 Suurimolekyylipainoinen desulfatohirudiini

Country Status (15)

Country Link
US (1) US5661001A (fi)
EP (1) EP0663009A1 (fi)
JP (1) JPH08502661A (fi)
KR (1) KR950703645A (fi)
CN (1) CN1113389A (fi)
AU (1) AU685835B2 (fi)
CA (1) CA2144523A1 (fi)
FI (1) FI951541A7 (fi)
HU (1) HUT72926A (fi)
IL (1) IL110540A0 (fi)
NO (1) NO951277D0 (fi)
NZ (1) NZ271088A (fi)
SG (1) SG49862A1 (fi)
WO (1) WO1995004823A1 (fi)
ZA (1) ZA945775B (fi)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CZ20032208A3 (cs) * 2001-02-23 2004-01-14 Immunex Corporation Zvýšený výtěžek aktivních proteinů
CN1328380C (zh) * 2001-09-24 2007-07-25 天津天士力制药股份有限公司 高效表达水蛭素及其生产方法
CA2613691A1 (en) * 2005-07-05 2007-01-11 Baker Medical Research Institute Anticoagulation agent and uses thereof
CN101993489B (zh) * 2009-08-20 2013-10-23 重庆富进生物医药有限公司 可逆转水蛭素
US7803762B1 (en) 2009-08-20 2010-09-28 The Medicines Company Ready-to-use bivalirudin compositions
US7985733B1 (en) 2010-01-06 2011-07-26 The Medicines Company Buffer-based method for preparing bivalirudin drug product
CN117534731B (zh) * 2021-09-24 2024-10-29 深圳市海伦海生物科技有限公司 一种抗凝血肽及其在抗凝血产品上的应用

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4620948A (en) * 1982-12-22 1986-11-04 Genentech, Inc. Purification and activity assurance of precipitated heterologous proteins
FI86746C (fi) * 1983-11-21 1992-10-12 Ciba Geigy Ag Foerfarande foer framstaellning av maensklig vaevnads-plasminogenaktivator (tpa) med hjaelp av saccharomyces cerevisiae -jaest och i foerfarandet anvaenda hybridvektorer
US4572798A (en) * 1984-12-06 1986-02-25 Cetus Corporation Method for promoting disulfide bond formation in recombinant proteins
GB8508340D0 (en) * 1985-03-29 1985-05-09 Creighton T E Production of protein
GB8528321D0 (en) * 1985-11-18 1985-12-24 Ciba Geigy Ag Modified fibrinolytic agents
IL86090A (en) * 1987-04-16 1993-03-15 Cetus Oncology Corp Production of purified, biologically active, bacterially produced recombinant human csf-1
AU622860B2 (en) * 1987-05-11 1992-04-30 Novartis Vaccines And Diagnostics, Inc. Process for recovering purified, oxidized, renatured recombinant interleukin-2 from microorganisms
ZA883443B (en) * 1987-05-21 1988-11-16 Merrell Dow Pharmaceuticals Inc. Cyclic anticoagulant peptides
US5236898A (en) * 1987-05-21 1993-08-17 Merrell Dow Pharmaceuticals Inc. Cyclic anticoagulant peptides
GB8809860D0 (en) * 1988-04-26 1988-06-02 Ciba Geigy Ag Process for production of polypeptides
AU614121B2 (en) * 1988-05-04 1991-08-22 Novartis Ag Improvements in the production of polypeptides
DE58907266T2 (de) * 1988-06-11 1994-09-29 Ciba Geigy Ag Polypeptide mit einer die Koagulierung hemmenden Wirkung.
US5112615A (en) * 1988-08-03 1992-05-12 New England Deaconess Hospital Corporation Soluble hirudin conjugates
DE59010205D1 (de) * 1989-12-01 1996-04-18 Basf Ag Hirudin-Muteine und deren Polyalkylenglykolkonjugate
GB8927722D0 (en) * 1989-12-07 1990-02-07 British Bio Technology Proteins and nucleic acids
IT1248565B (it) * 1991-06-27 1995-01-19 Erba Carlo Spa Anticorpi policlonali anti-irudina e loro utilizzo per la identificazione, l`immunopurificazione e la determinazione quantitativa dell`uridina.

Also Published As

Publication number Publication date
AU685835B2 (en) 1998-01-29
NZ271088A (en) 1996-10-28
US5661001A (en) 1997-08-26
KR950703645A (ko) 1995-09-20
IL110540A0 (en) 1994-11-11
WO1995004823A1 (en) 1995-02-16
ZA945775B (en) 1995-02-06
CN1113389A (zh) 1995-12-13
NO951277L (no) 1995-04-03
JPH08502661A (ja) 1996-03-26
AU7460594A (en) 1995-02-28
HU9500689D0 (en) 1995-06-28
EP0663009A1 (en) 1995-07-19
FI951541A0 (fi) 1995-03-31
SG49862A1 (en) 2002-03-19
HUT72926A (en) 1996-06-28
CA2144523A1 (en) 1995-02-16
NO951277D0 (no) 1995-04-03
FI951541A7 (fi) 1995-03-31

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Owner name: NOVARTIS AG