FI955336L - Varjoaineina käytettäviä trisyklopolyatsamakrosyklofosfonihappoja, niiden komplekseja ja johdannaisia - Google Patents
Varjoaineina käytettäviä trisyklopolyatsamakrosyklofosfonihappoja, niiden komplekseja ja johdannaisia Download PDFInfo
- Publication number
- FI955336L FI955336L FI955336A FI955336A FI955336L FI 955336 L FI955336 L FI 955336L FI 955336 A FI955336 A FI 955336A FI 955336 A FI955336 A FI 955336A FI 955336 L FI955336 L FI 955336L
- Authority
- FI
- Finland
- Prior art keywords
- complexes
- contrast agents
- derivatives used
- tricyclopolyazamacrocyclophosphonic
- acids
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/18—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed systems contains four or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
- G01R33/00—Arrangements or instruments for measuring magnetic variables
- G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
- G01R33/28—Details of apparatus provided for in groups G01R33/44 - G01R33/64
- G01R33/281—Means for the use of in vitro contrast agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Physics & Mathematics (AREA)
- Optics & Photonics (AREA)
- Condensed Matter Physics & Semiconductors (AREA)
- General Physics & Mathematics (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Luminescent Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/058,622 US5385893A (en) | 1993-05-06 | 1993-05-06 | Tricyclopolyazamacrocyclophosphonic acids, complexes and derivatives thereof, for use as contrast agents |
| PCT/US1994/005071 WO1994026276A1 (en) | 1993-05-06 | 1994-05-06 | Tricyclopolyazamacrocyclophosphonic acids, complexes and derivatives thereof, for use as contrast agents |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| FI955336A0 FI955336A0 (fi) | 1995-11-06 |
| FI955336A7 FI955336A7 (fi) | 1995-12-22 |
| FI955336L true FI955336L (fi) | 1995-12-22 |
Family
ID=22017946
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI955336A FI955336L (fi) | 1993-05-06 | 1994-05-06 | Varjoaineina käytettäviä trisyklopolyatsamakrosyklofosfonihappoja, niiden komplekseja ja johdannaisia |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US5385893A (fi) |
| EP (1) | EP0697872B1 (fi) |
| JP (1) | JP3553940B2 (fi) |
| KR (1) | KR960702462A (fi) |
| CN (1) | CN1125906A (fi) |
| AT (1) | ATE316377T1 (fi) |
| AU (1) | AU687400B2 (fi) |
| BG (1) | BG100194A (fi) |
| CA (1) | CA2162172A1 (fi) |
| DE (1) | DE69434618T2 (fi) |
| FI (1) | FI955336L (fi) |
| HU (1) | HUT72649A (fi) |
| LV (1) | LV11429B (fi) |
| NO (1) | NO954441L (fi) |
| PL (1) | PL311649A1 (fi) |
| SG (1) | SG46496A1 (fi) |
| WO (1) | WO1994026276A1 (fi) |
Families Citing this family (72)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5645818A (en) * | 1989-03-24 | 1997-07-08 | Guerbet S.A. | Diagnostic compositions comprising a complex formed by a nitrogenous macrocyclic ligand with metal ions |
| US5739294A (en) * | 1991-12-10 | 1998-04-14 | The Dow Chemical Company | Bicyclopol yazamacrocyclophosphonic acid complexes for use as contrast agents |
| US5714604A (en) * | 1993-05-06 | 1998-02-03 | The Dow Chemical Company | Process for the preparation of azamacrocyclic or acyclic aminophosphonate ester derivatives |
| US5672335A (en) * | 1994-11-30 | 1997-09-30 | Schering Aktiengesellschaft | Use of metal complexes as liver and gallbladder X-ray diagnostic agents |
| US6207826B1 (en) * | 1995-03-27 | 2001-03-27 | Isis Pharmaceuticals, Inc. | Macrocyclic compounds having nitrogen-containing linkages |
| EP0817787A4 (en) * | 1995-03-27 | 2000-09-13 | Isis Pharmaceuticals Inc | NITROGEN MACROCYCLIC COMPOUNDS |
| DE19546234C1 (de) * | 1995-12-04 | 1997-08-28 | Schering Ag | Neue makrobicyclische Verbindungen, Verfahren zu ihrer Herstellung und diese makrobicyclischen Verbindungen enthaltende pharmazeutische Mittel |
| US5834456A (en) * | 1996-02-23 | 1998-11-10 | The Dow Chemical Company | Polyazamacrocyclofluoromonoalkylphosphonic acids, and their complexes, for use as contrast agents |
| CA2251924C (en) * | 1996-04-19 | 2006-05-30 | The Dow Chemical Company | Fluorescent chelates as visual tissue specific imaging agents |
| US6649582B1 (en) | 1998-06-15 | 2003-11-18 | Unilever Patent Holdings B.V. | Bleach catalysts and formulations containing them |
| US6794371B1 (en) * | 1999-10-18 | 2004-09-21 | The Dow Chemical Company | Aminoalkylenephosphonates for treatment of bone disorders |
| JP2003512331A (ja) * | 1999-10-18 | 2003-04-02 | ザ ダウ ケミカル カンパニー | 骨障害治療用アミノアルキレンホスホネート |
| US20060210479A1 (en) * | 2004-08-10 | 2006-09-21 | Dow Global Technologies Inc. | Targeting chelants and chelates |
| NZ553500A (en) | 2004-09-23 | 2009-11-27 | Genentech Inc Genentech Inc | Cysteine engineered antibodies and conjugates withCysteine engineered antibodies and conjugates with a free cysteine amino acid in the heavy chain a free cysteine amino acid in the heavy chain |
| US20100111856A1 (en) | 2004-09-23 | 2010-05-06 | Herman Gill | Zirconium-radiolabeled, cysteine engineered antibody conjugates |
| RS54163B1 (sr) | 2006-05-30 | 2015-12-31 | Genentech Inc. | Anti-cd22 antitela, njihovi imunokonjugati i njihova upotreba |
| LT2845866T (lt) | 2006-10-27 | 2017-07-10 | Genentech, Inc. | Antikūnai ir imunokonjugatai bei jų panaudojimas |
| AU2008216495A1 (en) | 2007-02-09 | 2008-08-21 | Genentech, Inc. | Anti-Robo4 antibodies and uses therefor |
| DK2176296T3 (da) | 2007-07-16 | 2012-05-21 | Genentech Inc | Anti-CD79B-antistoffer og immunkonjugater og anvendelsesfremgangsmåder. |
| WO2009012256A1 (en) | 2007-07-16 | 2009-01-22 | Genentech, Inc. | Humanized anti-cd79b antibodies and immunoconjugates and methods of use |
| DK2247620T3 (en) | 2008-01-31 | 2016-08-22 | Genentech Inc | ANTI-CD79b ANTIBODIES AND IMMUNOCONJUGATES AND METHODS OF USE |
| CN102471380B (zh) | 2009-04-01 | 2015-01-14 | 霍夫曼-拉罗奇有限公司 | 抗FcRH5抗体和免疫偶联物及使用方法 |
| EP2896404B1 (en) | 2009-06-04 | 2017-08-02 | Novartis AG | Methods for identification of sites for IgG conjugation |
| PL2477740T3 (pl) * | 2009-09-18 | 2015-06-30 | Weylchem Lamotte | Sposób wytwarzania mostkowych manganowych kompleksów triazacyklononanu |
| EP3778917A3 (en) | 2009-12-04 | 2021-06-09 | F. Hoffmann-La Roche AG | Multispecific antibodies, antibody analogs, compositions, and methods |
| MX336109B (es) | 2010-06-03 | 2016-01-08 | Genentech Inc | Formacion de imagenes inmuno-tep de anticuerpos e inmunoconjugados y usos de lo mismo. |
| US9000130B2 (en) | 2010-06-08 | 2015-04-07 | Genentech, Inc. | Cysteine engineered antibodies and conjugates |
| ES2604012T3 (es) | 2012-07-04 | 2017-03-02 | F. Hoffmann-La Roche Ag | Conjugados de antígeno-anticuerpo unidos covalentemente |
| WO2014006123A1 (en) | 2012-07-04 | 2014-01-09 | F. Hoffmann-La Roche Ag | Anti-biotin antibodies and methods of use |
| RU2630664C2 (ru) | 2012-07-04 | 2017-09-11 | Ф. Хоффманн-Ля Рош Аг | Антитела к теофиллину и способы их применения |
| US10561737B2 (en) | 2014-01-03 | 2020-02-18 | Hoffmann-La Roche Inc. | Bispecific anti-hapten/anti-blood brain barrier receptor antibodies, complexes thereof and their use as blood brain barrier shuttles |
| JP6521464B2 (ja) | 2014-01-03 | 2019-05-29 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | 共有結合で連結されたポリペプチド毒素−抗体コンジュゲート |
| KR102278979B1 (ko) | 2014-01-03 | 2021-07-19 | 에프. 호프만-라 로슈 아게 | 공유적으로 연결된 헬리카-항-헬리카 항체 접합체 및 그의 용도 |
| MX2017003123A (es) | 2014-09-12 | 2017-05-12 | Genentech Inc | Anticuerpos y conjugados modificados geneticamente con cisteina. |
| JP6618539B2 (ja) | 2014-12-17 | 2019-12-11 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | ソルターゼを使用した酵素媒介性のポリペプチドコンジュゲーションのための方法 |
| JP6998862B2 (ja) | 2015-09-25 | 2022-02-04 | エフ.ホフマン-ラ ロシュ アーゲー | 可溶性ソルターゼa |
| ES2896475T3 (es) | 2015-09-25 | 2022-02-24 | Hoffmann La Roche | Cadenas pesadas de inmunoglobulina recombinante que comprenden un bucle de conjugación de sortasa y conjugados de las mismas |
| EP3353310B1 (en) | 2015-09-25 | 2020-04-29 | H. Hoffnabb-La Roche Ag | Process for producing thioesters employing a sortase a |
| EP3353314A1 (en) | 2015-09-25 | 2018-08-01 | H. Hoffnabb-La Roche Ag | Transamidation employing sortase a in deep eutectic solvents |
| EP3380473A1 (en) * | 2015-11-26 | 2018-10-03 | Debreceni Egyetem | New 2, 1 l -diaza-[3.3](2,6)pyridinophane compounds and their application as ligands of essential metal ion based mri contrast agents and 52mn based pet contrast agents |
| US10568976B2 (en) | 2015-11-26 | 2020-02-25 | Debreceni Egyetem | 3,6,9, 15-tetraaza-bicyclo [9.3.1 ]pentadeca-1(14), 11(15), 12-triene based compounds and their application as ligands of essential metal ion based MRI and 52MN based PET contrast agents |
| WO2017089849A1 (en) | 2015-11-26 | 2017-06-01 | Debreceni Egyetem | New 6-oxa-3,9, 15-triaza-bicyclo[9.3.1 ]pentadec a- 1 ( 14), 1 1 ( 15), 12-triene derivatives based compounds and their application as ligands of essential metal ion based mri and 52mn based pet contrast agents |
| FR3045053B1 (fr) * | 2015-12-09 | 2018-01-05 | Cisbio Bioassays | Agents complexants hydrosolubles a base de triazapyridinophane et complexes de lanthanide fluorescents correspondants |
| EP3436578B1 (en) | 2016-03-30 | 2022-01-19 | F. Hoffmann-La Roche AG | Improved sortase |
| WO2018191389A1 (en) | 2017-04-12 | 2018-10-18 | Roche Sequencing Solutions, Inc. | A method for sequencing reaction with tagged nucleoside obtained via pictet spengler reaction |
| KR102696526B1 (ko) | 2017-07-13 | 2024-08-19 | 에프. 호프만-라 로슈 아게 | Pivka에 대한 신규 결합제 및 어세이 |
| KR20200067193A (ko) | 2017-10-20 | 2020-06-11 | 에프. 호프만-라 로슈 아게 | 항체에 대한 카피 보호 |
| WO2019108755A1 (en) | 2017-11-30 | 2019-06-06 | Genentech, Inc. | Anti-pd-l1 antibodies and methods of using the same for detection of pd-l1 |
| KR20200131838A (ko) | 2018-03-14 | 2020-11-24 | 에프. 호프만-라 로슈 아게 | 항체의 친화성 성숙화를 위한 방법 |
| JP7734487B2 (ja) | 2018-03-14 | 2025-09-05 | エフ. ホフマン-ラ ロシュ アーゲー | 新規抗トロポニンt抗体 |
| CN111936522B (zh) | 2018-04-18 | 2024-07-02 | 豪夫迈·罗氏有限公司 | 新型抗胸苷激酶抗体 |
| EP3844503B1 (en) | 2018-08-31 | 2024-05-29 | F. Hoffmann-La Roche AG | Thymidine kinase (tk-1) in prognostic indices for dlbcl |
| US20220001043A1 (en) | 2018-09-28 | 2022-01-06 | Imaginab, Inc. | Cd8 imaging constructs and methods of use thereof |
| BR112022000945A2 (pt) | 2019-07-22 | 2022-03-08 | Hoffmann La Roche | Métodos para avaliar se uma paciente tem endometriose ou está em risco de desenvolver endometriose, para selecionar uma paciente para terapia e para monitorar uma paciente que sofre de endometriose ou que está sendo tratada para endometriose |
| JP7315780B2 (ja) | 2019-07-22 | 2023-07-26 | エフ. ホフマン-ラ ロシュ アーゲー | 子宮内膜症の非侵襲的診断のための血液バイオマーカーとしてのサブスタンスp |
| WO2021013786A1 (en) | 2019-07-22 | 2021-01-28 | F. Hoffmann-La Roche Ag | S100a6 as blood biomarker for the non-invasive diagnosis of endometriosis |
| BR112022001140A2 (pt) | 2019-07-22 | 2022-03-15 | Hoffmann La Roche | Métodos para avaliar se um paciente tem endometriose ou está em risco de desenvolver endometriose, selecionar um paciente para terapia e monitorar um paciente que sofre de endometriose ou que está sendo tratado para endometriose |
| CN114144675A (zh) | 2019-07-22 | 2022-03-04 | 豪夫迈·罗氏有限公司 | S100a9作为血液生物标志物用于子宫内膜异位症的非侵入性诊断 |
| KR20220100883A (ko) | 2019-11-15 | 2022-07-18 | 에프. 호프만-라 로슈 아게 | 환자 샘플의 질량분석법 측정을 위한 베타-락탐 항생제의 유도체화 |
| EP4237855A1 (en) | 2020-10-30 | 2023-09-06 | F. Hoffmann-La Roche AG | Timp1 as a marker for cholangiocarcinoma |
| CN116829951A (zh) | 2020-11-02 | 2023-09-29 | 豪夫迈·罗氏有限公司 | SARS-CoV-2核衣壳抗体 |
| WO2022207628A1 (en) | 2021-03-30 | 2022-10-06 | F. Hoffmann-La Roche Ag | Scf as blood biomarker for the non-invasive diagnosis of endometriosis |
| WO2022207685A1 (en) | 2021-04-01 | 2022-10-06 | F. Hoffmann-La Roche Ag | Psp94 as blood biomarker for the non-invasive diagnosis of endometriosis |
| US20240272177A1 (en) | 2021-05-17 | 2024-08-15 | Roche Diagnostics Operations, Inc. | sFRP4 AS BLOOD BIOMARKER FOR THE NON-INVASIVE DIAGNOSIS OF ADENOMYOSIS |
| WO2023072904A1 (en) | 2021-10-26 | 2023-05-04 | F. Hoffmann-La Roche Ag | Monoclonal antibodies specific for sars-cov-2 rbd |
| EP4448564A1 (en) | 2021-12-17 | 2024-10-23 | F. Hoffmann-La Roche AG | A novel antibody for detection of amyloid beta 42 (a-beta42) |
| WO2023131594A1 (en) | 2022-01-05 | 2023-07-13 | F. Hoffmann-La Roche Ag | Derivatization of compounds in patient samples for therapeutic drug monitoring (tdm) |
| WO2023247752A1 (en) | 2022-06-23 | 2023-12-28 | F. Hoffmann-La Roche Ag | Method for diagnosing endometriosis and for classifying the stage of endometriosis |
| CN119604768A (zh) | 2022-07-22 | 2025-03-11 | 豪夫迈·罗氏有限公司 | 白三烯a4水解酶(lta4h)作为(血液)生物标志物用于诊断多囊卵巢综合征 |
| CN119585617A (zh) | 2022-07-22 | 2025-03-07 | 豪夫迈·罗氏有限公司 | 镍纹蛋白样蛋白(metrnl)作为(血液)生物标志物用于诊断多囊卵巢综合征 |
| JP2025523884A (ja) | 2022-07-22 | 2025-07-25 | エフ. ホフマン-ラ ロシュ アーゲー | 多嚢胞性卵巣症候群の診断のための(血液)バイオマーカーとしての線維芽細胞増殖因子結合タンパク質1(fgfbp1) |
| WO2025026908A1 (en) | 2023-07-28 | 2025-02-06 | Roche Diagnostics Gmbh | Serum epha1 as biomarker for endometriosis |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2609390A (en) * | 1950-06-01 | 1952-09-02 | Frederick C Bersworth | Phosphonic alkylene polyamino acids and method of producing same |
| US3336221A (en) * | 1964-11-05 | 1967-08-15 | Calgon Corp | Method of inhibiting precipitation and scale formation |
| US3331773A (en) * | 1966-07-22 | 1967-07-18 | Grace W R & Co | Process for inhibiting precipitation in water |
| US3434969A (en) * | 1967-08-11 | 1969-03-25 | Calgon Corp | Scale inhibiting |
| GB1441081A (en) * | 1974-01-09 | 1976-06-30 | Ici Ltd | Tetra-aza-macrocycles and their metal complexes |
| US4980148A (en) * | 1985-02-06 | 1990-12-25 | Mallinckrodt, Inc. | Methods for enhancing magnetic resonance imaging |
| US4899755A (en) * | 1985-05-08 | 1990-02-13 | The General Hospital Corporation | Hepatobiliary NMR contrast agents |
| US4880008A (en) * | 1985-05-08 | 1989-11-14 | The General Hospital Corporation | Vivo enhancement of NMR relaxivity |
| DE3825040A1 (de) * | 1988-07-20 | 1990-01-25 | Schering Ag, 13353 Berlin | 5- oder 6-ring- enthaltende makrocyclische polyaza-verbindungen, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel |
| US5247077A (en) * | 1989-06-23 | 1993-09-21 | Celltech Limited | Tri-aza macrocycles and processes for their preparation |
| DE69230970T2 (de) * | 1991-12-10 | 2001-01-04 | The Dow Chemical Co., Midland | Bicylclische, polyazamakrocyclocarbonsäure-komplexe, konjugate, herstellung und verwendung als kontraststoffe |
| SG46598A1 (en) * | 1991-12-10 | 1998-02-20 | Dow Chemical Co | Bicycloazamacroyclophosphonic acid conjugates contrast agents and preparation |
| ZA929578B (en) * | 1991-12-10 | 1994-06-10 | Dow Chemical Co | Bicyclopolyazamacrocyclocarboxylic acid complexes their conjugates processes for their preparation and use as radiopharmaceuticals |
| US5428139A (en) * | 1991-12-10 | 1995-06-27 | The Dow Chemical Company | Bicyclopolyazamacrocyclophosphonic acid complexes for use as radiopharmaceuticals |
-
1993
- 1993-05-06 US US08/058,622 patent/US5385893A/en not_active Expired - Lifetime
-
1994
- 1994-05-06 CN CN94192528A patent/CN1125906A/zh active Pending
- 1994-05-06 WO PCT/US1994/005071 patent/WO1994026276A1/en not_active Ceased
- 1994-05-06 EP EP94916043A patent/EP0697872B1/en not_active Expired - Lifetime
- 1994-05-06 HU HU9502023A patent/HUT72649A/hu unknown
- 1994-05-06 AT AT94916043T patent/ATE316377T1/de not_active IP Right Cessation
- 1994-05-06 JP JP52558694A patent/JP3553940B2/ja not_active Expired - Fee Related
- 1994-05-06 DE DE69434618T patent/DE69434618T2/de not_active Expired - Fee Related
- 1994-05-06 FI FI955336A patent/FI955336L/fi unknown
- 1994-05-06 SG SG1996005135A patent/SG46496A1/en unknown
- 1994-05-06 CA CA002162172A patent/CA2162172A1/en not_active Abandoned
- 1994-05-06 KR KR1019950704947A patent/KR960702462A/ko not_active Withdrawn
- 1994-05-06 AU AU67849/94A patent/AU687400B2/en not_active Ceased
- 1994-05-06 PL PL94311649A patent/PL311649A1/xx unknown
-
1995
- 1995-11-06 NO NO954441A patent/NO954441L/no unknown
- 1995-12-05 BG BG100194A patent/BG100194A/xx unknown
- 1995-12-06 LV LVP-95-361A patent/LV11429B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE69434618D1 (de) | 2006-04-13 |
| ATE316377T1 (de) | 2006-02-15 |
| LV11429B (en) | 1997-04-20 |
| CA2162172A1 (en) | 1994-11-24 |
| JP3553940B2 (ja) | 2004-08-11 |
| KR960702462A (ko) | 1996-04-27 |
| BG100194A (bg) | 1996-12-31 |
| EP0697872B1 (en) | 2006-01-25 |
| HU9502023D0 (en) | 1995-09-28 |
| EP0697872A4 (en) | 2003-04-02 |
| CN1125906A (zh) | 1996-07-03 |
| FI955336A7 (fi) | 1995-12-22 |
| JPH08511003A (ja) | 1996-11-19 |
| US5385893A (en) | 1995-01-31 |
| NO954441D0 (no) | 1995-11-06 |
| WO1994026276A1 (en) | 1994-11-24 |
| FI955336A0 (fi) | 1995-11-06 |
| AU687400B2 (en) | 1998-02-26 |
| LV11429A (lv) | 1996-08-20 |
| DE69434618T2 (de) | 2006-08-10 |
| EP0697872A1 (en) | 1996-02-28 |
| HUT72649A (en) | 1996-05-28 |
| NO954441L (no) | 1996-01-05 |
| AU6784994A (en) | 1994-12-12 |
| PL311649A1 (en) | 1996-03-04 |
| SG46496A1 (en) | 1998-02-20 |
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