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FI954979A7 - Kemoherkistävinä aineina käytettävät 10,11-metanodibentsosuberaanijohdannaiset - Google Patents

Kemoherkistävinä aineina käytettävät 10,11-metanodibentsosuberaanijohdannaiset

Info

Publication number
FI954979A7
FI954979A7 FI954979A FI954979A FI954979A7 FI 954979 A7 FI954979 A7 FI 954979A7 FI 954979 A FI954979 A FI 954979A FI 954979 A FI954979 A FI 954979A FI 954979 A7 FI954979 A7 FI 954979A7
Authority
FI
Finland
Prior art keywords
methanedibenzosuberane
chemosensitizers
derivatives used
derivatives
methanedibenzosuberane derivatives
Prior art date
Application number
FI954979A
Other languages
English (en)
Swedish (sv)
Other versions
FI111161B (fi
FI954979A0 (fi
Inventor
Jurg Roland Pfister
Doris Lynne Slate
Original Assignee
Syntex Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Syntex Inc filed Critical Syntex Inc
Publication of FI954979A7 publication Critical patent/FI954979A7/fi
Publication of FI954979A0 publication Critical patent/FI954979A0/fi
Application granted granted Critical
Publication of FI111161B publication Critical patent/FI111161B/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/65—One oxygen atom attached in position 3 or 5
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/24—Oxygen atoms attached in position 8
    • C07D215/26—Alcohols; Ethers thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/40—Ortho- or ortho- and peri-condensed systems containing four condensed rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Addiction (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Quinoline Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Fats And Perfumes (AREA)
FI954979A 1993-04-19 1995-10-18 Menetelmä kemoherkistävinä aineina käyttökelpoisten 10,11-metanodibentsosuberaanijohdannaisten valmistamiseksi FI111161B (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US08/049,065 US5643909A (en) 1993-04-19 1993-04-19 10,11-Methanodibenzosuberane derivatives
US4906593 1993-04-19
PCT/US1994/004215 WO1994024107A1 (en) 1993-04-19 1994-04-13 10,11-methanodibenzosuberane derivatives used as chemosensitizing agents
US9404215 1994-04-13

Publications (3)

Publication Number Publication Date
FI954979A7 true FI954979A7 (fi) 1995-10-18
FI954979A0 FI954979A0 (fi) 1995-10-18
FI111161B FI111161B (fi) 2003-06-13

Family

ID=21957890

Family Applications (1)

Application Number Title Priority Date Filing Date
FI954979A FI111161B (fi) 1993-04-19 1995-10-18 Menetelmä kemoherkistävinä aineina käyttökelpoisten 10,11-metanodibentsosuberaanijohdannaisten valmistamiseksi

Country Status (21)

Country Link
US (5) US5643909A (fi)
EP (2) EP0866063A1 (fi)
JP (1) JP3020607B2 (fi)
KR (1) KR100248591B1 (fi)
CN (2) CN1045204C (fi)
AT (1) ATE172194T1 (fi)
AU (1) AU678470B2 (fi)
BR (1) BR9405965A (fi)
CA (1) CA2160881C (fi)
CZ (1) CZ287273B6 (fi)
DE (1) DE69413958T2 (fi)
DK (1) DK0695293T3 (fi)
ES (1) ES2121603T3 (fi)
FI (1) FI111161B (fi)
HU (2) HU227824B1 (fi)
NO (1) NO313284B1 (fi)
NZ (1) NZ265547A (fi)
PL (1) PL183375B1 (fi)
RU (1) RU2167154C2 (fi)
UA (1) UA42720C2 (fi)
WO (1) WO1994024107A1 (fi)

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Also Published As

Publication number Publication date
US5643909A (en) 1997-07-01
HK1011981A1 (en) 1999-07-23
EP0695293B1 (en) 1998-10-14
HU227824B1 (en) 2012-03-28
EP0695293A1 (en) 1996-02-07
PL183375B1 (pl) 2002-06-28
NO954161D0 (no) 1995-10-18
CN1235826A (zh) 1999-11-24
KR100248591B1 (ko) 2000-04-01
US5654304A (en) 1997-08-05
RU2167154C2 (ru) 2001-05-20
FI111161B (fi) 2003-06-13
BR9405965A (pt) 1996-01-30
US6087365A (en) 2000-07-11
EP0866063A1 (en) 1998-09-23
CA2160881C (en) 2000-12-12
PL311164A1 (en) 1996-02-05
DE69413958T2 (de) 1999-03-11
CN1045204C (zh) 1999-09-22
CA2160881A1 (en) 1994-10-27
NO954161L (no) 1995-12-05
CN1119149C (zh) 2003-08-27
WO1994024107A1 (en) 1994-10-27
HU9503004D0 (en) 1995-12-28
UA42720C2 (uk) 2001-11-15
CZ287273B6 (en) 2000-10-11
ES2121603T3 (es) 1998-12-01
HU211682A9 (en) 1995-12-28
US5889007A (en) 1999-03-30
AU6636294A (en) 1994-11-08
CZ272495A3 (en) 1996-04-17
FI954979A0 (fi) 1995-10-18
JPH08509223A (ja) 1996-10-01
CN1121346A (zh) 1996-04-24
DE69413958D1 (de) 1998-11-19
AU678470B2 (en) 1997-05-29
ATE172194T1 (de) 1998-10-15
NO313284B1 (no) 2002-09-09
HUT73180A (en) 1996-06-28
JP3020607B2 (ja) 2000-03-15
NZ265547A (en) 1997-03-24
US5874434A (en) 1999-02-23
DK0695293T3 (da) 1999-06-23

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