FI943618L - Uudet amidiinijohdannaiset, niiden valmistus ja käyttö lääkeaineina, joilla on LTB4-antagonistinen vaikutus - Google Patents

Uudet amidiinijohdannaiset, niiden valmistus ja käyttö lääkeaineina, joilla on LTB4-antagonistinen vaikutus Download PDF

Info

Publication number: FI943618L
Authority: FI; Finland
Prior art keywords: drugs; preparation; antagonistic activity; amidine derivatives; novel amidine
Prior art date: 1992-02-05

Application number

FI943618A

Other languages

English (en)

Finnish (fi)

Swedish (sv)

Other versions

FI943618A7 (fi

FI943618A0 (fi

Inventor

Ralf Anderskewitz

Kurt Schromm

Ernst-Otto Renth

Frank Himmelsbach

Franz Birke

Armin Fuegner

Original Assignee

Boehringer Ingelheim Kg

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-02-05

Filing date

1993-01-14

Publication date

1994-08-04

1992-02-05 Priority claimed from DE4203201A external-priority patent/DE4203201A1/de

1992-07-23 Priority claimed from DE4224289A external-priority patent/DE4224289A1/de

1992-12-24 Priority claimed from DE4244241A external-priority patent/DE4244241A1/de

1993-01-14 Application filed by Boehringer Ingelheim Kg filed Critical Boehringer Ingelheim Kg

1994-08-04 Publication of FI943618A7 publication Critical patent/FI943618A7/fi

1994-08-04 Publication of FI943618L publication Critical patent/FI943618L/fi

1994-08-04 Publication of FI943618A0 publication Critical patent/FI943618A0/fi

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C257/00—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines
- C07C257/10—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines
- C07C257/18—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines having carbon atoms of amidino groups bound to carbon atoms of six-membered aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/16—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C317/18—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton with sulfone or sulfoxide groups bound to acyclic carbon atoms of the carbon skeleton
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/16—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C317/22—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/10—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C323/18—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
- C07C323/20—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton with singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/62—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pulmonology (AREA)
Immunology (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Dermatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
Furan Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Pyrane Compounds (AREA)
Pyridine Compounds (AREA)
Saccharide Compounds (AREA)

FI943618A 1992-02-05 1993-01-14 Uudet amidiinijohdannaiset, niiden valmistus ja käyttö lääkeaineina, joilla on LTB4-antagonistinen vaikutus FI943618A0 (fi)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
DE4203201A DE4203201A1 (de)	1992-02-05	1992-02-05	Neue amidinderivate, ihre herstellung und verwendung
DE4224289A DE4224289A1 (de)	1992-07-23	1992-07-23	Neue Amidinderivate, ihre Herstellung und Verwendung
DE4244241A DE4244241A1 (de)	1992-12-24	1992-12-24	Neue Verbindungen, ihre Herstellung und ihre Verwendung
PCT/EP1993/000070 WO1993016036A1 (fr)	1992-02-05	1993-01-14	Nouveaux derives de l'amidine, leur fabrication et leur application en tant que medicaments ayant un effet antagoniste a ltb4

Publications (3)

Publication Number	Publication Date
FI943618A7 FI943618A7 (fi)	1994-08-04
FI943618L true FI943618L (fi)	1994-08-04
FI943618A0 FI943618A0 (fi)	1994-08-04

Family

ID=27203364

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
FI943618A FI943618A0 (fi)	1992-02-05	1993-01-14	Uudet amidiinijohdannaiset, niiden valmistus ja käyttö lääkeaineina, joilla on LTB4-antagonistinen vaikutus

Country Status (29)

Country	Link
US (3)	US6037377A (fr)
EP (2)	EP0625138B1 (fr)
JP (2)	JP3487851B2 (fr)
KR (1)	KR0163222B1 (fr)
AT (2)	ATE180770T1 (fr)
AU (1)	AU673343B2 (fr)
CA (2)	CA2129526A1 (fr)
CZ (2)	CZ287209B6 (fr)
DE (2)	DE59310252D1 (fr)
DK (2)	DK0902013T3 (fr)
ES (2)	ES2165122T3 (fr)
FI (1)	FI943618A0 (fr)
GR (1)	GR3030468T3 (fr)
HR (1)	HRP930102B1 (fr)
HU (1)	HU216191B (fr)
IL (1)	IL104589A0 (fr)
MX (1)	MX9300630A (fr)
NO (1)	NO301540B1 (fr)
NZ (1)	NZ246593A (fr)
PL (2)	PL173781B1 (fr)
PT (1)	PT902013E (fr)
RU (1)	RU2124002C1 (fr)
SG (1)	SG44837A1 (fr)
SI (1)	SI9300066B (fr)
SK (1)	SK281016B6 (fr)
TW (1)	TW232005B (fr)
UA (1)	UA43318C2 (fr)
WO (1)	WO1993016036A1 (fr)
YU (1)	YU49038B (fr)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5488160A (en) *	1991-06-11	1996-01-30	Ciba-Geigy Corporation	Amidino compounds, their manufacture and method of treatment
US5451700A (en) *	1991-06-11	1995-09-19	Ciba-Geigy Corporation	Amidino compounds, their manufacture and methods of treatment
US5455274A (en) *	1992-12-09	1995-10-03	Ciba-Geigy Corporation	Hydroxyamidine derivatives
DE4309285A1 (de) *	1993-03-23	1994-09-29	Boehringer Ingelheim Kg	Heterocyclen enthaltende Amidinderivate, ihre Herstellung und Verwendung
DE4424714A1 (de) *	1994-07-13	1996-01-18	Boehringer Ingelheim Kg	Neue chemische Verbindung, ihre Herstellung und ihre Verwendung als Arnzneistoff
DE4424713A1 (de) *	1994-07-13	1996-01-18	Boehringer Ingelheim Kg	Substituierte Benzamidine, ihre Herstellung und Verwendung als Arnzneistoffe
DE19546452A1 (de) *	1995-12-13	1997-06-19	Boehringer Ingelheim Kg	Neue Phenylamidinderivate, Verfahren zu ihrer Herstelung und ihre Verwendung als Arzneimittel
CZ206698A3 (cs)	1995-12-29	1998-11-11	3- Dimensional Pharmaceuticals, Inc.	Amidinové inhibitory proteas
US5942544A (en) *	1996-02-22	1999-08-24	Dupont Pharmaceuticals Company	α-branched anilines, toluenes, and analogs thereof as factor Xa inhibitors
DE19636689A1 (de) *	1996-09-10	1998-03-12	Boehringer Ingelheim Kg	Neue Benzamidinderivate
DE19637123A1 (de) *	1996-09-12	1998-03-19	Boehringer Ingelheim Kg	Neue Pyranosidderivate
WO1998013347A1 (fr) *	1996-09-26	1998-04-02	Novartis Ag	Acrylamides substitues par de l'aryle ayant une activite antagoniste du recepteur leucotriene b4 (ltb-4)
US6670398B2 (en) *	1997-05-14	2003-12-30	Atherogenics, Inc.	Compounds and methods for treating transplant rejection
CZ301985B6 (cs)	1997-05-14	2010-08-25	Atherogenics, Inc.	Lécivo pro lécení kardiovaskulárního onemocnení na bázi monoesteru probukolu s jantarovou kyselinou
US5872122A (en) *	1997-10-16	1999-02-16	Monsanto Company	Pyrimidinylamidino β-amino acid derivatives useful as inhibitors of platelet aggregation
ID24720A (id)	1997-12-12	2000-08-03	Novartis Ag	Senyawa amidino tersubstitusi dalam perawatan penyakit gangguan paru-paru kronis
CN1283115A (zh) *	1997-12-23	2001-02-07	先灵公司	用于治疗呼吸道和皮肤病的含有至少一种白三烯拮抗剂和至少一种抗组胺药的组合物
US6291514B1 (en)	1998-02-09	2001-09-18	3-Dimensional Pharmaceuticals, Inc.	Heteroaryl amidines, methylamidines and guanidines, preparation thereof, and use thereof as protease inhibitors
DE19948428A1 (de) *	1999-10-07	2001-04-12	Boehringer Ingelheim Pharma	Neuer LTB¶4¶-Antagonist, Verfahren zu dessen Herstellung und dessen Verwendung als Arzneimittel
FR2801053B1 (fr) *	1999-11-16	2004-06-25	Sod Conseils Rech Applic	Nouveaux derives d'amidines, leur preparation et leur application a titre de medicaments
DE10052333A1 (de) *	2000-10-24	2002-05-02	Boehringer Ingelheim Pharma	Neue Sulfooxybenzamide
US6528491B2 (en) *	2000-10-24	2003-03-04	Boehringer Ingelheim Pharma Kg	Pyranoside derivatives
AU2002320025A1 (en) *	2001-04-11	2002-11-11	Atherogenics, Inc.	Probucol monoesters and their use to increase plasma hdl cholesterol levels and improve hdl functionality
US20030119901A1 (en) *	2001-07-14	2003-06-26	Boehringer Ingelheim Pharma Kg	Pharmaceutical formulation containing an LTB4 antagonist
PL368613A1 (en) *	2001-07-14	2005-04-04	Boehringer Ingelheim Pharma Gmbh & Co.Kg	Pharmaceutical formulation containing an ltb4 antagonist
US20040006092A1 (en) *	2001-08-31	2004-01-08	Neurochem, Inc.	Amidine derivatives for treating amyloidosis
US20060229335A1 (en) *	2002-12-24	2006-10-12	Bradley Teegarden	Diarylamine and arylheteroarylamine pyrazole derivatives as modulators of 5ht2a
EP1493739A1 (fr) *	2003-07-03	2005-01-05	Warner-Lambert Company LLC	Dérivés thiophényliques d'aminoacides, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent
US7262223B2 (en)	2004-01-23	2007-08-28	Neurochem (International) Limited	Amidine derivatives for treating amyloidosis
ES2333739T3 (es) *	2004-11-23	2010-02-26	Dong Wha Pharmaceutical Co., Ltd.	Sal de n-hidroxi-4-(5-(4-(5-isopropil-2-metil-1,3-tiazol-4-il)fenoxi) pentoxi)benzamidina con acido 2-metanosulfonico.
GB2445920A (en) *	2007-01-25	2008-07-30	Mucokinetica Ltd	Amidino compounds for treatment of respiratory disease
WO2008118948A1 (fr) *	2007-03-26	2008-10-02	Atherogenics, Inc.	Procédés et compositions de dérivés de probucol pour le traitement du diabète
US20080280985A1 (en) *	2007-03-27	2008-11-13	Scott Robert A D	Methods and Compositions Using Certain Phenolic Derivatives for the Treatment of Diabetes
WO2010068794A2 (fr)	2008-12-10	2010-06-17	The General Hospital Corporation	Inhibiteurs de hif et leurs applications
AR094929A1 (es)	2013-02-28	2015-09-09	Bristol Myers Squibb Co	Derivados de fenilpirazol como inhibidores potentes de rock1 y rock2
EP2961746B1 (fr)	2013-02-28	2018-01-03	Bristol-Myers Squibb Company	Dérivés de phénylpyrazole en tant que puissants inhibiteurs de rock1 et rock2
CA3121202A1 (fr)	2018-11-30	2020-06-04	Nuvation Bio Inc.	Composes pyrrole et pyrazole et leurs procedes d'utilisation

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FR2516922A1 (fr) *	1981-11-25	1983-05-27	Lipha	Acides (oxo-4-4h-(1)-benzopyran-8-yl) alcanoiques, sels et derives, preparation et medicament les contenant
JPS62142168A (ja) *	1985-10-16	1987-06-25	Mitsubishi Chem Ind Ltd	チアゾ−ル誘導体及びそれを有効成分とするロイコトリエンきつ抗剤
US4889871A (en) *	1987-05-29	1989-12-26	G. D. Searle & Co.	Alkoxy-substituted dihydrobenzopyran-2-carboxylate derivatives
SU1591809A3 (ru) *	1987-09-16	1990-09-07	Pfizer	Способ получения производных 4-гвдрокси-2-замещенного хроман-4-уксусной кислоты в виде рацемического соединения или оптически активного соединения или их фар
AU626033B2 (en) *	1988-10-25	1992-07-23	Government Of The United States Of America, As Represented By The Secretary Of The Army, The	Methods for the treatment and prophylaxis of pneumocystis carinii pneumonia and other diseases and compounds and formulations for use in said methods
US5246965A (en) *	1991-06-11	1993-09-21	Ciba-Geigy	Arylethers, their manufacture and methods of treatment
DE69203797T2 (de) *	1991-06-11	1996-02-08	Ciba Geigy Ag	Amidino-Verbindungen, ihre Herstellung und Verwendung als Arzneimittel.
EP0518818A3 (en) *	1991-06-11	1993-04-28	Ciba-Geigy Ag	Arylethers, their manufacture and use as medicament
US5424334A (en) *	1991-12-19	1995-06-13	G. D. Searle & Co.	Peptide mimetic compounds useful as platelet aggregation inhibitors

1993
- 1993-01-14 PL PL93316750A patent/PL173781B1/pl unknown
- 1993-01-14 EP EP93902195A patent/EP0625138B1/fr not_active Expired - Lifetime
- 1993-01-14 CA CA002129526A patent/CA2129526A1/fr not_active Abandoned
- 1993-01-14 WO PCT/EP1993/000070 patent/WO1993016036A1/fr not_active Ceased
- 1993-01-14 SK SK914-94A patent/SK281016B6/sk unknown
- 1993-01-14 UA UA94095773A patent/UA43318C2/uk unknown
- 1993-01-14 NZ NZ246593A patent/NZ246593A/en unknown
- 1993-01-14 ES ES98121305T patent/ES2165122T3/es not_active Expired - Lifetime
- 1993-01-14 DK DK98121305T patent/DK0902013T3/da active
- 1993-01-14 KR KR1019940702669A patent/KR0163222B1/ko not_active Expired - Fee Related
- 1993-01-14 HU HU9402291A patent/HU216191B/hu not_active IP Right Cessation
- 1993-01-14 DK DK93902195T patent/DK0625138T3/da active
- 1993-01-14 JP JP51370193A patent/JP3487851B2/ja not_active Expired - Fee Related
- 1993-01-14 DE DE59310252T patent/DE59310252D1/de not_active Expired - Fee Related
- 1993-01-14 ES ES93902195T patent/ES2132216T3/es not_active Expired - Lifetime
- 1993-01-14 PT PT98121305T patent/PT902013E/pt unknown
- 1993-01-14 RU RU94041836A patent/RU2124002C1/ru not_active IP Right Cessation
- 1993-01-14 AU AU33497/93A patent/AU673343B2/en not_active Ceased
- 1993-01-14 AT AT93902195T patent/ATE180770T1/de not_active IP Right Cessation
- 1993-01-14 CZ CZ19941886A patent/CZ287209B6/cs unknown
- 1993-01-14 FI FI943618A patent/FI943618A0/fi unknown
- 1993-01-14 EP EP98121305A patent/EP0902013B1/fr not_active Expired - Lifetime
- 1993-01-14 SG SG1996008431A patent/SG44837A1/en unknown
- 1993-01-14 DE DE59309630T patent/DE59309630D1/de not_active Expired - Fee Related
- 1993-01-14 PL PL93304713A patent/PL173789B1/pl unknown
- 1993-01-14 CA CA002427890A patent/CA2427890A1/fr not_active Abandoned
- 1993-01-14 AT AT98121305T patent/ATE210634T1/de not_active IP Right Cessation
- 1993-01-29 TW TW082100562A patent/TW232005B/zh active
- 1993-02-03 HR HRP4244241.9A patent/HRP930102B1/xx not_active IP Right Cessation
- 1993-02-03 YU YU6393A patent/YU49038B/sh unknown
- 1993-02-03 IL IL104589A patent/IL104589A0/xx not_active IP Right Cessation
- 1993-02-04 MX MX9300630A patent/MX9300630A/es not_active IP Right Cessation
- 1993-02-05 SI SI9300066A patent/SI9300066B/sl not_active IP Right Cessation
1994
- 1994-08-04 NO NO942903A patent/NO301540B1/no not_active IP Right Cessation
1995
- 1995-06-05 US US08/460,961 patent/US6037377A/en not_active Expired - Lifetime
1997
- 1997-04-18 CZ CZ19971203A patent/CZ287173B6/cs unknown
1999
- 1999-06-09 GR GR990401541T patent/GR3030468T3/el unknown
2000
- 2000-01-18 US US09/484,073 patent/US6489365B1/en not_active Expired - Lifetime
2002
- 2002-03-18 JP JP2002073593A patent/JP2002322143A/ja active Pending
- 2002-09-23 US US10/252,976 patent/US20030130232A1/en not_active Abandoned

Also Published As

Publication number	Publication date
DK0625138T3 (da)	1999-11-15
PL173789B1 (pl)	1998-04-30
AU3349793A (en)	1993-09-03
CA2129526A1 (fr)	1993-08-06
SK281016B6 (sk)	2000-10-09
ES2165122T3 (es)	2002-03-01
RU94041836A (ru)	1997-02-20
EP0625138B1 (fr)	1999-06-02
CZ287209B6 (en)	2000-10-11
HU9402291D0 (en)	1994-10-28
SI9300066A (en)	1993-09-30
EP0902013A1 (fr)	1999-03-17
MX9300630A (es)	1993-09-01
FI943618A7 (fi)	1994-08-04
CZ287173B6 (cs)	2000-10-11
IL104589A0 (en)	1993-06-10
JP2002322143A (ja)	2002-11-08
PT902013E (pt)	2002-06-28
KR0163222B1 (ko)	1999-01-15
NZ246593A (en)	1997-07-27
AU673343B2 (en)	1996-11-07
EP0625138A1 (fr)	1994-11-23
US6037377A (en)	2000-03-14
YU6393A (sh)	1996-10-09
SK91494A3 (en)	1995-02-08
NO942903L (no)	1994-10-03
DE59309630D1 (de)	1999-07-08
NO942903D0 (fr)	1994-08-04
GR3030468T3 (en)	1999-10-29
UA43318C2 (uk)	2001-12-17
HRP930102A2 (en)	1998-12-31
WO1993016036A1 (fr)	1993-08-19
US6489365B1 (en)	2002-12-03
ATE180770T1 (de)	1999-06-15
HRP930102B1 (en)	2000-02-29
KR950700241A (ko)	1995-01-16
EP0902013B1 (fr)	2001-12-12
TW232005B (fr)	1994-10-11
JPH07503718A (ja)	1995-04-20
SG44837A1 (en)	1997-12-19
JP3487851B2 (ja)	2004-01-19
CA2427890A1 (fr)	1993-08-19
DE59310252D1 (de)	2002-01-24
CZ188694A3 (en)	1995-03-15
HUT68419A (en)	1995-06-28
US20030130232A1 (en)	2003-07-10
ES2132216T3 (es)	1999-08-16
YU49038B (sh)	2003-07-07
ATE210634T1 (de)	2001-12-15
RU2124002C1 (ru)	1998-12-27
NO301540B1 (no)	1997-11-10
DK0902013T3 (da)	2002-03-25
FI943618A0 (fi)	1994-08-04
HU216191B (hu)	1999-05-28
SI9300066B (sl)	2003-02-28
PL173781B1 (pl)	1998-04-30

Publication	Publication Date	Title
FI943618L (fi)	1994-08-04	Uudet amidiinijohdannaiset, niiden valmistus ja käyttö lääkeaineina, joilla on LTB4-antagonistinen vaikutus
FI935897A7 (fi)	1994-06-30	Pyridopyrimidiinijohdannaiset, niiden valmistus ja käyttö
FI955248A7 (fi)	1995-11-02	1-Bifenyylimetyyli-imitdatsolin johdannaiset, niiden valmistus ja terapeuttinen käyttö
NO910723D0 (no)	1991-02-22	Karbapenemderivater med antibiotisk aktivitet, samt fremstilling og anvendelse derav.
FI862029A7 (fi)	1986-11-18	Askorbiinihappojohdannaiset, niiden valmistus ja käyttö.
FI935887L (fi)	1994-06-29	Tiatzolidiinidionijohdannaiset, niiden valmistus ja käyttö
FI955140L (fi)	1995-10-27	Uusia kinoksaliinidionijohdannaisia, niiden valmistus ja käyttö lääkkeissä
EE04151B1 (et)	2003-10-15	Atsüülpiperasinüülpürimidiinide derivaadid, nendevalmistamine ja kasutamine ravimitena
FI954491A7 (fi)	1995-09-22	Heterosykliä sisältäviä amidiinijohdokset, niiden valmistus ja käyttö
DE3677445D1 (de)	1991-03-14	2-substituierte-e-kondensierte(1,5-c)-pyrimidine, pharmazeutische zubereitungen und ihre verwendung.
FI922983A7 (fi)	1992-12-28	Pyrimidiini-4-karboksamidijohdannaisia, niiden valmistus ja terapeuttinen käyttö
FI914611A7 (fi)	1992-04-03	2-aminopyrimidiini-4-karboksamidijohdannaiset, niiden valmistus ja terapeuttinen käyttö
FI941287A0 (fi)	1994-03-18	Triatsolokinoksalin-1,4-dioneja ja niiden valmistus ja käyttö
FI892344A7 (fi)	1989-11-18	6-fenyyli-3-piperatsinyylialkyyli-1H,3H-pyrimidiini-2,4-dionin johdannaisia, niiden valmistus ja niiden terapeuttinen käyttö
FI922982A7 (fi)	1992-12-28	2-aminopyrimidiini-4-karboksamidijohdannaisia, niiden valmistus ja niiden terapeuttinen käyttö
FI930716A7 (fi)	1993-08-21	Uusia aryylikarbonyyliaminoalkyylidihydro-oksopyridiinejä, niiden valmistus ja käyttö
FI861526A7 (fi)	1986-10-12	Nitrofuraanin johdannaiset, niiden valmistus ja soveltaminen terapiassa.
FI921814A7 (fi)	1992-10-25	2-aminopyrimidiini-4-karboksiamidijohdannaiset, niiden valmistus ja terapeuttinen käyttö
FI920663A7 (fi)	1992-08-16	Polyhydroksisyklopentaanin johdannaiset, niiden valmistus ja terapeuttinen käyttö
FI950533L (fi)	1995-02-07	Seco-nukleosidien liponulkeotidit, niiden valmistaminen sekä niiden käyttö virusten vastaisina lääkkeinä
FI20002501L (fi)	2000-11-15	Uudet amidiinijohdannaiset, niiden valmistus ja käyttö lääkeaineena, joilla on LTB4-antagonistinen vaikutus
FI894758A7 (fi)	1990-04-08	3-Aryylioksimetyyli-kefalosporiinin johdannaiset, niiden valmistus ja lääkinnällinen käyttö
FI922980A7 (fi)	1992-12-28	2-piperidinyylipyrimidiini-4-karboksamidijohdannaiset, niiden valmistus ja terapeuttinen käyttö
FI896170A7 (fi)	1990-06-23	Substituoituja guanidiini- ja amidiiniyhdisteitä sekä niiden valmistus ja fungisidinen käyttö
BR1100515A (pt)	2000-06-06	Derivados de amidina, sua preparação e utilização como medicamentos com ação antagonista de ltb4