FI940806A7 - Sykliset johdokset, näitä yhdisteitä sisältävät lääkeaineet ja menetelmä niiden valmistamiseksi - Google Patents

Sykliset johdokset, näitä yhdisteitä sisältävät lääkeaineet ja menetelmä niiden valmistamiseksi Download PDF

Info

Publication number: FI940806A7
Authority: FI; Finland
Prior art keywords: compounds; preparation; cyclic derivatives; pharmaceuticals containing; pharmaceuticals
Prior art date: 1993-02-22

Application number

FI940806A

Other languages

English (en)

Swedish (sv)

Other versions

FI940806A0 (fi

FI940806L (fi

Inventor

Volkhard Austel

Helmut Pieper

Johannes Weisenberger

Günter Linz

Thomas Müller

Brian Guth

Frank Himmelsbach

Original Assignee

Dr Karl Thomae Ges Mit

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-02-22

Filing date

1994-02-21

Publication date

1994-08-23

1993-02-22 Priority claimed from DE4305388A external-priority patent/DE4305388A1/de

1994-02-21 Application filed by Dr Karl Thomae Ges Mit filed Critical Dr Karl Thomae Ges Mit

1994-02-21 Publication of FI940806A0 publication Critical patent/FI940806A0/fi

1994-08-23 Publication of FI940806L publication Critical patent/FI940806L/fi

1994-08-23 Publication of FI940806A7 publication Critical patent/FI940806A7/fi

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Diabetes (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Hematology (AREA)
Endocrinology (AREA)
Pulmonology (AREA)
Obesity (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Emergency Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Medicinal Preparation (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Hydrogenated Pyridines (AREA)
Saccharide Compounds (AREA)

FI940806A 1993-02-22 1994-02-21 Sykliset johdokset, näitä yhdisteitä sisältävät lääkeaineet ja menetelmä niiden valmistamiseksi FI940806A7 (fi)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE4305388A DE4305388A1 (de)	1993-02-22	1993-02-22	Cyclische Derivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
DE4332168A DE4332168A1 (de)	1993-02-22	1993-09-22	Cyclische Derivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung

Publications (3)

Publication Number	Publication Date
FI940806A0 FI940806A0 (fi)	1994-02-21
FI940806L FI940806L (fi)	1994-08-23
FI940806A7 true FI940806A7 (fi)	1994-08-23

Family

ID=25923309

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
FI940806A FI940806A7 (fi)	1993-02-22	1994-02-21	Sykliset johdokset, näitä yhdisteitä sisältävät lääkeaineet ja menetelmä niiden valmistamiseksi

Country Status (22)

Country	Link
US (3)	US5519036A (fi)
EP (1)	EP0612741B1 (fi)
JP (1)	JP3545446B2 (fi)
KR (1)	KR100322319B1 (fi)
CN (1)	CN1048490C (fi)
AT (1)	ATE167185T1 (fi)
AU (1)	AU673875B2 (fi)
CA (1)	CA2116068A1 (fi)
CZ (1)	CZ37494A3 (fi)
DE (2)	DE4332168A1 (fi)
DK (1)	DK0612741T3 (fi)
ES (1)	ES2118992T3 (fi)
FI (1)	FI940806A7 (fi)
HU (1)	HU222112B1 (fi)
IL (1)	IL108733A (fi)
MX (1)	MX9401315A (fi)
NO (1)	NO305081B1 (fi)
NZ (1)	NZ250944A (fi)
PH (1)	PH30602A (fi)
PL (1)	PL178215B1 (fi)
SG (1)	SG52300A1 (fi)
UA (1)	UA39099C2 (fi)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE19624069A1 (de) *	1996-06-17	1997-12-18	Thomae Gmbh Dr K	Benzazepinderivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
DE4332168A1 (de) *	1993-02-22	1995-03-23	Thomae Gmbh Dr K	Cyclische Derivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
US5849736A (en) *	1993-11-24	1998-12-15	The Dupont Merck Pharmaceutical Company	Isoxazoline and isoxazole fibrinogen receptor antagonists
DE4424974A1 (de) *	1994-07-15	1996-01-18	Thomae Gmbh Dr K	Harnstoff- und Carbaminsäurederivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
DE4427838A1 (de) *	1994-08-05	1996-02-08	Thomae Gmbh Dr K	Kondensierte Azepinderivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
DE4429079A1 (de) *	1994-08-17	1996-02-22	Thomae Gmbh Dr K	Cyclische Harnstoffderivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
CA2207618A1 (en) *	1994-12-23	1996-07-04	Helmut Pieper	Piperazine derivatives, medicaments comprising these compounds, their use and processes for their preparation
ZA963391B (en) *	1995-05-24	1997-10-29	Du Pont Merck Pharma	Isoxazoline fibrinogen receptor antagonists.
US5925635A (en) *	1996-04-17	1999-07-20	Dupont Pharmaceuticals Company	N-(amidinophenyl) cyclourea analogs as factor XA inhibitors
IL123986A (en)	1997-04-24	2011-10-31	Organon Nv	Medicinal compounds
AU8875398A (en)	1997-08-29	1999-03-22	Proteus Molecular Design Ltd	1-amino-7-isoquinoline derivatives as serine protease inhibitors
US6340687B1 (en)	1997-09-03	2002-01-22	American Home Products Corporation	Substituted tetrahydro-pyrimidine-2(1H)-thione HDL-C elevators useful as antiatherosclerotic agents
EP1065200A4 (en) *	1998-03-19	2003-01-02	Ajinomoto Kk	Aminoisoquinoline DERIVATIVES
WO2000056725A1 (en) *	1999-03-19	2000-09-28	Du Pont Pharmaceuticals Company	N-adamant-1-yl-n'-[4-chlorobenzothiazol-2-yl] urea useful in the treatment of inflammation and as an anticancer radiosensitizing agent
US6492406B1 (en) *	1999-05-21	2002-12-10	Astrazeneca Ab	Pharmaceutically active compounds
CZ20032850A3 (cs)	2001-04-18	2004-02-18	Euro-Celtique, S. A.	Analogy nociceptinu
US7291603B2 (en)	2002-07-24	2007-11-06	Ptc Therapeutics, Inc.	Nucleoside compounds and their use for treating cancer and diseases associated with somatic mutations
CA2495589A1 (en) *	2002-08-14	2004-02-26	Abbott Laboratories	Azabicyclic compounds are central nervous system active agents
US7135484B2 (en)	2002-08-14	2006-11-14	Abbott Laboratories	Azabicyclic compounds are central nervous system active agents
KR100897642B1 (ko)	2002-12-20	2009-05-14	글락소 그룹 리미티드	신경 장애 치료용 벤즈아제핀 유도체
GB0405628D0 (en) *	2004-03-12	2004-04-21	Glaxo Group Ltd	Novel compounds
EP1621535A1 (en) *	2004-07-27	2006-02-01	Aventis Pharma S.A.	Substituted cyclic urea derivatives, preparation thereof and pharmaceutical use thereof as kinase inhibitors
WO2006041773A2 (en) *	2004-10-04	2006-04-20	Millennium Pharmaceuticals, Inc.	Lactam compounds useful as protein kinase inhibitors
WO2006117657A1 (en) *	2005-05-03	2006-11-09	Ranbaxy Laboratories Limited	Triazolone derivatives as anti-inflammatory agents
ES2580108T3 (es)	2005-07-11	2016-08-19	Aerie Pharmaceuticals, Inc	Compuestos de isoquinolina
PE20080145A1 (es)	2006-03-21	2008-02-11	Janssen Pharmaceutica Nv	Tetrahidro-pirimidoazepinas como moduladores de trpv1
CA2655574A1 (en)	2006-06-20	2007-12-27	Wyeth	Imidazole kv1.5 potassium channel inhibitors
JP2009543812A (ja) *	2006-07-20	2009-12-10	キャスケイド・セラピューティクス・インコーポレイテッド	５−ＨＴ２Ｃリガンドとしてのテトラヒドロ−５Ｈ−ピリド［２，３−ｄ］アゼピン
EP2526948A1 (en) *	2006-09-20	2012-11-28	Aerie Pharmaceuticals, Inc.	RHO kinase inhibitors
US8455513B2 (en)	2007-01-10	2013-06-04	Aerie Pharmaceuticals, Inc.	6-aminoisoquinoline compounds
PE20091102A1 (es)	2007-12-17	2009-07-25	Janssen Pharmaceutica Nv	Moduladores imidazolo-, oxazolo-, y tiazolopirimidina del trpv1
WO2009079765A1 (en) *	2007-12-21	2009-07-02	Cascade Therapeutics Inc.	Compounds with activity at the 5-ht2c receptor
US8455514B2 (en) *	2008-01-17	2013-06-04	Aerie Pharmaceuticals, Inc.	6-and 7-amino isoquinoline compounds and methods for making and using the same
US8450344B2 (en)	2008-07-25	2013-05-28	Aerie Pharmaceuticals, Inc.	Beta- and gamma-amino-isoquinoline amide compounds and substituted benzamide compounds
WO2010065134A1 (en)	2008-12-05	2010-06-10	Millennium Pharmaceuticals, Inc.	5, 7-dihydro- 6h-pyrimido [ 5, 4-d] [ 1 ] benzazepin-6-thiones as plk inhibitors
US8394826B2 (en)	2009-05-01	2013-03-12	Aerie Pharmaceuticals, Inc.	Dual mechanism inhibitors for the treatment of disease
JP5456891B2 (ja) *	2009-06-26	2014-04-02	ノバルティスアーゲー	Ｃｙｐ１７阻害剤としての１，３−二置換イミダゾリジン−２−オン誘導体
ES2656218T3 (es)	2011-04-28	2018-02-26	Novartis Ag	Inhibidores de 17 alfa-hidroxilasa/C17,20-liasa
EP2976080B1 (en)	2013-03-15	2019-12-25	Aerie Pharmaceuticals, Inc.	Conjugates of isoquinoline compounds and prostaglandins
AU2015414743B2 (en)	2015-11-17	2019-07-18	Alcon Inc.	Process for the preparation of kinase inhibitors and intermediates thereof
US9643927B1 (en)	2015-11-17	2017-05-09	Aerie Pharmaceuticals, Inc.	Process for the preparation of kinase inhibitors and intermediates thereof
KR102568082B1 (ko)	2016-08-31	2023-08-17	에어리 파마슈티컬즈, 인코포레이티드	안과용 조성물
AU2018243687C1 (en)	2017-03-31	2020-12-24	Alcon Inc.	Aryl cyclopropyl-amino-isoquinolinyl amide compounds
EP3849555A4 (en)	2018-09-14	2022-05-04	Aerie Pharmaceuticals, Inc.	Aryl cyclopropyl-amino-isoquinolinyl amide compounds
WO2022234339A2 (en) *	2021-05-05	2022-11-10	Diamond Therapeutics Inc.	5-ht2a and/or 5-ht2c receptor agonists

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9106571D0 (en) *	1991-03-27	1991-05-15	Erba Carlo Spa	Derivatives of substituted imidazol-2-one and process for their preparation
DE4107857A1 (de) *	1991-03-12	1992-09-17	Thomae Gmbh Dr K	Cyclische harnstoffderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
DE4112014A1 (de) *	1991-04-12	1992-10-15	Thomae Gmbh Dr K	Kondensierte diazepinone, verfahren zu ihrer herstellung und diese verbindungen enthaltende mittel zur behandlung von erkrankungen des zentralnervensystems und zur foerderung der cerebralen durchblutung
DE4127404A1 (de) *	1991-08-19	1993-02-25	Thomae Gmbh Dr K	Cyclische iminoderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
DE4332168A1 (de) *	1993-02-22	1995-03-23	Thomae Gmbh Dr K	Cyclische Derivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
AU675484B2 (en) *	1993-03-24	1997-02-06	Neurosearch A/S	Benzimidazole compounds, their use and preparation

1993
- 1993-09-22 DE DE4332168A patent/DE4332168A1/de not_active Ceased
1994
- 1994-02-21 AU AU56324/94A patent/AU673875B2/en not_active Ceased
- 1994-02-21 MX MX9401315A patent/MX9401315A/es unknown
- 1994-02-21 CZ CZ94374A patent/CZ37494A3/cs unknown
- 1994-02-21 CA CA002116068A patent/CA2116068A1/en not_active Abandoned
- 1994-02-21 NO NO940595A patent/NO305081B1/no not_active IP Right Cessation
- 1994-02-21 FI FI940806A patent/FI940806A7/fi unknown
- 1994-02-21 JP JP02272794A patent/JP3545446B2/ja not_active Expired - Fee Related
- 1994-02-21 DE DE59406157T patent/DE59406157D1/de not_active Expired - Fee Related
- 1994-02-21 DK DK94102557T patent/DK0612741T3/da active
- 1994-02-21 PH PH47791A patent/PH30602A/en unknown
- 1994-02-21 UA UA94005097A patent/UA39099C2/uk unknown
- 1994-02-21 HU HU9400493A patent/HU222112B1/hu not_active IP Right Cessation
- 1994-02-21 SG SG1996002477A patent/SG52300A1/en unknown
- 1994-02-21 PL PL94302302A patent/PL178215B1/pl unknown
- 1994-02-21 AT AT94102557T patent/ATE167185T1/de not_active IP Right Cessation
- 1994-02-21 EP EP94102557A patent/EP0612741B1/de not_active Expired - Lifetime
- 1994-02-21 ES ES94102557T patent/ES2118992T3/es not_active Expired - Lifetime
- 1994-02-21 KR KR1019940003193A patent/KR100322319B1/ko not_active Expired - Fee Related
- 1994-02-22 CN CN94102252A patent/CN1048490C/zh not_active Expired - Fee Related
- 1994-02-22 IL IL108733A patent/IL108733A/en not_active IP Right Cessation
- 1994-02-22 US US08/200,125 patent/US5519036A/en not_active Expired - Lifetime
- 1994-02-22 NZ NZ250944A patent/NZ250944A/en unknown
1995
- 1995-05-02 US US08/434,136 patent/US5612335A/en not_active Expired - Lifetime
1996
- 1996-12-17 US US08/768,365 patent/US5827849A/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
EP0612741A1 (de)	1994-08-31
CA2116068A1 (en)	1994-08-23
FI940806A0 (fi)	1994-02-21
NO940595L (no)	1994-08-23
AU673875B2 (en)	1996-11-28
FI940806L (fi)	1994-08-23
NO940595D0 (no)	1994-02-21
CN1099755A (zh)	1995-03-08
ATE167185T1 (de)	1998-06-15
KR940019704A (ko)	1994-09-14
PH30602A (en)	1997-07-31
US5519036A (en)	1996-05-21
DK0612741T3 (da)	1999-03-29
EP0612741B1 (de)	1998-06-10
SG52300A1 (en)	1998-09-28
MX9401315A (es)	1994-08-31
NO305081B1 (no)	1999-03-29
CN1048490C (zh)	2000-01-19
DE4332168A1 (de)	1995-03-23
KR100322319B1 (ko)	2002-06-26
HUT70768A (en)	1995-10-30
AU5632494A (en)	1994-08-25
IL108733A0 (en)	1994-05-30
JP3545446B2 (ja)	2004-07-21
CZ37494A3 (en)	1994-12-15
IL108733A (en)	1998-01-04
NZ250944A (en)	1996-02-27
US5827849A (en)	1998-10-27
UA39099C2 (uk)	2001-06-15
DE59406157D1 (de)	1998-07-16
ES2118992T3 (es)	1998-10-01
HU222112B1 (hu)	2003-04-28
HU9400493D0 (en)	1994-05-30
US5612335A (en)	1997-03-18
JPH06256343A (ja)	1994-09-13
PL178215B1 (pl)	2000-03-31

Publication	Publication Date	Title
FI940806A7 (fi)	1994-08-23	Sykliset johdokset, näitä yhdisteitä sisältävät lääkeaineet ja menetelmä niiden valmistamiseksi
FI943687L (fi)	1995-03-21	Uudet 11-bentsaldoksiimiestradieenijohdannaiset, menetelmät niiden valmistamiseksi ja näitä yhdisteitä sisältävät lääkeaineet
FI921030A7 (fi)	1992-09-13	Sykliset ureajohdannaiset, näitä yhdisteitä sisältävät lääkeaineet ja menetelmä niiden valmistamiseksi
FI933942A7 (fi)	1994-03-12	Sykliset ureajohdokset, näitä yhdisteitä sisältävät lääkeaineet ja menetelmä niiden valmistamiseksi
FI942074A7 (fi)	1994-11-09	nor-sappijohdannaisia, menetelmä niiden valmistamiseksi ja näiden yhdisteiden käyttö lääkeaineina
FI924687A7 (fi)	1993-04-19	Heterobiaryylijohdokset, näitä yhdisteitä sisältävät lääkeaineet ja menetelmä niiden valmistamiseksi
FI931880A7 (fi)	1993-10-29	Sykliset iminojohdokset, menetelmä niiden valmistamiseksi ja näitä yhdisteitä sisältävät lääkeaineet
FI953467A7 (fi)	1995-07-18	Aminohappojohdannaisia, näitä yhdisteitä sisältävät lääkeaineet ja men etelmä niiden valmistamiseksi
FI920286A7 (fi)	1992-07-25	Bifenyylijohdannaiset, näitä yhdisteitä sisältävät lääkeaineet ja menetelmä niiden valmistamiseksi
FI940378A7 (fi)	1994-07-27	5-jäseniset heterosyklit, menetelmä niiden valmistamiseksi ja näitä yhdisteitä sisältävät lääkeaineet
FI954105A7 (fi)	1995-09-01	Uusia 4-aminopyridiinejä, niiden valmistusmenetelmä sekä näitä yhdisteitä sisältäviä lääkkeitä
FI923366A7 (fi)	1993-01-28	5-jäseniset heterosyklit, menetelmä niiden valmistamiseksi ja näitä yhdisteitä sisältävät lääkeaineet
FI923960A7 (fi)	1993-03-07	5-jäseniset heterosyklit, menetelmä niiden valmistamiseksi ja näitä yhdisteitä sisältävät lääkeaineet
FI954246L (fi)	1995-09-11	Uusia A83543-yhdisteitä ja menetelmä niiden valmistamiseksi
FI973148A7 (fi)	1997-09-29	Substituoituja heterosyklisiä yhdisteitä, menetelmä niiden valmistamis eksi ja niitä sisältäviä farmaseuttisia koostumuksia
FI923691A7 (fi)	1993-02-20	Sykliset iminojohdokset, näitä yhdisteitä sisältävät farmaseuttiset seokset ja menetelmä niiden valmistamiseksi
FI972646A0 (fi)	1997-06-19	Piperatsiinijohdannaiset, näitä yhdisteitä sisältävät lääkeaineet, niiden käyttö ja menetelmä niiden valmistamiseksi
FI943316L (fi)	1994-07-12	Farmaseuttiset koostumukset, joissa on nifedipiiniä ja menetelmä sen valmistamiseksi
FI932649A7 (fi)	1993-12-12	Bifenyylijohdokset, näitä yhdisteitä sisältävät lääkeaineet ja menetelmä niiden valmistamiseksi
FI902734A7 (fi)	1990-12-02	2-hydroksi-n-propyyliamiinit, näitä yhdisteitä sisältävät lääkeaineet ja menetelmä niiden valmistamiseksi
FI931336A7 (fi)	1993-09-29	Polyhydroksimetyleenijohdannaisia sisältäviä lääkkeitä, menetelmä niiden valmistamiseksi ja käyttämiseksi
FI943688L (fi)	1995-03-21	Uudet 11-bentsaldoksiimi-17beta-metoksi-27alfa-metoksi-metyyli-estradieenijohdannaiset, menetelmät niiden valmistamiseksi ja näitä sisältävät lääkeaineet
FI941836A7 (fi)	1994-10-23	3-deoksioligosakkaridit, menetelmiä niiden valmistamiseksi ja niitä sisältävät farmaseuttiset koostumukset
FI940697A7 (fi)	1994-08-17	Kondensoidut 5-jäseniset heterosyklit, menetelmä niiden valmistamiseksi ja näitä yhdisteitä sisältävät lääkeaineet
FI921525A7 (fi)	1992-10-10	Amidinofenyylialaniinijohdannaisia, menetelmä niiden valmistamiseksi, niiden käyttö ja niitä sisältäviä aineita