FI940779L - Cetrorelix-lyofilisaatin uusi valmistusmenetelmä - Google Patents

Cetrorelix-lyofilisaatin uusi valmistusmenetelmä Download PDF

Info

Publication number: FI940779L
Authority: FI; Finland
Prior art keywords: new manufacturing; cetrorelix; lyophilisate; cetrorelix lyophilisate; manufacturing
Prior art date: 1993-02-19

Application number

FI940779A

Other languages

English (en)

Swedish (sv)

Other versions

FI940779A0 (fi

FI110059B (fi

Inventor

Juergen Engel

Burkhard Wichert

Dieter Sauerbier

Thomas Reissmann

Original Assignee

Asta Medica Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-02-19

Filing date

1994-02-18

Publication date

1994-08-20

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=6480924&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=FI940779(L) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1994-02-18 Application filed by Asta Medica Ag filed Critical Asta Medica Ag

1994-02-18 Publication of FI940779A0 publication Critical patent/FI940779A0/fi

1994-08-20 Publication of FI940779L publication Critical patent/FI940779L/fi

2002-11-29 Application granted granted Critical

2002-11-29 Publication of FI110059B publication Critical patent/FI110059B/fi

Links

SBNPWPIBESPSIF-MHWMIDJBSA-N cetrorelix Chemical compound C([C@@H](C(=O)N[C@H](CCCNC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1[C@@H](CCC1)C(=O)N[C@H](C)C(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](CC=1C=NC=CC=1)NC(=O)[C@@H](CC=1C=CC(Cl)=CC=1)NC(=O)[C@@H](CC=1C=C2C=CC=CC2=CC=1)NC(C)=O)C1=CC=C(O)C=C1 SBNPWPIBESPSIF-MHWMIDJBSA-N 0.000 title 1
229960003230 cetrorelix Drugs 0.000 title 1
108700008462 cetrorelix Proteins 0.000 title 1
238000004519 manufacturing process Methods 0.000 title 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/08—Peptides having 5 to 11 amino acids
- A61K38/09—Luteinising hormone-releasing hormone [LHRH], i.e. Gonadotropin-releasing hormone [GnRH]; Related peptides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Epidemiology (AREA)
Bioinformatics & Cheminformatics (AREA)
Reproductive Health (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Endocrinology (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
Oil, Petroleum & Natural Gas (AREA)
Gastroenterology & Hepatology (AREA)
Immunology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Dermatology (AREA)
Pregnancy & Childbirth (AREA)
Gynecology & Obstetrics (AREA)
Urology & Nephrology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicinal Preparation (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Polysaccharides And Polysaccharide Derivatives (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Peptides Or Proteins (AREA)
Steroid Compounds (AREA)
Manufacture Of Tobacco Products (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Compounds Of Unknown Constitution (AREA)

FI940779A 1993-02-19 1994-02-18 Cetrorelix-lyofilisaatin uusi valmistusmenetelmä FI110059B (fi)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE4305225A DE4305225A1 (de)	1993-02-19	1993-02-19	Neues Herstellverfahren für Cetrorelix Lyophilisat
DE4305225		1993-02-19

Publications (3)

Publication Number	Publication Date
FI940779A0 FI940779A0 (fi)	1994-02-18
FI940779L true FI940779L (fi)	1994-08-20
FI110059B FI110059B (fi)	2002-11-29

Family

ID=6480924

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
FI940779A FI110059B (fi)	1993-02-19	1994-02-18	Cetrorelix-lyofilisaatin uusi valmistusmenetelmä

Country Status (29)

Country	Link
EP (2)	EP0947200B1 (fi)
JP (1)	JP4033919B2 (fi)
KR (2)	KR100355686B1 (fi)
CN (1)	CN1109557C (fi)
AT (1)	ATE193653T1 (fi)
AU (1)	AU671881C (fi)
BR (1)	BR9400617A (fi)
CA (1)	CA2115943C (fi)
CZ (2)	CZ284314B6 (fi)
DE (2)	DE4305225A1 (fi)
DK (1)	DK0611572T3 (fi)
ES (1)	ES2148247T3 (fi)
FI (1)	FI110059B (fi)
GR (1)	GR3034237T3 (fi)
HR (1)	HRP940117B1 (fi)
HU (1)	HU218281B (fi)
IL (1)	IL108704A (fi)
MX (1)	MX9401312A (fi)
NO (1)	NO316601B1 (fi)
NZ (2)	NZ250906A (fi)
PL (1)	PL177177B1 (fi)
PT (1)	PT611572E (fi)
RU (1)	RU2145234C1 (fi)
SG (1)	SG46632A1 (fi)
SI (1)	SI9400087B (fi)
SK (2)	SK283022B6 (fi)
TW (1)	TW387812B (fi)
UA (1)	UA43829C2 (fi)
ZA (1)	ZA941136B (fi)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6828415B2 (en) *	1993-02-19	2004-12-07	Zentaris Gmbh	Oligopeptide lyophilisate, their preparation and use
PE63998A1 (es) *	1996-04-19	1998-10-30	Merck & Co Inc	Composiciones anti-fungosas
DE19712718C2 (de) *	1997-03-26	1999-09-23	Asta Medica Ag	Immobilisierte und aktivitätsstabilisierte Komplexe von LHRH-Antagonisten und Verfahren zu deren Herstellung
KR100632722B1 (ko) *	1998-04-23	2006-10-16	젠타리스 게엠베하	불임증 치료용 약제학적 제제
DE10024451A1 (de) *	2000-05-18	2001-11-29	Asta Medica Ag	Pharmazeutische Darreichungsform für Peptide, Verfahren zu deren Herstellung und Verwendung
DE10040700A1 (de) *	2000-08-17	2002-02-28	Asta Medica Ag	Salze von biologisch aktiven Peptiden, ihre Herstellung und Verwendung
DE10157628A1 (de) *	2001-11-26	2003-06-12	Zentaris Ag	Injektionslösung eines LHRH-Antagonisten
US20030186892A1 (en) *	2002-03-28	2003-10-02	Rajneesh Taneja	Enhancement of endogenous gonadotropin production
JP4898118B2 (ja) *	2002-09-27	2012-03-14	エテルナツェンタリスゲゼルシャフトミットベシュレンクテルハフツング	徐放性を有する薬剤学的に活性なペプチドのための投与形及びそれらの製造方法
EP1722819B1 (en)	2004-03-12	2007-12-26	Intercell AG	Method for solubilising peptide mixtures
EP1674082A1 (de) *	2004-12-22	2006-06-28	Zentaris GmbH	Verfahren zur Herstellung von sterilen Suspensionen oder Lyophilisaten schwerlöslicher basischer Peptidkomplexe, diese enthaltende pharmazeutische Formulierungen sowie ihre Verwendung als Arzneimittel
JOP20090061B1 (ar) *	2008-02-11	2021-08-17	Ferring Int Center Sa	طريقة معالجة سرطان البروستاتا بمضادات الهرمونات التناسلية GnRH
CN101629758B (zh) *	2008-07-19	2012-09-26	浙江家泰电器制造有限公司	液体加热器皿过热保护控制器组件
CN101630607B (zh) *	2008-07-19	2012-04-25	浙江家泰电器制造有限公司	液体加热器皿过热保护控制器组件
RU2454221C2 (ru) *	2010-07-06	2012-06-27	Общество с ограниченной ответственностью "Завод Медсинтез"	Способ получения лиофилизированного противовирусного средства
EP2648755A1 (en)	2010-12-06	2013-10-16	Astron Research Limited	A stable ready-to-use cetrorelix injection
GB201022147D0 (en) *	2010-12-31	2011-02-16	Immune Targeting Systems Its Ltd	Formulation
CN102423484B (zh) *	2011-11-23	2014-01-15	深圳翰宇药业股份有限公司	一种稳定的西曲瑞克药物组合物及其制备方法
EP3015553A1 (de)	2014-10-30	2016-05-04	Biotecon Diagnostics GmbH	Stabilisierte Reaktionsmischung
RU2667128C2 (ru) *	2016-12-29	2018-09-14	Герман Петрович Беккер	Композиция для приготовления противоопухолевого средства и способ приготовления противоопухолевого средства на ее основе
JP2022537957A (ja)	2019-06-17	2022-08-31	インタスファーマシューティカルズリミテッド	セトロレリクスの安定な製剤
CN112717119B (zh) *	2021-01-27	2024-04-30	南京羚诺生物医药技术研究院有限公司	一种西曲瑞克药物组合物及其制备方法
EP4164608A1 (en)	2021-06-25	2023-04-19	Extrovis AG	Pharmaceutical compositions
CN114159544A (zh) *	2022-01-24	2022-03-11	福州华为医药技术开发有限公司	注射用醋酸西曲瑞克及其制备方法
CN115969954A (zh) *	2023-01-09	2023-04-18	开封明仁药业有限公司	一种注射用西曲瑞克冻干药物组合物及其制备方法

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3816386A (en) *	1972-06-20	1974-06-11	Abbott Lab	Purification process for gn-rh
DD141996A1 (de) *	1979-02-21	1980-06-04	Ingrid Wolf	Verfahren zur herstellung von lyophilisierten lhrh-praeparationen
CS230614B1 (en) *	1982-08-06	1984-08-13	Martin Cs Flegel	Analogues of realising factor for luteining and folliculstimulated hormon
US4565804A (en) *	1984-09-07	1986-01-21	The Salk Institute For Biological Studies	GnRH Antagonists VI
EP0268066A3 (en) *	1986-10-17	1990-07-11	Syntex (U.S.A.) Inc.	Fertility control and uterine therapy in dogs with luteinizing hormone releasing hormone antagonists
DE3735614A1 (de) *	1986-10-31	1988-07-28	Asta Pharma Ag	Ifosfamid-lyophilisat und verfahren zu dessen herstellung
DK49987A (da) *	1987-01-30	1988-07-31	Nordisk Gentofte	Fremgangsmaade til behandling af infertilitet og middel til anvendelse ved fremgangsmaaden
US4801577A (en) *	1987-02-05	1989-01-31	Syntex (U.S.A.) Inc.	Nonapeptide and decapeptide analogs of LHRH useful as LHRH antagonists
US4800191A (en) *	1987-07-17	1989-01-24	Schally Andrew Victor	LHRH antagonists
NZ226170A (en) *	1987-09-18	1990-07-26	Ethicon Inc	Stable freeze-dried pharmaceutical composition containing epidermal growth factor
FR2635006B1 (fr) *	1988-08-02	1990-10-19	Letourneur Bernard	Medicament destine a regulariser les secretions hormonales et a traiter la sterilite
US5180711A (en) *	1990-06-14	1993-01-19	Applied Research Systems Ars Holding N.V.	Combined treatment with gnrh antagonist and gnrh to control gonadotropin levels in mammals
CN1036343C (zh) *	1990-11-10	1997-11-05	天津市计划生育研究所	新促黄体生成素释放激素拮抗类似物的制备方法

1993
- 1993-02-19 DE DE4305225A patent/DE4305225A1/de not_active Ceased
1994
- 1994-01-31 TW TW083100769A patent/TW387812B/zh not_active IP Right Cessation
- 1994-02-04 AT AT94101672T patent/ATE193653T1/de active
- 1994-02-04 PT PT94101672T patent/PT611572E/pt unknown
- 1994-02-04 DK DK94101672T patent/DK0611572T3/da active
- 1994-02-04 ES ES94101672T patent/ES2148247T3/es not_active Expired - Lifetime
- 1994-02-04 EP EP99102340.9A patent/EP0947200B1/de not_active Expired - Lifetime
- 1994-02-04 EP EP94101672A patent/EP0611572B1/de not_active Expired - Lifetime
- 1994-02-04 DE DE59409389T patent/DE59409389D1/de not_active Expired - Lifetime
- 1994-02-04 SG SG1996006874A patent/SG46632A1/en unknown
- 1994-02-14 CZ CZ94312A patent/CZ284314B6/cs not_active IP Right Cessation
- 1994-02-14 CZ CZ98974A patent/CZ285768B6/cs not_active IP Right Cessation
- 1994-02-17 PL PL94302266A patent/PL177177B1/pl unknown
- 1994-02-17 JP JP02053294A patent/JP4033919B2/ja not_active Expired - Lifetime
- 1994-02-17 NZ NZ250906A patent/NZ250906A/en not_active IP Right Cessation
- 1994-02-17 KR KR1019940002771A patent/KR100355686B1/ko not_active Expired - Lifetime
- 1994-02-17 AU AU55235/94A patent/AU671881C/en not_active Expired
- 1994-02-17 NZ NZ314707A patent/NZ314707A/xx not_active IP Right Cessation
- 1994-02-18 FI FI940779A patent/FI110059B/fi not_active IP Right Cessation
- 1994-02-18 CA CA002115943A patent/CA2115943C/en not_active Expired - Lifetime
- 1994-02-18 BR BR9400617A patent/BR9400617A/pt not_active Application Discontinuation
- 1994-02-18 UA UA94005526A patent/UA43829C2/uk unknown
- 1994-02-18 SK SK810-2001A patent/SK283022B6/sk not_active IP Right Cessation
- 1994-02-18 SK SK195-94A patent/SK283021B6/sk not_active IP Right Cessation
- 1994-02-18 CN CN94101378A patent/CN1109557C/zh not_active Expired - Lifetime
- 1994-02-18 ZA ZA941136A patent/ZA941136B/xx unknown
- 1994-02-18 IL IL10870494A patent/IL108704A/xx not_active IP Right Cessation
- 1994-02-18 HR HRP4305225.8 patent/HRP940117B1/xx not_active IP Right Cessation
- 1994-02-18 SI SI9400087A patent/SI9400087B/sl unknown
- 1994-02-18 RU RU94005001A patent/RU2145234C1/ru active
- 1994-02-18 NO NO940564A patent/NO316601B1/no not_active IP Right Cessation
- 1994-02-18 HU HU9400481A patent/HU218281B/hu unknown
- 1994-02-21 MX MX9401312A patent/MX9401312A/es unknown
2000
- 2000-08-23 GR GR20000401924T patent/GR3034237T3/el unknown
2001
- 2001-02-27 KR KR1020010009932A patent/KR100372187B1/ko not_active Expired - Lifetime

Also Published As

Publication number	Publication date
NO940564L (fi)	1994-08-22
SI9400087B (sl)	2002-02-28
NZ250906A (en)	1997-07-27
EP0611572B1 (de)	2000-06-07
CZ284314B6 (cs)	1998-10-14
BR9400617A (pt)	1994-09-27
DE4305225A1 (de)	1994-08-25
KR100355686B1 (ko)	2002-12-11
RU2145234C1 (ru)	2000-02-10
DK0611572T3 (da)	2000-09-25
EP0947200A3 (de)	2004-03-24
SK283022B6 (sk)	2003-02-04
UA43829C2 (uk)	2002-01-15
ATE193653T1 (de)	2000-06-15
CA2115943C (en)	2003-08-05
EP0947200A2 (de)	1999-10-06
PT611572E (pt)	2000-11-30
EP0611572A3 (de)	1995-01-11
AU671881C (en)	2004-01-15
EP0611572A2 (de)	1994-08-24
CA2115943A1 (en)	1994-08-20
HRP940117A2 (en)	1996-08-31
HU9400481D0 (en)	1994-12-28
FI940779A0 (fi)	1994-02-18
DE59409389D1 (de)	2000-07-13
FI110059B (fi)	2002-11-29
AU671881B2 (en)	1996-09-12
HUT67117A (en)	1995-02-28
EP0947200B1 (de)	2015-03-11
TW387812B (en)	2000-04-21
SG46632A1 (en)	1998-02-20
NO940564D0 (no)	1994-02-18
NZ314707A (en)	1999-02-25
IL108704A (en)	2005-05-17
SK283021B6 (sk)	2003-02-04
IL108704A0 (en)	1994-05-30
ES2148247T3 (es)	2000-10-16
HU218281B (en)	2000-07-28
MX9401312A (es)	1994-08-31
SI9400087A (en)	1994-12-31
AU5523594A (en)	1994-08-25
CN1112019A (zh)	1995-11-22
SK19594A3 (en)	1994-09-07
JPH06271476A (ja)	1994-09-27
JP4033919B2 (ja)	2008-01-16
CZ285768B6 (cs)	1999-11-17
GR3034237T3 (en)	2000-12-29
NO316601B1 (no)	2004-03-08
ZA941136B (en)	1994-08-29
CZ31294A3 (en)	1994-09-14
PL177177B1 (pl)	1999-10-29
CN1109557C (zh)	2003-05-28
HRP940117B1 (en)	2001-02-28
KR100372187B1 (ko)	2003-02-14

Publication	Publication Date	Title
FI940779L (fi)	1994-08-20	Cetrorelix-lyofilisaatin uusi valmistusmenetelmä
FI945507A0 (fi)	1994-11-23	Monikäyttömenetelmä
FI944619A7 (fi)	1994-10-04	Aldolisointi-dehydratointimenetelmä
FI951596L (fi)	1995-04-04	Menetelmä 10-desasetyylibakkatiini-III:n saamiseksi
FI962069L (fi)	1996-05-15	Menetelmä karpolaktaamin valmistamiseksi
DE69414001D1 (de)	1998-11-19	Bestimmungsmethode
FI961431L (fi)	1996-03-29	Prosessi II
DE69428362D1 (de)	2001-10-25	Flächenreissverschlusseinsatzherstellungsverfahren
FI960747L (fi)	1996-04-17	Antipsykoottinen menetelmä
FI951330A0 (fi)	1995-03-21	Sihti
DE69400308D1 (de)	1996-08-22	Verbrennungsverfahren
FI925357L (fi)	1994-05-26	Rakennusmenetelmä
FI960748A7 (fi)	1996-04-18	Antipsykoottinen menetelmä
FI955800L (fi)	1995-12-01	Menetelmä aminoalkyyliganidiinien valmistamiseksi
NO944120D0 (no)	1994-10-28	1-[2H-1-benzopyran-2-on-8-ylÅ-piperazinderivater
FI19992039A7 (fi)	1999-09-23	Menetelmä atsepinonien valmistamiseksi
DE69418832D1 (de)	1999-07-08	Stabilisiertes Thiotepa-Lyophilisat
FI942102L (fi)	1994-11-07	Menetelmä alumiinioksaanien valmistamiseksi
DK96392D0 (da)	1992-07-27	Modifikationsmetode
FI915193A7 (fi)	1991-11-04	Liitosmenetelmä
KR950702143A (ko)	1995-06-19	영역 지정 방법
FI945877L (fi)	1995-06-16	Menetelmä proteiini C:n tuottamiseksi
DE69419620D1 (de)	1999-08-26	Fluorierungsverfahren
FI931051A7 (fi)	1994-09-11	Kuvausmenetelmä
ID918B (id)	1996-09-12	Proses pembuatan vinir

Legal Events

Date	Code	Title	Description
2003-02-04	SPCF	Supplementary protection certificate application filed	Spc suppl protection certif: L20030002
2008-05-15	SPCG	Supplementary protection certificate granted	Spc suppl protection certif: NUMBER:217
2009-03-02	PC	Transfer of assignment of patent	Owner name: ZENTARIS IVF GMBH Free format text: ZENTARIS IVF GMBH
2014-03-28	MA	Patent expired