FI946066L - Hepatiitti-C viruksen genotyyppien uudet sekvenssit ja niiden käyttö terapeuttisina ja diagnostisina aineina - Google Patents
Hepatiitti-C viruksen genotyyppien uudet sekvenssit ja niiden käyttö terapeuttisina ja diagnostisina aineina Download PDFInfo
- Publication number
- FI946066L FI946066L FI946066A FI946066A FI946066L FI 946066 L FI946066 L FI 946066L FI 946066 A FI946066 A FI 946066A FI 946066 A FI946066 A FI 946066A FI 946066 L FI946066 L FI 946066L
- Authority
- FI
- Finland
- Prior art keywords
- hepatitis
- therapeutic
- diagnostic agents
- new sequences
- virus genotypes
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/24011—Flaviviridae
- C12N2770/24211—Hepacivirus, e.g. hepatitis C virus, hepatitis G virus
- C12N2770/24222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Virology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Gastroenterology & Hepatology (AREA)
- Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Peptides Or Proteins (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP93401099 | 1993-04-27 | ||
| EP93402019 | 1993-08-05 | ||
| PCT/EP1994/001323 WO1994025601A2 (en) | 1993-04-27 | 1994-04-27 | New sequences of hepatitis c virus genotypes and their use as therapeutic and diagnostic agents |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| FI946066A0 FI946066A0 (fi) | 1994-12-23 |
| FI946066A7 FI946066A7 (fi) | 1994-12-23 |
| FI946066L true FI946066L (fi) | 1994-12-23 |
Family
ID=26134679
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI946066A FI946066L (fi) | 1993-04-27 | 1994-04-27 | Hepatiitti-C viruksen genotyyppien uudet sekvenssit ja niiden käyttö terapeuttisina ja diagnostisina aineina |
Country Status (15)
| Country | Link |
|---|---|
| US (3) | US6762024B2 (ja) |
| EP (4) | EP0984068B1 (ja) |
| JP (5) | JPH07508423A (ja) |
| CN (1) | CN1108030A (ja) |
| AT (4) | ATE551423T1 (ja) |
| AU (1) | AU688323B2 (ja) |
| BR (1) | BR9405334A (ja) |
| CA (2) | CA2662090A1 (ja) |
| DE (1) | DE69435023T2 (ja) |
| ES (1) | ES2294779T3 (ja) |
| FI (1) | FI946066L (ja) |
| NO (1) | NO944967D0 (ja) |
| NZ (1) | NZ266148A (ja) |
| SG (1) | SG50563A1 (ja) |
| WO (1) | WO1994025601A2 (ja) |
Families Citing this family (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE610436T1 (de) * | 1991-11-21 | 1995-08-03 | Common Services Agency | Detektion des Hepatis-C Virus. |
| US6709828B1 (en) | 1992-03-06 | 2004-03-23 | N.V. Innogenetics S.A. | Process for the determination of peptides corresponding to immunologically important epitopes and their use in a process for determination of antibodies or biotinylated peptides corresponding to immunologically important epitopes, a process for preparing them and compositions containing them |
| US6667387B1 (en) | 1996-09-30 | 2003-12-23 | N.V. Innogenetics S.A. | HCV core peptides |
| US6380376B1 (en) * | 1992-10-30 | 2002-04-30 | Iowa State University Research Foundation | Proteins encoded by polynucleic acids of porcine reproductive and respiratory syndrome virus (PRRSV) |
| US7258977B1 (en) * | 1992-11-27 | 2007-08-21 | Innogenetics N.V. | Process for typing of HCV isolates |
| US7255997B1 (en) * | 1993-04-27 | 2007-08-14 | N.V. Innogenetics S.A. | Sequences of hepatitis C virus genotypes and their use as therapeutic and diagnostic agents |
| WO1994025601A2 (en) | 1993-04-27 | 1994-11-10 | N.V. Innogenetics S.A. | New sequences of hepatitis c virus genotypes and their use as therapeutic and diagnostic agents |
| ATE281526T1 (de) | 1993-05-05 | 2004-11-15 | Common Services Agency | Hepatitis-c virus typ 4,5 und 6 |
| US7070790B1 (en) | 1993-06-29 | 2006-07-04 | The United States Of America As Represented By The Department Of Health And Human Services | Nucleotide and deduced amino acid sequences of the envelope 1 and core genes of isolates of hepatitis C virus and the use of reagents derived from these sequences in diagnostic methods and vaccines |
| US5882852A (en) * | 1993-06-29 | 1999-03-16 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Hepatitic C virus (HCV) core gene nucleotide sequences and related methods of detecting major and minor genotypes of HCV isolates |
| US5514539A (en) * | 1993-06-29 | 1996-05-07 | The United States Of America As Represented By The Department Of Health And Human Services | Nucleotide and deduced amino acid sequences of the envelope 1 gene of 51 isolates of hepatitis C virus and the use of reagents derived from these sequences in diagnostic methods and vaccines |
| CA2201703A1 (en) | 1994-10-21 | 1996-05-09 | Geert Maertens | New sequences of hepatitis c virus genotypes and their use as prophylactic, therapeutic and diagnostic agents |
| US5851759A (en) * | 1996-04-19 | 1998-12-22 | Chiron Corporation | Heteroduplex tracking assay (HTA) for genotyping HCV |
| EP2298900A1 (en) * | 1996-09-17 | 2011-03-23 | Novartis Vaccines and Diagnostics, Inc. | Compositions and methods for treating intracellular diseases |
| TR200202213T2 (tr) | 1998-04-17 | 2002-11-21 | Innogenetics N.V. | İndirgeme ajanlarını kullanarak geliştirilen immünodiagnostik tahliller |
| AU4497999A (en) * | 1998-04-28 | 1999-11-16 | Ingrid-Corina Bergter | Radioimmunopharmaca for treating hepatitis c |
| EP1113777B1 (en) * | 1998-06-09 | 2007-01-10 | Andrea D. Branch | Novel hepatitis c virus peptides and uses thereof |
| US7052830B1 (en) | 1998-06-09 | 2006-05-30 | Branch Andrea D | Hepatitis C virus peptides and uses thereof |
| AU2001272948A1 (en) * | 2000-06-15 | 2001-12-24 | Chiron Corporation | Hcv antigen/antibody combination assay |
| US6680059B2 (en) * | 2000-08-29 | 2004-01-20 | Tripep Ab | Vaccines containing ribavirin and methods of use thereof |
| JP5175417B2 (ja) * | 2000-08-17 | 2013-04-03 | トリペップ アクチ ボラゲット | リバビリンを含むワクチンおよびその使用方法 |
| US6858590B2 (en) * | 2000-08-17 | 2005-02-22 | Tripep Ab | Vaccines containing ribavirin and methods of use thereof |
| US7022830B2 (en) * | 2000-08-17 | 2006-04-04 | Tripep Ab | Hepatitis C virus codon optimized non-structural NS3/4A fusion gene |
| US7196183B2 (en) * | 2001-08-31 | 2007-03-27 | Innogenetics N.V. | Hepatitis C virus genotype, and its use as prophylactic, therapeutic and diagnostic agent |
| MD2149G2 (ro) * | 2001-11-23 | 2003-10-31 | Институт Генетики И Физиологии Растений Академии Наук Молдовы | Primer oligonucleotidic pentru depistarea ARN-ului virusului hepatitei C |
| DK2014671T3 (da) * | 2002-03-11 | 2010-09-20 | Lab 21 Ltd | Fremgangsmåder og sammensætninger til identificering og karakterisering af hepatitis C |
| CA2484941A1 (en) | 2002-07-24 | 2004-02-05 | Intercell Ag | Antigens encoded by alternative reading frame from pathogenic viruses |
| EP1537418A2 (en) | 2002-09-13 | 2005-06-08 | Intercell AG | Method for isolating hepatitis c virus peptides |
| EP2345420B1 (en) | 2003-03-24 | 2016-01-06 | Valneva Austria GmbH | Use of a TH1 immune response inducing adjuvant for enhancing immune responses |
| EP2275131A3 (en) | 2003-07-11 | 2012-01-25 | Intercell AG | HCV Vaccines |
| US8124747B2 (en) | 2003-08-29 | 2012-02-28 | Innogenetics | HCV clade and prototype sequences thereof |
| WO2005067643A2 (en) | 2004-01-07 | 2005-07-28 | Third Wave Technologies, Inc. | Determination of hepatitis c virus genotype |
| US20060162667A1 (en) * | 2005-01-26 | 2006-07-27 | Papadoyianis Ernest D | Aquatic habitat and ecological tank |
| CA2618429A1 (en) * | 2005-05-25 | 2007-03-22 | Tripep Ab | A hepatitis c virus non-structural ns3/4a fusion gene |
| US20070072211A1 (en) | 2005-06-30 | 2007-03-29 | Roche Molecular Systems, Inc. | Asymmetric PCR coupled with post-PCR characterization for the identification of nucleic acids |
| MD3300G2 (ro) * | 2006-09-28 | 2007-11-30 | Институт Генетики, Физиологии И Защиты Растений Академии Наук Молдовы | Primer oligonucleotidic pentru depistarea ARN-ului virusului hepatitei C |
| EP2527474A1 (en) | 2006-10-20 | 2012-11-28 | Innogenetics N.V. | Methodology for analysis of sequence variations within the HCV NS3/4A genomic region |
| US20090325145A1 (en) | 2006-10-20 | 2009-12-31 | Erwin Sablon | Methodology for analysis of sequence variations within the hcv ns5b genomic region |
| EP2121990A2 (en) * | 2006-10-20 | 2009-11-25 | Innogenetics N.V. | Methodology for anaysis of sequence variations within the hcv ns5b genomic region |
| EA018102B1 (ru) * | 2007-08-09 | 2013-05-30 | Федеральное Государственное Бюджетное Учреждение Науки Институт Молекулярной Биологии Им. В.А. Энгельгардта Российской Академии Наук (Имб Ран) | Способ идентификации генотипа и подтипа вируса гепатита c на биологическом микрочипе |
| WO2009022236A2 (en) | 2007-08-16 | 2009-02-19 | Tripep Ab | Immunogen platform |
| US20090220943A1 (en) * | 2007-10-30 | 2009-09-03 | Intermune, Inc. | Hcv genotyping and phenotyping |
| WO2009130588A2 (en) * | 2008-04-22 | 2009-10-29 | Tripep Ab | Immunogen platform |
| WO2010112733A1 (fr) * | 2009-03-30 | 2010-10-07 | bioMérieux | Support solide de détection du vhc |
| WO2013150450A1 (en) * | 2012-04-02 | 2013-10-10 | Universidade Do Porto | Hcv homolog fragments, cell-lines and applications thereof |
| DK3274478T3 (da) * | 2015-03-27 | 2020-11-23 | Ortho Clinical Diagnostics K K | Hcv-ns4a/modificerede ns3-polypeptider og anvendelser deraf |
| EP3494227B1 (en) * | 2016-08-02 | 2024-12-11 | Roche Diagnostics GmbH | Helper oligonucleotide for improving efficiency of amplification and detection/quantitation of nucleic acids |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3886363T3 (de) * | 1987-11-18 | 2004-09-09 | Chiron Corp. (N.D.Ges.D. Staates Delaware), Emeryville | NANBV-Diagnostika |
| US5350671A (en) | 1987-11-18 | 1994-09-27 | Chiron Corporation | HCV immunoassays employing C domain antigens |
| GB2236819B (en) * | 1989-09-14 | 1993-07-14 | Gen Motors France | Dual master cylinder |
| CA2065287C (en) * | 1989-09-15 | 1999-12-21 | Tatsuo Miyamura | New hcv isolates |
| US5372928A (en) * | 1989-09-15 | 1994-12-13 | Chiron Corporation | Hepatitis C virus isolates |
| AU642942B2 (en) | 1989-12-18 | 1993-11-04 | Wellcome Foundation Limited, The | Viral agent |
| EP0435229A1 (en) * | 1989-12-27 | 1991-07-03 | Sanwa Kagaku Kenkyusho Co., Ltd. | DNA of non-A, non-B hepatitis virus gene, its clone and use thereof |
| WO1991014779A1 (fr) * | 1990-03-28 | 1991-10-03 | Mitsui Toatsu Chemicals, Incorporated | Diagnostic du virus de l'hepatite |
| EP0461863A1 (en) * | 1990-06-12 | 1991-12-18 | Immuno Japan Inc. | Oligonucleotide primers, and their application for high-fidelity detection of non-A, non-B hepatitis virus |
| NZ238681A (en) | 1990-06-25 | 1992-03-26 | Univ Osaka Res Found | Non-a, non-b hepatitis virus particles and their production |
| ATE185350T1 (de) | 1990-12-14 | 1999-10-15 | Innogenetics Nv | Synthetische antigene zum nachweis von antikörpern gegen hepatitis c virus |
| EP0510952A1 (en) * | 1991-04-26 | 1992-10-28 | Immuno Japan Inc. | Oligonucleotide primers and their application for high-fidelity detection of non-a, non-b hepatitis virus |
| RO117267B1 (ro) * | 1991-05-08 | 2001-12-28 | Chiron Corp | Secventa de acid nucleic si peptida codificata de aceasta, pentru diagnostic si tratament |
| EP0591431B1 (en) | 1991-06-24 | 2002-12-11 | Chiron Corporation | Hepatitis c virus (hcv) polypeptides |
| EP0532167A3 (en) * | 1991-08-09 | 1993-03-31 | Immuno Japan Inc. | Non-a, non-b hepatitis virus genome, polynucleotides, polypeptides, antigen, antibody and detection systems |
| AU2513592A (en) * | 1991-08-21 | 1993-03-16 | Abbott Laboratories | Hepatitis c assay utilizing recombinant antigens to ns1 |
| ES2182822T3 (es) | 1991-09-13 | 2003-03-16 | Chiron Corp | Composiciones de polipeptidos inmunorreactivos del virus de la hepatitis c. |
| DE610436T1 (de) * | 1991-11-21 | 1995-08-03 | Common Services Agency | Detektion des Hepatis-C Virus. |
| DE69324678T2 (de) * | 1992-11-27 | 1999-12-09 | Naamloze Vennootschap Innogenetics S.A., Gent | Verfahren zur typisierung von hcv-isolaten |
| WO1994025601A2 (en) | 1993-04-27 | 1994-11-10 | N.V. Innogenetics S.A. | New sequences of hepatitis c virus genotypes and their use as therapeutic and diagnostic agents |
| EP0698216B2 (en) | 1993-05-10 | 2009-02-25 | Novartis Vaccines and Diagnostics, Inc. | Methods of typing hepatitis c virus and reagents for use therein |
| JPH06319563A (ja) | 1993-05-13 | 1994-11-22 | Imuno Japan:Kk | C型肝炎ウイルス遺伝子、オリゴヌクレオチド、並びにc型 肝炎ウイルス遺伝子型判定方法 |
| US5882852A (en) | 1993-06-29 | 1999-03-16 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Hepatitic C virus (HCV) core gene nucleotide sequences and related methods of detecting major and minor genotypes of HCV isolates |
| US5514539A (en) * | 1993-06-29 | 1996-05-07 | The United States Of America As Represented By The Department Of Health And Human Services | Nucleotide and deduced amino acid sequences of the envelope 1 gene of 51 isolates of hepatitis C virus and the use of reagents derived from these sequences in diagnostic methods and vaccines |
| JP2687852B2 (ja) * | 1993-10-13 | 1997-12-08 | 日本電気株式会社 | 半導体メモリ装置 |
-
1994
- 1994-04-27 WO PCT/EP1994/001323 patent/WO1994025601A2/en not_active Ceased
- 1994-04-27 AT AT99118784T patent/ATE551423T1/de active
- 1994-04-27 JP JP6523877A patent/JPH07508423A/ja active Pending
- 1994-04-27 AT AT99118783T patent/ATE553201T1/de active
- 1994-04-27 BR BR9405334A patent/BR9405334A/pt not_active Application Discontinuation
- 1994-04-27 EP EP99118784A patent/EP0984068B1/en not_active Expired - Lifetime
- 1994-04-27 AT AT99118785T patent/ATE552340T1/de active
- 1994-04-27 EP EP99118785A patent/EP0984067B1/en not_active Expired - Lifetime
- 1994-04-27 EP EP94915550A patent/EP0651807B1/en not_active Expired - Lifetime
- 1994-04-27 NZ NZ266148A patent/NZ266148A/en not_active IP Right Cessation
- 1994-04-27 CA CA002662090A patent/CA2662090A1/en not_active Abandoned
- 1994-04-27 DE DE69435023T patent/DE69435023T2/de not_active Expired - Lifetime
- 1994-04-27 AU AU67222/94A patent/AU688323B2/en not_active Expired
- 1994-04-27 EP EP99118783A patent/EP1004670B1/en not_active Expired - Lifetime
- 1994-04-27 CA CA002139100A patent/CA2139100C/en not_active Expired - Lifetime
- 1994-04-27 US US09/878,281 patent/US6762024B2/en not_active Expired - Fee Related
- 1994-04-27 FI FI946066A patent/FI946066L/fi unknown
- 1994-04-27 CN CN94190232A patent/CN1108030A/zh active Pending
- 1994-04-27 AT AT94915550T patent/ATE373093T1/de active
- 1994-04-27 SG SG1996005012A patent/SG50563A1/en unknown
- 1994-04-27 US US08/362,455 patent/US7157226B1/en not_active Expired - Fee Related
- 1994-04-27 ES ES94915550T patent/ES2294779T3/es not_active Expired - Lifetime
- 1994-12-21 NO NO944967A patent/NO944967D0/no not_active Application Discontinuation
-
2001
- 2001-07-06 US US09/899,046 patent/US7195765B2/en not_active Expired - Fee Related
- 2001-11-21 JP JP2001355654A patent/JP2002233388A/ja active Pending
- 2001-11-21 JP JP2001356707A patent/JP2002233389A/ja active Pending
-
2003
- 2003-07-08 JP JP2003272022A patent/JP2004041206A/ja not_active Withdrawn
- 2003-07-09 JP JP2003272151A patent/JP2004041207A/ja not_active Withdrawn
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