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AU2001272948A1 - Hcv antigen/antibody combination assay - Google Patents

Hcv antigen/antibody combination assay

Info

Publication number
AU2001272948A1
AU2001272948A1 AU2001272948A AU7294801A AU2001272948A1 AU 2001272948 A1 AU2001272948 A1 AU 2001272948A1 AU 2001272948 A AU2001272948 A AU 2001272948A AU 7294801 A AU7294801 A AU 7294801A AU 2001272948 A1 AU2001272948 A1 AU 2001272948A1
Authority
AU
Australia
Prior art keywords
hcv
antigens
antigen
antibody combination
hcv antigen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001272948A
Inventor
Phillip Arcangel
David Y Chien
Doris Coit
Carlos George-Nasciemento
Angelica Medina-Selby
Laura Tandeske
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis Vaccines and Diagnostics Inc
Original Assignee
Chiron Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27395684&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AU2001272948(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Chiron Corp filed Critical Chiron Corp
Publication of AU2001272948A1 publication Critical patent/AU2001272948A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/576—Immunoassay; Biospecific binding assay; Materials therefor for hepatitis
    • G01N33/5767—Immunoassay; Biospecific binding assay; Materials therefor for hepatitis non-A, non-B hepatitis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/24011—Flaviviridae
    • C12N2770/24211—Hepacivirus, e.g. hepatitis C virus, hepatitis G virus
    • C12N2770/24222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/005—Assays involving biological materials from specific organisms or of a specific nature from viruses
    • G01N2333/08—RNA viruses
    • G01N2333/18—Togaviridae; Flaviviridae
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2469/00—Immunoassays for the detection of microorganisms
    • G01N2469/10—Detection of antigens from microorganism in sample from host
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2469/00—Immunoassays for the detection of microorganisms
    • G01N2469/20—Detection of antibodies in sample from host which are directed against antigens from microorganisms

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Microbiology (AREA)
  • Virology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Communicable Diseases (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Investigating Or Analyzing Materials By The Use Of Magnetic Means (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

The invention relates to a method of detecting HCV infection in a biological sample, the method comprising providing an immunoassay solid support, comprising an HCV anti-core antibody, an antigen comprising an HCV NS3/4a epitope, and an HCV multiple epitope fusion antigen, that can detect both HCV antigens and antibodies present in a sample. The invention also includes polynucleotides encoding multiple epitope fusion antigens for use in the assay, recombinant vectors and host cells comprising such polynucleotides, and methods of producing the multiple epitope fusion antigens.
AU2001272948A 2000-06-15 2001-06-14 Hcv antigen/antibody combination assay Abandoned AU2001272948A1 (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US21208200P 2000-06-15 2000-06-15
US60/212,082 2000-06-15
US28086701P 2001-04-02 2001-04-02
US28081101P 2001-04-02 2001-04-02
US60/280,867 2001-04-02
US60/280,811 2001-04-02
PCT/US2001/019369 WO2001096875A2 (en) 2000-06-15 2001-06-14 Hcv antigen/antibody combination assay

Publications (1)

Publication Number Publication Date
AU2001272948A1 true AU2001272948A1 (en) 2001-12-24

Family

ID=27395684

Family Applications (2)

Application Number Title Priority Date Filing Date
AU2001272948A Abandoned AU2001272948A1 (en) 2000-06-15 2001-06-14 Hcv antigen/antibody combination assay
AU2001272945A Abandoned AU2001272945A1 (en) 2000-06-15 2001-06-14 Immunoassays for anti-hcv antibodies

Family Applications After (1)

Application Number Title Priority Date Filing Date
AU2001272945A Abandoned AU2001272945A1 (en) 2000-06-15 2001-06-14 Immunoassays for anti-hcv antibodies

Country Status (22)

Country Link
US (5) US6632601B2 (en)
EP (2) EP1350105B1 (en)
JP (3) JP4834279B2 (en)
CN (3) CN1214244C (en)
AT (2) ATE348337T1 (en)
AU (2) AU2001272948A1 (en)
BG (1) BG66205B1 (en)
BR (2) BRPI0111682B8 (en)
CA (2) CA2413003C (en)
CY (2) CY1107537T1 (en)
CZ (1) CZ304185B6 (en)
DE (2) DE60125240T3 (en)
DK (2) DK1350105T3 (en)
ES (2) ES2288969T3 (en)
HU (1) HU228873B1 (en)
MX (2) MXPA02012401A (en)
NO (1) NO332275B1 (en)
PL (1) PL213363B1 (en)
PT (2) PT1354204E (en)
SI (1) SI1354204T2 (en)
SK (1) SK287694B6 (en)
WO (2) WO2001096875A2 (en)

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US7491808B2 (en) * 2000-06-15 2009-02-17 Novartis Vaccines And Diagnostics, Inc. HCV non-structural protein mutants and uses thereof
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US6680059B2 (en) 2000-08-29 2004-01-20 Tripep Ab Vaccines containing ribavirin and methods of use thereof
PL360990A1 (en) 2000-08-17 2004-09-20 Tripep Ab Vaccines containing ribavirin and methods of use thereof
RU2286172C2 (en) 2000-08-17 2006-10-27 Трипеп Аб Ribavirin-containing vaccines and methods for their application
US7022830B2 (en) 2000-08-17 2006-04-04 Tripep Ab Hepatitis C virus codon optimized non-structural NS3/4A fusion gene
DE10106295C1 (en) * 2001-02-02 2002-08-22 Gaifar German American Inst Fo Protein with multiple antigen-epitope sequences, which is immobilized
AR033448A1 (en) * 2001-03-28 2003-12-17 Ortho Clinical Diagnostics Inc ANTIGEN-ANTIBODY COMBINATION TEST FOR HEPATITIS C FOR AN EARLY DETECTION OF INFECTION
US7101683B2 (en) * 2001-06-26 2006-09-05 Abbott Laboratories Methods for the simultaneous detection of HCV antigens and HCV antibodies
JP4353793B2 (en) 2001-06-26 2009-10-28 アボット・ラボラトリーズ Method for simultaneous detection of HCV antigen and HCV antibody
US7049060B2 (en) * 2001-11-05 2006-05-23 Ortho-Clinical Diagnostics, Inc. HCV anti-core monoclonal antibodies
US7332269B2 (en) * 2001-11-11 2008-02-19 Ortho-Clinical Diagnostics, Inc. HCV core protein sequences
FR2839555B1 (en) 2002-05-10 2007-07-27 Bio Rad Pasteur METHOD FOR THE SIMULTANEOUS DETECTION OF ANTIGEN AND ANTIBODY OF AN INFECTIOUS MICROORGANISM
NZ538711A (en) * 2002-09-09 2007-01-26 Chiron Corp Antigen/antibody/antigen sandwich assays for detecting hepatitis C virus infections
US20040152070A1 (en) * 2003-02-04 2004-08-05 Shah Dinesh O. Method of detection of HCV antibodies in combination assay or sole antibody assay
WO2005019828A1 (en) 2003-08-20 2005-03-03 Amorfix Life Sciences Ltd. Epitope protection assay and method for detecting protein conformations
JP5070055B2 (en) * 2004-08-27 2012-11-07 ノバルティス バクシンズ アンド ダイアグノスティックス，インコーポレーテッド HCV multi-epitope fusion antigen having modified proteolytic cleavage site and use thereof
JP2008529015A (en) * 2005-02-02 2008-07-31 鵬 崔 Kit for detecting HCV antibody and preparation method thereof
EP2360175B1 (en) 2005-11-22 2014-07-16 Novartis Vaccines and Diagnostics, Inc. Norovirus and Sapovirus virus-like particles (VLPs)
US7887803B2 (en) 2005-12-02 2011-02-15 Amorfix Life Sciences Methods and compositions to treat misfolded-SOD1 mediated diseases
US7794692B2 (en) * 2005-12-02 2010-09-14 Amorfix Life Sciences Ltd. Methods and compositions for detecting amyotrophic lateral sclerosis
CA2642848C (en) 2006-03-03 2016-07-12 Amorfix Life Sciences Ltd. Methods and compositions to treat and detect misfolded-sod1 mediated diseases
CN1908666B (en) * 2006-08-14 2010-05-12 武汉大学 A double-sandwich enzyme-linked immunodiagnostic kit for detecting hepatitis B core antibody and its application
EP2185195A2 (en) 2007-08-16 2010-05-19 Tripep Ab Immunogen platform
CN102378914B (en) * 2009-03-30 2014-12-10 生物梅里埃公司 Solid support for the detection of hcv
US20100297607A1 (en) 2009-05-20 2010-11-25 Jian Zheng Reagents For HCV Antigen-Antibody Combination Assays
WO2011127316A1 (en) 2010-04-07 2011-10-13 Novartis Ag Method for generating a parvovirus b19 virus-like particle
CN106771219B (en) * 2010-06-17 2020-04-07 皇家飞利浦电子股份有限公司 Multi-epitope assay
EP3153578A1 (en) 2010-07-06 2017-04-12 Novartis Ag Norovirus derived immunogenic compositions and methods
US20120009196A1 (en) * 2010-07-08 2012-01-12 Abbott Laboratories Monoclonal antibodies against hepatitis c virus core protein
US8691950B2 (en) * 2011-01-13 2014-04-08 Orth-Clinical Diagnostics, Inc. Treponema pallidum triplet antigen
FR2984328B1 (en) 2011-12-20 2016-12-30 Bio-Rad Innovations METHOD FOR DETECTING HEPATITIS C VIRUS INFECTION
EP2968526A4 (en) * 2013-03-14 2016-11-09 Abbott Lab ANTIGEN-ANTIBODY COMBINATION ASSAY OF HEPATITIS C VIRUS AND METHODS AND COMPOSITIONS FOR USE THEREWITH
US9790478B2 (en) 2013-03-14 2017-10-17 Abbott Laboratories HCV NS3 recombinant antigens and mutants thereof for improved antibody detection
EP3564384A1 (en) 2013-03-14 2019-11-06 Abbott Laboratories Hcv core lipid binding domain monoclonal antibodies
CN103630690B (en) * 2013-12-17 2014-08-20 朱之炜 Hepatitis C virus antigen-antibody combined detection kit and detection method
CA2980718C (en) 2015-03-27 2021-06-01 Ortho-Clinical Diagnostics, Inc. Hcv ns4a/modified ns3 polypeptides and uses thereof
EP3285806A4 (en) * 2015-04-20 2019-03-27 Qoolabs, Inc. SINGLE DOMAIN CAMELID HCV ANTIBODIES AND METHODS OF USE THEREOF
EP4462123A3 (en) * 2017-09-27 2025-02-12 Bio-Rad Laboratories, Inc. Digital affinity linkage assay
CN110261616B (en) * 2019-04-30 2021-07-20 广东菲鹏生物有限公司 A kind of hepatitis C virus detection kit
CN115057943B (en) * 2022-06-22 2025-03-14 杭州水芭莎生物医药科技有限公司 Antimicrobial peptide fusion protein and its preparation method and application
CN115838420B (en) * 2022-10-31 2023-05-05 北京科跃中楷生物技术有限公司 Preparation method of soluble HCV recombinant protein and antibody detection reagent prepared by preparation method

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Also Published As

Publication number Publication date
SK287694B6 (en) 2011-06-06
CY1106820T1 (en) 2012-05-23
BG107441A (en) 2004-01-30
BRPI0111682B1 (en) 2017-09-19
ES2277932T5 (en) 2010-06-28
CN1489692A (en) 2004-04-14
NO332275B1 (en) 2012-08-13
BG66205B1 (en) 2012-01-31
CN1466682A (en) 2004-01-07
ATE368221T1 (en) 2007-08-15
DK1354204T3 (en) 2007-04-10
CN1660913A (en) 2005-08-31
NO20025878L (en) 2003-02-12
WO2001096875A2 (en) 2001-12-20
JP2004510133A (en) 2004-04-02
DE60125240D1 (en) 2007-01-25
US6797809B2 (en) 2004-09-28
BRPI0111731B8 (en) 2016-08-23
CA2413003A1 (en) 2001-12-20
PT1350105E (en) 2007-08-13
CZ20024058A3 (en) 2003-09-17
EP1354204B2 (en) 2010-04-21
WO2001096875A3 (en) 2003-08-28
BR0111731A (en) 2004-02-10
MXPA02012401A (en) 2003-04-25
BRPI0111731C1 (en) 2021-07-27
DE60129598T2 (en) 2008-04-17
US6632601B2 (en) 2003-10-14
US20020192639A1 (en) 2002-12-19
BRPI0111731B1 (en) 2016-07-05
NO20025878D0 (en) 2002-12-06
CN100463922C (en) 2009-02-25
CA2413003C (en) 2013-08-13
JP2004506878A (en) 2004-03-04
CY1107537T1 (en) 2013-03-13
CZ304185B6 (en) 2013-12-11
US20040096822A1 (en) 2004-05-20
JP4837229B2 (en) 2011-12-14
AU2001272945A1 (en) 2001-12-24
DK1354204T4 (en) 2010-06-14
DE60125240T3 (en) 2010-10-28
PL365599A1 (en) 2005-01-10
JP4834279B2 (en) 2011-12-14
SI1354204T2 (en) 2010-09-30
DE60129598D1 (en) 2007-09-06
US7241879B2 (en) 2007-07-10
HUP0500444A2 (en) 2005-08-29
DK1350105T3 (en) 2007-11-12
US20020146685A1 (en) 2002-10-10
HU228873B1 (en) 2013-06-28
BRPI0111682B8 (en) 2021-07-27
US6630298B2 (en) 2003-10-07
EP1354204B1 (en) 2006-12-13
BR0111682A (en) 2004-01-06
ES2277932T3 (en) 2007-08-01
ATE348337T1 (en) 2007-01-15
WO2001096875A9 (en) 2002-08-15
PL213363B1 (en) 2013-02-28
DE60125240T2 (en) 2007-07-12
SI1354204T1 (en) 2007-04-30
WO2001096870A3 (en) 2003-07-31
EP1350105A2 (en) 2003-10-08
PT1354204E (en) 2007-03-30
US20040265801A1 (en) 2004-12-30
WO2001096870A2 (en) 2001-12-20
JP2011125350A (en) 2011-06-30
HUP0500444A3 (en) 2010-03-29
HK1061861A1 (en) 2004-10-08
CA2412035C (en) 2012-04-10
EP1354204A2 (en) 2003-10-22
CA2412035A1 (en) 2001-12-20
CN1214244C (en) 2005-08-10
ES2288969T3 (en) 2008-02-01
MXPA02012424A (en) 2003-04-25
CN1256591C (en) 2006-05-17
SK17772002A3 (en) 2003-10-07
EP1350105B1 (en) 2007-07-25
US7319144B2 (en) 2008-01-15
HK1079796A1 (en) 2006-04-13
US20040063092A1 (en) 2004-04-01

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