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FI945703A0 - Framställning av 3,4,4-trisybstituerade piperidinyl-N-alkylkarboxylater och mellanprodukter - Google Patents

Framställning av 3,4,4-trisybstituerade piperidinyl-N-alkylkarboxylater och mellanprodukter

Info

Publication number
FI945703A0
FI945703A0 FI945703A FI945703A FI945703A0 FI 945703 A0 FI945703 A0 FI 945703A0 FI 945703 A FI945703 A FI 945703A FI 945703 A FI945703 A FI 945703A FI 945703 A0 FI945703 A0 FI 945703A0
Authority
FI
Finland
Prior art keywords
intermediates
preparation
trisubstituted
piperidinyl
alkyl carboxylates
Prior art date
Application number
FI945703A
Other languages
English (en)
Finnish (fi)
Other versions
FI945703L (sv
FI106455B (sv
Inventor
Scott Alan Frank
Douglas Edward Prather
Jeffrey Alan Ward
John Arnold Werner
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of FI945703A0 publication Critical patent/FI945703A0/sv
Publication of FI945703L publication Critical patent/FI945703L/sv
Application granted granted Critical
Publication of FI106455B publication Critical patent/FI106455B/sv

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
    • C07D211/14—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/34—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
    • C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
FI945703A 1993-12-08 1994-12-02 Förfarande för framställning av kristallin (alfaS,3R,4R)-4-(3-hydroxifenyl)-3,4-dimetyl-alfa-(fenylmetyl)-1-piperidinpropionsyramonohydrat och kristallina mellanprodukter FI106455B (sv)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US16407493 1993-12-08
US08/164,074 US5434171A (en) 1993-12-08 1993-12-08 Preparation of 3,4,4-trisubstituted-piperidinyl-N-alkylcarboxylates and intermediates

Publications (3)

Publication Number Publication Date
FI945703A0 true FI945703A0 (sv) 1994-12-02
FI945703L FI945703L (sv) 1995-06-09
FI106455B FI106455B (sv) 2001-02-15

Family

ID=22592858

Family Applications (2)

Application Number Title Priority Date Filing Date
FI945703A FI106455B (sv) 1993-12-08 1994-12-02 Förfarande för framställning av kristallin (alfaS,3R,4R)-4-(3-hydroxifenyl)-3,4-dimetyl-alfa-(fenylmetyl)-1-piperidinpropionsyramonohydrat och kristallina mellanprodukter
FI20000353A FI106860B (sv) 1993-12-08 2000-02-17 Förfarande för framställning av en kristallin dihydratförening och kristallin mellanprodukt

Family Applications After (1)

Application Number Title Priority Date Filing Date
FI20000353A FI106860B (sv) 1993-12-08 2000-02-17 Förfarande för framställning av en kristallin dihydratförening och kristallin mellanprodukt

Country Status (30)

Country Link
US (1) US5434171A (sv)
EP (3) EP0657428B1 (sv)
JP (2) JP3834075B2 (sv)
KR (1) KR100356239B1 (sv)
CN (2) CN1057294C (sv)
AT (1) ATE200279T1 (sv)
AU (1) AU681198B2 (sv)
BR (1) BR9404842A (sv)
CA (1) CA2137221C (sv)
CO (1) CO4290427A1 (sv)
CZ (1) CZ290559B6 (sv)
DE (1) DE69427017T2 (sv)
DK (1) DK0657428T3 (sv)
ES (1) ES2155844T3 (sv)
FI (2) FI106455B (sv)
GR (1) GR3036136T3 (sv)
HU (1) HUT71489A (sv)
IL (1) IL111843A (sv)
MY (1) MY121543A (sv)
NO (1) NO302884B1 (sv)
NZ (1) NZ270039A (sv)
PE (1) PE41495A1 (sv)
PL (1) PL181734B1 (sv)
PT (1) PT657428E (sv)
RU (1) RU2145958C1 (sv)
SI (1) SI0657428T1 (sv)
TW (1) TW290540B (sv)
UA (1) UA52577C2 (sv)
YU (2) YU49312B (sv)
ZA (1) ZA949584B (sv)

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GB9912417D0 (en) 1999-05-28 1999-07-28 Pfizer Ltd Compounds useful in therapy
GB9912415D0 (en) 1999-05-28 1999-07-28 Pfizer Ltd Compounds useful in therapy
GB9912413D0 (en) 1999-05-28 1999-07-28 Pfizer Ltd Compounds useful in therapy
GB9912416D0 (en) 1999-05-28 1999-07-28 Pfizer Ltd Compounds useful in therapy
GB9912411D0 (en) 1999-05-28 1999-07-28 Pfizer Ltd Compounds useful in therapy
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HRP20150037T4 (hr) 2003-04-08 2022-09-02 Progenics Pharmaceuticals, Inc. Farmaceutske formulacije koje sadrže metilnaltrekson
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US20060211733A1 (en) * 2005-03-04 2006-09-21 Adolor Corporation Methods of preventing and treating opioid bowel dysfunction
US8524731B2 (en) 2005-03-07 2013-09-03 The University Of Chicago Use of opioid antagonists to attenuate endothelial cell proliferation and migration
ES2714198T3 (es) * 2005-03-07 2019-05-27 Univ Chicago Uso de antagonistas opioideos para atenuar la proliferación y la migración de células endoteliales
US8518962B2 (en) 2005-03-07 2013-08-27 The University Of Chicago Use of opioid antagonists
US9662325B2 (en) 2005-03-07 2017-05-30 The University Of Chicago Use of opioid antagonists to attenuate endothelial cell proliferation and migration
AR057325A1 (es) 2005-05-25 2007-11-28 Progenics Pharm Inc Sintesis de (s)-n-metilnaltrexona, composiciones farmaceuticas y usos
AR057035A1 (es) 2005-05-25 2007-11-14 Progenics Pharm Inc SíNTESIS DE (R)-N-METILNALTREXONA, COMPOSICIONES FARMACÉUTICAS Y USOS
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Also Published As

Publication number Publication date
CZ299294A3 (en) 1995-10-18
FI106860B (sv) 2001-04-30
HU9403466D0 (en) 1995-02-28
EP0984004A2 (en) 2000-03-08
JP3834075B2 (ja) 2006-10-18
PE41495A1 (es) 1995-11-28
DE69427017D1 (de) 2001-05-10
NO944644L (no) 1995-06-09
CN1111239A (zh) 1995-11-08
KR100356239B1 (ko) 2002-12-26
TW290540B (sv) 1996-11-11
EP0657428B1 (en) 2001-04-04
KR950017957A (ko) 1995-07-22
NO944644D0 (no) 1994-12-02
DK0657428T3 (da) 2001-05-07
HUT71489A (en) 1995-11-28
EP1607387A2 (en) 2005-12-21
CN1223257A (zh) 1999-07-21
CN1121387C (zh) 2003-09-17
IL111843A0 (en) 1995-03-15
CA2137221C (en) 2011-02-22
AU7917094A (en) 1995-06-15
PL181734B1 (pl) 2001-09-28
GR3036136T3 (en) 2001-09-28
RU2145958C1 (ru) 2000-02-27
MY121543A (en) 2006-02-28
RU94042903A (ru) 1996-10-27
AU681198B2 (en) 1997-08-21
UA52577C2 (uk) 2003-01-15
FI945703L (sv) 1995-06-09
EP0984004A3 (en) 2003-10-15
YU70294A (sh) 1997-07-31
CO4290427A1 (es) 1996-04-17
NZ270039A (en) 1996-08-27
JPH07215937A (ja) 1995-08-15
ES2155844T3 (es) 2001-06-01
SI0657428T1 (en) 2001-08-31
PT657428E (pt) 2001-07-31
ZA949584B (en) 1996-06-03
CZ290559B6 (cs) 2002-08-14
YU49312B (sh) 2005-06-10
FI106455B (sv) 2001-02-15
HK1013826A1 (en) 1999-09-10
BR9404842A (pt) 1995-08-08
ATE200279T1 (de) 2001-04-15
DE69427017T2 (de) 2001-09-06
IL111843A (en) 2000-02-29
PL306068A1 (en) 1995-06-12
CA2137221A1 (en) 1995-06-09
FI20000353L (sv) 2000-02-17
US5434171A (en) 1995-07-18
EP0657428A1 (en) 1995-06-14
EP1607387A3 (en) 2007-01-03
NO302884B1 (no) 1998-05-04
CN1057294C (zh) 2000-10-11
JP2006070042A (ja) 2006-03-16
YU82304A (sh) 2006-03-03

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