FI945694L - Substituoiden triatsolin sulfaattisuola, sen farmaseuttisia koostumuksia ja niiden käyttö terapiassa - Google Patents

Substituoiden triatsolin sulfaattisuola, sen farmaseuttisia koostumuksia ja niiden käyttö terapiassa Download PDF

Info

Publication number: FI945694L
Authority: FI; Finland
Prior art keywords: substituting; therapy; pharmaceutical compositions; sulfate salt; triazole
Prior art date: 1992-06-05

Application number

FI945694A

Other languages

English (en)

Swedish (sv)

Other versions

FI945694A0 (fi

FI106201B (fi

Inventor

Raymond Baker

Victor G Matassa

Kendal G Pitt

Leslie J Street

Alexander R Guiblin

Carole Olive

David E Storey

Original Assignee

Merck Sharp & Dohme

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-06-05

Filing date

1994-12-02

Publication date

1994-12-02

1992-06-05 Priority claimed from GB929211903A external-priority patent/GB9211903D0/en

1993-04-07 Priority claimed from GB939307306A external-priority patent/GB9307306D0/en

1994-12-02 Application filed by Merck Sharp & Dohme filed Critical Merck Sharp & Dohme

1994-12-02 Publication of FI945694A0 publication Critical patent/FI945694A0/fi

1994-12-02 Publication of FI945694L publication Critical patent/FI945694L/fi

2000-12-15 Application granted granted Critical

2000-12-15 Publication of FI106201B publication Critical patent/FI106201B/fi

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Pain & Pain Management (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Plural Heterocyclic Compounds (AREA)
Indole Compounds (AREA)

FI945694A 1992-06-05 1994-12-02 Menetelmä substituoidun triatsolin sulfaattisuolan valmistamiseksi FI106201B (fi)

Applications Claiming Priority (6)

Application Number	Priority Date	Filing Date	Title
GB9211903		1992-06-05
GB929211903A GB9211903D0 (en)	1992-06-05	1992-06-05	Pharmaceutical composition
GB9301132		1993-01-21
GB939307306A GB9307306D0 (en)	1993-04-07	1993-04-07	Therapeutic agents
GB9307306		1993-04-07
PCT/GB1993/001132 WO1993025547A1 (en)	1992-06-05	1993-05-28	The sulphate salt of a substituted triazole, pharmaceutical compositions thereof, and their use in therapy

Publications (3)

Publication Number	Publication Date
FI945694A0 FI945694A0 (fi)	1994-12-02
FI945694L true FI945694L (fi)	1994-12-02
FI106201B FI106201B (fi)	2000-12-15

Family

ID=26301005

Family Applications (3)

Application Number	Title	Priority Date	Filing Date
FI945694A FI106201B (fi)	1992-06-05	1994-12-02	Menetelmä substituoidun triatsolin sulfaattisuolan valmistamiseksi
FI20001776A FI20001776A7 (fi)	1992-06-05	2000-08-10	Menetelmä farmaseuttisen koostumuksen valmistamiseksi
FI20001777A FI20001777L (fi)	1992-06-05	2000-08-10	Substituoidun triatsolin sulfaattisuola ja sen farmaseuttisia koostumuksia

Family Applications After (2)

Application Number	Title	Priority Date	Filing Date
FI20001776A FI20001776A7 (fi)	1992-06-05	2000-08-10	Menetelmä farmaseuttisen koostumuksen valmistamiseksi
FI20001777A FI20001777L (fi)	1992-06-05	2000-08-10	Substituoidun triatsolin sulfaattisuola ja sen farmaseuttisia koostumuksia

Country Status (27)

Country	Link
US (1)	US5527817A (fi)
EP (1)	EP0573221B1 (fi)
JP (2)	JP2619197B2 (fi)
KR (1)	KR100286411B1 (fi)
CN (1)	CN1043532C (fi)
AT (1)	ATE165602T1 (fi)
AU (2)	AU659311B2 (fi)
BG (1)	BG61976B1 (fi)
CA (1)	CA2097208C (fi)
CZ (1)	CZ282060B6 (fi)
DE (1)	DE69318212T2 (fi)
DK (1)	DK0573221T3 (fi)
ES (1)	ES2116411T3 (fi)
FI (3)	FI106201B (fi)
HK (1)	HK1010050A1 (fi)
HU (1)	HUT71403A (fi)
IL (1)	IL105847A (fi)
LV (1)	LV12210B (fi)
MX (1)	MX9303373A (fi)
NO (1)	NO307420B1 (fi)
NZ (1)	NZ253210A (fi)
RO (1)	RO114326B1 (fi)
RU (1)	RU2130022C1 (fi)
SG (1)	SG50406A1 (fi)
SK (1)	SK279211B6 (fi)
UA (1)	UA27908C2 (fi)
WO (1)	WO1993025547A1 (fi)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
RO114326B1 (ro) *	1992-06-05	1999-03-30	Merck Sharp & Dohme Limited Ho	Sarea sulfat a unui triazol substituit, procedeu de obtinere a acesteia, compozitie farmaceutica si procedeu de obtinere a acesteia
ZA965837B (en) *	1995-07-11	1997-01-31	Merck & Co Inc	A triazolylmethyl-indole ethylamine bisulfate salt
DE69616335T2 (de) *	1995-07-11	2002-07-11	MERCK & CO., INC.	Ein triazolylmethyl-indol-ethylamin-bisulfat-salz
US6349719B2 (en)	1997-02-24	2002-02-26	Aradigm Corporation	Formulation and devices for monitoring the efficacy of the delivery of aerosols
US6192882B1 (en) *	1997-02-24	2001-02-27	Aradigm Corporation	Formulation and devices for monitoring the efficacy of the delivery of aerosols
DE69922688T2 (de)	1998-11-02	2005-12-01	Merck & Co. Inc.	Zusammensetzungen aus einem 5ht1b/1d agonisten und einem selektiven cox-2 hemmer zur behandlung von migräne
DK3168218T3 (en)	2001-08-15	2019-01-14	Pharmacia & Upjohn Co Llc	Crystalline comprising an L-malic acid salt of N- [2- (DIETHYLAMINO) ETHYL] -5 - [(5-FLUOR-1,2-DIHYDRO-2-OXO-3H-INDOL-3-YLIDE) METHYL] -2,4 -DIMETHYL-1H-PYRROL-3-CARBOXAMIDE FOR USE AS A MEDICINE
WO2006137083A1 (en) *	2005-06-20	2006-12-28	Natco Pharma Limited	Improved process for the preparation of rizatriptan benzoate
ES2270717B1 (es) *	2005-08-08	2008-03-01	Ragactives, S.L.	Procedimiento para la obtencion de derivados de triptamina.
WO2007054979A1 (en) *	2005-11-14	2007-05-18	Matrix Laboratories Ltd	Process for the large scale production of rizatriptan benzoate
AU2008259518A1 (en) *	2007-06-04	2008-12-11	Generics [Uk] Limited	Novel process
CA3010568C (en)	2016-01-27	2023-10-17	Instar Technologies A.S.	Oromucosal nanofiber carriers for therapeutic treatment
WO2024144413A1 (ru) *	2022-12-28	2024-07-04	Общество С Ограниченной Ответственностью "Ферринг Продакшн"	Жидкая фармацевтическая композиция для назального введения, содержащая ризатриптан

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SU1528319A3 (ru) *	1985-07-23	1989-12-07	Глэксо Груп Лимитед (Фирма)	Способ получени производных имидазола или их физиологически приемлемых солей
GB8724912D0 (en) *	1987-10-23	1987-11-25	Wellcome Found	Indole derivatives
KR920011020B1 (ko) *	1989-07-03	1992-12-26	요시또미세이야꾸 가부시끼가이샤	벤즈아진 화합물 및 그의 의약용도
US5075313A (en) *	1990-09-13	1991-12-24	Eli Lilly And Company	3-aryl-4(3H)quinazolinone CCK antagonists and pharmaceutical formulations thereof
GB9026998D0 (en) *	1990-12-12	1991-01-30	Glaxo Group Ltd	Medicaments
SK278998B6 (sk) *	1991-02-01	1998-05-06	Merck Sharp & Dohme Limited	Deriváty imidazolu, triazolu a tetrazolu, spôsob i
RO114326B1 (ro) *	1992-06-05	1999-03-30	Merck Sharp & Dohme Limited Ho	Sarea sulfat a unui triazol substituit, procedeu de obtinere a acesteia, compozitie farmaceutica si procedeu de obtinere a acesteia

1993
- 1993-05-28 RO RO94-01910A patent/RO114326B1/ro unknown
- 1993-05-28 SG SG1996000374A patent/SG50406A1/en unknown
- 1993-05-28 DK DK93304158T patent/DK0573221T3/da active
- 1993-05-28 EP EP93304158A patent/EP0573221B1/en not_active Expired - Lifetime
- 1993-05-28 HU HU9403478A patent/HUT71403A/hu unknown
- 1993-05-28 SK SK1479-94A patent/SK279211B6/sk unknown
- 1993-05-28 JP JP5127463A patent/JP2619197B2/ja not_active Expired - Fee Related
- 1993-05-28 WO PCT/GB1993/001132 patent/WO1993025547A1/en not_active Ceased
- 1993-05-28 NZ NZ253210A patent/NZ253210A/en unknown
- 1993-05-28 RU RU94046380/04A patent/RU2130022C1/ru not_active IP Right Cessation
- 1993-05-28 CA CA002097208A patent/CA2097208C/en not_active Expired - Fee Related
- 1993-05-28 UA UA94129126A patent/UA27908C2/uk unknown
- 1993-05-28 ES ES93304158T patent/ES2116411T3/es not_active Expired - Lifetime
- 1993-05-28 CZ CZ943044A patent/CZ282060B6/cs not_active IP Right Cessation
- 1993-05-28 AU AU39875/93A patent/AU659311B2/en not_active Ceased
- 1993-05-28 AT AT93304158T patent/ATE165602T1/de not_active IP Right Cessation
- 1993-05-28 DE DE69318212T patent/DE69318212T2/de not_active Expired - Fee Related
- 1993-05-28 KR KR1019940704402A patent/KR100286411B1/ko not_active Expired - Fee Related
- 1993-05-28 AU AU43372/93A patent/AU4337293A/en not_active Abandoned
- 1993-05-31 IL IL10584793A patent/IL105847A/en not_active IP Right Cessation
- 1993-06-04 MX MX9303373A patent/MX9303373A/es not_active IP Right Cessation
- 1993-06-05 CN CN93108728A patent/CN1043532C/zh not_active Expired - Fee Related
1994
- 1994-10-21 BG BG99132A patent/BG61976B1/bg unknown
- 1994-12-02 FI FI945694A patent/FI106201B/fi active
- 1994-12-02 NO NO944656A patent/NO307420B1/no not_active IP Right Cessation
- 1994-12-07 US US08/350,760 patent/US5527817A/en not_active Expired - Lifetime
1996
- 1996-08-30 JP JP8230809A patent/JP2972150B2/ja not_active Expired - Fee Related
1998
- 1998-09-05 HK HK98110478A patent/HK1010050A1/en not_active IP Right Cessation
- 1998-10-26 LV LVP-98-237A patent/LV12210B/en unknown
2000
- 2000-08-10 FI FI20001776A patent/FI20001776A7/fi unknown
- 2000-08-10 FI FI20001777A patent/FI20001777L/fi unknown

Also Published As

Publication number	Publication date
JP2619197B2 (ja)	1997-06-11
BG99132A (bg)	1995-07-28
NZ253210A (en)	1995-09-26
RU94046380A (ru)	1996-12-10
SK147994A3 (en)	1995-07-11
KR100286411B1 (ko)	2001-04-16
SK279211B6 (sk)	1998-08-05
MX9303373A (es)	1995-01-31
FI20001777A7 (fi)	2000-08-10
CZ282060B6 (cs)	1997-05-14
HUT71403A (en)	1995-11-28
UA27908C2 (uk)	2000-10-16
JPH0641121A (ja)	1994-02-15
FI945694A0 (fi)	1994-12-02
JPH09176155A (ja)	1997-07-08
LV12210B (en)	1999-03-20
DE69318212T2 (de)	1998-11-19
AU4337293A (en)	1994-01-04
DE69318212D1 (de)	1998-06-04
CN1043532C (zh)	1999-06-02
BG61976B1 (bg)	1998-11-30
FI20001776L (fi)	2000-08-10
IL105847A0 (en)	1993-09-22
FI106201B (fi)	2000-12-15
EP0573221A1 (en)	1993-12-08
EP0573221B1 (en)	1998-04-29
ES2116411T3 (es)	1998-07-16
DK0573221T3 (da)	1998-10-07
CA2097208A1 (en)	1993-12-06
US5527817A (en)	1996-06-18
CN1089263A (zh)	1994-07-13
AU659311B2 (en)	1995-05-11
AU3987593A (en)	1993-12-09
CZ304494A3 (en)	1995-09-13
FI20001777L (fi)	2000-08-10
ATE165602T1 (de)	1998-05-15
FI20001776A7 (fi)	2000-08-10
WO1993025547A1 (en)	1993-12-23
IL105847A (en)	1998-09-24
SG50406A1 (en)	1998-07-20
JP2972150B2 (ja)	1999-11-08
NO944656D0 (no)	1994-12-02
KR950701922A (ko)	1995-05-17
NO944656L (no)	1994-12-02
RO114326B1 (ro)	1999-03-30
NO307420B1 (no)	2000-04-03
LV12210A (lv)	1999-01-20
CA2097208C (en)	2005-02-08
RU2130022C1 (ru)	1999-05-10
HU9403478D0 (en)	1995-02-28
HK1010050A1 (en)	1999-06-11

Publication	Publication Date	Title
FI934220A7 (fi)	1994-03-29	Piperidiinijohdannaisia, niiden valmistus ja niiden käyttö terapiassa
FI962589L (fi)	1996-08-20	2,4-disulfofenyylibutyylinitroni, sen suolat ja niiden käyttö farmaseuttisina aineina
FI952179A7 (fi)	1995-05-05	Uusia 3,3-difenyylipropyyliamiineja, niiden käyttö ja valmistus
FI955248A7 (fi)	1995-11-02	1-Bifenyylimetyyli-imitdatsolin johdannaiset, niiden valmistus ja terapeuttinen käyttö
EE9700039A (et)	1997-08-15	Teraapias kasutatavad spiro-asabitsüklilised ühendid ja nende valmistamise protsess
BR1100824A (pt)	1999-08-31	Composto e composição farmacêutica
FI953479A7 (fi)	1996-01-20	1-aryylipyrimidiinijohdannaiset ja niiden farmaseuttinen käyttö
FI20000516A7 (fi)	2000-03-07	Bis-indolyylimaleimidijohdannaiset ja niiden valmistus
FI944600A0 (fi)	1994-10-03	Imidatsol-4-yylipiperidiinijohdannaisia, niiden valmistus ja niiden käyttö terapiassa
FI945625A7 (fi)	1994-11-29	Indolokarbatsoli-imidit ja niiden käyttö
FI955140A7 (fi)	1995-10-27	Uusia kinoksaliinidionijohdannaisia, niiden valmistus ja käyttö lääkke issä
EE9600172A (et)	1997-06-16	Puriin-6-ooni derivaadid, nende valmistamismeetod, kasutamine ravimite valmistamiseks ja ravimid
FI945694L (fi)	1994-12-02	Substituoiden triatsolin sulfaattisuola, sen farmaseuttisia koostumuksia ja niiden käyttö terapiassa
EE9700288A (et)	1998-04-15	Asatsükloalkaani derivaadid, nende valmistamine ja kasutamine ravis
FI932145A7 (fi)	1993-05-12	Uudet b-karboliinijohdannaiset, niiden valmistus ja käyttö lääkeaineis sa
FI922982A7 (fi)	1992-12-28	2-aminopyrimidiini-4-karboksamidijohdannaisia, niiden valmistus ja niiden terapeuttinen käyttö
FI930716A7 (fi)	1993-08-21	Uusia aryylikarbonyyliaminoalkyylidihydro-oksopyridiinejä, niiden valmistus ja käyttö
FI940186A7 (fi)	1994-07-16	9H-imidatso/1,2-a/bentsimidatsoli-3-asetamidijohdannaisia, niiden valmistus ja niiden käyttö terapiassa
FI934221A7 (fi)	1994-03-29	Piperidiinijohdannaiset, niiden valmistus ja terapeuttinen käyttö
FI930293A7 (fi)	1993-01-25	Uusia heteroaryylioksi-b-karboliineja, niiden valmistus ja käyttö lääk keissä
IL101617A0 (en)	1992-12-30	2-aminopyrimidine-4-carboxamide derivatives,their preparation and their application in therapy
FI920663A7 (fi)	1992-08-16	Polyhydroksisyklopentaanin johdannaiset, niiden valmistus ja terapeuttinen käyttö
FI956353L (fi)	1995-12-29	Farmaseuttiset valmisteet ja niiden käyttö etenkin neurodegeneratiivisten sairauksien hoidossa
FI935196A7 (fi)	1994-05-25	Pyrrolijohdannaisia, niiden valmistus ja käyttö terapiassa
FI954141L (fi)	1996-03-06	Oksatsolokinolonijohdannaiset, niiden valmistus ja niiden käyttö terapiassa