FI944926L - Entsymaattinen hydroksylaatiomenetelmä HMG-CoA-reduktaasi-inhibiittorien ja niiden välituotteiden valmistamiseksi - Google Patents

Entsymaattinen hydroksylaatiomenetelmä HMG-CoA-reduktaasi-inhibiittorien ja niiden välituotteiden valmistamiseksi Download PDF

Info

Publication number: FI944926L
Authority: FI; Finland
Prior art keywords: hmg; intermediates; preparation; coa reductase; reductase inhibitors
Prior art date: 1993-10-22

Application number

FI944926A

Other languages

English (en)

Swedish (sv)

Other versions

FI944926A0 (fi

FI113279B (fi

Inventor

Brian L Davis

Paul M Cino

Laszlo Szarka

Original Assignee

Bristol Myers Squibb Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-10-22

Filing date

1994-10-20

Publication date

1995-04-23

1994-10-20 Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co

1994-10-20 Publication of FI944926A0 publication Critical patent/FI944926A0/fi

1995-04-23 Publication of FI944926L publication Critical patent/FI944926L/fi

2004-03-31 Application granted granted Critical

2004-03-31 Publication of FI113279B publication Critical patent/FI113279B/fi

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/62—Carboxylic acid esters
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/02—Oxygen as only ring hetero atoms
- C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/822—Microorganisms using bacteria or actinomycetales
- Y10S435/872—Nocardia
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/822—Microorganisms using bacteria or actinomycetales
- Y10S435/886—Streptomyces

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Health & Medical Sciences (AREA)
General Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
General Engineering & Computer Science (AREA)
Biotechnology (AREA)
Genetics & Genomics (AREA)
Biochemistry (AREA)
Microbiology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Obesity (AREA)
Diabetes (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Hematology (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

FI944926A 1993-10-22 1994-10-20 Menetelmiä HMG-CoA-reduktaasi-inhibiittorien valmistamiseksi FI113279B (fi)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US08/141,316 US6043064A (en)	1993-10-22	1993-10-22	Enzymatic hydroxylation process for the preparation of HMG-CoA reductase inhibitors and intermediates thereof
US14131693		1993-10-22

Publications (3)

Publication Number	Publication Date
FI944926A0 FI944926A0 (fi)	1994-10-20
FI944926L true FI944926L (fi)	1995-04-23
FI113279B FI113279B (fi)	2004-03-31

Family

ID=22495167

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
FI944926A FI113279B (fi)	1993-10-22	1994-10-20	Menetelmiä HMG-CoA-reduktaasi-inhibiittorien valmistamiseksi

Country Status (19)

Country	Link
US (1)	US6043064A (fi)
EP (1)	EP0649907B1 (fi)
JP (1)	JP3683606B2 (fi)
KR (1)	KR100342627B1 (fi)
CN (1)	CN1085250C (fi)
AT (1)	ATE196166T1 (fi)
AU (1)	AU679113B2 (fi)
CA (1)	CA2134025A1 (fi)
CY (1)	CY2216B1 (fi)
DE (1)	DE69425801T2 (fi)
DK (1)	DK0649907T3 (fi)
ES (1)	ES2150459T3 (fi)
FI (1)	FI113279B (fi)
GR (1)	GR3034835T3 (fi)
HU (1)	HU217104B (fi)
IL (1)	IL111084A (fi)
PT (1)	PT649907E (fi)
SG (1)	SG47504A1 (fi)
TW (1)	TW438888B (fi)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ATE389026T1 (de)	1997-08-07	2008-03-15	Kyowa Hakko Kogyo Kk	Verfahren für die herstellung von inhibitoren der hmg-coa-reduktase.
AU9264598A (en) *	1997-08-22	1999-03-16	Gist-Brocades B.V.	Statin production by fermentation
SI9800144A (sl)	1998-05-21	1999-12-31	LEK, tovarna farmacevtskih in kemičnih izdelkov, d.d.	Nov biotehnološki postopek pridobivanja 3-hidroksi-ML-236B derivatov poznanih kot M-4 in M-4'
CN1240844C (zh)	1999-01-20	2006-02-08	协和发酵工业株式会社	HMG－CoA还原酶抑制剂的制备方法
US7049111B1 (en) *	1999-01-29	2006-05-23	Kyowa Hakko Kogyo Co., Ltd.	Process for producing HMG-CoA reductase inhibitor
HUP9902352A1 (hu) *	1999-07-12	2000-09-28	Gyógyszerkutató Intézet Kft.	Eljárás pravasztatin mikrobiológiai előállítására
JP2003093045A (ja) *	2001-09-26	2003-04-02	Godo Shusei Co Ltd	有用変換微生物
BRPI0117138B1 (pt) *	2001-09-27	2015-08-04	Biocon Ltd	Processo para a produção de sal de sódio de pravastatina usando-se um microorganismo streptomyces flavidovirens dsm 14455
EP1452602A1 (en) *	2003-02-25	2004-09-01	Antibiotic Co.,	Method for production of pravastatin by fermentation
TWI252253B (en) *	2004-01-09	2006-04-01	Chinese Petroleum Corp	A novel Pseudonocardia sp RMRC PAH4 and a process for bioconverting compactin into pravastatin using the same
EP1956090A4 (en) *	2005-11-29	2009-04-08	Kyowa Hakko Kogyo Kk	NEW PROTEIN AND PROTEIN-CODING DNA
WO2007137816A1 (en) *	2006-05-30	2007-12-06	Dsm Ip Assets B.V.	Process for the preparation of epoxide intermediates for pharmaceutical compounds such as statins
EP1953233A1 (en) *	2007-02-02	2008-08-06	LEK Pharmaceuticals d.d.	Fermentation process for preparing pravastatin
CN110914425B (zh)	2017-06-06	2024-06-25	齐默尔根公司	用于改良刺糖多孢菌的高通量(htp)基因组工程改造平台

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS5612114B2 (fi) *	1974-06-07	1981-03-18
US4206206A (en) *	1977-03-24	1980-06-03	Kowa Company, Ltd.	Antibiotics of the KA-6606 series and pharmaceutical compositions thereof
US4444784A (en) *	1980-08-05	1984-04-24	Merck & Co., Inc.	Antihypercholesterolemic compounds
DK149080C (da) *	1980-06-06	1986-07-28	Sankyo Co	Fremgangsmaade til fremstilling af derivater af ml-236b-carboxylsyre
US4450171A (en) *	1980-08-05	1984-05-22	Merck & Co., Inc.	Antihypercholesterolemic compounds
EP0069442B1 (en) *	1981-06-06	1985-02-20	Pfizer Limited	Antifungal agents, processes for their preparation, and pharmaceutical compositions containing them
JPS5889191A (ja) *	1981-11-20	1983-05-27	Sankyo Co Ltd	３−ヒドロキシ−ｍｌ−２３６ｂ誘導体の製造法
JPS60176595A (ja) *	1984-02-21	1985-09-10	Akira Endo	生理活性物質ｍｌ−２３６ａ及びモナコリンｊの製造法
PT85109A (en) *	1986-06-23	1987-07-01	Merck & Co Inc	Process for the preparation of hydroxy-tetrahydropyranone derivatives or corresponding ring opened dihydroxy acids which are hmg-coa reductase inhibitors
US4857547A (en) *	1988-01-07	1989-08-15	Merck & Co., Inc.	Novel HMG-CoA reductase inhibitors
EP0337548A3 (en) *	1988-04-15	1991-08-14	Merck & Co. Inc.	HMG-COA reductase inhibitors produced by nocardia SP. (MA6455)(ATCC 53695)
JPH02245191A (ja) *	1989-02-01	1990-09-28	Merck & Co Inc	６―α―ヒドロキシメチルロバスタチン誘導体の製造方法
EP0408806A1 (en) *	1989-07-19	1991-01-23	Merck & Co. Inc.	Antihypercholesterolemic agents
TW227552B (fi) *	1990-07-06	1994-08-01	Squibb & Sons Inc
CA2053000C (en) *	1990-10-15	1995-08-29	Michael J. Conder	Biosynthetic production of 6(r)-[2-(8(s)-hydroxy-2(s), 6(r)-dimethyl-1,2,6,7,8,8a(r)-hexahydronaphthyl)-ethyl]-4 (r)-hydroxy-3,4,5,6-tetrahydro-2h-pyran-2-one triol acid by enzymatic hydrolysis of lovastatin acid using an enzyme derived from__lonostachys compactiuscula
IL108432A (en) *	1993-01-29	1997-09-30	Sankyo Co	DERIVATIVES OF 3, 5-DIHYDROXY-7- £1, 2, 6, 7, 8, 8a-HEXAHYDRO-2- METHYL-8- (SUBSTITUTED ALKANOYLOXY)-1-NAPHTHYL\| HEPTANOIC ACID AND THEIR LACTONES, THEIR PREPARATION, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

1993
- 1993-10-22 US US08/141,316 patent/US6043064A/en not_active Expired - Fee Related
1994
- 1994-09-29 IL IL111084A patent/IL111084A/en not_active IP Right Cessation
- 1994-10-01 TW TW083109094A patent/TW438888B/zh not_active IP Right Cessation
- 1994-10-18 DK DK94116409T patent/DK0649907T3/da active
- 1994-10-18 EP EP94116409A patent/EP0649907B1/en not_active Expired - Lifetime
- 1994-10-18 SG SG1996002486A patent/SG47504A1/en unknown
- 1994-10-18 AT AT94116409T patent/ATE196166T1/de not_active IP Right Cessation
- 1994-10-18 DE DE69425801T patent/DE69425801T2/de not_active Expired - Fee Related
- 1994-10-18 ES ES94116409T patent/ES2150459T3/es not_active Expired - Lifetime
- 1994-10-18 PT PT94116409T patent/PT649907E/pt unknown
- 1994-10-20 FI FI944926A patent/FI113279B/fi not_active IP Right Cessation
- 1994-10-21 JP JP25654894A patent/JP3683606B2/ja not_active Expired - Fee Related
- 1994-10-21 CA CA002134025A patent/CA2134025A1/en not_active Abandoned
- 1994-10-21 AU AU75972/94A patent/AU679113B2/en not_active Ceased
- 1994-10-21 HU HU9403061A patent/HU217104B/hu not_active IP Right Cessation
- 1994-10-21 KR KR1019940026933A patent/KR100342627B1/ko not_active Expired - Fee Related
- 1994-10-22 CN CN94117167A patent/CN1085250C/zh not_active Expired - Fee Related
2000
- 2000-11-13 GR GR20000402523T patent/GR3034835T3/el not_active IP Right Cessation
- 2000-11-28 CY CY0000057A patent/CY2216B1/xx unknown

Also Published As

Publication number	Publication date
EP0649907A1 (en)	1995-04-26
HUT69959A (en)	1995-09-28
FI944926A0 (fi)	1994-10-20
DK0649907T3 (da)	2000-10-09
FI113279B (fi)	2004-03-31
KR950011616A (ko)	1995-05-15
TW438888B (en)	2001-06-07
JPH07184670A (ja)	1995-07-25
CA2134025A1 (en)	1995-04-23
CY2216B1 (en)	2003-04-18
AU7597294A (en)	1995-05-11
ES2150459T3 (es)	2000-12-01
AU679113B2 (en)	1997-06-19
HU217104B (hu)	1999-11-29
IL111084A0 (en)	1994-11-28
HK1014740A1 (en)	1999-09-30
JP3683606B2 (ja)	2005-08-17
KR100342627B1 (ko)	2002-11-18
HU9403061D0 (en)	1994-12-28
EP0649907B1 (en)	2000-09-06
PT649907E (pt)	2000-12-29
CN1106067A (zh)	1995-08-02
CN1085250C (zh)	2002-05-22
SG47504A1 (en)	1998-04-17
IL111084A (en)	1998-01-04
GR3034835T3 (en)	2001-02-28
US6043064A (en)	2000-03-28
DE69425801T2 (de)	2001-05-03
DE69425801D1 (de)	2000-10-12
ATE196166T1 (de)	2000-09-15

Publication	Publication Date	Title
AU610591B2 (en)	1991-05-23	Phosphorus-containing hmg-coa reductase inhibitors, new intermediates and method
NO20000407D0 (no)	2000-01-27	Kombinasjoner av HMG-COA reduktase inhibitorer og nikotinsyre samt metoder for behandling av hyperlipidemi
AU1022795A (en)	1995-07-27	Method for preventing or reducing risk of onset of cardiovascular events employing an HMG CoA reductase inhibitor
HUP0103007A3 (en)	2003-10-28	New salts of hmg-coa reductase inhibitors and process for their preparation
AP2002002540A0 (en)	2002-06-30	Inhibitors of interleukin-1b converting enzyme
AU4237896A (en)	1996-06-06	Method and intermediates for the synthesis of korupensamines
AU6084686A (en)	1987-02-12	Novel hmg-coa reductase inhibitors
FI944926L (fi)	1995-04-23	Entsymaattinen hydroksylaatiomenetelmä HMG-CoA-reduktaasi-inhibiittorien ja niiden välituotteiden valmistamiseksi
AU2243497A (en)	1997-08-11	Laser induced improvement of surfaces
FI960949A7 (fi)	1996-02-29	Uusi lipaasi, lipaasia tuottavat mikro-organismit, menetelmä lipaasin tuottamiseksi ja lipaasin käyttö
PL331339A1 (en)	1999-07-05	Antihrombotic and antiarteriosclerotic pharmaceutical composition containing derivative of thiene pyridine as well as an inhibitor of hmg-coa reductase
AU2058992A (en)	1993-02-11	HMG-COA reductase inhibitors
AU610174B2 (en)	1991-05-16	Phosphorus-containing hmg-coa reductase inhibitors, new intermediates and method
AU7761398A (en)	1998-11-27	Hmg-coa reductase inhibitor preparation process
AU4543699A (en)	1999-12-30	Multibinding inhibitors of hmg-coa reductase
AU6212398A (en)	1998-08-26	2-amino-substituted pyridines which can be used for the treatment of arteriosclerosis and hyperclipoproteinaemia
AU2175088A (en)	1989-03-16	Novel hmg-coa reductase inhibitors
FI893004A7 (fi)	1989-12-30	5-oksygenoituja HMG-CoA-reduktaasi-inhibiittoreita
AU645287B2 (en)	1994-01-13	Quinoline and pyridine anchors for HMG-CoA reductase inhibitors
AU1221001A (en)	2001-05-14	Employee portal and method of use therefor
EP0320052A3 (en)	1989-08-16	Intermediates and processes for 6-carboxy hmg-coa reductase inhibitors
FI972620L (fi)	1997-06-18	Uusia prosesseja, joilla voidaan valmistaa enkefalinaasin ja angiotensiiniä konvertoivan entsyymin inhibiittoreiden välituotteita ja näiden välituotteita
PL337343A1 (en)	2000-08-14	Method of obtaining drugs comprising inhibitors of hmg coa reductase
AU2002300546A1 (en)	2003-02-13	Combinations of HMG-CoA Reductase Inhibitors and Nicotinic Acid and Methods for Treating Hyperlipidemia
GB2238545B (en)	1992-01-02	Phosphorus-containing hmg-coa reductase inhibitors,new intermediates and method

Legal Events

Date	Code	Title	Description
2008-04-30	MA	Patent expired