CY2216B1 - Enzymatic hydroxylation process for the preparation of hmg-coa reductase inhibitors and intermediates thereof - Google Patents

Enzymatic hydroxylation process for the preparation of hmg-coa reductase inhibitors and intermediates thereof

Info

Publication number: CY2216B1
Authority: CY; Cyprus
Prior art keywords: hmg; intermediates; preparation; coa reductase; reductase inhibitors
Prior art date: 1993-10-22

Application number

CY0000057A

Other languages

English (en)

Inventor

Brian L David

Paul M Cino

Laszlo Szarka

Original Assignee

Bristol Myers Quibb Company

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-10-22

Filing date

2000-11-28

Publication date

2003-04-18

2000-11-28 Application filed by Bristol Myers Quibb Company filed Critical Bristol Myers Quibb Company

2003-04-18 Publication of CY2216B1 publication Critical patent/CY2216B1/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/62—Carboxylic acid esters
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/02—Oxygen as only ring hetero atoms
- C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/822—Microorganisms using bacteria or actinomycetales
- Y10S435/872—Nocardia
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/822—Microorganisms using bacteria or actinomycetales
- Y10S435/886—Streptomyces

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Health & Medical Sciences (AREA)
General Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
General Engineering & Computer Science (AREA)
Biotechnology (AREA)
Genetics & Genomics (AREA)
Biochemistry (AREA)
Microbiology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Obesity (AREA)
Diabetes (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Hematology (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

CY0000057A 1993-10-22 2000-11-28 Enzymatic hydroxylation process for the preparation of hmg-coa reductase inhibitors and intermediates thereof CY2216B1 (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US08/141,316 US6043064A (en)	1993-10-22	1993-10-22	Enzymatic hydroxylation process for the preparation of HMG-CoA reductase inhibitors and intermediates thereof

Publications (1)

Publication Number	Publication Date
CY2216B1 true CY2216B1 (en)	2003-04-18

Family

ID=22495167

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CY0000057A CY2216B1 (en)	1993-10-22	2000-11-28	Enzymatic hydroxylation process for the preparation of hmg-coa reductase inhibitors and intermediates thereof

Country Status (19)

Country	Link
US (1)	US6043064A (xx)
EP (1)	EP0649907B1 (xx)
JP (1)	JP3683606B2 (xx)
KR (1)	KR100342627B1 (xx)
CN (1)	CN1085250C (xx)
AT (1)	ATE196166T1 (xx)
AU (1)	AU679113B2 (xx)
CA (1)	CA2134025A1 (xx)
CY (1)	CY2216B1 (xx)
DE (1)	DE69425801T2 (xx)
DK (1)	DK0649907T3 (xx)
ES (1)	ES2150459T3 (xx)
FI (1)	FI113279B (xx)
GR (1)	GR3034835T3 (xx)
HU (1)	HU217104B (xx)
IL (1)	IL111084A (xx)
PT (1)	PT649907E (xx)
SG (1)	SG47504A1 (xx)
TW (1)	TW438888B (xx)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ATE389026T1 (de)	1997-08-07	2008-03-15	Kyowa Hakko Kogyo Kk	Verfahren für die herstellung von inhibitoren der hmg-coa-reduktase.
AU9264598A (en) *	1997-08-22	1999-03-16	Gist-Brocades B.V.	Statin production by fermentation
SI9800144A (sl)	1998-05-21	1999-12-31	LEK, tovarna farmacevtskih in kemičnih izdelkov, d.d.	Nov biotehnološki postopek pridobivanja 3-hidroksi-ML-236B derivatov poznanih kot M-4 in M-4'
CN1240844C (zh)	1999-01-20	2006-02-08	协和发酵工业株式会社	HMG－CoA还原酶抑制剂的制备方法
US7049111B1 (en) *	1999-01-29	2006-05-23	Kyowa Hakko Kogyo Co., Ltd.	Process for producing HMG-CoA reductase inhibitor
HUP9902352A1 (hu) *	1999-07-12	2000-09-28	Gyógyszerkutató Intézet Kft.	Eljárás pravasztatin mikrobiológiai előállítására
JP2003093045A (ja) *	2001-09-26	2003-04-02	Godo Shusei Co Ltd	有用変換微生物
BRPI0117138B1 (pt) *	2001-09-27	2015-08-04	Biocon Ltd	Processo para a produção de sal de sódio de pravastatina usando-se um microorganismo streptomyces flavidovirens dsm 14455
EP1452602A1 (en) *	2003-02-25	2004-09-01	Antibiotic Co.,	Method for production of pravastatin by fermentation
TWI252253B (en) *	2004-01-09	2006-04-01	Chinese Petroleum Corp	A novel Pseudonocardia sp RMRC PAH4 and a process for bioconverting compactin into pravastatin using the same
EP1956090A4 (en) *	2005-11-29	2009-04-08	Kyowa Hakko Kogyo Kk	NEW PROTEIN AND PROTEIN-CODING DNA
WO2007137816A1 (en) *	2006-05-30	2007-12-06	Dsm Ip Assets B.V.	Process for the preparation of epoxide intermediates for pharmaceutical compounds such as statins
EP1953233A1 (en) *	2007-02-02	2008-08-06	LEK Pharmaceuticals d.d.	Fermentation process for preparing pravastatin
CN110914425B (zh)	2017-06-06	2024-06-25	齐默尔根公司	用于改良刺糖多孢菌的高通量(htp)基因组工程改造平台

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS5612114B2 (xx) *	1974-06-07	1981-03-18
US4206206A (en) *	1977-03-24	1980-06-03	Kowa Company, Ltd.	Antibiotics of the KA-6606 series and pharmaceutical compositions thereof
US4444784A (en) *	1980-08-05	1984-04-24	Merck & Co., Inc.	Antihypercholesterolemic compounds
DK149080C (da) *	1980-06-06	1986-07-28	Sankyo Co	Fremgangsmaade til fremstilling af derivater af ml-236b-carboxylsyre
US4450171A (en) *	1980-08-05	1984-05-22	Merck & Co., Inc.	Antihypercholesterolemic compounds
EP0069442B1 (en) *	1981-06-06	1985-02-20	Pfizer Limited	Antifungal agents, processes for their preparation, and pharmaceutical compositions containing them
JPS5889191A (ja) *	1981-11-20	1983-05-27	Sankyo Co Ltd	３−ヒドロキシ−ｍｌ−２３６ｂ誘導体の製造法
JPS60176595A (ja) *	1984-02-21	1985-09-10	Akira Endo	生理活性物質ｍｌ−２３６ａ及びモナコリンｊの製造法
PT85109A (en) *	1986-06-23	1987-07-01	Merck & Co Inc	Process for the preparation of hydroxy-tetrahydropyranone derivatives or corresponding ring opened dihydroxy acids which are hmg-coa reductase inhibitors
US4857547A (en) *	1988-01-07	1989-08-15	Merck & Co., Inc.	Novel HMG-CoA reductase inhibitors
EP0337548A3 (en) *	1988-04-15	1991-08-14	Merck & Co. Inc.	HMG-COA reductase inhibitors produced by nocardia SP. (MA6455)(ATCC 53695)
JPH02245191A (ja) *	1989-02-01	1990-09-28	Merck & Co Inc	６―α―ヒドロキシメチルロバスタチン誘導体の製造方法
EP0408806A1 (en) *	1989-07-19	1991-01-23	Merck & Co. Inc.	Antihypercholesterolemic agents
TW227552B (xx) *	1990-07-06	1994-08-01	Squibb & Sons Inc
CA2053000C (en) *	1990-10-15	1995-08-29	Michael J. Conder	Biosynthetic production of 6(r)-[2-(8(s)-hydroxy-2(s), 6(r)-dimethyl-1,2,6,7,8,8a(r)-hexahydronaphthyl)-ethyl]-4 (r)-hydroxy-3,4,5,6-tetrahydro-2h-pyran-2-one triol acid by enzymatic hydrolysis of lovastatin acid using an enzyme derived from__lonostachys compactiuscula
IL108432A (en) *	1993-01-29	1997-09-30	Sankyo Co	DERIVATIVES OF 3, 5-DIHYDROXY-7- £1, 2, 6, 7, 8, 8a-HEXAHYDRO-2- METHYL-8- (SUBSTITUTED ALKANOYLOXY)-1-NAPHTHYL\| HEPTANOIC ACID AND THEIR LACTONES, THEIR PREPARATION, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

1993
- 1993-10-22 US US08/141,316 patent/US6043064A/en not_active Expired - Fee Related
1994
- 1994-09-29 IL IL111084A patent/IL111084A/en not_active IP Right Cessation
- 1994-10-01 TW TW083109094A patent/TW438888B/zh not_active IP Right Cessation
- 1994-10-18 DK DK94116409T patent/DK0649907T3/da active
- 1994-10-18 EP EP94116409A patent/EP0649907B1/en not_active Expired - Lifetime
- 1994-10-18 SG SG1996002486A patent/SG47504A1/en unknown
- 1994-10-18 AT AT94116409T patent/ATE196166T1/de not_active IP Right Cessation
- 1994-10-18 DE DE69425801T patent/DE69425801T2/de not_active Expired - Fee Related
- 1994-10-18 ES ES94116409T patent/ES2150459T3/es not_active Expired - Lifetime
- 1994-10-18 PT PT94116409T patent/PT649907E/pt unknown
- 1994-10-20 FI FI944926A patent/FI113279B/fi not_active IP Right Cessation
- 1994-10-21 JP JP25654894A patent/JP3683606B2/ja not_active Expired - Fee Related
- 1994-10-21 CA CA002134025A patent/CA2134025A1/en not_active Abandoned
- 1994-10-21 AU AU75972/94A patent/AU679113B2/en not_active Ceased
- 1994-10-21 HU HU9403061A patent/HU217104B/hu not_active IP Right Cessation
- 1994-10-21 KR KR1019940026933A patent/KR100342627B1/ko not_active Expired - Fee Related
- 1994-10-22 CN CN94117167A patent/CN1085250C/zh not_active Expired - Fee Related
2000
- 2000-11-13 GR GR20000402523T patent/GR3034835T3/el not_active IP Right Cessation
- 2000-11-28 CY CY0000057A patent/CY2216B1/xx unknown

Also Published As

Publication number	Publication date
EP0649907A1 (en)	1995-04-26
HUT69959A (en)	1995-09-28
FI944926A0 (fi)	1994-10-20
DK0649907T3 (da)	2000-10-09
FI113279B (fi)	2004-03-31
KR950011616A (ko)	1995-05-15
TW438888B (en)	2001-06-07
JPH07184670A (ja)	1995-07-25
CA2134025A1 (en)	1995-04-23
AU7597294A (en)	1995-05-11
ES2150459T3 (es)	2000-12-01
AU679113B2 (en)	1997-06-19
FI944926L (fi)	1995-04-23
HU217104B (hu)	1999-11-29
IL111084A0 (en)	1994-11-28
HK1014740A1 (en)	1999-09-30
JP3683606B2 (ja)	2005-08-17
KR100342627B1 (ko)	2002-11-18
HU9403061D0 (en)	1994-12-28
EP0649907B1 (en)	2000-09-06
PT649907E (pt)	2000-12-29
CN1106067A (zh)	1995-08-02
CN1085250C (zh)	2002-05-22
SG47504A1 (en)	1998-04-17
IL111084A (en)	1998-01-04
GR3034835T3 (en)	2001-02-28
US6043064A (en)	2000-03-28
DE69425801T2 (de)	2001-05-03
DE69425801D1 (de)	2000-10-12
ATE196166T1 (de)	2000-09-15

Publication	Publication Date	Title
AU1022795A (en)	1995-07-27	Method for preventing or reducing risk of onset of cardiovascular events employing an HMG CoA reductase inhibitor
IL134272A0 (en)	2001-04-30	Combinations of hmg-coa reductase inhibitors and nicotinic acid and methods for treating hyperlipidemia
AU4237896A (en)	1996-06-06	Method and intermediates for the synthesis of korupensamines
AP2002002540A0 (en)	2002-06-30	Inhibitors of interleukin-1b converting enzyme
AU610591B2 (en)	1991-05-23	Phosphorus-containing hmg-coa reductase inhibitors, new intermediates and method
HUP0103007A3 (en)	2003-10-28	New salts of hmg-coa reductase inhibitors and process for their preparation
AP9700960A0 (en)	1997-04-30	Inhibitors of interleukin-1B converting enzyme
AU7204694A (en)	1995-01-03	Fastening device for furniture construction and method of manufacture
CY2216B1 (en)	2003-04-18	Enzymatic hydroxylation process for the preparation of hmg-coa reductase inhibitors and intermediates thereof
AU2058992A (en)	1993-02-11	HMG-COA reductase inhibitors
AU7761398A (en)	1998-11-27	Hmg-coa reductase inhibitor preparation process
HUP0100820A3 (en)	2003-07-28	Process for the obtaining of hmg-coa reductase inhibitors of high purity
AU643501B2 (en)	1993-11-18	Phosphorus-containing HMG-CoA reductase inhibitors, new intermediates and method
AU4543699A (en)	1999-12-30	Multibinding inhibitors of hmg-coa reductase
AU2175088A (en)	1989-03-16	Novel hmg-coa reductase inhibitors
AU6212398A (en)	1998-08-26	2-amino-substituted pyridines which can be used for the treatment of arteriosclerosis and hyperclipoproteinaemia
JPS6426556A (en)	1989-01-27	Manufacture of novel intermediate and hmg-coa reductase inhibitor
EP0415488A3 (en)	1991-09-11	7-substituted hmg-coa reductase inhibitors
EP0320052A3 (en)	1989-08-16	Intermediates and processes for 6-carboxy hmg-coa reductase inhibitors
AU4131797A (en)	1998-04-02	Pre-treatment of steel
ZA964107B (en)	1996-12-03	Enzyme degrading rhamnogalacturonane ii methods for obtaining said enzyme and rhamnogalacturonane ii and use of said enzyme
AU1557697A (en)	1997-08-22	Method for the quantitative determination of telomerase activity
AU6491294A (en)	1994-10-24	Inhibitors of endothelin converting enzyme
AU2177701A (en)	2001-06-12	Use of hmg-coa reductase inhibitors for treating seborrhea
EP0922770A3 (en)	1999-06-30	A microbiological process for the transformation of 17beta-carboxy substituted 3-oxo-4-azasteroids and the use of such products as inhibitors of the enzyme 5alpha-reductase