FI944276A7 - Proteiinikinaasi C-proteiinin modulaatio oligonukleotideilla - Google Patents

Proteiinikinaasi C-proteiinin modulaatio oligonukleotideilla

Info

Publication number: FI944276A7
Authority: FI; Finland
Prior art keywords: oligonucleotides; modulation; protein kinase; kinase; protein
Prior art date: 1992-03-16

Application number

FI944276A

Other languages

English (en)

Swedish (sv)

Other versions

FI944276A0 (fi

FI112379B (fi

Inventor

Frank C Bennett

Nicholas M Dean

Original Assignee

Isis Pharmaceuticals Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-03-16

Filing date

1994-09-15

Publication date

1994-09-15

1994-09-15 Application filed by Isis Pharmaceuticals Inc filed Critical Isis Pharmaceuticals Inc

1994-09-15 Publication of FI944276A0 publication Critical patent/FI944276A0/fi

1994-09-15 Publication of FI944276A7 publication Critical patent/FI944276A7/fi

2003-11-28 Application granted granted Critical

2003-11-28 Publication of FI112379B publication Critical patent/FI112379B/fi

Links

108091034117 Oligonucleotide Proteins 0.000 title 1
102000003923 Protein Kinase C Human genes 0.000 title 1
108090000315 Protein Kinase C Proteins 0.000 title 1
JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 title 1

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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
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- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
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- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
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- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
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- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
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- C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
- C12Y207/11—Protein-serine/threonine kinases (2.7.11)
- C12Y207/11013—Protein kinase C (2.7.11.13)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- C12N2310/00—Structure or type of the nucleic acid
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- C12N2310/315—Phosphorothioates
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- C12N2310/34—Spatial arrangement of the modifications
- C12N2310/341—Gapmers, i.e. of the type ===---===
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- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers

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Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Genetics & Genomics (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
General Health & Medical Sciences (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
Bioinformatics & Cheminformatics (AREA)
Proteomics, Peptides & Aminoacids (AREA)
General Engineering & Computer Science (AREA)
Microbiology (AREA)
Analytical Chemistry (AREA)
Biomedical Technology (AREA)
Biophysics (AREA)
Physics & Mathematics (AREA)
Medicinal Chemistry (AREA)
Immunology (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Pathology (AREA)
Virology (AREA)
Epidemiology (AREA)
Plant Pathology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Enzymes And Modification Thereof (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Saccharide Compounds (AREA)

FI944276A 1992-03-16 1994-09-15 Menetelmä terapeuttisesti käyttökelpoisten oligonukleotidien valmistamiseksi FI112379B (fi)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
US85285292A	1992-03-16	1992-03-16
US85285292		1992-03-16
US9302213		1993-02-25
PCT/US1993/002213 WO1993019203A1 (en)	1992-03-16	1993-02-25	Oligonucleotide modulation of protein kinase c

Publications (3)

Publication Number	Publication Date
FI944276A0 FI944276A0 (fi)	1994-09-15
FI944276A7 true FI944276A7 (fi)	1994-09-15
FI112379B FI112379B (fi)	2003-11-28

Family

ID=25314390

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
FI944276A FI112379B (fi)	1992-03-16	1994-09-15	Menetelmä terapeuttisesti käyttökelpoisten oligonukleotidien valmistamiseksi
FI20030248A FI113059B (fi)	1992-03-16	2003-02-18	Proteiinikinaasi C:tä koodaavaan mRNA:han hybridisoituvia oligonukleotideja

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
FI20030248A FI113059B (fi)	1992-03-16	2003-02-18	Proteiinikinaasi C:tä koodaavaan mRNA:han hybridisoituvia oligonukleotideja

Country Status (14)

Country	Link
US (1)	US5703054A (fi)
EP (3)	EP0672180B1 (fi)
JP (1)	JP2635216B2 (fi)
KR (1)	KR0157487B1 (fi)
AT (1)	ATE212063T1 (fi)
AU (1)	AU675638B2 (fi)
CA (1)	CA2132094A1 (fi)
DE (1)	DE69331467T2 (fi)
DK (1)	DK0672180T3 (fi)
ES (1)	ES2170065T3 (fi)
FI (2)	FI112379B (fi)
HU (1)	HU217179B (fi)
NO (1)	NO943438L (fi)
WO (1)	WO1993019203A1 (fi)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5789573A (en) *	1990-08-14	1998-08-04	Isis Pharmaceuticals, Inc.	Antisense inhibition of ICAM-1, E-selectin, and CMV IE1/IE2
US7015315B1 (en) *	1991-12-24	2006-03-21	Isis Pharmaceuticals, Inc.	Gapped oligonucleotides
US6537973B1 (en) *	1992-03-16	2003-03-25	Isis Pharmaceuticals, Inc.	Oligonucleotide inhibition of protein kinase C
US6153599A (en) *	1992-03-16	2000-11-28	Isis Pharmaceuticals, Inc.	Methoxyethoxy oligonucleotides for modulation of protein kinase C expression
US5922686A (en) *	1992-03-16	1999-07-13	Isis Pharmaceuticals, Inc.	Oligonucleotide modulation of protein kinase C
US5681747A (en) *	1992-03-16	1997-10-28	Isis Pharmaceuticals, Inc.	Nucleic acid sequences encoding protein kinase C and antisense inhibition of expression thereof
US6117847A (en) *	1992-03-16	2000-09-12	Isis Pharmaceuticals, Inc.	Oligonucleotides for enhanced modulation of protein kinase C expression
AU713740B2 (en) *	1992-03-16	1999-12-09	Isis Pharmaceuticals, Inc.	Oligonucleotide modulation of protein kinase C
NO180167C (no) *	1994-09-08	1997-02-26	Photocure As	Fotokjemisk fremgangsmåte til å innföre molekyler i cellers cytosol
US6645943B1 (en)	1994-10-25	2003-11-11	Hybridon, Inc.	Method of down-regulating gene expression
US5744460A (en) *	1996-03-07	1998-04-28	Novartis Corporation	Combination for treatment of proliferative diseases
AU4205597A (en) *	1996-08-20	1998-03-06	Novartis Ag	Methods for prevention of cellular proliferation and restenosis
GB9618376D0 (en)	1996-09-04	1996-10-16	Ciba Geigy Ag	Pharmaceutical compositions
US5989912A (en)	1996-11-21	1999-11-23	Oligos Etc. Inc.	Three component chimeric antisense oligonucleotides
US5849902A (en) *	1996-09-26	1998-12-15	Oligos Etc. Inc.	Three component chimeric antisense oligonucleotides
JP2002515513A (ja) *	1998-05-21	2002-05-28	アイシス・ファーマシューティカルス・インコーポレーテッド	核酸の肺送達のための組成物および方法
EP1086116A4 (en) *	1998-05-21	2004-03-17	Isis Pharmaceuticals Inc	COMPOSITIONS AND METHODS FOR THE PULMONATIVE TRANSPORT OF NUCLEIC ACIDS
US6077709A (en)	1998-09-29	2000-06-20	Isis Pharmaceuticals Inc.	Antisense modulation of Survivin expression
US6492111B1 (en)	1998-11-25	2002-12-10	Isis Pharmaceuticals, Inc.	In situ binary synthesis of biologically effective molecules
DE19956568A1 (de)	1999-01-30	2000-08-17	Roland Kreutzer	Verfahren und Medikament zur Hemmung der Expression eines vorgegebenen Gens
AU6071300A (en) *	1999-07-06	2001-01-22	Isis Pharmaceuticals, Inc.	Oligonucleotides incorporating both 2-aminoadenine and 5-substituted pyrimidines
US6190869B1 (en)	1999-10-26	2001-02-20	Isis Pharmaceuticals, Inc.	Antisense inhibition of protein kinase C-theta expression
US8008071B2 (en) *	1999-11-08	2011-08-30	University Of South Florida	Compositions and methods for detecting intracellular glucose and analogs thereof
US6852529B1 (en) *	1999-11-08	2005-02-08	University Of South Florida	Gloucose-regulated mRNA instability element
CN1274072C (zh) *	2000-08-03	2006-09-06	松下电器产业株式会社	无刷电机及其制造方法
US20050182006A1 (en) *	2001-05-18	2005-08-18	Sirna Therapeutics, Inc	RNA interference mediated inhibition of protein kinase C alpha (PKC-alpha) gene expression using short interfering nucleic acid (siNA)
US20030054381A1 (en) *	2001-05-25	2003-03-20	Pfizer Inc.	Genetic polymorphisms in the human neurokinin 1 receptor gene and their uses in diagnosis and treatment of diseases
US20040014049A1 (en) *	2002-07-19	2004-01-22	Isis Pharmaceuticals Inc.	Antisense modulation of protein kinase C-iota expression
FR2864539B1 (fr) *	2003-12-30	2012-10-26	Lvmh Rech	Oligonucleotide et son utilisation pour moduler l'expression de la proteine-kinase c isoforme beta-1 comme agent de depigmentation cutanee
WO2024028476A1 (en) *	2022-08-05	2024-02-08	Institut National de la Santé et de la Recherche Médicale	Methods for the treatment of th2-mediated diseases

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4511713A (en) *	1980-11-12	1985-04-16	The Johns Hopkins University	Process for selectively controlling unwanted expression or function of foreign nucleic acids in animal or mammalian cells
US5034506A (en) *	1985-03-15	1991-07-23	Anti-Gene Development Group	Uncharged morpholino-based polymers having achiral intersubunit linkages
WO1988001303A1 (en) *	1986-08-13	1988-02-25	Genetics Institute, Inc.	Protein kinase c enzymes
US5098890A (en) *	1988-11-07	1992-03-24	Temple University-Of The Commonwealth System Of Higher Education	Antisence oligonucleotides to c-myb proto-oncogene and uses thereof
US5138045A (en) *	1990-07-27	1992-08-11	Isis Pharmaceuticals	Polyamine conjugated oligonucleotides
EP0678029A1 (en) *	1993-01-13	1995-10-25	BURCOGLU, Arsinur	Method for using polynucleotides, oligonucleotides and derivatives thereof to treat various disease states
JPH08500018A (ja) *	1993-02-06	1996-01-09	ガーヴァンインスティチュートオブメディカルリサーチ	プロテインキナーゼｃ（イオタ）

1993
- 1993-02-25 AU AU38025/93A patent/AU675638B2/en not_active Ceased
- 1993-02-25 JP JP5516616A patent/JP2635216B2/ja not_active Expired - Fee Related
- 1993-02-25 KR KR1019940703206A patent/KR0157487B1/ko not_active Expired - Fee Related
- 1993-02-25 ES ES93907417T patent/ES2170065T3/es not_active Expired - Lifetime
- 1993-02-25 AT AT93907417T patent/ATE212063T1/de not_active IP Right Cessation
- 1993-02-25 EP EP93907417A patent/EP0672180B1/en not_active Expired - Lifetime
- 1993-02-25 HU HU9402657A patent/HU217179B/hu not_active IP Right Cessation
- 1993-02-25 CA CA002132094A patent/CA2132094A1/en not_active Abandoned
- 1993-02-25 EP EP02029096A patent/EP1310555A3/en not_active Withdrawn
- 1993-02-25 DE DE69331467T patent/DE69331467T2/de not_active Expired - Fee Related
- 1993-02-25 WO PCT/US1993/002213 patent/WO1993019203A1/en not_active Ceased
- 1993-02-25 EP EP01201830A patent/EP1126025A3/en not_active Withdrawn
- 1993-02-25 DK DK93907417T patent/DK0672180T3/da active
- 1993-07-09 US US08/089,996 patent/US5703054A/en not_active Expired - Fee Related
1994
- 1994-09-15 NO NO943438A patent/NO943438L/no unknown
- 1994-09-15 FI FI944276A patent/FI112379B/fi not_active IP Right Cessation
2003
- 2003-02-18 FI FI20030248A patent/FI113059B/fi not_active IP Right Cessation

Also Published As

Publication number	Publication date
EP1126025A3 (en)	2002-02-13
JPH07503856A (ja)	1995-04-27
US5703054A (en)	1997-12-30
FI113059B (fi)	2004-02-27
EP0672180A1 (en)	1995-09-20
ES2170065T3 (es)	2002-08-01
EP1310555A3 (en)	2003-08-27
EP0672180A4 (en)	1997-05-02
FI20030248L (fi)	2003-02-18
JP2635216B2 (ja)	1997-07-30
EP0672180B1 (en)	2002-01-16
HU217179B (hu)	1999-12-28
DE69331467T2 (de)	2002-11-07
HU9402657D0 (en)	1994-12-28
KR950700999A (ko)	1995-02-20
DE69331467D1 (de)	2002-02-21
FI944276A0 (fi)	1994-09-15
EP1126025A2 (en)	2001-08-22
CA2132094A1 (en)	1993-09-30
AU675638B2 (en)	1997-02-13
NO943438D0 (no)	1994-09-15
FI112379B (fi)	2003-11-28
WO1993019203A1 (en)	1993-09-30
KR0157487B1 (ko)	1998-10-15
DK0672180T3 (da)	2002-03-04
EP1310555A2 (en)	2003-05-14
ATE212063T1 (de)	2002-02-15
HUT69939A (en)	1995-09-28
AU3802593A (en)	1993-10-21
NO943438L (no)	1994-11-11

Publication	Publication Date	Title
FI944276A7 (fi)	1994-09-15	Proteiinikinaasi C-proteiinin modulaatio oligonukleotideilla
FI960089L (fi)	1996-03-07	Proteiinikinaasi C:n oligonukleotidimodulaatio
DK91192D0 (da)	1992-07-10	Protein
FI932282A7 (fi)	1993-11-22	Proteiini C-johdannaisia
FI933001L (fi)	1994-01-07	Antigastrit-aemne
DE69306530D1 (de)	1997-01-23	Heizapparat
FI930853L (fi)	1993-08-30	Haerdningsmedel foer epoxidharts
FI922002A0 (fi)	1992-05-04	Pipettilaitteisto
DE69309586D1 (de)	1997-05-15	Heizapparat
IT231472Y1 (it)	1999-08-03	Tramezza perfezionata per calzature.
FI934610A0 (fi)	1993-10-19	Ventilsammansaettning foer roerledning, omfattande loestagbart ventilsaete
FI952574L (fi)	1995-05-26	Glykosyylitransferaasiaktiiviset proteiinit
DK132892D0 (da)	1992-10-30	Proteiner
FI932516A7 (fi)	1993-12-04	Styrkonsol, i synnerhet foer motorfordon
FI931747A0 (fi)	1993-04-16	Reflexkropp, isynnerhet foer vaegmarkeringar
EP0668864A4 (en)	1995-07-10	SUBSTITUTED BIPHENYLMETHYLIMIDAZOPYRIDINE.
FR2687529B1 (fr)	1995-06-09	Repartiteur.
ATA20792A (de)	1995-11-15	Heizgerät
FI923709A0 (fi)	1992-08-19	I en saekerhetsskena laosbar vagn.
FI931825A7 (fi)	1993-10-24	Hydraulisk tryck- och draganordning, speciellt foer jaernvaegsskenor
NO944353D0 (no)	1994-11-15	Varmeanordning
DE69302869D1 (de)	1996-07-04	Heizapparat
FI266U1 (fi)	1992-09-16	Kapningsanordning foer aemnesbana, saosom en pappersbana
FI932595L (fi)	1993-12-09	En vattenhaltig, polymerisk, viskositet upphoejande komposition
DK120792D0 (da)	1992-09-30	Protein

Legal Events

Date	Code	Title	Description
2006-08-31	MA	Patent expired