NO180167C - Fotokjemisk fremgangsmåte til å innföre molekyler i cellers cytosol - Google Patents
Fotokjemisk fremgangsmåte til å innföre molekyler i cellers cytosolInfo
- Publication number
- NO180167C NO180167C NO943327A NO943327A NO180167C NO 180167 C NO180167 C NO 180167C NO 943327 A NO943327 A NO 943327A NO 943327 A NO943327 A NO 943327A NO 180167 C NO180167 C NO 180167C
- Authority
- NO
- Norway
- Prior art keywords
- cells
- cytosol
- introducing molecules
- photochemical method
- photodynamic treatment
- Prior art date
Links
- 210000004027 cell Anatomy 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 3
- 210000000172 cytosol Anatomy 0.000 title 1
- 238000002428 photodynamic therapy Methods 0.000 abstract 2
- 210000001163 endosome Anatomy 0.000 abstract 1
- 230000001939 inductive effect Effects 0.000 abstract 1
- 230000002132 lysosomal effect Effects 0.000 abstract 1
- 210000003712 lysosome Anatomy 0.000 abstract 1
- 230000001868 lysosomic effect Effects 0.000 abstract 1
- 239000012528 membrane Substances 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
- A61K41/0071—PDT with porphyrins having exactly 20 ring atoms, i.e. based on the non-expanded tetrapyrrolic ring system, e.g. bacteriochlorin, chlorin-e6, or phthalocyanines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Catalysts (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Priority Applications (24)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NO943327A NO180167C (no) | 1994-09-08 | 1994-09-08 | Fotokjemisk fremgangsmåte til å innföre molekyler i cellers cytosol |
| CZ97658A CZ65897A3 (en) | 1994-09-08 | 1995-09-04 | Method of transferring molecules into cytosol of cells, set for making the method and a mixture for modification neoplastic or other cellular processes |
| NZ509519A NZ509519A (en) | 1994-09-08 | 1995-09-04 | Transfer of molecules into the cytosol of cells |
| AU35347/95A AU700797B2 (en) | 1994-09-08 | 1995-09-04 | Transfer of molecules into the cytosol of cells |
| PCT/NO1995/000149 WO1996007432A1 (en) | 1994-09-08 | 1995-09-04 | Transfer of molecules into the cytosol of cells |
| HK98103468.0A HK1004110B (en) | 1994-09-08 | 1995-09-04 | Transfer of molecules into the cytosol of cells |
| CA2199290A CA2199290C (en) | 1994-09-08 | 1995-09-04 | Transfer of molecules into the cytosol of cells |
| NZ293008A NZ293008A (en) | 1994-09-08 | 1995-09-04 | Photoactivatable compound-carrier molecule conjugates for transfer into a cell cytosol where they are taken up by endosomes and lysosomes |
| US08/793,794 US5876989A (en) | 1994-09-08 | 1995-09-04 | Transfer of molecules into the cytosol of cells |
| MX9701676A MX9701676A (es) | 1994-09-08 | 1995-09-04 | Transferencia de moleculas al citosol de celulas. |
| JP50940496A JP4148328B2 (ja) | 1994-09-08 | 1995-09-04 | 細胞サイトゾルへの化合物の移入 |
| CNB951960652A CN1222309C (zh) | 1994-09-08 | 1995-09-04 | 将分子导入细胞溶质 |
| ES95932244T ES2163527T3 (es) | 1994-09-08 | 1995-09-04 | Transferencia de moleculas hacia el interior del citosol de las celulas por medio de sustancias fotosensibilizadoras. |
| BRPI9508825A BRPI9508825B8 (pt) | 1994-09-08 | 1995-09-04 | processo de transferência de moléculas para o citosol de células, composição e kit |
| PT95932244T PT783323E (pt) | 1994-09-08 | 1995-09-04 | Transferencia de moleculas para o citosol de celulas por meio de compostos fotossensibilizantes |
| DE69524238T DE69524238T2 (de) | 1994-09-08 | 1995-09-04 | Transfer von molekülen in das zytosol von zellen durch photosensibilisierende substanzen |
| EP95932244A EP0783323B1 (en) | 1994-09-08 | 1995-09-04 | Transfer of molecules into the cytosol of cells by photosensitizing compounds |
| AT95932244T ATE209507T1 (de) | 1994-09-08 | 1995-09-04 | Transfer von molekülen in das zytosol von zellen durch photosensibilisierende substanzen |
| HU9800153A HU222984B1 (hu) | 1994-09-08 | 1995-09-04 | Eljárás molekulák in vitro bevezetésére élő sejtek citoszoljába, fotoszenzibilizáló vegyület alkalmazásával |
| KR1019970701520A KR100395615B1 (ko) | 1994-09-08 | 1995-09-14 | 세포의시토졸내로분자를전달시키는방법 |
| KR10-2003-7005142A KR100529967B1 (ko) | 1994-09-08 | 1995-09-14 | 세포의 시토졸내로 분자를 전달시키는 조성물 |
| FI970983A FI121328B (fi) | 1994-09-08 | 1997-03-07 | Molekyylien siirto solujen sytosoliin |
| US09/144,750 US6680301B2 (en) | 1994-09-08 | 1998-09-01 | Transfer of molecules into the cytosol of cells |
| US10/286,632 US20030134813A1 (en) | 1994-09-08 | 2002-11-01 | Transfer of molecules into the cytosol of cells |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NO943327A NO180167C (no) | 1994-09-08 | 1994-09-08 | Fotokjemisk fremgangsmåte til å innföre molekyler i cellers cytosol |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| NO943327D0 NO943327D0 (no) | 1994-09-08 |
| NO943327L NO943327L (no) | 1996-03-11 |
| NO180167B NO180167B (no) | 1996-11-18 |
| NO180167C true NO180167C (no) | 1997-02-26 |
Family
ID=19897382
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO943327A NO180167C (no) | 1994-09-08 | 1994-09-08 | Fotokjemisk fremgangsmåte til å innföre molekyler i cellers cytosol |
Country Status (19)
| Country | Link |
|---|---|
| US (3) | US5876989A (no) |
| EP (1) | EP0783323B1 (no) |
| JP (1) | JP4148328B2 (no) |
| KR (2) | KR100529967B1 (no) |
| CN (1) | CN1222309C (no) |
| AT (1) | ATE209507T1 (no) |
| AU (1) | AU700797B2 (no) |
| BR (1) | BRPI9508825B8 (no) |
| CA (1) | CA2199290C (no) |
| CZ (1) | CZ65897A3 (no) |
| DE (1) | DE69524238T2 (no) |
| ES (1) | ES2163527T3 (no) |
| FI (1) | FI121328B (no) |
| HU (1) | HU222984B1 (no) |
| MX (1) | MX9701676A (no) |
| NO (1) | NO180167C (no) |
| NZ (2) | NZ509519A (no) |
| PT (1) | PT783323E (no) |
| WO (1) | WO1996007432A1 (no) |
Families Citing this family (85)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NO180167C (no) * | 1994-09-08 | 1997-02-26 | Photocure As | Fotokjemisk fremgangsmåte til å innföre molekyler i cellers cytosol |
| US6210356B1 (en) * | 1998-08-05 | 2001-04-03 | Ekos Corporation | Ultrasound assembly for use with a catheter |
| US6176842B1 (en) * | 1995-03-08 | 2001-01-23 | Ekos Corporation | Ultrasound assembly for use with light activated drugs |
| ATE409005T1 (de) * | 1997-03-19 | 2008-10-15 | Lucid Inc | Zellchirurgie unter benutzung konfokaler mikroskopie |
| US6676626B1 (en) | 1998-05-01 | 2004-01-13 | Ekos Corporation | Ultrasound assembly with increased efficacy |
| US6582392B1 (en) * | 1998-05-01 | 2003-06-24 | Ekos Corporation | Ultrasound assembly for use with a catheter |
| US6835393B2 (en) * | 1998-01-05 | 2004-12-28 | University Of Washington | Enhanced transport using membrane disruptive agents |
| US6399769B1 (en) * | 1998-01-20 | 2002-06-04 | Kimberly-Clark Worldwide, Inc. | Method of making sulfanatophenyl substituted porphines |
| GB9905911D0 (en) * | 1999-03-15 | 1999-05-05 | Photocure As | Method |
| WO2001019953A1 (en) | 1999-09-09 | 2001-03-22 | Center For Advanced Science And Technology Incubation, Ltd. | Method of piercing membrane and apparatus therefor |
| US20040220100A1 (en) * | 2000-07-21 | 2004-11-04 | Essentia Biosystems, Inc. | Multi-component biological transport systems |
| EP1301213B1 (en) * | 2000-07-21 | 2017-01-18 | ReVance Therapeutics, Inc. | Multi-component biological transport systems |
| CZ303792B6 (cs) * | 2000-11-29 | 2013-05-09 | Pci Biotech As | Zpusob zavedení molekuly do bunky |
| AU2002220853B2 (en) * | 2000-11-29 | 2007-06-28 | Pci Biotech As | Photochemical internalization for delivery of molecules into the cytosol |
| US20020098472A1 (en) * | 2000-11-30 | 2002-07-25 | Erlach Julian Van | Method for inserting a microdevice or a nanodevice into a body fluid stream |
| US20020137901A1 (en) * | 2001-01-22 | 2002-09-26 | Cavanaugh Philip Gerard | Synthesis, and photodynamic therapy-mediated anti-cancer, and other uses of chlorin e6-transferrin |
| AU2002250034A1 (en) * | 2001-02-08 | 2002-08-19 | Sequitur, Inc. | Methods of light activated release 0f ligands from endosomes |
| DE60232149D1 (de) * | 2001-06-20 | 2009-06-10 | Dainippon Sumitomo Pharma Co | Verfahren zur förderung des nukleinsäuretransfers |
| GB0121023D0 (en) * | 2001-08-30 | 2001-10-24 | Norwegian Radium Hospital Res | Compound |
| AU2002359576A1 (en) | 2001-12-03 | 2003-06-17 | Ekos Corporation | Catheter with multiple ultrasound radiating members |
| US7141044B2 (en) * | 2001-12-11 | 2006-11-28 | Ekos Corporation | Alternate site gene therapy |
| US20060009409A1 (en) * | 2002-02-01 | 2006-01-12 | Woolf Tod M | Double-stranded oligonucleotides |
| EP2128248B2 (en) | 2002-02-01 | 2017-01-11 | Life Technologies Corporation | Oligonucleotide compositions with enhanced efficiency |
| EP1572902B1 (en) * | 2002-02-01 | 2014-06-11 | Life Technologies Corporation | HIGH POTENCY siRNAS FOR REDUCING THE EXPRESSION OF TARGET GENES |
| US8226629B1 (en) | 2002-04-01 | 2012-07-24 | Ekos Corporation | Ultrasonic catheter power control |
| US20040248094A1 (en) * | 2002-06-12 | 2004-12-09 | Ford Lance P. | Methods and compositions relating to labeled RNA molecules that reduce gene expression |
| GB0215534D0 (en) * | 2002-07-04 | 2002-08-14 | Ecole Polytech | Selective photochemotherapy using oligonucleotide targeting agents |
| US20040029275A1 (en) * | 2002-08-10 | 2004-02-12 | David Brown | Methods and compositions for reducing target gene expression using cocktails of siRNAs or constructs expressing siRNAs |
| US6921371B2 (en) * | 2002-10-14 | 2005-07-26 | Ekos Corporation | Ultrasound radiating members for catheter |
| JP2006517790A (ja) * | 2003-01-09 | 2006-08-03 | インヴィトロジェン コーポレーション | ポリペプチド−核酸複合体の細胞の送達および活性化 |
| US7332477B2 (en) * | 2003-07-10 | 2008-02-19 | Nitto Denko Corporation | Photocleavable DNA transfer agent |
| WO2005032597A1 (en) * | 2003-09-29 | 2005-04-14 | Nitto Denko Corporation | Biodegradable polyacetals for in vivo polynucleotide delivery |
| WO2005061717A1 (ja) * | 2003-12-19 | 2005-07-07 | Dainippon Sumitomo Pharma Co., Ltd. | 新規な核酸導入法 |
| AU2005218665A1 (en) * | 2004-03-03 | 2005-09-15 | Revance Therapeutics, Inc. | Compositions and methods for topical application and transdermal delivery of botulinum toxins |
| SG150570A1 (en) * | 2004-03-03 | 2009-03-30 | Revance Therapeutics Inc | Compositions and methods for topical diagnostic and therapeutic transport |
| US9211248B2 (en) | 2004-03-03 | 2015-12-15 | Revance Therapeutics, Inc. | Compositions and methods for topical application and transdermal delivery of botulinum toxins |
| GB0415263D0 (en) * | 2004-07-07 | 2004-08-11 | Norwegian Radium Hospital Res | Method |
| US20060094781A1 (en) * | 2004-11-04 | 2006-05-04 | Syneron Medical Ltd. | Method of treating extracellular matrix |
| FR2877943B1 (fr) * | 2004-11-16 | 2008-09-05 | Univ De Coimbra | Nouveaux derives de porphyrine, notamment chlorines et/ou bacteriochlorine, et leurs applications en therapie photodynamique |
| SG160357A1 (en) | 2005-03-03 | 2010-04-29 | Revance Therapeutics Inc | Compositions and methods for topical application and transdermal delivery of botulinum toxins |
| NZ560799A (en) * | 2005-03-03 | 2009-10-30 | Revance Therapeutics Inc | Compositions and methods for topical application and transdermal delivery of an oligopeptide |
| US7674452B2 (en) * | 2005-03-16 | 2010-03-09 | Nitto Denko Corporation | Polymer coating of cells |
| BRPI0501037B8 (pt) * | 2005-03-18 | 2021-07-27 | Fund De Amparo A Pesquisa Do Estado De Sao Paulo | uso de crotamina e composição |
| CN103126971A (zh) * | 2005-11-17 | 2013-06-05 | 雷文斯治疗公司 | 减少非毒素蛋白质的肉毒杆菌毒素组合物和其局部施用及透皮递送方法 |
| WO2007109584A1 (en) * | 2006-03-16 | 2007-09-27 | University Of Washington | Temperature-and ph-responsive polymer compositions |
| GB0613753D0 (en) | 2006-07-11 | 2006-08-23 | Norwegian Radium Hospital Res | Method |
| EP2099496A2 (en) * | 2006-12-08 | 2009-09-16 | Massachusetts Institute of Technology | Delivery of nanoparticles and/or agents to cells |
| BRPI0720730A2 (pt) * | 2006-12-29 | 2014-04-08 | Revance Therapeutics Inc | Composições e métodos de aplicação tópica e liberação transdérmica de toxinas botulínicas estabilizadas com fragmentos de polipeptídeo derivados de hiv-tat. |
| US20080226551A1 (en) * | 2006-12-29 | 2008-09-18 | Revance Therapeutics, Inc. | Transport Molecules Using Reverse Sequence HIV-TAT Polypeptides |
| US10182833B2 (en) | 2007-01-08 | 2019-01-22 | Ekos Corporation | Power parameters for ultrasonic catheter |
| US7981688B2 (en) | 2007-03-08 | 2011-07-19 | University Of Washington | Stimuli-responsive magnetic nanoparticles and related methods |
| ES2471118T3 (es) | 2007-06-22 | 2014-06-25 | Ekos Corporation | Método y aparato para el tratamiento de hemorragias intracraneales |
| WO2009079415A1 (en) * | 2007-12-14 | 2009-06-25 | Ekos Corporation | Ultrasound pulse shaping |
| GB0811955D0 (en) | 2008-06-30 | 2008-07-30 | Pci Biotech As | Method |
| US8426214B2 (en) * | 2009-06-12 | 2013-04-23 | University Of Washington | System and method for magnetically concentrating and detecting biomarkers |
| GB0914287D0 (en) | 2009-08-14 | 2009-09-30 | Pci Biotech As | Compositions |
| GB0914286D0 (en) * | 2009-08-14 | 2009-09-30 | Pci Biotech As | Method |
| US9080933B2 (en) | 2009-11-09 | 2015-07-14 | University Of Washington Through Its Center For Commercialization | Stimuli-responsive polymer diagnostic assay comprising magnetic nanoparticles and capture conjugates |
| US20110117668A1 (en) * | 2009-11-09 | 2011-05-19 | University Of Washington Through Its Center For Commercialization | Self-powered smart diagnostic devices |
| GB201208548D0 (en) | 2012-05-15 | 2012-06-27 | Pci Biotech As | Compound and method |
| US20160040128A1 (en) | 2013-03-15 | 2016-02-11 | Pci Biotech As | Method |
| GB2517707B (en) | 2013-08-28 | 2020-09-02 | Pci Biotech As | A device for light-induced rupture of endocytic vesicles to effect the delivery of an antigen |
| CA2922320C (en) | 2013-08-28 | 2022-11-22 | Pci Biotech As | Enhanced photochemical internalisation using a tlr ligand |
| WO2015154832A1 (en) | 2014-04-11 | 2015-10-15 | Pci Biotech As | Method of treating melanoma |
| KR102678732B1 (ko) | 2014-08-28 | 2024-06-25 | 피씨아이 바이오테크 에이에스 | 화합물 및 방법 |
| GB201503776D0 (en) | 2015-03-05 | 2015-04-22 | Pci Biotech As | Compound and method |
| EP3307388B1 (en) | 2015-06-10 | 2022-06-22 | Ekos Corporation | Ultrasound catheter |
| KR20190068573A (ko) | 2016-10-14 | 2019-06-18 | 피씨아이 바이오테크 에이에스 | 젬시타빈의 tpcs-2a 유도된 광화학 내재화로의 담관암의 치료 |
| GB201718631D0 (en) | 2017-11-10 | 2017-12-27 | Pci Biotech As | Method |
| GB201801169D0 (en) * | 2018-01-24 | 2018-03-07 | Pci Biotech As | Method |
| WO2020017962A1 (en) | 2018-07-16 | 2020-01-23 | Dcprime B.V. | A combination product for use in tumor vaccination. |
| US11052144B2 (en) | 2019-04-25 | 2021-07-06 | Dcprime B.V. | Methods of tumor vaccination |
| CN110711249B (zh) * | 2019-09-19 | 2020-10-27 | 北京化工大学 | 一种溶酶体膜包覆纳米颗粒的制备方法 |
| CA3172447A1 (en) | 2020-03-27 | 2021-09-30 | Erik Hans MANTING | In vivo use of modified cells of leukemic origin for enhancing the efficacy of adoptive cell therapy |
| AU2021243864A1 (en) | 2020-03-27 | 2022-11-03 | Mendus B.V. | Ex vivo use of modified cells of leukemic origin for enhancing the efficacy of adoptive cell therapy |
| CA3182607A1 (en) | 2020-06-30 | 2022-01-06 | Erik Hans MANTING | Use of leukemia-derived cells in ovarian cancer vaccines |
| CN114163508B (zh) * | 2020-09-11 | 2024-07-16 | 王月志 | 能破坏细胞的氨基酸序列及相关核苷酸序列和相关的应用 |
| CA3196677A1 (en) | 2020-11-05 | 2022-05-12 | Erik Hans MANTING | Use of tumor-independent antigens in immunotherapies |
| AU2022211682A1 (en) | 2021-01-22 | 2023-08-03 | Mendus B.V. | Methods of tumor vaccination |
| GB202101726D0 (en) | 2021-02-08 | 2021-03-24 | Pci Biotech As | Method |
| WO2022190058A1 (en) | 2021-03-12 | 2022-09-15 | Dcprime B.V. | Methods of vaccination and use of cd47 blockade |
| GB202115451D0 (en) | 2021-10-27 | 2021-12-08 | Pci Biotech As | Method |
| IL319617A (en) | 2022-09-27 | 2025-05-01 | Pci Biotech As | Method for releasing viral vectors |
| GB202301312D0 (en) | 2023-01-30 | 2023-03-15 | Pci Biotech As | Method and product |
| GB202404168D0 (en) | 2024-03-22 | 2024-05-08 | Pci Biotech As | Method |
Family Cites Families (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU563827B2 (en) | 1982-07-01 | 1987-07-23 | Millipore Corp. | Filtration apparatus |
| US4649151A (en) * | 1982-09-27 | 1987-03-10 | Health Research, Inc. | Drugs comprising porphyrins |
| US4704255A (en) | 1983-07-15 | 1987-11-03 | Pandex Laboratories, Inc. | Assay cartridge |
| US5066274A (en) * | 1985-04-30 | 1991-11-19 | Nippon Petrochemicals Company, Ltd. | Tetrapyrrole therapeutic agents |
| US5076950A (en) | 1985-12-20 | 1991-12-31 | Syntex (U.S.A.) Inc. | Magnetic composition for particle separation |
| US4895706A (en) | 1986-10-28 | 1990-01-23 | Costar Corporation | Multi-well filter strip and composite assemblies |
| US5095030A (en) * | 1987-01-20 | 1992-03-10 | University Of British Columbia | Wavelength-specific cytotoxic agents |
| NO891491L (no) * | 1987-08-12 | 1989-04-11 | Peter Nemeth | Prosedyre for befrielse av celleblandinger og vev for uoenskede populasjoner. |
| HU204856B (en) | 1987-08-12 | 1992-02-28 | Orszagos Mueszaki Fejlesztesi | Process for releasing cell mixtures and tissues from undesired populations and for producing monoclonal antibody - hematoporphyrin conjugates |
| GB8721108D0 (en) * | 1987-09-08 | 1987-10-14 | Salford University Of | Liposomes |
| US5284647A (en) * | 1988-03-18 | 1994-02-08 | Schering Aktiengesellschaft | Mesotetraphenylporphyrin complex compounds, process for their production and pharmaceutical agents containing them |
| US5256532A (en) | 1988-05-02 | 1993-10-26 | Zynaxis Technologies, Inc. | Methods, reagents and test kits for determination of subpopulations of biological entities |
| US4925736A (en) * | 1988-07-06 | 1990-05-15 | Long Island Jewish Medical Center | Topical hematoporphyrin |
| GB8905001D0 (en) | 1989-03-04 | 1989-04-19 | Univ Leicester | Screening for natural products of microbial metabolism |
| US5567687A (en) * | 1989-03-06 | 1996-10-22 | University Of Texas | Texaphyrins and uses thereof |
| US4935498A (en) * | 1989-03-06 | 1990-06-19 | Board Of Regents, The University Of Texas System | Expanded porphyrins: large porphyrin-like tripyrroledimethine-derived macrocycles |
| US5328470A (en) * | 1989-03-31 | 1994-07-12 | The Regents Of The University Of Michigan | Treatment of diseases by site-specific instillation of cells or site-specific transformation of cells and kits therefor |
| US5059619A (en) * | 1989-06-14 | 1991-10-22 | Quadra Logic Technologies, Inc. | Stable freeze-dried polyhematoporphyrin ether/ester |
| DE3919873A1 (de) | 1989-06-19 | 1990-12-20 | Behringwerke Ag | Magnetische protein-konjugate, verfahren zu ihrer herstellung und ihre verwendung |
| GB8916859D0 (en) | 1989-07-24 | 1989-09-06 | Dynal As | Hapten linking |
| GB8929297D0 (en) | 1989-12-29 | 1990-02-28 | Dynal As | Method of separation |
| US5200084A (en) | 1990-09-26 | 1993-04-06 | Immunicon Corporation | Apparatus and methods for magnetic separation |
| US5491068A (en) | 1991-02-14 | 1996-02-13 | Vicam, L.P. | Assay method for detecting the presence of bacteria |
| US5179120A (en) * | 1991-06-28 | 1993-01-12 | Cytopharm, Inc. | Porphycene compounds for photodynamic therapy |
| PL165249B1 (pl) * | 1991-10-29 | 1994-11-30 | Wojskowa Akad Tech | Sposób otrzymywania soli kompleksowych hematoporfiryny i jej pochodnych PL PL PL PL PL PL PL |
| US5376546A (en) * | 1991-11-04 | 1994-12-27 | Xoma Corporation | Analogs of ribosome-inactivating proteins |
| US5258453A (en) * | 1992-01-21 | 1993-11-02 | University Of Utah | Drug delivery system for the simultaneous delivery of drugs activatable by enzymes and light |
| CA2132094A1 (en) * | 1992-03-16 | 1993-09-30 | C. Frank Bennett | Oligonucleotide modulation of protein kinase c |
| JPH07509120A (ja) | 1992-03-20 | 1995-10-12 | セルシス・インターナショナル・パブリック・リミテッド・カンパニー | 生物学的物質の分析方法およびその装置 |
| DE69333955D1 (de) * | 1992-04-24 | 2006-02-02 | Stanford Res Inst Int | Targeting homologer sequenzen in eukaryotenzellen |
| WO1994007138A1 (en) | 1992-09-14 | 1994-03-31 | Fodstad Oystein | Detection of specific target cells in specialized or mixed cell population and solutions containing mixed cell populations |
| WO1994010301A1 (en) * | 1992-11-03 | 1994-05-11 | Gene Shears Pty. Limited | TNF-α RIBOZYMES AND DEGRADATION RESISTANT mRNA DERIVATIVES LINKED TO TNF-α RIBOZYMES |
| FR2700010B1 (fr) | 1992-12-24 | 1995-03-17 | Rocher Yves Biolog Vegetale | Méthode et dispositif pour tester la réactivité de cellules à l'égard de produits. |
| US5374531A (en) | 1993-03-22 | 1994-12-20 | Zynaxis, Inc. | Immunoassay for determination of cells |
| US5861310A (en) * | 1993-11-03 | 1999-01-19 | Dana-Farber Cancer Institute | Tumor cells modified to express B7-2 with increased immunogenicity and uses therefor |
| US5491084A (en) * | 1993-09-10 | 1996-02-13 | The Trustees Of Columbia University In The City Of New York | Uses of green-fluorescent protein |
| US6015897A (en) * | 1993-12-07 | 2000-01-18 | Neorx Corporation | Biotinamido-n-methylglycyl-seryl-o-succinamido-benzyl dota |
| US5514340A (en) | 1994-01-24 | 1996-05-07 | Magnetix Biotechnology, Inc. | Device for separating magnetically labelled cells |
| NO180658C (no) | 1994-03-10 | 1997-05-21 | Oeystein Fodstad | Fremgangsmåte og anordning for deteksjon av spesifikke målceller i spesialiserte eller blandede cellepopulasjoner og opplösninger som inneholder blandede cellepopulasjoner |
| NO180167C (no) * | 1994-09-08 | 1997-02-26 | Photocure As | Fotokjemisk fremgangsmåte til å innföre molekyler i cellers cytosol |
| US5872007A (en) * | 1995-02-17 | 1999-02-16 | Hybridon, Inc. | CAPL-specific oligonucleotides and methods of inhibiting metastatic cancer |
-
1994
- 1994-09-08 NO NO943327A patent/NO180167C/no not_active IP Right Cessation
-
1995
- 1995-09-04 PT PT95932244T patent/PT783323E/pt unknown
- 1995-09-04 ES ES95932244T patent/ES2163527T3/es not_active Expired - Lifetime
- 1995-09-04 BR BRPI9508825A patent/BRPI9508825B8/pt not_active IP Right Cessation
- 1995-09-04 NZ NZ509519A patent/NZ509519A/en not_active IP Right Cessation
- 1995-09-04 JP JP50940496A patent/JP4148328B2/ja not_active Expired - Fee Related
- 1995-09-04 CA CA2199290A patent/CA2199290C/en not_active Expired - Lifetime
- 1995-09-04 CN CNB951960652A patent/CN1222309C/zh not_active Expired - Lifetime
- 1995-09-04 AU AU35347/95A patent/AU700797B2/en not_active Expired
- 1995-09-04 US US08/793,794 patent/US5876989A/en not_active Expired - Lifetime
- 1995-09-04 HU HU9800153A patent/HU222984B1/hu active IP Right Grant
- 1995-09-04 EP EP95932244A patent/EP0783323B1/en not_active Expired - Lifetime
- 1995-09-04 WO PCT/NO1995/000149 patent/WO1996007432A1/en not_active Ceased
- 1995-09-04 MX MX9701676A patent/MX9701676A/es unknown
- 1995-09-04 NZ NZ293008A patent/NZ293008A/en not_active IP Right Cessation
- 1995-09-04 CZ CZ97658A patent/CZ65897A3/cs unknown
- 1995-09-04 AT AT95932244T patent/ATE209507T1/de active
- 1995-09-04 DE DE69524238T patent/DE69524238T2/de not_active Expired - Lifetime
- 1995-09-14 KR KR10-2003-7005142A patent/KR100529967B1/ko not_active Expired - Fee Related
- 1995-09-14 KR KR1019970701520A patent/KR100395615B1/ko not_active Expired - Lifetime
-
1997
- 1997-03-07 FI FI970983A patent/FI121328B/fi not_active IP Right Cessation
-
1998
- 1998-09-01 US US09/144,750 patent/US6680301B2/en not_active Expired - Fee Related
-
2002
- 2002-11-01 US US10/286,632 patent/US20030134813A1/en not_active Abandoned
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| NO180167C (no) | Fotokjemisk fremgangsmåte til å innföre molekyler i cellers cytosol | |
| MXPA03002413A (es) | Moleculas tipo b7 y uso de las mismas. | |
| AU2001290706A1 (en) | Antisense modulation of clusterin expression | |
| BR0210839A (pt) | Sistema de recombinação, método para remover uma sequência de dna do dna cromossÈmico de uma célula ou organismo eucarióticos, organismo, cultura de célula, órgão, tecido, parte ou material de propagação transgênico, e, uso de um organismo ou de uma cultura de célula, órgão, tecido, parte ou material de propagação transgênico | |
| EP0883344A4 (en) | THERAPEUTIC MOLECULES OBTAINED BY TRANS-SPLITTING | |
| AU5753598A (en) | Novel genes coding for amino acid deacetylases with specificity for N-acetyl-L-phosphinothricin, their isolation and use | |
| CA2394984A1 (en) | Novel plant expression constructs | |
| DK0923592T3 (da) | Fremgangsmåder til rensning af nukleinsyrer | |
| EP2199299A3 (en) | Antisense modulation of survivin expression | |
| BR0012325A (pt) | Métodos e composições para prevenção da formação de rna anormal durante a transcrição de uma sequência de plasmìdeo | |
| WO2003011887A3 (en) | Antisense modulation of apolipoprotein b expression | |
| TR200000755T2 (tr) | Karşıt olma-karşı gelme bozukluğunun tedavisi. | |
| AR023482A1 (es) | Acidos nucleicos que codifican polipeptidos quimericos cd40/cd4ol, metodos para su produccion y usos de los mismos | |
| WO2001029175A3 (en) | Antisense modulation of fra-1 expression | |
| ATE402257T1 (de) | Antisense gegen c-myc zur behandlung von polyzystischer nierenkrankheit | |
| WO2002050248A3 (en) | Antisense modulation of hepsin expression | |
| MXPA03010728A (es) | Moleculas de proteina-2 relacionadas con b7 y uso de las mismas. | |
| WO2003056897A3 (en) | Highly phosphorylated acid beta-glucocerebrosidase and methods of treating gaucher's disease | |
| GEP19991780B (en) | Use of Pyrrolidine Derivatives for Treating Alcoholism | |
| WO2003050247A3 (en) | Antisense modulation of mhc class ii transactivator expression | |
| WO2003027229A3 (en) | Antisense modulation of rip2 expression | |
| AU6113098A (en) | Compositions for treatment of disorders involving programmed cell death | |
| WO2003040161A3 (en) | Antisense modulation of activating transcription factor 3 expression | |
| WO2000061786A3 (en) | Antisense modulation of pdk-1 expression | |
| ATE301721T1 (de) | In vivo herstellung von replicativen molekülen |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MK1K | Patent expired |