FI932561A0 - Proteiner med foeraendrade epitoper och foerfaranden foer deras framstaellning - Google Patents
Proteiner med foeraendrade epitoper och foerfaranden foer deras framstaellningInfo
- Publication number
- FI932561A0 FI932561A0 FI932561A FI932561A FI932561A0 FI 932561 A0 FI932561 A0 FI 932561A0 FI 932561 A FI932561 A FI 932561A FI 932561 A FI932561 A FI 932561A FI 932561 A0 FI932561 A0 FI 932561A0
- Authority
- FI
- Finland
- Prior art keywords
- protein
- pharyngeal
- intact epithelium
- variants
- epithelium
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6878—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids in epitope analysis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/38—Products with no well-defined composition, e.g. natural products
- C11D3/386—Preparations containing enzymes, e.g. protease or amylase
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/38—Products with no well-defined composition, e.g. natural products
- C11D3/386—Preparations containing enzymes, e.g. protease or amylase
- C11D3/38627—Preparations containing enzymes, e.g. protease or amylase containing lipase
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/38—Products with no well-defined composition, e.g. natural products
- C11D3/386—Preparations containing enzymes, e.g. protease or amylase
- C11D3/38645—Preparations containing enzymes, e.g. protease or amylase containing cellulase
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/38—Products with no well-defined composition, e.g. natural products
- C11D3/386—Preparations containing enzymes, e.g. protease or amylase
- C11D3/38654—Preparations containing enzymes, e.g. protease or amylase containing oxidase or reductase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
- C12N9/54—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea bacteria being Bacillus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Wood Science & Technology (AREA)
- Biochemistry (AREA)
- Zoology (AREA)
- Immunology (AREA)
- Genetics & Genomics (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Biotechnology (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Food Science & Technology (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Analytical Chemistry (AREA)
- Cell Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Physics & Mathematics (AREA)
- Veterinary Medicine (AREA)
- Diabetes (AREA)
- General Engineering & Computer Science (AREA)
- Nutrition Science (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP90610072 | 1990-12-05 | ||
| PCT/DK1991/000382 WO1992010755A1 (en) | 1990-12-05 | 1991-12-05 | Proteins with changed epitopes and methods for the production thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| FI932561A0 true FI932561A0 (fi) | 1993-06-04 |
| FI932561A7 FI932561A7 (fi) | 1993-06-04 |
| FI932561L FI932561L (fi) | 1993-06-04 |
Family
ID=8205875
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI932561A FI932561L (fi) | 1990-12-05 | 1991-12-05 | Proteiner med foeraendrade epitoper och foerfaranden foer deras framstaellning |
Country Status (11)
| Country | Link |
|---|---|
| EP (1) | EP0561907B1 (fi) |
| JP (3) | JP3355186B2 (fi) |
| KR (1) | KR100237968B1 (fi) |
| AT (1) | ATE170630T1 (fi) |
| AU (1) | AU9052891A (fi) |
| BR (1) | BR9107206A (fi) |
| CA (2) | CA2095852C (fi) |
| DE (1) | DE69130113T2 (fi) |
| DK (1) | DK0561907T3 (fi) |
| FI (1) | FI932561L (fi) |
| WO (1) | WO1992010755A1 (fi) |
Families Citing this family (78)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL178045B1 (pl) * | 1992-07-17 | 2000-02-29 | Genencor Int | Mutant proteazy do stosowania w detergentach, sekwencja DNA kodująca mutanta proteazy, sposób otrzymywania mutanta proteazy oraz kompozycja detergentowa |
| EP0786085A4 (en) * | 1994-10-14 | 1999-02-03 | Chiron Mimotopes Pty Ltd | EFFICIENT METHOD OF DISCOVERING MIMOTOPES AND APPARATUS THEREOF |
| EP1017794A1 (en) * | 1997-02-06 | 2000-07-12 | Novo Nordisk A/S | Polypeptide-polymer conjugates having added and/or removed attachment groups |
| US6284246B1 (en) | 1997-07-30 | 2001-09-04 | The Procter & Gamble Co. | Modified polypeptides with high activity and reduced allergenicity |
| ES2590912T3 (es) | 1997-12-08 | 2016-11-24 | Merck Patent Gmbh | Proteínas de fusión heterodiméricas útiles para inmunoterapia dirigida y estimulación general del sistema inmunitario |
| CA2324422A1 (en) * | 1998-03-26 | 1999-09-30 | The Procter & Gamble Company | Serine protease variants having amino acid deletions and substitutions |
| US6495136B1 (en) | 1998-03-26 | 2002-12-17 | The Procter & Gamble Company | Proteases having modified amino acid sequences conjugated to addition moieties |
| US6908757B1 (en) | 1998-03-26 | 2005-06-21 | The Procter & Gamble Company | Serine protease variants having amino acid deletions and substitutions |
| AU2742499A (en) * | 1998-03-26 | 1999-10-18 | Procter & Gamble Company, The | Serine protease variants having amino acid substitutions |
| US6838269B1 (en) * | 1998-04-15 | 2005-01-04 | Genencor International, Inc. | Proteins producing an altered immunogenic response and methods of making and using the same |
| US6642011B2 (en) * | 1998-04-15 | 2003-11-04 | Genencor International, Inc. | Human protease and use of such protease for pharmaceutical applications and for reducing the allergenicity of non-human proteins |
| US6835550B1 (en) * | 1998-04-15 | 2004-12-28 | Genencor International, Inc. | Mutant proteins having lower allergenic response in humans and methods for constructing, identifying and producing such proteins |
| US6936249B1 (en) | 1998-04-15 | 2005-08-30 | Genencor International, Inc. | Proteins producing an altered immunogenic response and methods of making and using the same |
| US6461849B1 (en) * | 1998-10-13 | 2002-10-08 | Novozymes, A/S | Modified polypeptide |
| US6686164B1 (en) | 1998-10-30 | 2004-02-03 | Novozymes A/S | Low allergenic protein variants |
| NZ511291A (en) * | 1998-10-30 | 2003-08-29 | Novozymes As | A method for selecting a protein variant that has reduced immunogenicity as compared with the parent or wild-type protein |
| ATE352559T1 (de) * | 1998-12-08 | 2007-02-15 | Biovation Ltd | Verfahren zur verminderung der immunogenität von proteinen |
| CA2379729A1 (en) | 1999-07-22 | 2001-02-01 | The Procter & Gamble Company | Protease conjugates having sterically protected clip sites |
| CN1369008A (zh) * | 1999-07-22 | 2002-09-11 | 宝洁公司 | 免疫原性降低的分子内交联的枯草杆菌蛋白酶 |
| CZ2002211A3 (cs) * | 1999-07-22 | 2002-05-15 | The Procter & Gamble Company | Proteázové konjugáty se stericky chráněnými oblastmi epitopu |
| BR0012660A (pt) * | 1999-07-22 | 2002-04-09 | Procter & Gamble | Variante de protease tipo subtilisina; composição de limpeza; e composição de cuidado pessoal |
| US6946128B1 (en) | 1999-07-22 | 2005-09-20 | The Procter & Gamble Company | Protease conjugates having sterically protected epitope regions |
| BR0012693A (pt) * | 1999-07-22 | 2002-04-09 | Procter & Gamble | Variante, de protease tipo subtilisina; composição de limpeza; e composição de cuidado pessoal |
| JP4793971B2 (ja) | 1999-08-09 | 2011-10-12 | メルク パテント ゲーエムベーハー | 複合サイトカイン−抗体複合体 |
| EP1228214A2 (en) | 1999-11-12 | 2002-08-07 | MERCK PATENT GmbH | Erythropoietin forms with improved properties |
| ATE336514T1 (de) | 2000-02-11 | 2006-09-15 | Merck Patent Gmbh | Steigerung der zirkulierenden halbwertzeit von auf antikörpern basierenden fusionsproteinen |
| WO2001083761A1 (en) * | 2000-04-28 | 2001-11-08 | Novozymes A/S | Laccase mutants |
| RU2272644C2 (ru) | 2000-06-29 | 2006-03-27 | Мерк Патент Гмбх | Усиление иммунной реакции, медиатором которой является слитый протеин антитело-цитокин, при помощи комбинированного лечения агентами, увеличивающими поглощение иммуноцитокина |
| EP1307547B1 (de) | 2000-07-28 | 2005-10-26 | Henkel Kommanditgesellschaft auf Aktien | Neues amylolytisches enzym aus bacillus sp. a 7-7 (dsm 12368) sowie wasch- und reinigungsmittel mit diesem neuen amylolytischen enzym |
| JP5126761B2 (ja) * | 2000-10-02 | 2013-01-23 | ジェネンコー・インターナショナル・インク | 変化した免疫反応をもたらすタンパク質及びその作成または使用方法 |
| US6673580B2 (en) | 2000-10-27 | 2004-01-06 | Genentech, Inc. | Identification and modification of immunodominant epitopes in polypeptides |
| ZA200305980B (en) * | 2001-02-12 | 2007-01-31 | Res Dev Foundation | Modified proteins, designer toxins, and methods of making thereof |
| DK1366067T3 (da) | 2001-03-07 | 2012-10-22 | Merck Patent Gmbh | Ekspressionsteknologi for proteiner indeholdende en hybrid isotype-antistof-enhed |
| CA2441595C (en) * | 2001-03-23 | 2012-07-03 | Genencor International, Inc. | Proteins producing an altered immunogenic response and methods of making and using the same |
| US6992174B2 (en) | 2001-03-30 | 2006-01-31 | Emd Lexigen Research Center Corp. | Reducing the immunogenicity of fusion proteins |
| US6969517B2 (en) | 2001-05-03 | 2005-11-29 | Emd Lexigen Research Center Corp. | Recombinant tumor specific antibody and use thereof |
| KR20040039323A (ko) * | 2001-09-04 | 2004-05-10 | 메르크 파텐트 게엠베하 | 개질된 인간 성장 호르몬 |
| BR0214650A (pt) | 2001-12-04 | 2005-05-03 | Merck Patent Gmbh | Imunocitoquinas com seletividade modulada |
| WO2003057246A1 (en) * | 2001-12-31 | 2003-07-17 | Genencor International, Inc. | Proteases producing an altered immunological response and methods of making and using the same |
| US7332320B2 (en) | 2001-12-31 | 2008-02-19 | Genencor International, Inc. | Protease producing an altered immunogenic response and methods of making and using the same |
| CN101177675B (zh) | 2002-02-08 | 2014-05-21 | 诺维信公司 | 肌醇六磷酸酶变体 |
| CA2486112A1 (en) * | 2002-05-16 | 2003-11-27 | Alk Abello A/S | Allergen mutants |
| CN1684657A (zh) | 2002-07-30 | 2005-10-19 | 金克克国际有限公司 | 气溶胶产生减少的配剂 |
| US20040121953A1 (en) * | 2002-08-09 | 2004-06-24 | Chirino Arthur J. | Thrombopoiesis-stimulating proteins having reduced immunogenicity |
| DE60335640D1 (de) | 2002-10-01 | 2011-02-17 | Novozymes As | Polypeptide der gh-61-familie |
| ATE471946T1 (de) | 2002-12-17 | 2010-07-15 | Merck Patent Gmbh | Humanisierter antikörper (h14.18) des maus antikörpers 14.18, der gd2 bindet und seine fusion mit il-2 |
| EP2500423B1 (en) | 2003-02-26 | 2015-06-17 | Danisco US Inc. | Amylases producing an altered immunogenic response and methods of making and using the same |
| JP2006513709A (ja) | 2003-02-26 | 2006-04-27 | ジェネンコー・インターナショナル・インク | 修飾されたアミラーゼ免疫反応を示すアミラーゼ変異体、及び、これらの製造方法並びに用途 |
| DK1639106T3 (da) | 2003-06-19 | 2010-09-27 | Novozymes As | Proteaser |
| WO2004111224A1 (en) | 2003-06-19 | 2004-12-23 | Novozymes A/S | Improved proteases and methods for producing them |
| EP2284259A3 (en) | 2003-10-10 | 2011-06-15 | Novozymes A/S | Protease variants |
| PL1673398T3 (pl) | 2003-10-16 | 2011-05-31 | Amgen Res Munich Gmbh | Multispecyficzne deimmunizowane cząsteczki wiążące CD3 |
| RU2369616C2 (ru) | 2003-12-30 | 2009-10-10 | Мерк Патент Гмбх | Слитые белки il-7 |
| EP1699821B1 (en) | 2003-12-31 | 2012-06-20 | Merck Patent GmbH | Fc-ERYTHROPOIETIN FUSION PROTEIN WITH IMPROVED PHARMACOKINETICS |
| WO2005066339A2 (en) | 2004-01-06 | 2005-07-21 | Novozymes A/S | Polypeptides of alicyclobacillus sp. |
| WO2005070967A2 (en) | 2004-01-22 | 2005-08-04 | Merck Patent Gmbh | Anti-cancer antibodies with reduced complement fixation |
| EP1735433B1 (en) | 2004-04-02 | 2010-12-08 | Novozymes A/S | Subtilase variants having altered immunogenicity |
| ATE541034T1 (de) | 2004-06-21 | 2012-01-15 | Novozymes As | Nocardiopsis-proteasen |
| AR050895A1 (es) | 2004-10-04 | 2006-11-29 | Novozymes As | Polipeptidos que tienen actividad de fitasa y polinucleotidos que los codifican |
| BRPI0517539A (pt) | 2004-10-04 | 2008-10-14 | Novozymes As | polipeptìdeo isolado, polinucleotìdeo isolado, construto de ácido nucleico, vetor de expressão recombinante, célula hospedeira recombinante, métodos para produzir o polipeptìdeo, e para melhorar o valor nutricional de uma ração animal, célula de planta, parte de planta ou planta transgênica, animal não-humano, transgênico, ou produtos, ou elementos do mesmo, uso de pelo menos um polipeptìdeo, aditivo de ração animal, e, composição de ração animal |
| RU2437893C2 (ru) | 2004-12-09 | 2011-12-27 | Мерк Патент Гмбх | Варианты il-7 со сниженной иммуногенностью |
| DE602006020923D1 (de) | 2005-08-16 | 2011-05-05 | Novozymes As | Polypeptide von Stammbakterien SP P203 |
| ES2856451T3 (es) | 2005-10-11 | 2021-09-27 | Amgen Res Munich Gmbh | Composiciones que comprenden anticuerpos específicos para diferentes especies, y usos de las mismas |
| EP1960517A2 (en) | 2005-12-06 | 2008-08-27 | Genencor International, Inc. | Perhydrolase epitopes |
| CA2633766C (en) | 2005-12-21 | 2016-06-28 | Micromet Ag | Pharmaceutical compositions comprising a bispecific single chain antibody with specificity for human cd3 and human cea and having resistance to soluble cea |
| DK2270050T3 (da) | 2005-12-30 | 2013-08-12 | Merck Patent Gmbh | Anti-CD19-antistoffer med nedsat immunogenicitet |
| CA2635618C (en) | 2005-12-30 | 2015-10-06 | Merck Patent Gesellschaft Mit Beschraekter Haftung | Interleukin-12p40 variants with improved stability |
| WO2007107573A1 (en) | 2006-03-22 | 2007-09-27 | Novozymes A/S | Use of polypeptides having antimicrobial activity |
| MX2008012632A (es) | 2006-04-04 | 2008-10-13 | Novozymes As | Variantes de fitasa. |
| WO2008079685A2 (en) | 2006-12-21 | 2008-07-03 | Novozymes A/S | Lipase variants for pharmaceutical use |
| US8221743B2 (en) | 2006-12-22 | 2012-07-17 | Novozymes A/S | Use of polypeptides against diseases caused by protozoans |
| US7923232B2 (en) | 2007-03-26 | 2011-04-12 | Novozymes A/S | Hafnia phytase |
| DK2650364T3 (en) | 2008-09-26 | 2015-06-08 | Novozymes As | Hafniaphytase variants |
| JP5781501B2 (ja) | 2009-04-22 | 2015-09-24 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングMerck Patent Gesellschaft mit beschraenkter Haftung | 改変されたFcRn結合部位を有する抗体融合タンパク質 |
| US8932588B2 (en) | 2009-11-05 | 2015-01-13 | Teva Pharmaceuticals Australia Pty. Ltd. | Treatment of cancer involving mutated KRAS or BRAF genes |
| WO2012119989A2 (en) | 2011-03-04 | 2012-09-13 | Oryzon Genomics, S.A. | Methods and antibodies for the diagnosis and treatment of cancer |
| US20170269092A1 (en) | 2014-12-02 | 2017-09-21 | Cemm - Forschungszentrum Fuer Molekulare Medizin Gmbh | Anti-mutant calreticulin antibodies and their use in the diagnosis and therapy of myeloid malignancies |
| CA3189083A1 (en) | 2020-08-13 | 2022-02-17 | Novozymes A/S | Phytase variants and polynucleotides encoding same |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3903068A (en) * | 1972-12-26 | 1975-09-02 | Us Health Education & Welfare | Facile synthesis of human insulin by modification of porcine insulin |
| DK6488D0 (da) * | 1988-01-07 | 1988-01-07 | Novo Industri As | Enzymer |
| DK316989D0 (da) * | 1989-06-26 | 1989-06-26 | Novo Nordisk As | Enzymer |
-
1991
- 1991-12-05 CA CA002095852A patent/CA2095852C/en not_active Expired - Lifetime
- 1991-12-05 BR BR919107206A patent/BR9107206A/pt not_active IP Right Cessation
- 1991-12-05 FI FI932561A patent/FI932561L/fi not_active Application Discontinuation
- 1991-12-05 AU AU90528/91A patent/AU9052891A/en not_active Abandoned
- 1991-12-05 DK DK92900779T patent/DK0561907T3/da active
- 1991-12-05 JP JP50164192A patent/JP3355186B2/ja not_active Expired - Lifetime
- 1991-12-05 CA CA002331936A patent/CA2331936C/en not_active Expired - Lifetime
- 1991-12-05 AT AT92900779T patent/ATE170630T1/de not_active IP Right Cessation
- 1991-12-05 KR KR1019930701690A patent/KR100237968B1/ko not_active Expired - Lifetime
- 1991-12-05 EP EP92900779A patent/EP0561907B1/en not_active Revoked
- 1991-12-05 DE DE69130113T patent/DE69130113T2/de not_active Revoked
- 1991-12-05 WO PCT/DK1991/000382 patent/WO1992010755A1/en not_active Ceased
-
2001
- 2001-07-16 JP JP2001215943A patent/JP3450840B2/ja not_active Expired - Lifetime
-
2002
- 2002-12-04 JP JP2002352804A patent/JP2003174871A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| JP2003174871A (ja) | 2003-06-24 |
| JP2002101880A (ja) | 2002-04-09 |
| JP3355186B2 (ja) | 2002-12-09 |
| KR100237968B1 (ko) | 2000-01-15 |
| CA2095852A1 (en) | 1992-06-06 |
| DE69130113D1 (de) | 1998-10-08 |
| WO1992010755A1 (en) | 1992-06-25 |
| BR9107206A (pt) | 1993-11-03 |
| ATE170630T1 (de) | 1998-09-15 |
| JPH06502994A (ja) | 1994-04-07 |
| CA2331936C (en) | 2007-07-31 |
| EP0561907B1 (en) | 1998-09-02 |
| DK0561907T3 (da) | 1999-05-31 |
| FI932561A7 (fi) | 1993-06-04 |
| FI932561L (fi) | 1993-06-04 |
| CA2331936A1 (en) | 1992-06-06 |
| KR930703610A (ko) | 1993-11-30 |
| CA2095852C (en) | 2001-05-08 |
| EP0561907A1 (en) | 1993-09-29 |
| DE69130113T2 (de) | 1999-05-12 |
| JP3450840B2 (ja) | 2003-09-29 |
| AU9052891A (en) | 1992-07-08 |
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