FI935381L - 6,7-modifioituja paklitakseleita - Google Patents

6,7-modifioituja paklitakseleita Download PDF

Info

Publication number: FI935381L
Authority: FI; Finland
Prior art keywords: modified paclitaxels; paclitaxels; modified
Prior art date: 1992-12-04

Application number

FI935381A

Other languages

English (en)

Swedish (sv)

Other versions

FI109795B (fi

FI935381A0 (fi

Inventor

Shu-Hui Chen

Vittorio Farina

Gregory Roth

John Kadow

Original Assignee

Bristol Myers Squibb Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-12-04

Filing date

1993-12-01

Publication date

1994-06-05

1993-09-28 Priority claimed from US08/128,619 external-priority patent/US5380751A/en

1993-12-01 Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co

1993-12-01 Publication of FI935381A0 publication Critical patent/FI935381A0/fi

1994-06-05 Publication of FI935381L publication Critical patent/FI935381L/fi

2002-10-15 Application granted granted Critical

2002-10-15 Publication of FI109795B publication Critical patent/FI109795B/fi

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
- C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Epoxy Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Saccharide Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)

FI935381A 1992-12-04 1993-12-01 Menetelmä terapeuttisesti käyttökelpoisten 6,7-modifioitujen paklitakseleiden valmistamiseksi FI109795B (fi)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
US98576192A	1992-12-04	1992-12-04
US98576192		1992-12-04
US12861993		1993-09-28
US08/128,619 US5380751A (en)	1992-12-04	1993-09-28	6,7-modified paclitaxels

Publications (3)

Publication Number	Publication Date
FI935381A0 FI935381A0 (fi)	1993-12-01
FI935381L true FI935381L (fi)	1994-06-05
FI109795B FI109795B (fi)	2002-10-15

Family

ID=26826766

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
FI935381A FI109795B (fi)	1992-12-04	1993-12-01	Menetelmä terapeuttisesti käyttökelpoisten 6,7-modifioitujen paklitakseleiden valmistamiseksi

Country Status (20)

Country	Link
EP (1)	EP0600517B1 (fi)
JP (1)	JP3360186B2 (fi)
CN (1)	CN1049433C (fi)
AT (1)	ATE195939T1 (fi)
AU (1)	AU668777B2 (fi)
CA (1)	CA2109861C (fi)
CZ (1)	CZ287599B6 (fi)
DE (1)	DE69329327T2 (fi)
DK (1)	DK0600517T3 (fi)
ES (1)	ES2149188T3 (fi)
FI (1)	FI109795B (fi)
GR (1)	GR3034686T3 (fi)
HU (2)	HU222347B1 (fi)
IL (1)	IL107819A (fi)
MX (1)	MX9307555A (fi)
NO (1)	NO305756B1 (fi)
NZ (1)	NZ250343A (fi)
PL (1)	PL178135B1 (fi)
PT (1)	PT600517E (fi)
SG (1)	SG55014A1 (fi)

Families Citing this family (47)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5998656A (en)	1991-09-23	1999-12-07	Florida State University	C10 tricyclic taxanes
MX9307777A (es)	1992-12-15	1994-07-29	Upjohn Co	7-HALO-Y 7ß, 8ß-METANO-TAXOLES, USO ANTINEOPLASTICO Y COMPOSICIONES FARMACEUTICAS QUE LOS CONTIENEN.
IL108316A (en) *	1993-01-15	2006-10-31	Univ Florida State	C10 taxane derivatives and pharmaceutical compositions containing them
EP0703909B1 (en) *	1993-06-11	2000-04-26	PHARMACIA & UPJOHN COMPANY	Delta 6,7 -taxols antineoplastic use and pharmaceutical compositions containing them
IL127598A (en) *	1994-01-28	2003-04-10	Upjohn Co	Process for preparing isotaxol analogs
US5395850A (en) *	1994-03-10	1995-03-07	Bristol-Myers Squibb Company	6,7-epoxy paclitaxels
GB9409131D0 (en) *	1994-05-09	1994-06-29	Erba Carlo Spa	Unsaturated taxane compounds
FR2721026B1 (fr) *	1994-06-09	1996-07-12	Rhone Poulenc Rorer Sa	Nouveaux taxoïdes, leur préparation et les compositions pharmaceutiques qui les contiennent.
FR2721025B1 (fr) *	1994-06-09	1996-07-12	Rhone Poulenc Rorer Sa	Nouveaux taxoïdes, leur préparation et les compositions pharmaceutiques qui les contiennent.
US5840929A (en) *	1995-04-14	1998-11-24	Bristol-Myers Squibb Company	C4 methoxy ether derivatives of paclitaxel
FR2742753B1 (fr) *	1995-12-22	1998-01-30	Rhone Poulenc Rorer Sa	Nouveaux taxoides, leur preparation et les compositions pharmaceutiques qui les contiennent
US5773461A (en) *	1996-06-06	1998-06-30	Bristol-Myers Squibb Company	7-deoxy-6-substituted paclitaxels
US5635531A (en) *	1996-07-08	1997-06-03	Bristol-Myers Squibb Company	3'-aminocarbonyloxy paclitaxels
US5773464A (en) *	1996-09-30	1998-06-30	Bristol-Myers Squibb Company	C-10 epoxy taxanes
US5977386A (en) *	1996-12-24	1999-11-02	Bristol-Myers Squibb Company	6-thio-substituted paclitaxels
US5902822A (en) *	1997-02-28	1999-05-11	Bristol-Myers Squibb Company	7-methylthiooxomethyl and 7-methylthiodioxomethyl paclitaxels
US5912264A (en) *	1997-03-03	1999-06-15	Bristol-Myers Squibb Company	6-halo-or nitrate-substituted paclitaxels
US6017935A (en) *	1997-04-24	2000-01-25	Bristol-Myers Squibb Company	7-sulfur substituted paclitaxels
IT1317731B1 (it) *	2000-01-18	2003-07-15	Indena Spa	Tassani semisintetici con attivita' antitumorale ed antiangiogenetica.
US6649632B2 (en)	2000-02-02	2003-11-18	Fsu Research Foundation, Inc.	C10 ester substituted taxanes
PL350331A1 (en)	2000-02-02	2002-12-02	Univ Florida State Res Found	C10 carbamoyloxy substituted taxanes as antitumor agents
HK1047937A1 (zh)	2000-02-02	2003-03-14	佛罗里达州立大学研究基金有限公司	C7氨基甲酰氧基取代的紫衫烷抗肿瘤剂
PL350028A1 (en)	2000-02-02	2002-10-21	Univ Florida State Res Found	C10 carbonate substituted taxanes as antitumor agents
KR100788092B1 (ko)	2001-06-20	2007-12-21	제넨테크, 인크.	종양의 진단 및 치료를 위한 방법 및 이를 위한 조성물
EP2143438B1 (en)	2001-09-18	2011-07-13	Genentech, Inc.	Compositions and methods for the diagnosis and treatment of tumors
EP2067472A1 (en)	2002-01-02	2009-06-10	Genentech, Inc.	Compositions and methods for the diagnosis and treatment of tumor
AU2003230874A1 (en)	2002-04-16	2003-11-03	Genentech, Inc.	Compositions and methods for the diagnosis and treatment of tumor
WO2003103725A1 (en)	2002-06-07	2003-12-18	Genentech, Inc.	Compositions and methods for the diagnosis and treatment of tumor
DK2161283T3 (da)	2003-11-17	2014-09-01	Genentech Inc	SAMMENSÆTNINGER OMFATTENDE ANTISTOFFER MOD CD79b, SOM ER KONJUGERET TIL ET VÆKSTINHIBERENDE MIDDEL ELLER ET CYTOTOKSISK MIDDEL, OG FREMGANGSMÅDER TIL BEHANDLING AF TUMOR AF HÆMATOPOIETISK OPRINDELSE
PE20050693A1 (es) *	2004-02-13	2005-09-27	Univ Florida State Res Found	Taxanos sustituidos con esteres de ciclopentilo en c10
GT200500025A (es) *	2004-02-13	2005-09-30		Taxanos sustituidos con esteres de ciclopentilo en c10
EP2230517A1 (en)	2005-01-07	2010-09-22	Diadexus, Inc.	OVR110 antibody compositions and methods of use
AU2007243946B2 (en)	2006-04-05	2012-11-29	Curis, Inc.	Method for using BOC/CDO to modulate hedgehog signaling
CA2670696A1 (en)	2006-11-27	2008-06-05	Diadexus, Inc.	Ovr110 antibody compositions and methods of use
CA2676790A1 (en)	2007-02-22	2008-08-28	Genentech, Inc.	Methods for detecting inflammatory bowel disease
DK2176296T3 (da)	2007-07-16	2012-05-21	Genentech Inc	Anti-CD79B-antistoffer og immunkonjugater og anvendelsesfremgangsmåder.
WO2009012256A1 (en)	2007-07-16	2009-01-22	Genentech, Inc.	Humanized anti-cd79b antibodies and immunoconjugates and methods of use
DK2247620T3 (en)	2008-01-31	2016-08-22	Genentech Inc	ANTI-CD79b ANTIBODIES AND IMMUNOCONJUGATES AND METHODS OF USE
JP2011517455A (ja)	2008-03-31	2011-06-09	フロリダ・ステイト・ユニバーシティ・リサーチ・ファウンデイション・インコーポレイテッド	Ｃ（１０）エチルエステルおよびｃ（１０）シクロプロピルエステル置換タキサン
CN102471380B (zh)	2009-04-01	2015-01-14	霍夫曼-拉罗奇有限公司	抗FcRH5抗体和免疫偶联物及使用方法
WO2011050194A1 (en)	2009-10-22	2011-04-28	Genentech, Inc.	Methods and compositions for modulating hepsin activation of macrophage-stimulating protein
CN102741294A (zh)	2009-11-30	2012-10-17	霍夫曼-拉罗奇有限公司	治疗和诊断表达slc34a2(tat211=seqid2)的肿瘤的抗体
WO2011106297A2 (en)	2010-02-23	2011-09-01	Genentech, Inc.	Compositions and methods for the diagnosis and treatment of tumor
AU2011248354A1 (en)	2010-05-03	2012-11-08	Genentech, Inc.	Compositions and methods for the diagnosis and treatment of tumor
CN104650012A (zh) *	2013-11-22	2015-05-27	天士力控股集团有限公司	一种紫杉烷类化合物
WO2015116902A1 (en)	2014-01-31	2015-08-06	Genentech, Inc.	G-protein coupled receptors in hedgehog signaling
CR20250325A (es)	2018-04-13	2025-08-29	Genentech Inc	Formulaciones inmunoconjugadas anti-cd79b estables (divisional expediente 2020-0550)

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2601675B1 (fr) *	1986-07-17	1988-09-23	Rhone Poulenc Sante	Derives du taxol, leur preparation et les compositions pharmaceutiques qui les contiennent
US4876399A (en) *	1987-11-02	1989-10-24	Research Corporation Technologies, Inc.	Taxols, their preparation and intermediates thereof
US5175315A (en) *	1989-05-31	1992-12-29	Florida State University	Method for preparation of taxol using β-lactam
US5015744A (en) *	1989-11-14	1991-05-14	Florida State University	Method for preparation of taxol using an oxazinone
MX9102128A (es) *	1990-11-23	1992-07-08	Rhone Poulenc Rorer Sa	Derivados de taxano,procedimiento para su preparacion y composicion farmaceutica que los contiene
US5227400A (en) *	1991-09-23	1993-07-13	Florida State University	Furyl and thienyl substituted taxanes and pharmaceutical compositions containing them
US5272171A (en) *	1992-02-13	1993-12-21	Bristol-Myers Squibb Company	Phosphonooxy and carbonate derivatives of taxol
EP0703909B1 (en) *	1993-06-11	2000-04-26	PHARMACIA & UPJOHN COMPANY	Delta 6,7 -taxols antineoplastic use and pharmaceutical compositions containing them

1993
- 1993-11-24 CA CA002109861A patent/CA2109861C/en not_active Expired - Fee Related
- 1993-11-26 NO NO934277A patent/NO305756B1/no unknown
- 1993-12-01 FI FI935381A patent/FI109795B/fi not_active IP Right Cessation
- 1993-12-01 IL IL10781993A patent/IL107819A/xx not_active IP Right Cessation
- 1993-12-01 CZ CZ19932603A patent/CZ287599B6/cs not_active IP Right Cessation
- 1993-12-01 MX MX9307555A patent/MX9307555A/es not_active IP Right Cessation
- 1993-12-02 NZ NZ250343A patent/NZ250343A/en unknown
- 1993-12-03 AT AT93119554T patent/ATE195939T1/de not_active IP Right Cessation
- 1993-12-03 CN CN93120068A patent/CN1049433C/zh not_active Expired - Fee Related
- 1993-12-03 SG SG1996002081A patent/SG55014A1/en unknown
- 1993-12-03 PL PL93301305A patent/PL178135B1/pl not_active IP Right Cessation
- 1993-12-03 HU HU9303428A patent/HU222347B1/hu not_active IP Right Cessation
- 1993-12-03 JP JP34215393A patent/JP3360186B2/ja not_active Expired - Fee Related
- 1993-12-03 EP EP93119554A patent/EP0600517B1/en not_active Expired - Lifetime
- 1993-12-03 AU AU52121/93A patent/AU668777B2/en not_active Ceased
- 1993-12-03 DE DE69329327T patent/DE69329327T2/de not_active Expired - Fee Related
- 1993-12-03 ES ES93119554T patent/ES2149188T3/es not_active Expired - Lifetime
- 1993-12-03 PT PT93119554T patent/PT600517E/pt unknown
- 1993-12-03 DK DK93119554T patent/DK0600517T3/da active
- 1993-12-03 HU HU0103602A patent/HU221817B1/hu not_active IP Right Cessation
2000
- 2000-10-26 GR GR20000402373T patent/GR3034686T3/el not_active IP Right Cessation

Also Published As

Publication number	Publication date
SG55014A1 (en)	1998-12-21
FI109795B (fi)	2002-10-15
NO305756B1 (no)	1999-07-19
CZ260393A3 (en)	1994-07-13
HU9303428D0 (en)	1994-04-28
HU222347B1 (hu)	2003-06-28
ATE195939T1 (de)	2000-09-15
DE69329327D1 (de)	2000-10-05
NZ250343A (fi)	1996-11-26
GR3034686T3 (en)	2001-01-31
HUT65640A (en)	1994-07-28
AU5212193A (en)	1994-06-16
EP0600517A1 (en)	1994-06-08
FI935381A0 (fi)	1993-12-01
ES2149188T3 (es)	2000-11-01
EP0600517B1 (en)	2000-08-30
IL107819A (en)	2000-06-29
PT600517E (pt)	2000-12-29
HU221817B1 (hu)	2003-01-28
CA2109861C (en)	1999-03-16
PL178135B1 (pl)	2000-03-31
DE69329327T2 (de)	2001-04-05
NO934277L (no)	1994-06-06
CN1094041A (zh)	1994-10-26
NO934277D0 (no)	1993-11-26
CA2109861A1 (en)	1994-06-05
JP3360186B2 (ja)	2002-12-24
AU668777B2 (en)	1996-05-16
JPH06211823A (ja)	1994-08-02
DK0600517T3 (da)	2000-10-30
CZ287599B6 (en)	2001-01-17
MX9307555A (es)	1995-01-31
PL301305A1 (en)	1994-06-13
IL107819A0 (en)	1994-04-12
CN1049433C (zh)	2000-02-16

Publication	Publication Date	Title
FI935381L (fi)	1994-06-05	6,7-modifioituja paklitakseleita
ZA938436B (en)	1995-05-11	6,7-modified paclitaxels
FI953489A0 (fi)	1995-07-19	2,6-diaminopuriinijohdannaisia
FI954651A7 (fi)	1995-09-29	Mahdollisesti substituoidut 6,8-kinoliinit
NO920018L (no)	1992-01-02	1,3-oksatiolannukleosidanaloger
FI923314L (fi)	1993-01-26	Substituerade cyklopropylamino-1,3,5-triaziner
AT397656B (de)	1994-06-27	(6,7-substituierte-8-alkoxy-1-cyclopropyl-1,4-
FI933151L (fi)	1994-01-14	5,10 metylentetrahydrofolsyre-cyklodextrin-inneslutningsfoereningar
FI930296L (fi)	1993-01-25	1,4-disubstituerade piperaziner
DE59010722D1 (de)	1997-07-10	2,4-Dimethyl-6-s-alkylphenole
NO932842L (no)	1994-02-14	1,4-benzodioksanderivater
FI931459L (fi)	1993-10-02	Sammansaettningar med 1-klor-2,2,2-trifluoretyldifluor-metyleter
FI932874A7 (fi)	1993-06-21	6,7-muunnetut 11b-aryyli-4-estreenit
DE59308564D1 (de)	1998-06-25	2,4-Dialkyl-6-sec-alkylphenole
FI934928A7 (fi)	1994-05-11	Foerfarande foer framstaellning av 3,7-dialkylxantiner fraon 3-alkylxantiner
FI925258A7 (fi)	1993-05-27	Foerfarande foer framstaellning av 2-substituerade 4,6-dialkoxipyrimidiner
FI932396A7 (fi)	1993-11-27	Foerfarande foer framstaellning av en dubbelskyddad 2,3-hydroximetylcyklobutanol
DK0391849T3 (da)	1995-06-26	Pyridyl-methylenamino-1,2,4-triazinoner
FI930237L (fi)	1993-07-24	Foerfarande foer framstaellning av 4,6-dialkoxipyrimidiner
FI935657L (fi)	1993-12-16	Foerfarande foer framstaellning av 3,4-dihydroxi-5-nitrobensaldehyd
FI94U1 (fi)	1992-04-28	Kompostor
FI906116A0 (fi)	1990-12-12	17/21-alkylerade 19-norprogesteronderivat.
FI933872A7 (fi)	1994-03-05	Foerfarande foer framstaellning av terapeutiskt anvaendbara 1,3,4-bensotriazepin-5(4H)-on-derivat
NO944024L (no)	1995-04-24	1,2-dihydro-2-okso-pyridin
NO922732D0 (no)	1992-07-10	3,4-dehydropiperidinderivater

Legal Events

Date	Code	Title	Description
2005-06-30	MA	Patent expired