[go: up one dir, main page]

PE20050693A1 - Taxanos sustituidos con esteres de ciclopentilo en c10 - Google Patents

Taxanos sustituidos con esteres de ciclopentilo en c10

Info

Publication number
PE20050693A1
PE20050693A1 PE2005000166A PE2005000166A PE20050693A1 PE 20050693 A1 PE20050693 A1 PE 20050693A1 PE 2005000166 A PE2005000166 A PE 2005000166A PE 2005000166 A PE2005000166 A PE 2005000166A PE 20050693 A1 PE20050693 A1 PE 20050693A1
Authority
PE
Peru
Prior art keywords
taxans
esters
cyclopentil
replaced
taxan
Prior art date
Application number
PE2005000166A
Other languages
English (en)
Inventor
Robert A Holton
Phong Vu
Original Assignee
Univ Florida State Res Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Florida State Res Found filed Critical Univ Florida State Res Found
Publication of PE20050693A1 publication Critical patent/PE20050693A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Epoxy Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

REFERIDA A UN TAXANO DE FORMULA I DONDE X3 ES TIENILO, Ac ES ACETILO Y Bz ES BENZOILO. TAMBIEN REFERIDA A LA PREPARACION DE UN MEDICAMENTO DONDE LA CONCENTRACION DEL TAXANO ESTA ENTRE 0.01 mg/mL Y 400 mg/mL Y EL VEHICULO ESTA FORMADO POR ACEITES, AMIDAS, ESTERES, ETERES, ENTRE OTROS. LOS TAXANOS SE EMPLEAN COMO AGENTES QUIMIOTERAPEUTICOS CON ACTIVIDAD INHIBIDORA DE TUMORES
PE2005000166A 2004-02-13 2005-02-11 Taxanos sustituidos con esteres de ciclopentilo en c10 PE20050693A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US54475504P 2004-02-13 2004-02-13
US61350304P 2004-09-27 2004-09-27

Publications (1)

Publication Number Publication Date
PE20050693A1 true PE20050693A1 (es) 2005-09-27

Family

ID=34890477

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2005000166A PE20050693A1 (es) 2004-02-13 2005-02-11 Taxanos sustituidos con esteres de ciclopentilo en c10

Country Status (21)

Country Link
US (2) US7589111B2 (es)
EP (1) EP1713798B1 (es)
JP (1) JP4879757B2 (es)
KR (1) KR101169818B1 (es)
AR (1) AR047704A1 (es)
AT (1) ATE486596T1 (es)
AU (1) AU2005214065B2 (es)
BR (1) BRPI0507671A (es)
CA (1) CA2556200C (es)
CR (1) CR8554A (es)
DE (1) DE602005024518D1 (es)
EC (1) ECSP066765A (es)
HN (1) HN2005000054A (es)
IL (1) IL177372A (es)
NO (1) NO20064090L (es)
NZ (1) NZ548769A (es)
PE (1) PE20050693A1 (es)
RU (1) RU2006132741A (es)
SV (1) SV2006002010A (es)
TW (1) TWI353354B (es)
WO (1) WO2005079319A2 (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1303077C (zh) * 2004-01-16 2007-03-07 桂林晖昂生化药业有限责任公司 合成紫杉烷的制备工艺
JP4833126B2 (ja) * 2007-03-26 2011-12-07 Ｎｔｎ株式会社 潤滑剤劣化検出装置および検出装置付き軸受
CN113209287B (zh) * 2021-02-04 2022-07-08 中国农业科学院农业环境与可持续发展研究所 油包水型纳米疫苗佐剂、制备方法及其应用

Family Cites Families (71)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2601675B1 (fr) * 1986-07-17 1988-09-23 Rhone Poulenc Sante Derives du taxol, leur preparation et les compositions pharmaceutiques qui les contiennent
US5175315A (en) * 1989-05-31 1992-12-29 Florida State University Method for preparation of taxol using β-lactam
US5714512A (en) * 1991-07-08 1998-02-03 Rhone-Poulenc Rorer, S.A. Compositions containing taxane derivatives
US5250683A (en) * 1991-09-23 1993-10-05 Florida State University Certain substituted taxanes and pharmaceutical compositions containing them
US5739362A (en) * 1991-09-23 1998-04-14 Florida State University Taxanes having an alkoxy, alkenoxy or aryloxy substituted side-chain and pharmaceutical compositions containing them
US5243045A (en) * 1991-09-23 1993-09-07 Florida State University Certain alkoxy substituted taxanes and pharmaceutical compositions containing them
US5714513A (en) * 1991-09-23 1998-02-03 Florida State University C10 taxane derivatives and pharmaceutical compositions
US5283253A (en) * 1991-09-23 1994-02-01 Florida State University Furyl or thienyl carbonyl substituted taxanes and pharmaceutical compositions containing them
ATE178060T1 (de) 1991-09-23 1999-04-15 Univ Florida State Darstellung von substituierten isoserinestern unter verwendung von metallalkoxiden und s- lactamen
US5227400A (en) * 1991-09-23 1993-07-13 Florida State University Furyl and thienyl substituted taxanes and pharmaceutical compositions containing them
US5430160A (en) * 1991-09-23 1995-07-04 Florida State University Preparation of substituted isoserine esters using β-lactams and metal or ammonium alkoxides
US5350866A (en) * 1991-09-23 1994-09-27 Bristol-Myers Squibb Company 10-desacetoxytaxol derivatives
US5710287A (en) * 1991-09-23 1998-01-20 Florida State University Taxanes having an amino substituted side-chain and pharmaceutical compositions containing them
US5721268A (en) * 1991-09-23 1998-02-24 Florida State University C7 taxane derivatives and pharmaceutical compositions containing them
US5274124A (en) * 1991-09-23 1993-12-28 Florida State University Metal alkoxides
US5445908A (en) 1991-10-17 1995-08-29 Matsushita Electric Industrial Co., Ltd. Alkaline dry cell
ATE195973T1 (de) * 1992-01-15 2000-09-15 Squibb & Sons Inc Enzymatische verfahren zur resolution von enantiomeren-mischungen nützlich wie zwischenprodukte zur herstellung von taxanen
US5272171A (en) 1992-02-13 1993-12-21 Bristol-Myers Squibb Company Phosphonooxy and carbonate derivatives of taxol
US5200534A (en) * 1992-03-13 1993-04-06 University Of Florida Process for the preparation of taxol and 10-deacetyltaxol
FR2691460B1 (fr) 1992-05-21 1994-07-22 Rhone Poulenc Rorer Sa Nouveaux derives du taxane, leur preparation et les compositions qui les contiennent.
US5254580A (en) * 1993-01-19 1993-10-19 Bristol-Myers Squibb Company 7,8-cyclopropataxanes
CA2100808A1 (en) * 1992-10-01 1994-04-02 Vittorio Farina Deoxy paclitaxels
FR2696461B1 (fr) 1992-10-05 1994-11-10 Rhone Poulenc Rorer Sa Nouveaux dérivés d'analogues du taxol, leur préparation et les compositions qui les contiennent.
CA2109861C (en) * 1992-12-04 1999-03-16 Shu-Hui Chen 6,7-modified paclitaxels
IL107950A (en) 1992-12-15 2001-04-30 Upjohn Co 7β, 8β - METHANO-TAXOLS, THEIR PREPARATION AND ANTINEOPLASTIC PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
NO310238B1 (no) 1992-12-24 2001-06-11 Bristol Myers Squibb Co Kjemiske forbindelser og farmasöytisk preparat samt anvendelse av slike preparater
US6593482B2 (en) * 1993-02-01 2003-07-15 Aventis Pharma S.A. Methods for preparing new taxoids and pharmaceutical compositions containing them
FR2702212B1 (fr) 1993-03-02 1995-04-07 Rhone Poulenc Rorer Sa Nouveaux taxoïdes, leur préparation et les compositions pharmaceutiques qui les contiennent.
US5703247A (en) * 1993-03-11 1997-12-30 Virginia Tech Intellectual Properties, Inc. 2-Debenzoyl-2-acyl taxol derivatives and methods for making same
US5475011A (en) * 1993-03-26 1995-12-12 The Research Foundation Of State University Of New York Anti-tumor compounds, pharmaceutical compositions, methods for preparation thereof and for treatment
IT1261667B (it) * 1993-05-20 1996-05-29 Tassano ad attivita' antitumorale.
AU7138894A (en) * 1993-06-11 1995-01-03 Pharmacia & Upjohn Company Delta 6,7--taxols antineoplastic use and pharmaceutical compositions containing them
IL109926A (en) 1993-06-15 2000-02-29 Bristol Myers Squibb Co Methods for the preparation of taxanes and microorganisms and enzymes utilized therein
TW397866B (en) * 1993-07-14 2000-07-11 Bristol Myers Squibb Co Enzymatic processes for the resolution of enantiomeric mixtures of compounds useful as intermediates in the preparation of taxanes
JPH07177879A (ja) 1993-07-27 1995-07-18 Nippon Steel Corp 微生物によるタキソール及びその類縁化合物の製造法
CA2129288C (en) 1993-08-17 2000-05-16 Jerzy Golik Phosphonooxymethyl esters of taxane derivatives
JP2986550B2 (ja) * 1994-07-26 1999-12-06 インデナ・ソシエタ・ペル・アチオニ 抗腫瘍活性を有する半合成タキサン
US6100411A (en) 1994-10-28 2000-08-08 The Research Foundation Of State University Of New York Taxoid anti-tumor agents and pharmaceutical compositions thereof
WO1996013495A1 (en) 1994-10-28 1996-05-09 The Research Foundation Of State University Of New York Taxoid derivatives, their preparation and their use as antitumor agents
WO1996014308A1 (en) 1994-11-04 1996-05-17 Pharmacia S.P.A. Taxane derivatives
MA23823A1 (fr) * 1995-03-27 1996-10-01 Aventis Pharma Sa Nouveaux taxoides, leur preparation et les compositions qui les contiennent
FR2732342B1 (fr) 1995-04-03 1997-04-30 Rhone Poulenc Rorer Sa Nouveaux taxoides, leur preparation et les compositions pharmaceutiques qui les contiennent
FR2732968B1 (fr) * 1995-04-14 1997-05-16 Rhone Poulenc Rorer Sa Nouveaux taxoides, leur preparation et les compositions pharmaceutiques qui les contiennent
US5780653A (en) * 1995-06-07 1998-07-14 Vivorx Pharmaceuticals, Inc. Nitrophenyl, 10-deacetylated substituted taxol derivatives as dual functional cytotoxic/radiosensitizers
US5760251A (en) 1995-08-11 1998-06-02 Sepracor, Inc. Taxol process and compounds
CA2231837A1 (en) 1995-09-13 1997-03-20 Florida State University Radiosensitizing taxanes and their pharmaceutical preparations
US5767297A (en) * 1997-02-05 1998-06-16 Ensuiko Sugar Refining Co., Ltd. Taxoid derivative and method of producing thereof
US6545168B1 (en) 1996-05-06 2003-04-08 Florida State University 1-deoxy baccatin III, 1-deoxy taxol and 1-deoxy taxol analogs and method for the preparation thereof
US5795909A (en) 1996-05-22 1998-08-18 Neuromedica, Inc. DHA-pharmaceutical agent conjugates of taxanes
JP4172726B2 (ja) 1996-05-22 2008-10-29 ルイトポルド・ファーマシューティカルズ・インコーポレーテッド シス―ドコサヘキサエン酸とドセタキセルとの共有複合体を含有する製剤
US6576636B2 (en) * 1996-05-22 2003-06-10 Protarga, Inc. Method of treating a liver disorder with fatty acid-antiviral agent conjugates
CN1097044C (zh) * 1996-07-15 2002-12-25 亚库尔特株式会社总社 紫杉烷衍生物以及含有该衍生物的药物
US5811452A (en) * 1997-01-08 1998-09-22 The Research Foundation Of State University Of New York Taxoid reversal agents for drug-resistance in cancer chemotherapy and pharmaceutical compositions thereof
US5912264A (en) * 1997-03-03 1999-06-15 Bristol-Myers Squibb Company 6-halo-or nitrate-substituted paclitaxels
HU224589B1 (hu) 1997-06-03 2005-11-28 Ensuiko Sugar Refining Co., Ltd. Taxoidszármazékok és eljárás előállításukra
US7288665B1 (en) 1997-08-18 2007-10-30 Florida State University Process for selective derivatization of taxanes
JPH1192468A (ja) 1997-09-17 1999-04-06 Yakult Honsha Co Ltd 新規なタキサン誘導体
CN1221539C (zh) * 1997-12-19 2005-10-05 株式会社益力多本社 紫杉烷衍生物
US6156789A (en) * 1998-03-17 2000-12-05 Rhone-Poulenc Rorer S.A. Method for treating abnormal cell proliferation in the brain
JP2003026673A (ja) 1999-03-05 2003-01-29 Asahi Kasei Corp 骨形成促進剤
IL145635A0 (en) 2000-02-02 2002-06-30 Univ Florida State Res Found Taxane formulations having improved solubility
PL202957B1 (pl) 2000-02-02 2009-08-31 Univ Florida State Res Found Podstawione grupą estrową C10 taksany, kompozycja farmaceutyczna zawierająca te związki i zastosowanie tych związków do wytwarzania leku
JP2003521545A (ja) * 2000-02-02 2003-07-15 フロリダ・ステイト・ユニバーシティ・リサーチ・ファウンデイション・インコーポレイテッド 改良された溶解性を有するタキサン製剤
HUP0200756A3 (en) * 2000-02-02 2005-02-28 Univ Florida State Res Found C7 carbonate substituted taxanes as antitumor agents and pharmaceutical compositions containing them
WO2001057031A1 (en) * 2000-02-02 2001-08-09 Florida State University Research Foundation, Inc. C10 carbonate substituted taxanes as antitumor agents
US6649632B2 (en) * 2000-02-02 2003-11-18 Fsu Research Foundation, Inc. C10 ester substituted taxanes
IT1319168B1 (it) 2000-03-17 2003-09-26 Indena Spa Derivati di condensazione ad attivita' antitumorale, loro metodo dipreparazione e formulazioni che li contengono.
JP4717252B2 (ja) * 2001-04-25 2011-07-06 株式会社小松製作所 プレスのスライド駆動装置
CA2354471A1 (en) * 2001-07-31 2003-01-31 Florida State University Research Foundation, Inc. C10 ester substituted taxanes
AU2006214498A1 (en) 2005-02-14 2006-08-24 Florida State University Research Foundation, Inc. C10 cyclopropyl ester substituted taxane compositions
WO2012020322A2 (en) * 2010-08-13 2012-02-16 Roilblue Corporation Oil containment assembly and method of using same

Also Published As

Publication number Publication date
BRPI0507671A (pt) 2007-07-17
DE602005024518D1 (en) 2010-12-16
NO20064090L (no) 2006-11-10
US20100056614A1 (en) 2010-03-04
ATE486596T1 (de) 2010-11-15
WO2005079319A3 (en) 2005-11-17
RU2006132741A (ru) 2008-03-20
WO2005079319A2 (en) 2005-09-01
AU2005214065A1 (en) 2005-09-01
HK1097534A1 (en) 2007-06-29
IL177372A0 (en) 2006-12-10
EP1713798A2 (en) 2006-10-25
KR20060129018A (ko) 2006-12-14
JP2007522236A (ja) 2007-08-09
ECSP066765A (es) 2006-12-29
AU2005214065A2 (en) 2005-09-01
HN2005000054A (es) 2009-02-18
CR8554A (es) 2008-04-25
TWI353354B (en) 2011-12-01
CA2556200A1 (en) 2005-09-01
TW200530209A (en) 2005-09-16
AU2005214065B2 (en) 2009-11-12
IL177372A (en) 2011-09-27
NZ548769A (en) 2009-10-30
JP4879757B2 (ja) 2012-02-22
SV2006002010A (es) 2006-08-23
US7589111B2 (en) 2009-09-15
EP1713798A4 (en) 2007-12-05
AR047704A1 (es) 2006-02-08
US8003812B2 (en) 2011-08-23
KR101169818B1 (ko) 2012-07-30
EP1713798B1 (en) 2010-11-03
US20050228037A1 (en) 2005-10-13
CA2556200C (en) 2012-06-26

Similar Documents

Publication Publication Date Title
ES2190440T3 (es) Compuestos antitumorales, composiciones farmaceuticas, modos de preparacion y para el tratamiento.
EA201070988A1 (ru) Противовирусные терапевтические средства
PA8534601A1 (es) Activadores de glucocinasa del tipo isoindolin-1-ona
CL2008003399A1 (es) Compuestos derivados de bis-(sulfonilamino), moduladores de la actividad de la sintasa de prostaglandina e1 microsomal; proceso de preparacion; composicion farmaceutica; proceso de preparacion; y uso en el tratamiento de dolor, osteoartritis, neoplasias, apnea, muerte subita del lactante, alzheimer, entre otars.
ECSP099436A (es) Acilaminopirazoles como inhibidores de fgfr
CO6440524A2 (es) Derivados de n-(hetero)aril-pirrolidina de pirazol-4-il-pirrolo[2,3-d]pirimidinas y pirrol-3-il-pirrolo[2,3-d]pirimidinas como inhibidores de la quinasa janus.
UY31728A (es) Derivados polisustituidos de 2-aril-6-fenil-imidazo[1,2-a]piridinas, su preparación y su aplicación en terapéutica
ES2109219T3 (es) Derivos de acidos 7-(1-pirrolidinil)-3-quinolon- y -naftiridoncarboxilicos, procedimiento para su preparacion, asi como derivados de pirrolidina mono- y biciclicos-sustituidos como productos intermedios para su preparacion, y sus composiciones antibacterianas y como aditivos para
UY26186A1 (es) Inhibidores de metaloproteasas
PE20090605A1 (es) Composiciones de fenilalanina amoniaco-liasa procariotica y metodos del tratamiento del cancer usando composiciones de la misma
UY29300A1 (es) Compuestos quimicos
UY31730A (es) Derivados polisustituidos de 6-heteroaril-imidazo[1,2-a]piridinas, su preparación y su aplicación en terapéutica.
UY31729A (es) Derivados polisustituidos de 2-heteroaril-6-fenil-imidazo[1,2-a]piridinas, su preparación y su aplicación en terapeútica
PE20060464A1 (es) Composicion farmaceutica que comprende flibanserina para el tratamiento de trastornos sexuales
CL2011000352A1 (es) Compuestos heterociclicos, con al menos un atomo de nitrogeno y opcionalmente atomos de nitrogeno, sustituidos; composicion farmaceutica; utiles en el tratamiento de enfermedades asociadas con alta epresion de mif, tales como enfermedades autoinmunitarias, cancer, anemia de enfermedades cronicas, malaria o asma, entre otras.
MXPA05009015A (es) Nuevos derivados de bencimidazol e imidazo-piridina y su utilizacion como medicamentos.
CL2010001159A1 (es) Compuestos derivados de 3,8-diazabiciclo[2.4.0]octano y 3,6-diazabiciclo[3.2.0]heptano disustituidos, moduladores del receptor de orexina; composicion farmaceutica; utiles en el tratamiento de trastornos del sueño, trastornos metabolicos, entre otros.
CL2011001760A1 (es) Combinación que comprende metotrexato y un inhibidor de dhodh no hepatotóxico; y uso en el tratamiento de enfermedades tales como artritis psoriatica, esclerosis multiple, psoriasis, entre otras.
EA201200918A1 (ru) Производные пирролидин карбоновой кислоты как агонисты сопряженного с g-белком рецептора 43 (gpr43), фармацевтическая композиция и методы их использования при лечении метаболических нарушений
AR074124A1 (es) Composiciones y metodos para inhibir la expresion de genes del factor vii
CL2009000727A1 (es) Compuestos derivados de n-hidroxi-3-fenilprop-2-enemida y n-hidroxi-3-fenilpropanamida sustituidos; inhibidores de la enzima desacetilasa; su composicion farmaceutica; utiles en el tratamiento del cancer, tumores, psoriasis, alzheimer, entre otras.
BR112012015437A2 (pt) composição tópica substancialmente anidra de armazenamento estável
AR034059A1 (es) Producto que comprende mikanolido, dihidromikanolido o analogos de los mismos en combinacion con otro agente anticanceroso para uso terapeutico en el tratamiento del cancer
ECSP045477A (es) COMPUESTOS DE AMIDAS DE ÁCIDO3-AMINO-TIENO[2,3-b]PIRIDINO-2-CARBOXÍLICO SUSTITUIDOY PROCEDIMIENTOS PARA PREPARARLOS Y SUS USOS.
EP1909783A4 (en) ILLUDIN ANALOGUE AS CANCER

Legal Events

Date Code Title Description
FG Grant, registration
FD Application declared void or lapsed