FI934185L - Antiarrytmiska och hjaertskyddande substituerade 1(2H)-isokinoliner, metod foer deras framstaellning, laekemedel innehaollande dem och deras anvaendning foer framstaellning av laekemedel foer att bekaempa hjaertsjukdomar - Google Patents

Antiarrytmiska och hjaertskyddande substituerade 1(2H)-isokinoliner, metod foer deras framstaellning, laekemedel innehaollande dem och deras anvaendning foer framstaellning av laekemedel foer att bekaempa hjaertsjukdomar Download PDF

Info

Publication number: FI934185L
Authority: FI; Finland
Prior art keywords: foer; laekemedel; framstaellning; och; deras
Prior art date: 1992-09-28

Application number

FI934185A

Other languages

English (en)

Other versions

FI934185A0 (fi

FI103884B1 (fi

FI103884B (fi

Inventor

Bansi Lal

Ramesh Matioram Gidwani

Ramanujam Rajagopalan

Radha Panicker

Chinnakulandai Sankar

Hans-Jochen Lang

Heinrich Englert

Wolfgang Scholz

Original Assignee

Hoechst Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-09-28

Filing date

1993-09-24

Publication date

1994-03-29

1993-09-24 Application filed by Hoechst Ag filed Critical Hoechst Ag

1993-09-24 Publication of FI934185A0 publication Critical patent/FI934185A0/fi

1994-03-29 Publication of FI934185L publication Critical patent/FI934185L/fi

1999-10-15 Application granted granted Critical

1999-10-15 Publication of FI103884B1 publication Critical patent/FI103884B1/fi

1999-10-15 Publication of FI103884B publication Critical patent/FI103884B/fi

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Cardiology (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Heart & Thoracic Surgery (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Vascular Medicine (AREA)
Urology & Nephrology (AREA)
Hospice & Palliative Care (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Other In-Based Heterocyclic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Medicinal Preparation (AREA)

FI934185A 1992-09-28 1993-09-24 Menetelmä farmaseuttisesti tehokkaiden guanidinokarbonyylisubstituoitujen isokinoliinien valmistamiseksi FI103884B (fi)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP92116535		1992-09-28
EP92116535		1992-09-28

Publications (4)

Publication Number	Publication Date
FI934185A0 FI934185A0 (fi)	1993-09-24
FI934185L true FI934185L (fi)	1994-03-29
FI103884B1 FI103884B1 (fi)	1999-10-15
FI103884B FI103884B (fi)	1999-10-15

Family

ID=8210063

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
FI934185A FI103884B (fi)	1992-09-28	1993-09-24	Menetelmä farmaseuttisesti tehokkaiden guanidinokarbonyylisubstituoitujen isokinoliinien valmistamiseksi

Country Status (18)

Country	Link
US (1)	US5416094A (fi)
EP (1)	EP0590455B1 (fi)
JP (1)	JP3645579B2 (fi)
AT (1)	ATE198328T1 (fi)
AU (1)	AU662079B2 (fi)
CA (1)	CA2107008C (fi)
DE (1)	DE69329787T2 (fi)
DK (1)	DK0590455T3 (fi)
ES (1)	ES2152938T3 (fi)
FI (1)	FI103884B (fi)
GR (1)	GR3035537T3 (fi)
HU (1)	HU218208B (fi)
IL (1)	IL107118A (fi)
NO (1)	NO180374C (fi)
NZ (1)	NZ248761A (fi)
PT (1)	PT590455E (fi)
TW (1)	TW272189B (fi)
ZA (1)	ZA937141B (fi)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE4344550A1 (de) *	1993-12-24	1995-06-29	Hoechst Ag	Substituierte 1-Oxo-1,2-dihydro-isochinolinoyl- und 1,1-Dioxo-2H-1,2-benzothiazinoylguanidine, Verfahrenzu ihrer Herstellung, ihre Verwendung als Medikamentt oder Diagnostikum sowie sie enthaltendes Medikamen
DE4412334A1 (de) *	1994-04-11	1995-10-19	Hoechst Ag	Substituierte N-Heteroaroylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
DE4415873A1 (de) *	1994-05-05	1995-11-09	Hoechst Ag	Substituierte bizyklische Heteroaroylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
US5627193A (en) *	1995-02-09	1997-05-06	Mitsui Toatsu Chemicals, Inc.	Quinoline-4-carbonylguanidine derivatives, process for producing the same and pharmaceutical preparations containing the compounds
WO1997016428A1 (en) *	1995-10-19	1997-05-09	Torrey Pines Institute For Molecular Studies	Isoquinoline derivatives and isoquinoline combinatorial libraries
US5874443A (en) *	1995-10-19	1999-02-23	Trega Biosciences, Inc.	Isoquinoline derivatives and isoquinoline combinatorial libraries
DE19540995A1 (de) *	1995-11-03	1997-05-07	Hoechst Ag	Substituierte Sulfonimidamide, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
DE19542306A1 (de) *	1995-11-14	1997-05-15	Hoechst Ag	Sulfonylamino-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
PL316439A1 (en) *	1995-11-20	1997-05-26	Hoechst Ag	Novel substituted derivatives of benzoyloguanidine, method of obtaining them, their application in production of pharmaceutic and diagnostic agents and pharmaceutic agent as such
DE19546736A1 (de) *	1995-12-14	1997-06-19	Hoechst Ag	Substituierte Chromanylsulfonyl(thio)harnstoffe, Verfahren zu ihrer Herstellung und ihre Verwendung zur Herstellung pharmazeutischer Präparate
DE19548708A1 (de) *	1995-12-23	1997-06-26	Merck Patent Gmbh	Cyclische Sulfone
US20040122096A1 (en) *	1996-06-03	2004-06-24	Hoechst Aktiengesellschaft	Use of inhibitors of the cellular Na+/H+ exchanger (NHE) for preparing a medicament for normalizing serum lipids
US5916899A (en) *	1996-10-18	1999-06-29	Trega Biosciences, Inc.	Isoquinoline derivatives and isoquinoline combinatorial libraries
US5952328A (en) *	1997-11-12	1999-09-14	Cephalon, Inc.	Benzothiazo and related heterocyclic group-containing cysteine and serine protease inhibitors
JP2002514192A (ja) *	1996-11-13	2002-05-14	セフアロン・インコーポレーテツド	ベンゾチアゾおよび関連の複素環基を含有するシステインおよびセリンプロテアーゼ阻害剤
JP2002502414A (ja) *	1997-06-02	2002-01-22	藤沢薬品工業株式会社	細胞中のＮａ▲上＋▼／Ｈ▲上＋▼交換の阻害剤としてのグアニジン誘導体
US6284735B1 (en)	1998-04-28	2001-09-04	Lion Bioscience Ag	HP-3228 and related peptides to treat sexual dysfunction
US6534503B1 (en)	1998-04-28	2003-03-18	Lion Bioscience Ag	Melanocortin receptor-3 ligands to treat sexual dysfunction
WO1999055679A1 (en)	1998-04-28	1999-11-04	Trega Biosciences, Inc.	Isoquinoline compound melanocortin receptor ligands and methods of using same
DE19859727A1 (de) *	1998-12-23	2000-06-29	Aventis Pharma Gmbh	Die Verwendung von Hemmern des Natrium-Wasserstoff-Austauschers zur Herstellung eines Medikaments zur Verhinderung von altersbedingten Organ-Dysfunktionen, altersbedingten Erkrankungen zur Lebensverlängerung
CN102516170A (zh) *	2004-12-24	2012-06-27	阿斯利康(瑞典)有限公司	酰胺衍生物
WO2007053610A2 (en) *	2005-11-01	2007-05-10	The Regents Of The University Of California	Methods of treating atrial fibrillation wtih pirfenidone
RU2008136898A (ru) *	2006-02-15	2010-03-20	Санофи-Авентис (Fr)	Азациклил-замещенные арилдигидроизохинолиноны, способ их получения и их применение в качестве лекарственных средств
US9604931B2 (en)	2007-01-22	2017-03-28	Gtx, Inc.	Nuclear receptor binding agents
KR101763674B1 (ko)	2007-01-22	2017-08-01	지티엑스, 인코포레이티드	핵 수용체에 결합하는 물질
US9623021B2 (en) *	2007-01-22	2017-04-18	Gtx, Inc.	Nuclear receptor binding agents
US10344002B2 (en)	2016-09-26	2019-07-09	Nusirt Sciences, Inc.	Compositions and methods for treating metabolic disorders
AU2019247653B2 (en) *	2018-04-06	2024-12-19	The Board Of Trustees Of The University Of Illinois	1,4-substituted isoquinoline inhibitors of KEAP1/NRF2 protein-protein interaction
KR102605163B1 (ko) *	2021-06-01	2023-11-23	연세대학교 산학협력단	뇌암의 예방 또는 치료용 조성물

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3780027A (en) *	1970-04-29	1973-12-18	Merck & Co Inc	Anthranilic acid derivatives
DE2818423A1 (de) *	1978-04-27	1979-11-08	Hoechst Ag	Neue isochinolinderivate und verfahren zu ihrer herstellung
DE3013906A1 (de) *	1980-04-11	1981-10-15	C.H. Boehringer Sohn, 6507 Ingelheim	Substituierte (alpha) -aminocarbonyl-l-benzyl-3,4-dihydro-isochinoline, verfahren zu deren herstellung und deren verwendung
DE3233424A1 (de) *	1982-09-09	1984-03-15	Hoechst Ag, 6230 Frankfurt	Isochinolinderivate, verfahren zu ihrer herstellung, pharmazeutische praeparate auf basis dieser verbindungen und ihre verwendung
JP2930399B2 (ja) *	1990-10-18	1999-08-03	雪印乳業株式会社	新規イソキノリン誘導体またはその酸付加塩

1993
- 1993-09-20 AT AT93115081T patent/ATE198328T1/de not_active IP Right Cessation
- 1993-09-20 EP EP93115081A patent/EP0590455B1/en not_active Expired - Lifetime
- 1993-09-20 ES ES93115081T patent/ES2152938T3/es not_active Expired - Lifetime
- 1993-09-20 PT PT93115081T patent/PT590455E/pt unknown
- 1993-09-20 DK DK93115081T patent/DK0590455T3/da active
- 1993-09-20 DE DE69329787T patent/DE69329787T2/de not_active Expired - Lifetime
- 1993-09-24 FI FI934185A patent/FI103884B/fi active
- 1993-09-24 US US08/126,200 patent/US5416094A/en not_active Expired - Lifetime
- 1993-09-24 NZ NZ248761A patent/NZ248761A/en unknown
- 1993-09-27 JP JP23996693A patent/JP3645579B2/ja not_active Expired - Fee Related
- 1993-09-27 ZA ZA937141A patent/ZA937141B/xx unknown
- 1993-09-27 NO NO933450A patent/NO180374C/no unknown
- 1993-09-27 CA CA002107008A patent/CA2107008C/en not_active Expired - Lifetime
- 1993-09-27 IL IL107118A patent/IL107118A/en not_active IP Right Cessation
- 1993-09-27 AU AU48659/93A patent/AU662079B2/en not_active Ceased
- 1993-09-27 HU HU9302725A patent/HU218208B/hu not_active IP Right Cessation
- 1993-10-14 TW TW082108497A patent/TW272189B/zh active
2001
- 2001-03-09 GR GR20010400378T patent/GR3035537T3/el not_active IP Right Cessation

Also Published As

Publication number	Publication date
GR3035537T3 (en)	2001-06-29
JPH06211799A (ja)	1994-08-02
AU4865993A (en)	1994-04-14
DE69329787D1 (de)	2001-02-01
HU9302725D0 (en)	1993-12-28
AU662079B2 (en)	1995-08-17
ES2152938T3 (es)	2001-02-16
DE69329787T2 (de)	2001-06-13
NO933450D0 (no)	1993-09-27
ZA937141B (en)	1994-05-18
IL107118A (en)	1998-06-15
NO180374C (no)	1997-04-09
ATE198328T1 (de)	2001-01-15
NO933450L (no)	1994-03-29
CA2107008C (en)	2004-11-16
EP0590455B1 (en)	2000-12-27
DK0590455T3 (da)	2001-01-22
HU218208B (hu)	2000-06-28
CA2107008A1 (en)	1994-03-29
FI934185A0 (fi)	1993-09-24
NZ248761A (en)	1995-04-27
JP3645579B2 (ja)	2005-05-11
TW272189B (fi)	1996-03-11
FI103884B1 (fi)	1999-10-15
US5416094A (en)	1995-05-16
NO180374B (no)	1996-12-30
HUT70149A (en)	1995-09-28
PT590455E (pt)	2001-04-30
FI103884B (fi)	1999-10-15
EP0590455A1 (en)	1994-04-06
IL107118A0 (en)	1993-12-28

Publication	Publication Date	Title
FI934185L (fi)	1994-03-29	Antiarrytmiska och hjaertskyddande substituerade 1(2H)-isokinoliner, metod foer deras framstaellning, laekemedel innehaollande dem och deras anvaendning foer framstaellning av laekemedel foer att bekaempa hjaertsjukdomar
FI935174L (fi)	1993-11-22	Tumoeravstoetande antigenprekursorer, tumoeravstoetande antigener och anvaendning av dem
FI922474L (fi)	1992-12-01	Nedbrytbara sulfonatgrupphaltiga kelatmedel, anvaendning av dem och kompositioner innehaollande dem
FI916182A7 (fi)	1992-07-19	Kombinerad metod foer faststaellande av brand.
FI934440L (fi)	1994-04-09	Fibrintaeckmedelskompositioner och foerfaranden foer anvaendning av dem
FI933472A0 (fi)	1993-08-05	Peptider med foermaoga att inhibera effekten av hiv-proteas, deras framstaellning och terapeutiska anvaendning
FI931763L (fi)	1993-10-21	4,1-bensoxazepinderivat och deras anvaendning
FI922649A0 (fi)	1992-06-08	Foerfarande och anordning foer att effektivera funktionen av ett yankeepressparti i en mjukpappersmaskin.
FI923923A0 (fi)	1992-09-01	Utvidgning av ett radiotelefonsystem foer att minska stroemfoerbrukningen.
FI921488L (fi)	1992-04-03	Metod foer att lagra roedceller under bibehaollandet av atp- och 2,3-dpg-koncentrationerna i cellerna.
FI932718A7 (fi)	1993-12-18	Aotervinning av raoaemnen ur pappersindustrins avlut och aoteranvaendning av dem
FI932255L (fi)	1993-11-19	Alkalinproteaser, bakterier producerande dem, foerfarande foer framstaellning av dessa alkalinproteaser, anvaendning av dessa alkalinproteaser och tvaettmedelskompositioner innehaollande dem
FI935936A0 (fi)	1993-12-30	Foerfarande och anlaeggning foer att hindra avkylning av elektrokemiska anlaeggningar
FI914030L (fi)	1992-02-29	Metod foer behandling av i oeverlappspackform fallande tryckeriprodukter.
FI923170A7 (fi)	1993-01-13	Spicamycinderivat och anvaendning av dem
FI933065L (fi)	1993-07-02	Foerfarande foer framstaellning av azabicyklo (2.2.2)oktan-3-iminer och foerfarandet anvaenda mellanprodukter
FI922867A0 (fi)	1992-06-18	Dikarbonsyraderivat och foerfarande foer framstaellning av dem.
FI933544A0 (fi)	1993-08-11	Tiadiazinkarboxamidderivat, foerfaranden foer framstaellning av dem och laekemedel
FI920754A0 (fi)	1992-02-21	Foerfarande foer att definiera laeget av ett laongstraeckt stycke.
FI933543L (fi)	1993-08-11	3-substituerade 1,2,3,4-oxatriatzol-5-iminfoereningar och en metod att framstaella dem och ett farmaceutiskt preparat, som innehaoller naemnda foereningar
FI933605A0 (fi)	1993-08-16	Sammansaettningar av 1-klor-2,2,2-trifluoretyldifluormetyleter och partiellt fluorerade alkanoler
FI934928A7 (fi)	1994-05-11	Foerfarande foer framstaellning av 3,7-dialkylxantiner fraon 3-alkylxantiner
FI925258A7 (fi)	1993-05-27	Foerfarande foer framstaellning av 2-substituerade 4,6-dialkoxipyrimidiner
FI930117L (fi)	1993-07-14	Blandningar av 1,1,1-trifluoretan och perfluorpropan och deras anvaendning som kylvaetskor, som aerosoldrivgaser och som expansionsmedel foer plastskum
FI924607L (fi)	1993-04-15	Konstgjorda standard- och kontrollsera, foerfarande foer framstaellning och anvaendning av dem