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FI924227A0 - Nya alkoxisubstituerade taxaner och farmaceutiska kompositioner innehaollande dessa. - Google Patents

Nya alkoxisubstituerade taxaner och farmaceutiska kompositioner innehaollande dessa.

Info

Publication number
FI924227A0
FI924227A0 FI924227A FI924227A FI924227A0 FI 924227 A0 FI924227 A0 FI 924227A0 FI 924227 A FI924227 A FI 924227A FI 924227 A FI924227 A FI 924227A FI 924227 A0 FI924227 A0 FI 924227A0
Authority
FI
Finland
Prior art keywords
taxaner
nya
substitutes
alcoholic
pharmaceutical composition
Prior art date
Application number
FI924227A
Other languages
English (en)
Other versions
FI112478B (fi
FI924227L (fi
Inventor
Robert A Holton
Ronald J Biediger
Original Assignee
Univ Florida State
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Florida State filed Critical Univ Florida State
Publication of FI924227A0 publication Critical patent/FI924227A0/fi
Publication of FI924227L publication Critical patent/FI924227L/fi
Application granted granted Critical
Publication of FI112478B publication Critical patent/FI112478B/fi

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D407/00Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D305/00Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/003Compounds containing elements of Groups 4 or 14 of the Periodic Table without C-Metal linkages
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02Silicon compounds
    • C07F7/08Compounds having one or more C—Si linkages
    • C07F7/18Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804Compounds having Si-O-C linkages
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/55Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Polyethers (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
FI924227A 1991-09-23 1992-09-21 Menetelmä lääkeaineena käyttökelpoisten 3'-alkoksikarbonyyliamino-substituoitujen taksaanijohdannaisten valmistamiseksi FI112478B (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US76380591A 1991-09-23 1991-09-23
US76380591 1991-09-23
US86319892 1992-04-03
US07/863,198 US5243045A (en) 1991-09-23 1992-04-03 Certain alkoxy substituted taxanes and pharmaceutical compositions containing them

Publications (3)

Publication Number Publication Date
FI924227A0 true FI924227A0 (fi) 1992-09-21
FI924227L FI924227L (fi) 1993-03-24
FI112478B FI112478B (fi) 2003-12-15

Family

ID=27117341

Family Applications (1)

Application Number Title Priority Date Filing Date
FI924227A FI112478B (fi) 1991-09-23 1992-09-21 Menetelmä lääkeaineena käyttökelpoisten 3'-alkoksikarbonyyliamino-substituoitujen taksaanijohdannaisten valmistamiseksi

Country Status (15)

Country Link
US (1) US5243045A (fi)
EP (1) EP0534707B1 (fi)
JP (1) JP3217155B2 (fi)
AT (1) ATE146464T1 (fi)
AU (1) AU653247B2 (fi)
CA (1) CA2077598C (fi)
DE (1) DE69216028T2 (fi)
DK (1) DK0534707T3 (fi)
ES (1) ES2101044T3 (fi)
FI (1) FI112478B (fi)
GR (1) GR3022853T3 (fi)
HU (1) HU218283B (fi)
MX (1) MX9205310A (fi)
NO (1) NO303633B1 (fi)
NZ (1) NZ244456A (fi)

Families Citing this family (72)

* Cited by examiner, † Cited by third party
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US5728850A (en) * 1991-09-23 1998-03-17 Florida State University Taxanes having a butenyl substituted side-chain and pharmaceutical compositions containing them
US6495704B1 (en) 1991-09-23 2002-12-17 Florida State University 9-desoxotaxanes and process for the preparation of 9-desoxotaxanes
ZA926829B (en) * 1991-09-23 1993-03-15 Univ Florida State Novel substituted taxanes and pharmaceutical compositions containing them.
US5998656A (en) 1991-09-23 1999-12-07 Florida State University C10 tricyclic taxanes
US6794523B2 (en) 1991-09-23 2004-09-21 Florida State University Taxanes having t-butoxycarbonyl substituted side-chains and pharmaceutical compositions containing them
US5728725A (en) * 1991-09-23 1998-03-17 Florida State University C2 taxane derivaties and pharmaceutical compositions containing them
US6018073A (en) * 1991-09-23 2000-01-25 Florida State University Tricyclic taxanes having an alkoxy, alkenoxy or aryloxy substituted side-chain and pharmaceutical compositions containing them
US5654447A (en) * 1991-09-23 1997-08-05 Florida State University Process for the preparation of 10-desacetoxybaccatin III
US5710287A (en) * 1991-09-23 1998-01-20 Florida State University Taxanes having an amino substituted side-chain and pharmaceutical compositions containing them
US6011056A (en) 1991-09-23 2000-01-04 Florida State University C9 taxane derivatives and pharmaceutical compositions containing them
US5489601A (en) * 1991-09-23 1996-02-06 Florida State University Taxanes having a pyridyl substituted side-chain and pharmaceutical compositions containing them
US6005138A (en) * 1991-09-23 1999-12-21 Florida State University Tricyclic taxanes having a butenyl substituted side-chain and pharmaceutical compositions containing them
US6028205A (en) * 1991-09-23 2000-02-22 Florida State University C2 tricyclic taxanes
US6335362B1 (en) 1991-09-23 2002-01-01 Florida State University Taxanes having an alkyl substituted side-chain and pharmaceutical compositions containing them
US5739362A (en) * 1991-09-23 1998-04-14 Florida State University Taxanes having an alkoxy, alkenoxy or aryloxy substituted side-chain and pharmaceutical compositions containing them
US5714513A (en) * 1991-09-23 1998-02-03 Florida State University C10 taxane derivatives and pharmaceutical compositions
US5721268A (en) 1991-09-23 1998-02-24 Florida State University C7 taxane derivatives and pharmaceutical compositions containing them
PT552041E (pt) * 1992-01-15 2000-12-29 Squibb & Sons Inc Processo enzimaticos para a resolucao de misturas enantiomericas de compostos uteis como intermediarios para a preparacao de taxanos
US5272171A (en) * 1992-02-13 1993-12-21 Bristol-Myers Squibb Company Phosphonooxy and carbonate derivatives of taxol
US5445809A (en) * 1992-03-03 1995-08-29 Research And Development Institute At Montana State University Production of taxol from the yew tree
US5451392A (en) * 1992-03-03 1995-09-19 The Research And Development Institute At Montana State University Production of taxol
US5294637A (en) * 1992-07-01 1994-03-15 Bristol-Myers Squibb Company Fluoro taxols
US5254580A (en) * 1993-01-19 1993-10-19 Bristol-Myers Squibb Company 7,8-cyclopropataxanes
FR2696461B1 (fr) * 1992-10-05 1994-11-10 Rhone Poulenc Rorer Sa Nouveaux dérivés d'analogues du taxol, leur préparation et les compositions qui les contiennent.
US5380751A (en) * 1992-12-04 1995-01-10 Bristol-Myers Squibb Company 6,7-modified paclitaxels
FR2698871B1 (fr) 1992-12-09 1995-02-24 Rhone Poulenc Rorer Sa Nouveau taxoïdes, leur préparation et les compositions pharmaceutiques qui les contiennent.
US5973160A (en) 1992-12-23 1999-10-26 Poss; Michael A. Methods for the preparation of novel sidechain-bearing taxanes
US5646176A (en) * 1992-12-24 1997-07-08 Bristol-Myers Squibb Company Phosphonooxymethyl ethers of taxane derivatives
DK0679156T3 (da) * 1993-01-15 2000-09-04 Univ Florida State Fremgangsmåde til fremstilling af 10-desacetoxybaccatin III og 10-desacetoxytaxol og derivater deraf
IL108316A (en) * 1993-01-15 2006-10-31 Univ Florida State C10 taxane derivatives and pharmaceutical compositions containing them
US6710191B2 (en) * 1993-03-05 2004-03-23 Florida State University 9β-hydroxytetracyclic taxanes
EP0687260B1 (en) * 1993-03-05 2003-02-19 Florida State University Process for the preparation of 9-desoxotaxanes
TW467896B (en) * 1993-03-19 2001-12-11 Bristol Myers Squibb Co Novel β-lactams, methods for the preparation of taxanes and sidechain-bearing taxanes
JPH08508469A (ja) * 1993-03-22 1996-09-10 フロリダ・ステート・ユニバーシティー アルコキシ、アルケンオキシまたはアリールオキシ置換側鎖を有するタキサンおよびそれを含有する薬剤組成物
IT1261667B (it) * 1993-05-20 1996-05-29 Tassano ad attivita' antitumorale.
TW397866B (en) * 1993-07-14 2000-07-11 Bristol Myers Squibb Co Enzymatic processes for the resolution of enantiomeric mixtures of compounds useful as intermediates in the preparation of taxanes
US5965566A (en) * 1993-10-20 1999-10-12 Enzon, Inc. High molecular weight polymer-based prodrugs
US6201140B1 (en) 1994-07-28 2001-03-13 Bristol-Myers Squibb Company 7-0-ethers of taxane derivatives
US6500858B2 (en) 1994-10-28 2002-12-31 The Research Foundation Of The State University Of New York Taxoid anti-tumor agents and pharmaceutical compositions thereof
US5840748A (en) * 1995-10-02 1998-11-24 Xechem International, Inc. Dihalocephalomannine and methods of use therefor
US5654448A (en) * 1995-10-02 1997-08-05 Xechem International, Inc. Isolation and purification of paclitaxel from organic matter containing paclitaxel, cephalomannine and other related taxanes
US5807888A (en) * 1995-12-13 1998-09-15 Xechem International, Inc. Preparation of brominated paclitaxel analogues and their use as effective antitumor agents
US5854278A (en) * 1995-12-13 1998-12-29 Xechem International, Inc. Preparation of chlorinated paclitaxel analogues and use thereof as antitumor agents
US6177456B1 (en) 1995-10-02 2001-01-23 Xechem International, Inc. Monohalocephalomannines having anticancer and antileukemic activity and method of preparation therefor
IL126856A0 (en) * 1996-05-06 1999-09-22 Univ Florida State 1-Deoxy baccatin iii 1-deoxy taxol and 1-deoxy taxol analogs and method for the preparation thereof
US6017935A (en) * 1997-04-24 2000-01-25 Bristol-Myers Squibb Company 7-sulfur substituted paclitaxels
JPH1192468A (ja) * 1997-09-17 1999-04-06 Yakult Honsha Co Ltd 新規なタキサン誘導体
US6156789A (en) * 1998-03-17 2000-12-05 Rhone-Poulenc Rorer S.A. Method for treating abnormal cell proliferation in the brain
US6136988A (en) * 1998-04-10 2000-10-24 Hauser, Inc. 7-hexanoyltaxol and methods for preparing the same
ES2273698T3 (es) 1999-05-28 2007-05-16 Bristol-Myers Squibb Company Semisintesis de pactitaxel usando dialquildiclorosilanos.
WO2001024763A2 (en) 1999-10-01 2001-04-12 Immunogen, Inc. Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents
GEP20043239B (en) * 2000-02-02 2004-05-25 Florida State Univ Research Foundation Us C10 Carbonate Substituted Taxanes as Antitumor Agents
AR030188A1 (es) * 2000-02-02 2003-08-13 Univ Florida State Res Found Compuestos de taxano sustituidos con esteres en el c7; composiciones farmaceuticas que los contienen y proceso para tratar un sujeto mamifero que sufre de una condicion que responde a los taxanos
IL145643A0 (en) 2000-02-02 2002-06-30 Univ Florida State Res Found C7 carbamoyloxy substituted taxanes as antitumor agents
GEP20043323B (en) * 2000-02-02 2004-02-10 Univ Florida State Res Found C10 Carbonate Substituted Taxanes as Antitumor Agents
US6649632B2 (en) * 2000-02-02 2003-11-18 Fsu Research Foundation, Inc. C10 ester substituted taxanes
CN1362876A (zh) * 2000-02-02 2002-08-07 佛罗里达州立大学研究基金有限公司 C10杂取代的乙酸基紫衫烷抗肿瘤剂
CZ20013498A3 (cs) * 2000-02-02 2002-04-17 Florida State University Research Foundation, Inc. Taxanové formulace mající zlepąenou rozpustnost
IL145640A (en) * 2000-02-02 2007-02-11 Univ Florida State Res Found Texans are converted to C10 in myamloxy as anti-cancer agents
AU776122B2 (en) 2000-02-02 2004-08-26 Florida State University Research Foundation, Inc. C7 carbonate substituted taxanes as antitumor agents
AU776765B2 (en) * 2000-02-02 2004-09-23 Florida State University Research Foundation, Inc. C7 heterosubstituted acetate taxanes as antitumor agents
EP1175414A1 (en) * 2000-02-02 2002-01-30 Florida State University Research Foundation, Inc. Taxane formulations having improved solubility
US6638742B1 (en) 2000-07-07 2003-10-28 University Of Portland Methods for obtaining taxanes
PL366100A1 (en) * 2000-09-22 2005-01-24 Bristol-Myers Squibb Company Method for reducing toxicity of combined chemotherapies
SG129990A1 (en) * 2001-08-01 2007-03-20 Univ Florida State Res Found C10 ester substituted taxanes
US7063977B2 (en) * 2001-08-21 2006-06-20 Bristol-Myers Squibb Company Enzymatic resolution of t-butyl taxane derivatives
CN1596250A (zh) * 2001-11-30 2005-03-16 布里斯托尔-迈尔斯斯奎布公司 紫杉醇溶剂化物
US7064980B2 (en) * 2003-09-17 2006-06-20 Sandisk Corporation Non-volatile memory and method with bit line coupled compensation
PE20050693A1 (es) * 2004-02-13 2005-09-27 Univ Florida State Res Found Taxanos sustituidos con esteres de ciclopentilo en c10
WO2005087222A1 (en) 2004-03-05 2005-09-22 Florida State University Research Foundation, Inc. C7 lactyloxy-substituted taxanes
JP2008530122A (ja) * 2005-02-14 2008-08-07 フロリダ・ステイト・ユニバーシティ・リサーチ・ファウンデイション・インコーポレイテッド C10シクロプロピルエステル置換タキサン組成物
WO2009145981A1 (en) * 2008-03-31 2009-12-03 Florida State University Research Foundation, Inc. C(10) ethyl ester and c(10) cyclopropyl ester substituted taxanes

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2601675B1 (fr) * 1986-07-17 1988-09-23 Rhone Poulenc Sante Derives du taxol, leur preparation et les compositions pharmaceutiques qui les contiennent
FR2601676B1 (fr) * 1986-07-17 1988-09-23 Rhone Poulenc Sante Procede de preparation du taxol et du desacetyl-10 taxol
US4942184A (en) * 1988-03-07 1990-07-17 The United States Of America As Represented By The Department Of Health And Human Services Water soluble, antineoplastic derivatives of taxol
FR2629819B1 (fr) * 1988-04-06 1990-11-16 Rhone Poulenc Sante Procede de preparation de derives de la baccatine iii et de la desacetyl-10 baccatine iii
FR2629818B1 (fr) * 1988-04-06 1990-11-16 Centre Nat Rech Scient Procede de preparation du taxol
US5015744A (en) * 1989-11-14 1991-05-14 Florida State University Method for preparation of taxol using an oxazinone
US5250683A (en) * 1991-09-23 1993-10-05 Florida State University Certain substituted taxanes and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
CA2077598A1 (en) 1993-03-24
HU9203016D0 (en) 1992-12-28
DE69216028D1 (de) 1997-01-30
EP0534707A1 (en) 1993-03-31
US5243045A (en) 1993-09-07
NO923678D0 (no) 1992-09-22
MX9205310A (es) 1993-07-01
FI112478B (fi) 2003-12-15
CA2077598C (en) 1997-11-25
JPH05239044A (ja) 1993-09-17
FI924227L (fi) 1993-03-24
JP3217155B2 (ja) 2001-10-09
EP0534707B1 (en) 1996-12-18
NZ244456A (en) 1995-04-27
GR3022853T3 (en) 1997-06-30
AU2212392A (en) 1993-03-25
HU218283B (en) 2000-07-28
NO923678L (no) 1993-03-24
ATE146464T1 (de) 1997-01-15
HUT62873A (en) 1993-06-28
DE69216028T2 (de) 1997-07-03
NO303633B1 (no) 1998-08-10
ES2101044T3 (es) 1997-07-01
AU653247B2 (en) 1994-09-22
DK0534707T3 (da) 1997-06-09

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