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FI911885A7 - Menetelmä terapeuttisesti käyttökelpoisten 2,9-disubstituoitujen 3-/2-/4-(6-fluori-1,2-bentsisoksatsol-3-yyli)-piperidinyyli/etyyli/-4H-pyrido/1,2-a/pyrimidin-4-onien valmistamiseksi - Google Patents

Menetelmä terapeuttisesti käyttökelpoisten 2,9-disubstituoitujen 3-/2-/4-(6-fluori-1,2-bentsisoksatsol-3-yyli)-piperidinyyli/etyyli/-4H-pyrido/1,2-a/pyrimidin-4-onien valmistamiseksi

Info

Publication number
FI911885A7
FI911885A7 FI911885A FI911885A FI911885A7 FI 911885 A7 FI911885 A7 FI 911885A7 FI 911885 A FI911885 A FI 911885A FI 911885 A FI911885 A FI 911885A FI 911885 A7 FI911885 A7 FI 911885A7
Authority
FI
Finland
Prior art keywords
benzisoxazol
pyrido
pyrimidin
disubstituted
piperidinyl
Prior art date
Application number
FI911885A
Other languages
English (en)
Swedish (sv)
Other versions
FI96206C (fi
FI911885A0 (fi
FI96206B (fi
Inventor
Ludo Edmond Josephine Kennis
Jan Vandenberk
Heertum Albertus Hendricus Van
Original Assignee
Jansson Pharmaceutica N V
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Jansson Pharmaceutica N V filed Critical Jansson Pharmaceutica N V
Publication of FI911885A0 publication Critical patent/FI911885A0/fi
Publication of FI911885A7 publication Critical patent/FI911885A7/fi
Application granted granted Critical
Publication of FI96206B publication Critical patent/FI96206B/fi
Publication of FI96206C publication Critical patent/FI96206C/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Psychiatry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyridine Compounds (AREA)
  • Electrochromic Elements, Electrophoresis, Or Variable Reflection Or Absorption Elements (AREA)
FI911885A 1990-04-19 1991-04-18 Menetelmä terapeuttisesti käyttökelpoisten 2,9-disubstituoitujen 3-/2-/4-(6-fluori-1,2-bentsisoksatsol-3-yyli)-piperidinyyli/etyyli/-4H-pyrido/1,2-a/pyrimidin-4-onien valmistamiseksi FI96206C (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB909008850A GB9008850D0 (en) 1990-04-19 1990-04-19 Novel 2,9-disubstituted-4h-pyridol(1,2-a)pyrimidin-4-ones
GB9008850 1990-04-19

Publications (4)

Publication Number Publication Date
FI911885A0 FI911885A0 (fi) 1991-04-18
FI911885A7 true FI911885A7 (fi) 1991-10-20
FI96206B FI96206B (fi) 1996-02-15
FI96206C FI96206C (fi) 1996-05-27

Family

ID=10674694

Family Applications (1)

Application Number Title Priority Date Filing Date
FI911885A FI96206C (fi) 1990-04-19 1991-04-18 Menetelmä terapeuttisesti käyttökelpoisten 2,9-disubstituoitujen 3-/2-/4-(6-fluori-1,2-bentsisoksatsol-3-yyli)-piperidinyyli/etyyli/-4H-pyrido/1,2-a/pyrimidin-4-onien valmistamiseksi

Country Status (26)

Country Link
US (1) US5482943A (fi)
EP (1) EP0453042B1 (fi)
JP (1) JP3216889B2 (fi)
KR (1) KR100190297B1 (fi)
CN (1) CN1027506C (fi)
AT (1) ATE186301T1 (fi)
AU (1) AU636969B2 (fi)
BG (2) BG60394B1 (fi)
CA (1) CA2040086C (fi)
CZ (1) CZ281135B6 (fi)
DE (1) DE69131759T2 (fi)
DK (1) DK0453042T3 (fi)
ES (1) ES2140381T3 (fi)
FI (1) FI96206C (fi)
GB (1) GB9008850D0 (fi)
GR (1) GR3032122T3 (fi)
HU (1) HUT57763A (fi)
IE (1) IE911301A1 (fi)
IL (1) IL97892A (fi)
NO (1) NO176840C (fi)
NZ (1) NZ237713A (fi)
PL (2) PL169740B1 (fi)
PT (1) PT97395B (fi)
RU (1) RU2037495C1 (fi)
SK (1) SK279005B6 (fi)
ZA (1) ZA912913B (fi)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2050069B1 (es) * 1992-07-10 1994-12-16 Vita Invest Sa Procedimiento para la obtencion de 3-(2-(4-(6-fluoro-1,2-benzisoxazol-3-il)piperidino)etil)-2-metil-6,7,8,9-tetrahidro-4h-pirido(1,2-a) pirimidin-4-ona.
JPH07508741A (ja) 1992-07-13 1995-09-28 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ 新規４−（３−ベンゾフラニル）ピペリジニル及び４−（３−ベンゾチエニル）ピペリジニル誘導体，ならびにそれらを含む製薬学的組成物
TW376319B (en) * 1993-04-28 1999-12-11 Janssen Pharmaceutica Nv Pharmaceutical composition containing risperidone pamoate and having a long acting activity for treating psychoses induced by the release of dopamine
DK0730594T3 (da) * 1993-11-23 2000-03-27 Janssen Pharmaceutica Nv 9-hydroxy-pyrido{1,2-a}pyrimidin-4-on-ether-derivater
ES2085234B1 (es) * 1994-02-24 1997-01-16 Vita Invest Sa Agente activo sobre el sistema nervioso central, procedimiento para su preparacion y composiciones farmaceuticas que lo contienen.
JP3274579B2 (ja) * 1995-01-12 2002-04-15 住友製薬株式会社 脳血管障害に伴う精神症候治療剤
ES2141671B1 (es) * 1997-12-26 2001-01-01 Vita Invest Sa Compuesto pirimidinico activo sobre el sistema nervioso central, procedimiento para su preparacion y composiciones farmaceuticas que lo contienen.
HU227118B1 (en) * 2001-11-13 2010-07-28 Egis Gyogyszergyar Nyilvanosan Process for the preparation of 3-{2-[4-(6-fluoro-1,2-benzizoxazol-3-yl)-1-piperidinyl]-ethyl}-6,7,8,9-tetrahydro-2-methyl-4h-pyrido[1,2-a]pyrimidin-4-one
ES2197801B1 (es) * 2002-03-05 2005-03-16 Ferrer Internacional,S.A Procedimiento de obtencion de la 3-(2-(4-(6-fluoro-benzo(d)isoxazol-3-il) piperidin-1-il)-etil)-2-metil-6,7,8,9-tetrahidro-4h-pirido-(1,2-a ) pirimidin-4-ona.
WO2004009591A1 (en) * 2002-07-22 2004-01-29 Aurobindo Pharma Ltd. A process for the preparation of antipsychotic risperidone
BR0306204A (pt) * 2002-08-30 2004-09-08 Torrent Pharmaceuticals Ltd Processo melhorado para a preparação de risperidona
KR20040025224A (ko) * 2002-09-18 2004-03-24 주식회사 대웅 2-(2-메틸-4-옥소-6,7,8,9-테트라하이드로-4Ｈ-피리도[1,2-ａ]피리미딘-3-일)아세트알데히드 및 그 제조방법
AU2003288017A1 (en) 2002-11-13 2004-06-03 Synthon B.V. Process for making risperidone and intermediates therefor
EP1615923A1 (en) * 2003-04-22 2006-01-18 Synthon B.V. Risperidone monohydrochloride
HUP0401379A3 (en) * 2004-07-08 2006-04-28 Richter Gedeon Vegyeszet Process for the preparation of risperidon
HUP0402163A2 (en) * 2004-10-25 2006-05-29 Richter Gedeon Vegyeszet Process for the preparation of risperidone
EP1690540A1 (en) * 2005-02-15 2006-08-16 Neuro3D Composition comprising ocaperidone
EP1695973A1 (en) * 2005-02-24 2006-08-30 Neuro3D Ocaperidone salt and pharmaceutical compositions containing the same
JO2769B1 (en) * 2005-10-26 2014-03-15 جانسين فارماسوتيكا ان. في Rapid decomposition of physiologically antagonistic agents of the 2-dopamine receptor
WO2009077551A1 (en) * 2007-12-18 2009-06-25 Janssen Pharmaceutica Nv Process for preparing risperidone
CN118541369A (zh) 2022-01-11 2024-08-23 苏文生命科学有限公司 杂脂环衍生物及其在治疗cns病症中的用途

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4485107A (en) * 1982-11-01 1984-11-27 Janssen Pharmaceutica N.V. [[Bis(aryl)methylene]-1-piperidinyl]alkyl-pyrimidinones
US4804663A (en) * 1985-03-27 1989-02-14 Janssen Pharmaceutica N.V. 3-piperidinyl-substituted 1,2-benzisoxazoles and 1,2-benzisothiazoles
NZ223654A (en) * 1987-03-09 1990-03-27 Janssen Pharmaceutica Nv 1-alkyl-substituted-benzimidazole-4-piperidinamines and pharmaceutical compositions
US4777252A (en) * 1987-08-13 1988-10-11 E. R. Squibb & Sons, Inc. 2-oxo-1-[[(substituted sulfonyl)amino]-carbonyl]azetidines
CA2000786C (en) * 1988-11-07 1999-01-26 Cornelus G. M. Janssen 3-piperidinyl-1,2-benzisoxazoles
GB8900382D0 (en) * 1989-01-09 1989-03-08 Janssen Pharmaceutica Nv 2-aminopyrimidinone derivatives

Also Published As

Publication number Publication date
FI96206C (fi) 1996-05-27
ATE186301T1 (de) 1999-11-15
SK279005B6 (sk) 1998-05-06
EP0453042B1 (en) 1999-11-03
IE911301A1 (en) 1991-10-23
DE69131759D1 (de) 1999-12-09
CZ281135B6 (cs) 1996-06-12
PT97395A (pt) 1992-01-31
JPH04234882A (ja) 1992-08-24
FI911885A0 (fi) 1991-04-18
NO911525L (no) 1991-10-21
PL169744B1 (pl) 1996-08-30
KR910018380A (ko) 1991-11-30
CN1055929A (zh) 1991-11-06
AU7436691A (en) 1991-10-24
NO176840B (no) 1995-02-27
NZ237713A (en) 1992-09-25
BG95241A (bg) 1993-12-24
NO176840C (no) 1995-06-07
DE69131759T2 (de) 2000-06-21
CN1027506C (zh) 1995-01-25
BG60394B1 (bg) 1995-02-28
CA2040086A1 (en) 1991-10-20
KR100190297B1 (ko) 1999-06-01
IL97892A0 (en) 1992-06-21
RU2037495C1 (ru) 1995-06-19
PL169740B1 (pl) 1996-08-30
FI96206B (fi) 1996-02-15
NO911525D0 (no) 1991-04-18
ES2140381T3 (es) 2000-03-01
PL289935A1 (en) 1992-04-06
ZA912913B (en) 1992-12-30
AU636969B2 (en) 1993-05-13
IL97892A (en) 1995-03-30
GB9008850D0 (en) 1990-06-13
US5482943A (en) 1996-01-09
JP3216889B2 (ja) 2001-10-09
CA2040086C (en) 2003-12-30
HUT57763A (en) 1991-12-30
CS9101099A2 (en) 1991-11-12
GR3032122T3 (en) 2000-04-27
PT97395B (pt) 1998-08-31
EP0453042A1 (en) 1991-10-23
BG94282A (bg) 1993-12-24
DK0453042T3 (da) 2000-04-25
HU911301D0 (en) 1991-10-28

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