FI911529A7 - Halogeenietyylisubstituoituja steroidientsyymiinhibiittoreita - Google Patents

Halogeenietyylisubstituoituja steroidientsyymiinhibiittoreita Download PDF

Info

Publication number: FI911529A7
Authority: FI; Finland
Prior art keywords: haloethyl; enzyme inhibitors; substituted steroid; steroid enzyme; substituted
Prior art date: 1990-04-02

Application number

FI911529A

Other languages

English (en)

Swedish (sv)

Other versions

FI911529A0 (fi

FI911529L (fi

Inventor

John O'neal Johnston

Joseph Paul Burkhart

Norton P Peet

Original Assignee

Merrell Dow Pharma

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-04-02

Filing date

1991-03-28

Publication date

1991-10-03

1991-03-28 Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma

1991-03-28 Publication of FI911529A0 publication Critical patent/FI911529A0/fi

1991-10-03 Publication of FI911529A7 publication Critical patent/FI911529A7/fi

1991-10-03 Publication of FI911529L publication Critical patent/FI911529L/fi

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
- C07J5/0007—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond not substituted in position 17 alfa
- C07J5/0015—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond not substituted in position 17 alfa not substituted in position 16
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/32—Antioestrogens
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0051—Estrane derivatives
- C07J1/0059—Estrane derivatives substituted in position 17 by a keto group
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0051—Estrane derivatives
- C07J1/0066—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa
- C07J1/007—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa the substituent being an OH group free esterified or etherified
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0051—Estrane derivatives
- C07J1/0066—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa
- C07J1/007—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa the substituent being an OH group free esterified or etherified
- C07J1/0074—Esters
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J21/005—Ketals
- C07J21/006—Ketals at position 3
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J21/005—Ketals
- C07J21/008—Ketals at position 17
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0094—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 containing nitrile radicals, including thiocyanide radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
- C07J7/0005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21
- C07J7/001—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group
- C07J7/0015—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group not substituted in position 17 alfa
- C07J7/002—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group not substituted in position 17 alfa not substituted in position 16

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Endocrinology (AREA)
Diabetes (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Hematology (AREA)
Obesity (AREA)
Reproductive Health (AREA)
Toxicology (AREA)
Urology & Nephrology (AREA)
Steroid Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Saccharide Compounds (AREA)
Paper (AREA)

FI911529A 1990-04-02 1991-03-28 Halogenetylsubstituerade steroidenzyminhibitorer. FI911529L (fi)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US50319190A	1990-04-02	1990-04-02

Publications (3)

Publication Number	Publication Date
FI911529A0 FI911529A0 (fi)	1991-03-28
FI911529A7 true FI911529A7 (fi)	1991-10-03
FI911529L FI911529L (fi)	1991-10-03

Family

ID=24001090

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
FI911529A FI911529L (fi)	1990-04-02	1991-03-28	Halogenetylsubstituerade steroidenzyminhibitorer.

Country Status (17)

Country	Link
EP (1)	EP0450515B1 (fi)
JP (1)	JP3058710B2 (fi)
KR (1)	KR0186004B1 (fi)
CN (1)	CN1055365A (fi)
AT (1)	ATE124952T1 (fi)
AU (1)	AU636023B2 (fi)
CA (1)	CA2038985C (fi)
DE (1)	DE69111108T2 (fi)
ES (1)	ES2077097T3 (fi)
FI (1)	FI911529L (fi)
HU (1)	HUT57232A (fi)
IE (1)	IE911062A1 (fi)
IL (1)	IL97696A0 (fi)
NO (1)	NO911236L (fi)
NZ (1)	NZ237559A (fi)
PT (1)	PT97202A (fi)
ZA (1)	ZA912235B (fi)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE4433374A1 (de) *	1994-09-20	1996-03-21	Hoechst Ag	17-Desoxi-corticosteroid-21-/O/-Carbonsäure- ester, Verfahren zu deren Herstellung und diese enthaltende Arzneimittel

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3449381A (en) *	1962-06-12	1969-06-10	Syntex Corp	19-oxo- and 19-lower alkyl-19-oxoandrostane derivatives
US3213085A (en) *	1962-06-12	1965-10-19	Syntex Corp	19-lower alkyl-delta4-pregnen-20-one derivatives
GB8531747D0 (en) *	1985-12-24	1986-02-05	Erba Farmitalia	10beta-alkynylestrene derivatives
GB8531743D0 (en) *	1985-12-24	1986-02-05	Erba Farmitalia	10beta-halo-alkynyl-estrene derivatives

1991
- 1991-03-25 ZA ZA912235A patent/ZA912235B/xx unknown
- 1991-03-25 NZ NZ237559A patent/NZ237559A/xx unknown
- 1991-03-25 CA CA002038985A patent/CA2038985C/en not_active Expired - Fee Related
- 1991-03-26 AU AU73784/91A patent/AU636023B2/en not_active Ceased
- 1991-03-26 NO NO91911236A patent/NO911236L/no unknown
- 1991-03-27 IL IL97696A patent/IL97696A0/xx unknown
- 1991-03-28 DE DE69111108T patent/DE69111108T2/de not_active Expired - Fee Related
- 1991-03-28 AT AT91105003T patent/ATE124952T1/de not_active IP Right Cessation
- 1991-03-28 ES ES91105003T patent/ES2077097T3/es not_active Expired - Lifetime
- 1991-03-28 PT PT97202A patent/PT97202A/pt not_active Application Discontinuation
- 1991-03-28 FI FI911529A patent/FI911529L/fi unknown
- 1991-03-28 IE IE106291A patent/IE911062A1/en unknown
- 1991-03-28 EP EP91105003A patent/EP0450515B1/en not_active Expired - Lifetime
- 1991-03-29 HU HU911038A patent/HUT57232A/hu unknown
- 1991-03-30 KR KR1019910005136A patent/KR0186004B1/ko not_active Expired - Fee Related
- 1991-04-01 CN CN91102036A patent/CN1055365A/zh active Pending
- 1991-04-02 JP JP3094976A patent/JP3058710B2/ja not_active Expired - Fee Related

Also Published As

Publication number	Publication date
DE69111108D1 (de)	1995-08-17
CA2038985C (en)	2002-10-15
IL97696A0 (en)	1992-06-21
DE69111108T2 (de)	1996-01-18
IE911062A1 (en)	1991-10-09
NZ237559A (en)	1993-04-28
NO911236L (no)	1991-10-03
EP0450515A3 (en)	1992-09-30
CN1055365A (zh)	1991-10-16
CA2038985A1 (en)	1991-10-03
AU636023B2 (en)	1993-04-08
HU911038D0 (en)	1991-10-28
KR910018402A (ko)	1991-11-30
ES2077097T3 (es)	1995-11-16
EP0450515A2 (en)	1991-10-09
NO911236D0 (no)	1991-03-26
ZA912235B (en)	1991-12-24
FI911529A0 (fi)	1991-03-28
KR0186004B1 (ko)	1999-04-01
FI911529L (fi)	1991-10-03
ATE124952T1 (de)	1995-07-15
JP3058710B2 (ja)	2000-07-04
JPH04253994A (ja)	1992-09-09
AU7378491A (en)	1991-10-03
HUT57232A (en)	1991-11-28
EP0450515B1 (en)	1995-07-12
PT97202A (pt)	1991-11-29

Publication	Publication Date	Title
FI962315A0 (fi)	1996-06-03	Entsyymi-inhibiittorit
DK226888D0 (da)	1988-04-26	Steroid 5-alfa-reduktase inhibitor
FI965019A7 (fi)	1996-12-13	Entsyymi-inhibiittoreita
FI940903A7 (fi)	1994-04-20	Steroidisulfataasi-inhibiittorit
HU9300610D0 (en)	1993-05-28	Enzyme inhibitors
DK478684D0 (da)	1984-10-05	Enzyminhibitorer
NO942064D0 (no)	1994-06-03	yminhibitorer
FI933277L (fi)	1994-01-21	Amindiol proteas inhibitorer
FI963597L (fi)	1996-11-14	Isoprenyylitransferaasi-inhibiittoreita
NO972930D0 (no)	1997-06-23	Fibronectin-adhesjonsinhibitorer
FI972160A0 (fi)	1997-05-21	Matriisimetalloproteaasi-inhibiittorit
FI932521A0 (fi)	1993-06-02	Nytt endoglukanasenzym
FI934812L (fi)	1993-10-29	Stabiliserade entzymer
DK317287D0 (da)	1987-06-22	Reduktase-inhibitorer
FI933363L (fi)	1994-01-30	17-spirometylensteroider
BR8907457A (pt)	1991-04-02	Inibidores de interleucina-1
FI945416L (fi)	1994-11-17	Dolastatiinijohdannaisia
DK154492D0 (da)	1992-12-23	Enzym
DE69224225D1 (de)	1998-03-05	Modifiziertes Enzym
FI101796B1 (fi)	1998-08-31	Uusia -glukosidaasi-inhibiittoreita
DK87592D0 (da)	1992-07-03	Enzym
MX9100121A (es)	1992-02-28	Inhibidores de proteasas asparticas
FI931749L (fi)	1993-04-16	Nytt isomerisationsenzym
FI915232A7 (fi)	1992-05-08	Esteri-inhibiittorit
DE69431454D1 (de)	2002-11-07	Amylase Inhibitoren