FI933363L - 17-spirometylensteroider - Google Patents

17-spirometylensteroider Download PDF

Info

Publication number: FI933363L
Authority: FI; Finland
Prior art keywords: spiromethylene; steroid; spiromethylene steroid
Prior art date: 1992-07-29

Application number

FI933363A

Other languages

English (en)

Other versions

FI113371B (fi

FI933363A0 (fi

Inventor

Johannes Antonius Mar Hamersma

Everardus Otto Maria Orlemans

Johannes Bernardus Ma Rewinkel

Original Assignee

Akzo Nv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-07-29

Filing date

1993-07-27

Publication date

1994-01-30

1993-07-27 Application filed by Akzo Nv filed Critical Akzo Nv

1993-07-27 Publication of FI933363A0 publication Critical patent/FI933363A0/fi

1994-01-30 Publication of FI933363L publication Critical patent/FI933363L/fi

2004-04-15 Application granted granted Critical

2004-04-15 Publication of FI113371B publication Critical patent/FI113371B/fi

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/18—Feminine contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J21/005—Ketals
- C07J21/006—Ketals at position 3
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
- C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
- C07J41/0016—Oximes
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0077—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom
- C07J41/0083—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom substituted in position 11-beta by an optionally substituted phenyl group not further condensed with other rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0094—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 containing nitrile radicals, including thiocyanide radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
- C07J53/002—Carbocyclic rings fused
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0005—Oxygen-containing hetero ring
- C07J71/001—Oxiranes
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0005—Oxygen-containing hetero ring
- C07J71/001—Oxiranes
- C07J71/0015—Oxiranes at position 9(11)

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Reproductive Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Endocrinology (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Toxicology (AREA)
Gynecology & Obstetrics (AREA)
Pregnancy & Childbirth (AREA)
Diabetes (AREA)
Steroid Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

FI933363A 1992-07-29 1993-07-27 17-spirometyleenisteroideja FI113371B (fi)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
EP92202339		1992-07-29
EP92202339		1992-07-29
EP93201657		1993-06-10
EP93201657		1993-06-10

Publications (3)

Publication Number	Publication Date
FI933363A0 FI933363A0 (fi)	1993-07-27
FI933363L true FI933363L (fi)	1994-01-30
FI113371B FI113371B (fi)	2004-04-15

Family

ID=26131593

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
FI933363A FI113371B (fi)	1992-07-29	1993-07-27	17-spirometyleenisteroideja

Country Status (16)

Country	Link
US (2)	US5712264A (fi)
EP (1)	EP0582338B1 (fi)
JP (1)	JP3418428B2 (fi)
KR (1)	KR100341169B1 (fi)
CN (1)	CN1054133C (fi)
AT (1)	ATE185812T1 (fi)
AU (1)	AU665430B2 (fi)
CA (1)	CA2100514C (fi)
DE (1)	DE69326805T2 (fi)
DK (1)	DK0582338T3 (fi)
ES (1)	ES2140436T3 (fi)
FI (1)	FI113371B (fi)
GR (1)	GR3032257T3 (fi)
MX (1)	MX9304541A (fi)
NO (1)	NO303338B1 (fi)
NZ (1)	NZ248260A (fi)

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ATE174917T1 (de) *	1991-04-22	1999-01-15	Otsuka Pharma Co Ltd	Pyrazolo(1,5-a>pyrimidinderivate und sie enthaltende antiinflammatorische mittel
DE4417880A1 (de) *	1994-05-18	1995-11-23	Schering Ag	19,11beta-Überbrückte 18-Nor-Steroide, Verfahren zu ihrer Herstellung, diese Steroide enthaltende Arzneimittel sowie deren Verwendung zur Herstellung von Arzneimitteln
IL119649A (en) *	1995-11-30	2002-03-10	Akzo Nobel Nv	Preparation of Cyclic Kills of History - 3 keto- (5) 10, (-9) 11 steroidadians
US6020328A (en) *	1998-03-06	2000-02-01	Research Triangle Institute	20-keto-11β-arylsteroids and their derivatives having agonist or antagonist hormonal properties
CA2330611A1 (en)	1998-05-22	1999-12-02	The Board Of Trustees Of The Leland Stanford Junior University	Bifunctional molecules and therapies based thereon
EP1554572B1 (en)	2001-07-25	2009-10-14	Raptor Pharmaceutical Inc.	Compositions and methods for modulating blood-brain barrier transport
AU2004278414B2 (en)	2003-10-01	2012-05-24	Adolor Corporation	Spirocyclic heterocyclic derivatives and methods of their use
TW200531977A (en)	2004-03-25	2005-10-01	Akzo Nobel Nv	Progesterone receptor modulators
US7598261B2 (en)	2005-03-31	2009-10-06	Adolor Corporation	Spirocyclic heterocyclic derivatives and methods of their use
JP2008539047A (ja)	2005-04-28	2008-11-13	プロテウスバイオメディカルインコーポレイテッド	ファーマインフォーマティックスシステム
US9062126B2 (en)	2005-09-16	2015-06-23	Raptor Pharmaceuticals Inc.	Compositions comprising receptor-associated protein (RAP) variants specific for CR-containing proteins and uses thereof
US7678781B2 (en) *	2006-02-17	2010-03-16	Janssen Pharmaceutica N.V.	11-phosphorous steroid derivatives useful as progesterone receptor modulators
EP1989218B1 (en)	2006-02-17	2009-12-30	Janssen Pharmaceutica, N.V.	17-phosphorous steroid derivatives useful as progesterone receptor modulators
US7576207B2 (en)	2006-04-06	2009-08-18	Adolor Corporation	Spirocyclic heterocyclic derivatives and methods of their use
DE102006054535A1 (de) *	2006-11-15	2008-05-21	Bayer Schering Pharma Aktiengesellschaft	Progesteronrezeptorantagonisten
PT2398500T (pt)	2009-02-20	2019-06-14	2 Bbb Medicines B V	Sistema de entrega de medicamentos à base de glutationas
US8673968B2 (en) *	2009-04-06	2014-03-18	Evestra, Inc.	Progesterone antagonists
CN102458374A (zh)	2009-05-06	2012-05-16	实验室护肤股份有限公司	包含活性剂-磷酸钙颗粒复合物的皮肤递送组合物及其使用方法
DE102009034362A1 (de) *	2009-07-20	2011-01-27	Bayer Schering Pharma Aktiengesellschaft	17-Hydroxy-17-pentafluorethyl-estra-4,9(10)-dien-11-aryl-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung zur Behandlung von Krankheiten
DE102009034368A1 (de)	2009-07-20	2011-01-27	Bayer Schering Pharma Aktiengesellschaft	17-Hydroxy-17-pentafluorethyl-estra-4,9(10)-dien-11-acyloxyalkylenphenyl-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung zur Behandlung von Krankheiten
DE102009034366A1 (de)	2009-07-20	2011-01-27	Bayer Schering Pharma Aktiengesellschaft	17-Hydroxy-17-pentafluorethyl-estra-4,9(10)-dien-11-methylenoxyalkylenaryl-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung zur Behandlung von Krankheiten
DE102009034367A1 (de)	2009-07-20	2011-01-27	Bayer Schering Pharma Aktiengesellschaft	17-Hydroxy-17-pentafluorethyl-estra-4,9(10)-dien-11-benzyliden-Derivate, Verfahren zu deren Herstellung und deren Verwendung zur Behandlung von Krankheiten
DE102009034525A1 (de)	2009-07-21	2011-01-27	Bayer Schering Pharma Aktiengesellschaft	17-Hydroxy-17-pentafluorethyl-estra-4,9(10)-dien-11-aryl-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung zur Behandlung von Krankheiten
DE102009034526A1 (de)	2009-07-21	2011-02-10	Bayer Schering Pharma Aktiengesellschaft	17-Hydroxy-17-pentafluorethyl-estra-4,9(10)-dien-11-ethinylphenyl-Derivate, Verfahren zu deren Herstellung und deren Verwendung zur Behandlung von Krankheiten
DE102010007719A1 (de)	2010-02-10	2011-08-11	Bayer Schering Pharma Aktiengesellschaft, 13353	Progesteronrezeptorantagonisten
DE102010007722A1 (de)	2010-02-10	2011-08-11	Bayer Schering Pharma Aktiengesellschaft, 13353	Progesteronrezeptorantagonisten
WO2011157443A1 (en)	2010-06-17	2011-12-22	N.V. Organon	(11b,17a)-11-(4-(2-11c-acetyl)phenyl)-17,23-epoxy-19,24-dinorchola-4,9,20-trien-3-one
US9096641B2 (en)	2013-06-05	2015-08-04	Evestra, Inc.	Imidazolyl progesterone antagonists
CN105237606B (zh) *	2014-07-11	2018-08-24	上海创诺制药有限公司	一种用于合成去氧孕烯的中间体及其制备方法和应用

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BE623844A (fi) *
US2744122A (en) *	1951-11-22	1956-05-01	Syntex Sa	delta 4-19-nor-17alpha-ethinylandrosten-17beta-ol-3-one and process
US3338892A (en) *	1964-11-24	1967-08-29	Lilly Co Eli	Steroidal carbamic acid-gamma-lactones
US3280157A (en) *	1965-10-22	1966-10-18	Schering Corp	Peroxy steroids and methods for their manufacture
NL129874C (fi) *	1966-03-15
US3764596A (en) *	1971-06-22	1973-10-09	Sandoz Ag	17-dihydrofuranyl-substituted steroids
US3833621A (en) *	1972-03-20	1974-09-03	Richardson Merrell Inc	3-keto-7(alpha,beta)-loweralkyl-delta5 steroids and process for preparing same
FI54128C (fi) *	1972-12-09	1978-10-10	Akzo Nv	Foerfarande foer framstaellning av nya 11,11-alkylidensteroider ur oestran- och 19-norpregnanserien med foerbaettrad hormonell verkan
US4081537A (en) *	1975-10-10	1978-03-28	Schering Aktiengesellschaft	Δ15 -Steroids and pharmaceutical compositions thereof
ZA8231B (en) *	1981-01-09	1982-11-24	Roussel Uclaf	New 11 -substituted steroid derivatives, their preparation, their use as medicaments, the compositions containing them and the new intermediates thus obtained
DE3461090D1 (en) *	1983-02-18	1986-12-04	Schering Ag	11-beta-aryl-estradienes, process for their preparation and pharmaceutical compositions containing them
FR2596395B1 (fr) *	1986-03-26	1989-05-26	Roussel Uclaf	Nouveaux steroides comportant un cycle spirannique en position 17, leur procede de preparation, leur application comme medicaments et les compositions les renfermant
US5272140A (en) *	1987-01-23	1993-12-21	Akzo N.V.	11-aryl steroid derivatives
DE3702383A1 (de) *	1987-01-23	1988-08-04	Schering Ag	11ss-alkinylestrene und -estradiene, deren herstellung und diese enthaltende pharmazeutische praeparate
ATE69820T1 (de) *	1987-04-24	1991-12-15	Akzo Nv	11-arylestranderivate und 11-arylpregnanderivate.
FR2620707B1 (fr) *	1987-09-18	1989-12-08	Roussel Uclaf	Nouveaux steroides comportant un cycle spirannique a 3, 4 ou 6 chainons en position 17, leur procede et des intermediaires de preparation, leur application comme medicaments et les compositions pharmaceutiques les renfermant
EP0321010B1 (en) *	1987-12-12	1993-02-03	Akzo N.V.	New 11-arylsteroid compounds
IT1230907B (it) *	1989-06-23	1991-11-08	Ocean Spa	Macchina lavabiancheria perfezionata
DE3921059A1 (de) *	1989-06-23	1991-01-10	Schering Ag	11(beta)-aryl-4-estrene, verfahren zu ihrer herstellung sowie deren verwendung als arzneimittel
ZA929315B (en) *	1991-12-20	1993-05-24	Akzo Nv	17-spirofuran-3'-ylidene steroids.

1993
- 1993-07-14 CA CA002100514A patent/CA2100514C/en not_active Expired - Fee Related
- 1993-07-16 AU AU42037/93A patent/AU665430B2/en not_active Ceased
- 1993-07-26 DK DK93202204T patent/DK0582338T3/da active
- 1993-07-26 DE DE69326805T patent/DE69326805T2/de not_active Expired - Fee Related
- 1993-07-26 ES ES93202204T patent/ES2140436T3/es not_active Expired - Lifetime
- 1993-07-26 AT AT93202204T patent/ATE185812T1/de not_active IP Right Cessation
- 1993-07-26 EP EP93202204A patent/EP0582338B1/en not_active Expired - Lifetime
- 1993-07-27 NZ NZ248260A patent/NZ248260A/en not_active IP Right Cessation
- 1993-07-27 FI FI933363A patent/FI113371B/fi active
- 1993-07-28 US US08/098,665 patent/US5712264A/en not_active Expired - Fee Related
- 1993-07-28 NO NO932723A patent/NO303338B1/no not_active IP Right Cessation
- 1993-07-28 CN CN93108470A patent/CN1054133C/zh not_active Expired - Fee Related
- 1993-07-28 MX MX9304541A patent/MX9304541A/es not_active IP Right Cessation
- 1993-07-28 KR KR1019930014397A patent/KR100341169B1/ko not_active Expired - Fee Related
- 1993-07-29 JP JP18846093A patent/JP3418428B2/ja not_active Expired - Fee Related
1997
- 1997-11-03 US US08/962,798 patent/US5854235A/en not_active Expired - Fee Related
1999
- 1999-12-23 GR GR990403342T patent/GR3032257T3/el unknown

Also Published As

Publication number	Publication date
NZ248260A (en)	1995-07-26
KR940005663A (ko)	1994-03-22
CA2100514A1 (en)	1994-01-30
EP0582338B1 (en)	1999-10-20
FI113371B (fi)	2004-04-15
DE69326805D1 (de)	1999-11-25
KR100341169B1 (ko)	2002-10-25
EP0582338A2 (en)	1994-02-09
JPH06157587A (ja)	1994-06-03
NO303338B1 (no)	1998-06-29
US5854235A (en)	1998-12-29
US5712264A (en)	1998-01-27
AU665430B2 (en)	1996-01-04
DE69326805T2 (de)	2000-05-31
HK1002011A1 (en)	1998-07-24
MX9304541A (es)	1994-05-31
EP0582338A3 (en)	1995-08-23
CA2100514C (en)	2005-03-29
GR3032257T3 (en)	2000-04-27
NO932723D0 (no)	1993-07-28
JP3418428B2 (ja)	2003-06-23
NO932723L (no)	1994-01-31
FI933363A0 (fi)	1993-07-27
CN1084857A (zh)	1994-04-06
CN1054133C (zh)	2000-07-05
DK0582338T3 (da)	2000-03-20
ATE185812T1 (de)	1999-11-15
AU4203793A (en)	1994-02-03
ES2140436T3 (es)	2000-03-01

Publication	Publication Date	Title
FI933363L (fi)	1994-01-30	17-spirometylensteroider
DE69331692D1 (de)	2002-04-18	Ultraschallbestrahlungsgeraet
DE69323643D1 (de)	1999-04-08	Hydrazoadenosinen
FI933450A7 (fi)	1993-08-03	Uudet steroidit
NO931117D0 (no)	1993-03-25	Steroidderivater
FI953130L (fi)	1995-06-22	Uudet steroidit
DE59305364D1 (de)	1997-03-13	Rotornut
FI946081L (fi)	1994-12-23	Steroidaalinen beta-0-sellobiosidihepta-alkanoaattimenetelmä
ATA151292A (de)	1994-06-15	Beschlag
FI932116L (fi)	1993-11-14	Nytt hoegtemperatur-dehydreringsfoerfarande
DE59304139D1 (de)	1996-11-14	Polyanile
FI934724A0 (fi)	1993-10-26	Kylbehaollare
FI201U1 (fi)	1992-08-04	Skidspaorsunderhaollsmaskin
ATA151392A (de)	1996-09-15	Beschlag
FI269U1 (fi)	1992-09-17	Golvstruktur
DE59301762D1 (de)	1996-04-11	Chlorethylsulfonylbenzaldehyde
KR940005332U (ko)	1994-03-18	수첩
FI146U1 (fi)	1992-06-29	Patientskjorta
FI273U1 (fi)	1992-09-17	Reglerbart stoed foer maetgivare
FI218U1 (fi)	1992-08-17	Foerpackningsbricka
FI1008U1 (fi)	1993-11-16	Stubbehandlingsanordning
FI227U1 (fi)	1992-08-25	Stoedarm
FI398U1 (fi)	1992-11-26	Hoerselfoerstaerkare
FI397U1 (fi)	1992-11-26	Klaedhaengare
FI395U1 (fi)	1992-11-26	Bryggstolpe

Legal Events

Date	Code	Title	Description
2006-12-07	PC	Transfer of assignment of patent	Owner name: N.V. ORGANON Free format text: N.V. ORGANON

Date

Code

Title

Description

2006-12-07

Transfer of assignment of patent

Owner name: N.V. ORGANON

Free format text: N.V. ORGANON