FI911083A7 - Förfarande för framställning av såsom kolinergiska ämnen användbara 1-azabicyklo/2.2.1/heptan- eller -/2.2.2/octan-3-on-O-oximer - Google Patents

Förfarande för framställning av såsom kolinergiska ämnen användbara 1-azabicyklo/2.2.1/heptan- eller -/2.2.2/octan-3-on-O-oximer

Info

Publication number: FI911083A7
Authority: FI; Finland
Prior art keywords: octan; azabicyclo; heptane; preparation; cholinergic agents
Prior art date: 1990-03-06

Application number

FI911083A

Other languages

English (en)

Finnish (fi)

Other versions

FI95705C (sv

FI911083A0 (sv

FI95705B (sv

Inventor

David Jeffrey Lauffer

Walter Hamilton Moos

Michael Raymond Pavia

Haile Tecle

Original Assignee

Warner Lambert Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-03-06

Filing date

1991-03-04

Publication date

1991-09-07

1991-03-04 Application filed by Warner Lambert Co filed Critical Warner Lambert Co

1991-03-04 Publication of FI911083A0 publication Critical patent/FI911083A0/sv

1991-09-07 Publication of FI911083A7 publication Critical patent/FI911083A7/sv

1994-06-22 Priority to FI943029A priority Critical patent/FI114472B/sv

1995-11-30 Application granted granted Critical

1995-11-30 Publication of FI95705B publication Critical patent/FI95705B/sv

1996-03-11 Publication of FI95705C publication Critical patent/FI95705C/sv

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Veterinary Medicine (AREA)
Biomedical Technology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Neurosurgery (AREA)
Medicinal Chemistry (AREA)
Neurology (AREA)
Pain & Pain Management (AREA)
Hospice & Palliative Care (AREA)
Psychiatry (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Other In-Based Heterocyclic Compounds (AREA)
Hydrogenated Pyridines (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Plural Heterocyclic Compounds (AREA)
Pyrrole Compounds (AREA)

FI911083A 1990-03-06 1991-03-04 Förfarande för framställning av såsom kolinergiska ämnen användbara 1-azabicyklo/2.2.1/heptan- eller -/2.2.2/octan-3-on-O-oximer FI95705C (sv)

Priority Applications (1)

Application Number	Priority Date	Filing Date	Title
FI943029A FI114472B (sv)	1990-03-06	1994-06-22	Förfarande för framställning av såsom kolinergiska ämnen användbara azabicyklo- och azacyklooximer

Applications Claiming Priority (6)

Application Number	Priority Date	Filing Date
US48891690A	1990-03-06	1990-03-06
US48891690		1990-03-06
US59164790A	1990-10-02	1990-10-02
US59164790		1990-10-02
US64147891A	1991-01-22	1991-01-22
US64147891		1991-01-22

Publications (4)

Publication Number	Publication Date
FI911083A0 FI911083A0 (sv)	1991-03-04
FI911083A7 true FI911083A7 (sv)	1991-09-07
FI95705B FI95705B (sv)	1995-11-30
FI95705C FI95705C (sv)	1996-03-11

Family

ID=27413829

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
FI911083A FI95705C (sv)	1990-03-06	1991-03-04	Förfarande för framställning av såsom kolinergiska ämnen användbara 1-azabicyklo/2.2.1/heptan- eller -/2.2.2/octan-3-on-O-oximer

Country Status (18)

Country	Link
EP (1)	EP0445731B1 (sv)
JP (3)	JP3223192B2 (sv)
KR (1)	KR0182268B1 (sv)
CN (1)	CN1054601A (sv)
AT (1)	ATE132868T1 (sv)
AU (1)	AU630542B2 (sv)
CA (1)	CA2037541C (sv)
DE (1)	DE69116185T2 (sv)
DK (1)	DK0445731T3 (sv)
ES (1)	ES2082024T3 (sv)
FI (1)	FI95705C (sv)
GR (1)	GR3019226T3 (sv)
HU (1)	HUT57210A (sv)
IE (1)	IE70322B1 (sv)
IL (1)	IL97266A0 (sv)
NO (1)	NO177711C (sv)
NZ (1)	NZ237300A (sv)
PT (1)	PT96946B (sv)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5306718A (en) *	1990-03-06	1994-04-26	Warner-Lambert Company	Oxime and amine substituted azabicyclo and azocyclo muscarinic agonists and methods of treatment
US5264502A (en) *	1990-08-03	1993-11-23	The Dow Chemical Company	Diamino-alpha-alkylstilbene curing agents for epoxy resins
US5391651A (en) *	1990-08-03	1995-02-21	The Dow Chemical Company	Curable mixtures of mesogenic epoxy resins and mesogenic polyamines and cured compositions
US5296570A (en) *	1990-08-03	1994-03-22	The Dow Chemical Company	Curable mixtures of mesogenic epoxy resins and mesogenic polyamines and cured compositions
US5262509A (en) *	1990-08-03	1993-11-16	The Dow Chemical Company	Mesogenic glycidyl amines
US5276184A (en) *	1990-08-03	1994-01-04	The Dow Chemical Company	Sulfonamide compounds containing mesogenic moieties
US5414125A (en) *	1990-08-03	1995-05-09	The Dow Chemical Company	Diamino-alpha-alkylstilbenes
US5268434A (en) *	1990-08-03	1993-12-07	The Dow Chemical Company	Diamino-alpha-alkylstilbenes as epoxy resin curing agents
GB2258652A (en) *	1991-08-15	1993-02-17	Merck Sharp & Dohme	Pharmaceutically useful azabicyclic oxime ethers
WO1993008191A1 (en) *	1991-10-15	1993-04-29	Warner-Lambert Company	Azabicyclo oxime and amine cholinergic agents and methods of treatment
ZA931109B (en) *	1992-03-04	1993-09-22	Akzo Nv	Tetrahydropyrimidine derivatives.
US5298575A (en) *	1992-11-30	1994-03-29	The Dow Chemical Company	Nitro group terminated mesogenic epoxy resin adducts
US5552407A (en) *	1993-06-11	1996-09-03	New York University Medical Center	Anhydroecgonine compounds and their use as anticholinergic agents
US5514812A (en) *	1994-06-10	1996-05-07	Warner-Lambert Company	Preparation of stereochemically pure oximes with muscarinic activity
JP2000502094A (ja) *	1995-12-20	2000-02-22	パイン，エクハルト	鎮痙性鎮痛薬としてのα，α−ジフェニル酢酸−４−（Ｎ−メチル−ピペリジル）エステルの使用
AU741566B2 (en) *	1997-01-27	2001-12-06	Warner-Lambert Company	Single pot process for producing (Z)-azabicyclo oxime ethers
US5733912A (en) *	1997-02-19	1998-03-31	Abbott Laboratories	7A-heterocycle substituted hexahydro-1H-pyrrolizine compounds useful in controlling chemical synaptic transmission
AU2206599A (en) *	1997-12-23	1999-07-12	Alcon Laboratories, Inc.	Oximino-piperidine, -pyrrolidine and -azepine derivatives, their preparation andtheir use as muscarinic receptor (ant-)agonists
CN1370048A (zh) *	1999-08-27	2002-09-18	阿温提斯作物科学有限公司	用作农药的氮杂二环－和氮杂环肟及胺化合物
KR100465277B1 (ko) *	2002-01-24	2005-01-13	한국과학기술연구원	신규한 옥심계 아자 두 고리 화합물 및 그 제조방법
DE10302912A1 (de) *	2003-01-24	2004-08-12	Bayer Faser Gmbh	Chlorbeständige Elastanfasern
RU2315047C1 (ru) *	2006-09-04	2008-01-20	Институт нефтехимии и катализа РАН	Способ получения 8-этил-6,7-фуллеро[60]-3-окса-8-азабицикло[3.2.1]октана

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE2019536A1 (de) *	1970-04-23	1971-11-11	Basf Ag	Oximcarbamate
DE2552176A1 (de) *	1975-11-21	1977-06-02	Hoechst Ag	Neue piperidin-derivate, ihre herstellung und verwendung
US4353922A (en) *	1981-03-13	1982-10-12	Syntex (U.S.A.) Inc.	Anticholinergic bronchodilators

1991
- 1991-02-18 IL IL97266A patent/IL97266A0/xx unknown
- 1991-03-04 AU AU72602/91A patent/AU630542B2/en not_active Ceased
- 1991-03-04 NZ NZ237300A patent/NZ237300A/xx unknown
- 1991-03-04 FI FI911083A patent/FI95705C/sv not_active IP Right Cessation
- 1991-03-05 DK DK91103308.2T patent/DK0445731T3/da active
- 1991-03-05 HU HU91712A patent/HUT57210A/hu unknown
- 1991-03-05 CA CA002037541A patent/CA2037541C/en not_active Expired - Fee Related
- 1991-03-05 KR KR1019910003542A patent/KR0182268B1/ko not_active Expired - Fee Related
- 1991-03-05 EP EP91103308A patent/EP0445731B1/en not_active Expired - Lifetime
- 1991-03-05 NO NO910860A patent/NO177711C/no not_active IP Right Cessation
- 1991-03-05 IE IE73191A patent/IE70322B1/en not_active IP Right Cessation
- 1991-03-05 ES ES91103308T patent/ES2082024T3/es not_active Expired - Lifetime
- 1991-03-05 AT AT91103308T patent/ATE132868T1/de not_active IP Right Cessation
- 1991-03-05 DE DE69116185T patent/DE69116185T2/de not_active Expired - Fee Related
- 1991-03-05 JP JP06239891A patent/JP3223192B2/ja not_active Expired - Fee Related
- 1991-03-06 CN CN91101359A patent/CN1054601A/zh active Pending
- 1991-03-06 PT PT96946A patent/PT96946B/pt active IP Right Revival
1996
- 1996-03-06 GR GR960400634T patent/GR3019226T3/el unknown
2000
- 2000-02-01 JP JP2000023519A patent/JP2000239166A/ja active Pending
- 2000-02-01 JP JP2000023520A patent/JP2000212163A/ja active Pending

Also Published As

Publication number	Publication date
IE70322B1 (en)	1996-11-13
ATE132868T1 (de)	1996-01-15
HK1005025A1 (en)	1998-12-18
DK0445731T3 (da)	1996-04-29
GR3019226T3 (en)	1996-06-30
JP2000239166A (ja)	2000-09-05
KR910016728A (ko)	1991-11-05
PT96946B (pt)	1998-07-31
NO177711B (no)	1995-07-31
PT96946A (pt)	1991-10-31
NZ237300A (en)	1993-12-23
KR0182268B1 (ko)	1999-05-01
FI95705C (sv)	1996-03-11
IL97266A0 (en)	1992-05-25
EP0445731B1 (en)	1996-01-10
DE69116185D1 (de)	1996-02-22
NO910860L (no)	1991-09-09
NO910860D0 (no)	1991-03-05
FI911083A0 (sv)	1991-03-04
EP0445731A1 (en)	1991-09-11
HU910712D0 (en)	1991-09-30
CA2037541A1 (en)	1992-08-11
CA2037541C (en)	2001-10-02
CN1054601A (zh)	1991-09-18
ES2082024T3 (es)	1996-03-16
JP2000212163A (ja)	2000-08-02
DE69116185T2 (de)	1996-05-15
JP3223192B2 (ja)	2001-10-29
AU630542B2 (en)	1992-10-29
NO177711C (no)	1995-11-08
JPH04217660A (ja)	1992-08-07
AU7260291A (en)	1991-09-12
HUT57210A (en)	1991-11-28
IE910731A1 (en)	1991-09-11
FI95705B (sv)	1995-11-30

Publication	Publication Date	Title
FI911083A7 (sv)	1991-09-07	Förfarande för framställning av såsom kolinergiska ämnen användbara 1-azabicyklo/2.2.1/heptan- eller -/2.2.2/octan-3-on-O-oximer
FI914174A7 (sv)	1992-03-06	Förfarande för framställning av piperidylalkylaminer
MA22668A1 (fr)	1993-07-01	Procede de preparation d'oxamides .
DE69131967D1 (de)	2000-03-09	Verfahren zur Herstellung von 1,1-Diarylprolinolen
NO912346L (no)	1991-12-19	Fremgangsmaate for fremstilling av aminobenzodiazepiner.
NO911122D0 (no)	1991-03-20	Fremgangsmaate for fremstilling av antihyperkolesterolemiske midler.
FI880467A0 (sv)	1988-02-02	Förfarande för framställning av terapeutiskt användbara substituerade 3,4-dihydro-2H-benzopyraner
DE59105348D1 (de)	1995-06-08	Verfahren zur Herstellung von 1,4-Alkylendiaminen.
FI911080A7 (sv)	1991-09-09	Förfarande för framställning av 1,5-bensotiazepinderivat
IS4081A (is)	1994-04-17	Aðferð við framleiðslu efnasamsetninga
NO910559L (no)	1991-08-14	Fremgangsmaate for fremstilling av polyfosfasener ved substitusjon av polydiklorfosfasen.
EE03027B1 (et)	1997-08-15	Meetod 8-klorokinolooni derivaatide valmistamiseks
NO913692D0 (no)	1991-09-19	Fremgangsmaate for fremstilling av karbapenemforbindelser.
NO905453L (no)	1991-09-06	Fremgangsmaate ved fremstilling av klordioksyd.
NO179101C (no)	1996-08-07	Fremgangsmåte for fremstilling av dibeskyttet 2,3-hydroksymetyl-cyklobutanol
FI943833A0 (sv)	1994-08-19	Förfarande för framställning av 2,3,5,6-tetraklorpyridin
NO180675C (no)	1997-05-28	Fremgangsmåte for fremstilling av aromatiske forbindelser
DE59104221D1 (de)	1995-02-23	Verfahren zur Herstellung von 2,3,5-Trimethyl-p-benzochinon.
NO920636L (no)	1992-08-20	Fremgangsmaate for fremstilling av 9-amino-1,2,3,4-tetra-hydroakridin
FI923866A7 (sv)	1992-08-28	Förfarande för framställning av 1-hydroxialkyl-1-nitro-5 imidazoler
FI930237A7 (sv)	1993-07-24	Förfarande för framställning av 4,6-dialkoxipyrimidiner
DE59106016D1 (de)	1995-08-24	Verfahren zur Herstellung von 2,3-Dihydrobenzofuranen.
DE69109738D1 (de)	1995-06-22	Verfahren zur Herstellung von Triethylendiamin.
FI911282L (sv)	1991-09-17	Förfarande för framställning av nya terapeutiskt användbara 3,4-dihydroxi-2,5-dihydrofuranoner
NO178577C (no)	1996-04-24	Fremgangsmåte til fremstilling av cefalosporin

Legal Events

Date	Code	Title	Description
1995-11-01	BB	Publication of examined application
2005-09-30	MA	Patent expired