FI900813A0 - Menetelmä uusien terapeuttisesti käyttökelpoisten bentsatsepiini- ja bentsotiatsepiinijohdannaisten valmistamiseksi - Google Patents

Menetelmä uusien terapeuttisesti käyttökelpoisten bentsatsepiini- ja bentsotiatsepiinijohdannaisten valmistamiseksi

Info

Publication number: FI900813A0
Authority: FI; Finland
Prior art keywords: benzazepine; preparation; therapeutically useful; benzothiazepine derivatives; new therapeutically
Prior art date: 1988-06-20

Application number

FI900813A

Other languages

English (en)

Swedish (sv)

Other versions

FI94246B (fi

FI94246C (fi

Inventor

David M Floyd

John T Hunt

Spencer D Kimball

John Krapcho

Jagabandhu Das

George C Rovnyak

Joel C Barrish

Original Assignee

Squibb & Sons Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-06-20

Filing date

1990-02-19

Publication date

1990-02-19

1990-02-19 Application filed by Squibb & Sons Inc filed Critical Squibb & Sons Inc

1990-02-19 Publication of FI900813A0 publication Critical patent/FI900813A0/fi

1995-04-28 Publication of FI94246B publication Critical patent/FI94246B/fi

1995-08-10 Application granted granted Critical

1995-08-10 Publication of FI94246C publication Critical patent/FI94246C/fi

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/16—Benzazepines; Hydrogenated benzazepines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D281/02—Seven-membered rings
- C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
- C07D281/08—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D281/10—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Cardiology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Heart & Thoracic Surgery (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
Hydrogenated Pyridines (AREA)

FI900813A 1988-06-20 1990-02-19 Menetelmä uusien terapeuttisesti käyttökelpoisten bentsatsepiini- ja bentsotiatsepiinijohdannaisten valmistamiseksi FI94246C (fi)

Applications Claiming Priority (6)

Application Number	Priority Date	Filing Date	Title
US20852188A	1988-06-20	1988-06-20
US20852188		1988-06-20
US35380689		1989-05-22
US07/353,806 US4902684A (en)	1988-06-20	1989-05-22	Benzazepine and benzothiazepine derivatives
US8902270		1989-05-23
PCT/US1989/002270 WO1989012633A1 (en)	1988-06-20	1989-05-23	Benzazepine and benzothiazepine derivatives

Publications (3)

Publication Number	Publication Date
FI900813A0 true FI900813A0 (fi)	1990-02-19
FI94246B FI94246B (fi)	1995-04-28
FI94246C FI94246C (fi)	1995-08-10

Family

ID=26903265

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
FI900813A FI94246C (fi)	1988-06-20	1990-02-19	Menetelmä uusien terapeuttisesti käyttökelpoisten bentsatsepiini- ja bentsotiatsepiinijohdannaisten valmistamiseksi

Country Status (29)

Country	Link
US (1)	US4902684A (fi)
JP (1)	JP2793674B2 (fi)
KR (1)	KR970002633B1 (fi)
CN (1)	CN1027262C (fi)
AT (1)	AT398567B (fi)
AU (1)	AU614399B2 (fi)
BE (1)	BE1003305A4 (fi)
CA (1)	CA1336975C (fi)
CH (1)	CH681723A5 (fi)
EG (1)	EG19071A (fi)
ES (1)	ES2016467A6 (fi)
FI (1)	FI94246C (fi)
FR (1)	FR2632953B1 (fi)
GB (1)	GB2231329B (fi)
GR (1)	GR1002099B (fi)
HU (1)	HU210929B (fi)
IE (1)	IE64242B1 (fi)
IL (1)	IL90515A (fi)
IT (1)	IT1230884B (fi)
LU (1)	LU87865A1 (fi)
NL (1)	NL8920642A (fi)
NO (1)	NO179449C (fi)
NZ (1)	NZ229612A (fi)
PL (1)	PL162313B1 (fi)
PT (1)	PT90914B (fi)
RU (1)	RU2090562C1 (fi)
SE (1)	SE9004060L (fi)
WO (1)	WO1989012633A1 (fi)
YU (1)	YU121389A (fi)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5008284A (en) *	1989-02-15	1991-04-16	E. R. Squibb & Sons, Inc.	Method of reducing pre- and post-ischemic myocardial arrhythmias and fibrillation
US4946840A (en) *	1989-04-06	1990-08-07	E. R. Squibb & Sons, Inc.	Benzazepine and benzothiazepine derivatives
US4963671A (en) *	1989-11-20	1990-10-16	E. R. Squibb & Sons, Inc.	Process for resolving chiral intermediates used in making calcium channel blockers
US5112969A (en) *	1990-04-02	1992-05-12	Merrell Dow Pharmaceuticals Inc.	Cyano esters and azepinones
IT1240686B (it) *	1990-04-27	1993-12-17	Luso Farmaco Inst	Derivati 1,5-benzotiazepinonici, loro preparazione e uso farmaceutico
IT1244878B (it) *	1990-12-11	1994-09-12	Lusochimica Spa	Processo per la preparazione del (+)-cis-3-(acetossi)-5-!2-( dimetilammino)etil!-2,3-diidro-2-(4-metossifenil)-1,5-benzotiazepin- 4-(5h)-one cloridrato
EP0593603B1 (en) *	1991-06-28	2002-11-20	Smithkline Beecham Corporation	Bicyclic fibrinogen antagonists
IT1255545B (it) *	1992-10-23	1995-11-09		Procedimento per la preparazione di diltiazem
CA2098446A1 (en) *	1992-09-30	1994-03-31	Eckard Weber	2,5-dihydro-2,5-dioxo-1h-azepines and 2,5-dihydro-2-oxo-1h-azepines and the use thereof as excitatory amino acid and glycine receptor antagonists
ATE216580T1 (de) *	1993-07-16	2002-05-15	Merck & Co Inc	Benzoxazinon- und benzopyrimidinon- piperidinyl- verbindungen als tokolytische oxytocin-rezeptor- antagonisten
US5854233A (en) *	1993-09-08	1998-12-29	Pharmacy And Therapeutic Advisory Consultancy Ltd.	Method of treating liver disease and like indications with vasodilating agents
US6174917B1 (en)	1993-09-08	2001-01-16	Pharmacy And Therapeutic Advisory Consultancy Ltd.	Method of treating liver disease and like indications with vasodilating agents
EP0751774B1 (en) *	1994-03-24	2003-08-13	Merrell Pharmaceuticals Inc.	Hypocholesterolemic mercaptoacetylamide disulfide derivatives
US5580867A (en) *	1994-09-09	1996-12-03	Universite De Montreal	Myocardial protection during ischemia and reperfusion
GB9423172D0 (en)	1994-11-17	1995-01-04	Wellcom Foundation The Limited	Hypolipidemic benzothiazepines
WO1998025920A1 (en) *	1996-12-10	1998-06-18	Abbott Laboratories	3-pyridyl enantiomers and their use as analgesics
US6277844B1 (en)	1998-09-14	2001-08-21	Sydney Spector	Compound for selective treatment of malignant cells by inhibiting cell cycle progression, decreasing Bcl2, and increasing apoptosis
GB9907895D0 (en) *	1999-04-08	1999-06-02	Texas A & M Univ Sys	Novel ligands for chiral catalysis
US6472533B1 (en)	1999-04-08	2002-10-29	The Texas A & M University System	Ligands for chiral catalysis
CA2482320C (en) *	2002-04-19	2010-02-09	Georg T. Wondrak	Methods for modulating phototoxicity
TWI289141B (en) *	2003-03-11	2007-11-01	Hoffmann La Roche F. Ag.	Quinolinone derivatives and uses thereof

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3312691A (en) *	1963-08-23	1967-04-04	Ciba Geigy Corp	2, 3, 4, 5-tetrahydro-1-benzazepin-2-ones
US3562257A (en) *	1967-10-28	1971-02-09	Tanabe Seiyaku Co	Benzothiazepine derivatives
JPS59191036A (ja) *	1983-04-14	1984-10-30	Fuji Photo Film Co Ltd	ハロゲン化銀写真感光材料
US4567175A (en) *	1983-06-03	1986-01-28	Tanabe Seiyaku Co., Ltd.	8-Chloro-1,5-benzothiazepine derivatives
GB8316032D0 (en) *	1983-06-11	1983-07-13	Tanabe Seiyaku Co	Benzothiazepine derivatives
GB2154578A (en) *	1984-02-18	1985-09-11	Tanabe Seiyaku Co	Novel 1,5-benzothiazepine derivatives and processes for preparing the same
US4590188A (en) *	1984-02-18	1986-05-20	Tanabe Seiyaku Co., Ltd.	1,5-benzothiazepine derivatives and their pharmaceutical use
GB2154577A (en) *	1984-02-18	1985-09-11	Tanabe Seiyaku Co	1,5-benzothiazepines
GB2167063A (en) *	1984-11-17	1986-05-21	Tanabe Seiyaku Co	6 or 9-chloro-1, 5-benzothiazepine derivatives
CA1271747A (en) *	1985-06-12	1990-07-17	David M. Floyd	Benzazepines derivatives
US4748239A (en) *	1985-06-12	1988-05-31	E. R. Squibb & Sons, Inc.	Benzazepine derivatives
US4584131A (en) *	1985-06-20	1986-04-22	E. R. Squibb & Sons, Inc.	Benzothiazepine derivatives
DE3717561A1 (de) *	1987-05-25	1988-12-08	Thomae Gmbh Dr K	Indol-, isochinolin- und benzazepinderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
CA1271748C (en) *	1985-12-12	1990-07-17		BENZAZEPINE DERIVATIVES
FR2597097B1 (fr) *	1986-04-15	1988-12-02	Synthelabo	Derives de benzothiazepine-1, 5, leur preparation et leur application en therapeutique
EP0256888B1 (en) *	1986-08-20	1991-07-03	McNeilab, Inc.	Benzothiazepine vasodilators having aralkyl substitution
US4729994A (en) *	1986-08-20	1988-03-08	Mcneilab, Inc.	Benzothiazepine vasodilators having aralkyl substitution
US4694002A (en) *	1986-08-21	1987-09-15	E. R. Squibb & Sons, Inc.	Benzothiazepine derivatives
US4752645A (en) *	1986-10-09	1988-06-21	E. R. Squibb & Sons, Inc.	Benzazepine derivatives
ZA893392B (en) *	1988-05-24	1990-01-31	Hoffmann La Roche	Process for the manufacture of optically active naphthothiazepinones

1989
- 1989-05-22 US US07/353,806 patent/US4902684A/en not_active Expired - Lifetime
- 1989-05-23 RU SU895011155A patent/RU2090562C1/ru active
- 1989-05-23 HU HU894298A patent/HU210929B/hu not_active IP Right Cessation
- 1989-05-23 WO PCT/US1989/002270 patent/WO1989012633A1/en not_active Ceased
- 1989-05-23 JP JP1507318A patent/JP2793674B2/ja not_active Expired - Lifetime
- 1989-05-23 AT AT0901089A patent/AT398567B/de not_active IP Right Cessation
- 1989-05-23 CH CH615/90A patent/CH681723A5/fr not_active IP Right Cessation
- 1989-05-23 NL NL8920642A patent/NL8920642A/nl not_active Application Discontinuation
- 1989-05-23 AU AU38593/89A patent/AU614399B2/en not_active Ceased
- 1989-05-26 CA CA000600891A patent/CA1336975C/en not_active Expired - Fee Related
- 1989-06-02 IL IL9051589A patent/IL90515A/en not_active IP Right Cessation
- 1989-06-14 YU YU01213/89A patent/YU121389A/xx unknown
- 1989-06-16 IE IE195789A patent/IE64242B1/en not_active IP Right Cessation
- 1989-06-19 NZ NZ229612A patent/NZ229612A/en unknown
- 1989-06-19 ES ES8902132A patent/ES2016467A6/es not_active Expired - Lifetime
- 1989-06-20 EG EG30389A patent/EG19071A/xx active
- 1989-06-20 IT IT8920933A patent/IT1230884B/it active
- 1989-06-20 PL PL89280122A patent/PL162313B1/pl unknown
- 1989-06-20 CN CN89104877A patent/CN1027262C/zh not_active Expired - Fee Related
- 1989-06-20 BE BE8900666A patent/BE1003305A4/fr not_active IP Right Cessation
- 1989-06-20 PT PT90914A patent/PT90914B/pt not_active IP Right Cessation
- 1989-06-20 FR FR898908204A patent/FR2632953B1/fr not_active Expired - Fee Related
- 1989-06-20 GR GR890100410A patent/GR1002099B/el not_active IP Right Cessation
1990
- 1990-02-06 GB GB9002587A patent/GB2231329B/en not_active Expired - Fee Related
- 1990-02-19 KR KR90700338A patent/KR970002633B1/ko not_active Expired - Fee Related
- 1990-02-19 FI FI900813A patent/FI94246C/fi not_active IP Right Cessation
- 1990-12-19 NO NO905485A patent/NO179449C/no not_active IP Right Cessation
- 1990-12-19 LU LU87865A patent/LU87865A1/de unknown
- 1990-12-19 SE SE9004060A patent/SE9004060L/xx not_active Application Discontinuation

Also Published As

Publication number	Publication date
HU894298D0 (en)	1991-01-28
FI94246B (fi)	1995-04-28
FR2632953B1 (fr)	1992-05-29
NO905485D0 (no)	1990-12-19
PL162313B1 (pl)	1993-09-30
GB2231329A (en)	1990-11-14
FI94246C (fi)	1995-08-10
NZ229612A (en)	1992-07-28
ES2016467A6 (es)	1990-11-01
CN1027262C (zh)	1995-01-04
KR920700207A (ko)	1992-02-19
BE1003305A4 (fr)	1992-02-25
IE64242B1 (en)	1995-07-26
PT90914B (pt)	1994-12-30
IL90515A (en)	1994-07-31
NL8920642A (nl)	1990-06-01
YU121389A (en)	1991-04-30
ATA901089A (de)	1994-05-15
RU2090562C1 (ru)	1997-09-20
LU87865A1 (de)	1991-12-16
IT8920933A0 (it)	1989-06-20
CN1039585A (zh)	1990-02-14
AU3859389A (en)	1990-01-12
PT90914A (pt)	1989-12-29
IE891957L (en)	1989-12-20
SE9004060L (sv)	1992-06-20
SE9004060D0 (sv)	1990-12-19
AU614399B2 (en)	1991-08-29
US4902684A (en)	1990-02-20
CA1336975C (en)	1995-09-12
GB9002587D0 (en)	1990-08-29
NO905485L (no)	1991-02-19
CH681723A5 (fi)	1993-05-14
WO1989012633A1 (en)	1989-12-28
JPH04502002A (ja)	1992-04-09
NO179449C (no)	1996-10-09
GR1002099B (en)	1995-12-28
HUT59908A (en)	1992-07-28
IT1230884B (it)	1991-11-08
NO179449B (no)	1996-07-01
GR890100410A (el)	1990-05-11
IL90515A0 (en)	1990-01-18
GB2231329B (en)	1992-10-21
EG19071A (en)	1994-07-30
JP2793674B2 (ja)	1998-09-03
KR970002633B1 (en)	1997-03-06
HU210929B (en)	1995-09-28
AT398567B (de)	1994-12-27
FR2632953A1 (fr)	1989-12-22

Publication	Publication Date	Title
FI881900A7 (fi)	1988-10-25	Analogiamenetelmä terapeuttisesti käyttökelpoisten substituoitujen imidatsolyylialkyylipiperatsiini- ja -diatsepiinijohdannaisten valmistamiseksi
FI900813A0 (fi)	1990-02-19	Menetelmä uusien terapeuttisesti käyttökelpoisten bentsatsepiini- ja bentsotiatsepiinijohdannaisten valmistamiseksi
FI96861C (fi)	1996-09-10	Menetelmä terapeuttisesti aktiivisten substituoitujen indolyylipyrrolijohdannaisten valmistamiseksi
FI905941A0 (fi)	1990-12-03	Menetelmä terapeuttisesti käyttökelpoisten heterosyklisten 2-asyyliaminotiatsolijohdannaisten valmistamiseksi
FI875660L (fi)	1987-12-22	Menetelmä terapeuttisesti käyttökelpoisten 5-fenyyli-2-pyrimidinonijohdannaisten valmistamiseksi
FI875024A7 (fi)	1988-05-15	Menetelmä terapeuttisesti käyttökelpoisten 1-alkyyli-6-halogeenitetrahydronaftaleenijohdannaisten valmistamiseksi
FI883739A7 (fi)	1989-02-15	Menetelmä terapeuttisesti aktiivisten fenoksi-indaanimetyyliamiinijohdannaisten valmistamiseksi
FI892682A0 (fi)	1989-06-01	Analogiamenetelmä terapeuttisesti käyttökelpoisten 1-deoksinojirimysiinijohdannaisten valmistamiseksi
NO175478C (no)	1994-10-19	Analogifremgangsmåte for fremstilling av terapeutisk aktive diazepin-derivater
FI890072A7 (fi)	1989-07-09	Menetelmä farmaseuttisesti käyttökelpoisten isokinoliinijohdannaisten valmistamiseksi
FI923527L (fi)	1992-08-05	Menetelmä terapeuttisesti käyttökelpoisten 3-piperidino-4-hydroksikromaanijohdannaisten valmistamiseksi
FI895417A0 (fi)	1989-11-14	Menetelmä uusien terapeuttisesti käyttökelpoisten 2'-halometylideeninukleosidien valmistamiseksi
FI95570C (fi)	1996-02-26	Menetelmä lääkinnällisesti vaikuttavien pyridatsinoni-3(2H)-onijohdannaisten valmistamiseksi
FI891003A7 (fi)	1989-09-04	Menetelmä terapeuttisesti käyttökelpoisten 6-substituoitujen purinyylipiperatsiinijohdannaisten valmistamiseksi
FI906408L (fi)	1991-06-29	Menetelmä terapeuttisesti käyttökelpoisten 2-aminopyrimidiini-4-karboksamidijohdannaisten valmistamiseksi
NO173334C (no)	1993-12-01	Analogifremgangsm}te for fremstilling av terapeutisk aktive alkylaminoalkylenderivater 2H-1-benzopyraner
FI884553A7 (fi)	1989-04-06	Analogiamenetelmä terapeuttisesti käyttökelpoisten 9-aminotetrahydroakridiinijohdannaisten valmistamiseksi
FI894604L (fi)	1990-03-29	Menetelmä uusien terapeuttisesti käyttökelpoisten pyridyyli- ja pyrimidyylipiperatsiinijohdannaisten valmistamiseksi
FI904838A7 (fi)	1991-04-04	Menetelmä farmaseuttisesti aktiivisten karboksitetrahydroisokinoliinien ja niiden johdannaisten valmistamiseksi
FI912124A7 (fi)	1991-11-04	Menetelmä terapeuttisesti aktiivisten pyrido/2,3-f//1,4/tiatsepiini- ja pyrido/3,2-b//1,5/bentsotiatsepiinijohdannaisten valmistamiseksi
NO174774C (no)	1994-07-06	Analogifremgangsmåte for fremstilling av terapeutisk aktive benzodiazepiner
FI890186A7 (fi)	1989-07-16	Menetelmä 1-hydroksialkyyli-5-nitroimidatsolien valmistamiseksi
NO174203C (no)	1994-04-06	Analogifremgangsmåte for fremstilling av terapeutisk aktive
FI890185A7 (fi)	1989-07-16	Menetelmä 1-alkyyli-5-nitroimidatsolien valmistamiseksi
NO173606C (no)	1994-01-05	Analogifremgangsmaate for fremstilling av terapeutisk aktive tieno- triazolo-diazepin-derivater

Legal Events

Date	Code	Title	Description
1995-04-03	BB	Publication of examined application
2004-08-31	MM	Patent lapsed	Owner name: E.R. SQUIBB & SONS, INC.