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FI900464A7 - Uudet aryyli- tai heteroaryyli-1-alkyyli-pyrroli-2-karboksyylihappoyhdisteet, jotka ovat hyödyllisiä interleukiini-1:n välittämiä tiloja hoidettaessa - Google Patents

Uudet aryyli- tai heteroaryyli-1-alkyyli-pyrroli-2-karboksyylihappoyhdisteet, jotka ovat hyödyllisiä interleukiini-1:n välittämiä tiloja hoidettaessa Download PDF

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Publication number
FI900464A7
FI900464A7 FI900464A FI900464A FI900464A7 FI 900464 A7 FI900464 A7 FI 900464A7 FI 900464 A FI900464 A FI 900464A FI 900464 A FI900464 A FI 900464A FI 900464 A7 FI900464 A7 FI 900464A7
Authority
FI
Finland
Prior art keywords
pyrrole
heteroaryl
alkyl
carboxylic acid
acid compounds
Prior art date
Application number
FI900464A
Other languages
English (en)
Swedish (sv)
Other versions
FI900464A0 (fi
Inventor
Roger Alan Parker
George Ku
Original Assignee
Merrell Dow Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma
Publication of FI900464A0 publication Critical patent/FI900464A0/fi
Publication of FI900464A7 publication Critical patent/FI900464A7/fi

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D207/00Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/325Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D207/00Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Vascular Medicine (AREA)
  • Obesity (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
FI900464A 1989-01-31 1990-01-30 Uudet aryyli- tai heteroaryyli-1-alkyyli-pyrroli-2-karboksyylihappoyhdisteet, jotka ovat hyödyllisiä interleukiini-1:n välittämiä tiloja hoidettaessa FI900464A7 (fi)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US30414189A 1989-01-31 1989-01-31

Publications (2)

Publication Number Publication Date
FI900464A0 FI900464A0 (fi) 1990-01-30
FI900464A7 true FI900464A7 (fi) 1990-08-01

Family

ID=23175237

Family Applications (1)

Application Number Title Priority Date Filing Date
FI900464A FI900464A7 (fi) 1989-01-31 1990-01-30 Uudet aryyli- tai heteroaryyli-1-alkyyli-pyrroli-2-karboksyylihappoyhdisteet, jotka ovat hyödyllisiä interleukiini-1:n välittämiä tiloja hoidettaessa

Country Status (17)

Country Link
EP (1) EP0381141B1 (fi)
JP (1) JP2841305B2 (fi)
KR (1) KR0139288B1 (fi)
CN (1) CN1022754C (fi)
AR (1) AR245694A1 (fi)
AT (1) ATE135702T1 (fi)
AU (1) AU629290B2 (fi)
CA (1) CA2008616C (fi)
DE (1) DE69025967T2 (fi)
ES (1) ES2087093T3 (fi)
FI (1) FI900464A7 (fi)
HU (1) HU209290B (fi)
IL (1) IL93187A (fi)
NO (1) NO174887C (fi)
NZ (1) NZ232278A (fi)
PT (1) PT93009A (fi)
ZA (1) ZA90554B (fi)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5015651A (en) * 1988-01-07 1991-05-14 E. I. Du Pont De Nemours And Company Treatment of hypertension with 1,2,4-angiotensin II antagonists
ZA90555B (en) * 1989-01-31 1990-10-31 Merrell Pharma Inc Method of using aryl-or heteroaryl-1-alkyl-pyrrole-2-carboxylic acid compounds in the treatment of interleukin-1 mediated conditions
WO2011005969A2 (en) * 2009-07-10 2011-01-13 The General Hospital Corporation Etomidate analogues that do not inhibit adrenocortical steroid synthesis
CN102114430B (zh) * 2009-12-30 2013-06-05 上海睿智化学研究有限公司 催化剂、其制备方法及n-烷基吡咯衍生物的制备方法
DK2802325T3 (en) 2012-01-13 2017-03-13 Massachusetts Gen Hospital ANESTHETIC RELATIONS AND RELATED APPLICATIONS THEREOF

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4112112A (en) * 1976-06-29 1978-09-05 Merck & Co., Inc. Pyrrolo[2,1-b] [3]benzazepines useful for producing a skeletal muscle relaxing or tranquilizing effect

Also Published As

Publication number Publication date
ATE135702T1 (de) 1996-04-15
FI900464A0 (fi) 1990-01-30
KR0139288B1 (ko) 1998-05-15
KR900011725A (ko) 1990-08-02
CN1022754C (zh) 1993-11-17
NZ232278A (en) 1992-07-28
IL93187A (en) 1994-12-29
AU629290B2 (en) 1992-10-01
NO900432D0 (no) 1990-01-30
HU209290B (en) 1994-04-28
PT93009A (pt) 1990-07-31
CA2008616C (en) 2000-07-18
ES2087093T3 (es) 1996-07-16
DE69025967T2 (de) 1996-08-29
AR245694A1 (es) 1994-02-28
JPH02247165A (ja) 1990-10-02
AU4875990A (en) 1990-08-09
HU900592D0 (en) 1990-04-28
EP0381141B1 (en) 1996-03-20
NO174887C (no) 1994-07-27
EP0381141A2 (en) 1990-08-08
DE69025967D1 (de) 1996-04-25
JP2841305B2 (ja) 1998-12-24
NO900432L (no) 1990-08-01
ZA90554B (en) 1990-10-31
IL93187A0 (en) 1990-11-05
EP0381141A3 (en) 1991-11-21
NO174887B (no) 1994-04-18
CN1044653A (zh) 1990-08-15
HUT53868A (en) 1990-12-28
CA2008616A1 (en) 1990-07-31

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Legal Events

Date Code Title Description
FD Application lapsed
MM Patent lapsed

Owner name: MERRELL DOW PHARMACEUTICALS INC.