FI905956A0 - Foerfarande foer producering av ett biologiskt aktivt protein. - Google Patents

Foerfarande foer producering av ett biologiskt aktivt protein.

Info

Publication number: FI905956A0
Authority: FI; Finland
Prior art keywords: aktivt; biologiskt; ett; protein; foerfarande foer
Prior art date: 1989-12-06

Application number

FI905956A

Other languages

English (en)

Other versions

FI103278B (fi

FI103278B1 (fi

FI905956L (fi

Inventor

Nico Cerletti

Gary Kent Mcmaster

David Cox

Albert Schmitz

Bernd Meyhack

Original Assignee

Ciba Geigy Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-12-06

Filing date

1990-12-03

Publication date

1990-12-03

1990-12-03 Application filed by Ciba Geigy Ag filed Critical Ciba Geigy Ag

1990-12-03 Publication of FI905956A0 publication Critical patent/FI905956A0/fi

1991-06-07 Publication of FI905956L publication Critical patent/FI905956L/fi

1999-05-31 Application granted granted Critical

1999-05-31 Publication of FI103278B publication Critical patent/FI103278B/fi

1999-05-31 Publication of FI103278B1 publication Critical patent/FI103278B1/fi

Links

102000004169 proteins and genes Human genes 0.000 title 1
108090000623 proteins and genes Proteins 0.000 title 1
ZRKFYGHZFMAOKI-QMGMOQQFSA-N tgfbeta Chemical compound C([C@H](NC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCSC)C(C)C)[C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(O)=O)C1=CC=C(O)C=C1 ZRKFYGHZFMAOKI-QMGMOQQFSA-N 0.000 abstract 3
239000008194 pharmaceutical composition Substances 0.000 abstract 1
230000001225 therapeutic effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
- C07K1/1136—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure by reversible modification of the secondary, tertiary or quarternary structure, e.g. using denaturating or stabilising agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1841—Transforming growth factor [TGF]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
- C07K1/1133—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure by redox-reactions involving cystein/cystin side chains
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/495—Transforming growth factor [TGF]

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Genetics & Genomics (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Zoology (AREA)
Immunology (AREA)
Gastroenterology & Hepatology (AREA)
Analytical Chemistry (AREA)
Biomedical Technology (AREA)
Epidemiology (AREA)
Wood Science & Technology (AREA)
Crystallography & Structural Chemistry (AREA)
General Engineering & Computer Science (AREA)
Biotechnology (AREA)
Toxicology (AREA)
Pain & Pain Management (AREA)
Physics & Mathematics (AREA)
Dermatology (AREA)
Transplantation (AREA)
Plant Pathology (AREA)
Microbiology (AREA)
Rheumatology (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Peptides Or Proteins (AREA)

FI905956A 1989-12-06 1990-12-03 Menetelmä biologisesti aktiivisen TGF- :n kaltaisen proteiinin tuottamiseksi FI103278B1 (fi)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB8927546		1989-12-06
GB898927546A GB8927546D0 (en)	1989-12-06	1989-12-06	Process for the production of biologically active tgf-beta

Publications (4)

Publication Number	Publication Date
FI905956A0 true FI905956A0 (fi)	1990-12-03
FI905956L FI905956L (fi)	1991-06-07
FI103278B FI103278B (fi)	1999-05-31
FI103278B1 FI103278B1 (fi)	1999-05-31

Family

ID=10667491

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
FI905956A FI103278B1 (fi)	1989-12-06	1990-12-03	Menetelmä biologisesti aktiivisen TGF- :n kaltaisen proteiinin tuottamiseksi

Country Status (23)

Country	Link
US (2)	US5650494A (fi)
EP (2)	EP0891985A1 (fi)
JP (1)	JP3048061B2 (fi)
KR (1)	KR100203230B1 (fi)
AT (1)	ATE178616T1 (fi)
AU (1)	AU638075B2 (fi)
CA (1)	CA2031430C (fi)
DE (1)	DE69033040T2 (fi)
DK (1)	DK0433225T3 (fi)
ES (1)	ES2132066T3 (fi)
FI (1)	FI103278B1 (fi)
GB (1)	GB8927546D0 (fi)
GR (1)	GR3030703T3 (fi)
HU (1)	HU218144B (fi)
IE (2)	IE904386A1 (fi)
IL (1)	IL96549A (fi)
MX (1)	MX172600B (fi)
NO (1)	NO301768B1 (fi)
NZ (1)	NZ236333A (fi)
PH (1)	PH31649A (fi)
PT (1)	PT96068B (fi)
SG (1)	SG52690A1 (fi)
ZA (1)	ZA909762B (fi)

Families Citing this family (119)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6150328A (en)	1986-07-01	2000-11-21	Genetics Institute, Inc.	BMP products
GB8927546D0 (en) *	1989-12-06	1990-02-07	Ciba Geigy	Process for the production of biologically active tgf-beta
WO1992004382A1 (en) *	1990-09-05	1992-03-19	Bunge (Australia) Pty. Ltd.	Solubilization of proteins in active forms
GB9106678D0 (en) *	1991-03-28	1991-05-15	Ferguson Mark W J	Wound healing
AU674500B2 (en) *	1991-11-04	1997-01-02	Genetics Institute, Llc	Recombinant bone morphogenetic protein heterodimers, compositions and methods of use
US20080070842A1 (en) *	1991-11-04	2008-03-20	David Israel	Recombinant bone morphogenetic protein heterodimers, compositions and methods of use
AU2738392A (en) *	1991-11-11	1993-05-13	Ciba-Geigy Ag	Novel hybrid transforming growth factors
US5288931A (en) *	1991-12-06	1994-02-22	Genentech, Inc.	Method for refolding insoluble, misfolded insulin-like growth factor-I into an active conformation
UA48105C2 (uk) *	1992-02-12	2002-08-15	Біофарм Гезельшафт Цур Біотехнологішен Ентвіклунг Вон Фармака Мбх	ФРАГМЕНТ ДНК, ЯКИЙ КОДУЄ БІЛОК РОДИНИ TGF-<font face="Symbol">b</font> (ВАРІАНТИ), РЕКОМБІНАНТНА МОЛЕКУЛА ДНК (ВАРІАНТИ), КЛІТИНА-ХАЗЯЇН (ВАРІАНТИ), СПОСІБ ОДЕРЖАННЯ БІЛКУ РОДИНИ TGF-<font face="Symbol">b</font> (ВАРІАНТИ), БІЛОК РОДИНИ TGF-<font face="Symbol">b</font> (ВАРІАНТИ), ФАРМАЦЕВТИЧНА КОМПОЗИЦІЯ (ВАРІАНТИ), АНТИТІЛО АБО ФРАГМЕНТ АНТИТІЛА (ВАРІАНТИ), МОЛЕКУЛА КДНК (ВАРІАНТИ)
GB9206861D0 (en)	1992-03-28	1992-05-13	Univ Manchester	Wound healing and treatment of fibrotic disorders
US6884787B2 (en) *	2001-07-14	2005-04-26	Isis Pharmaceuticals, Inc.	Antisense modulation of transforming growth factor-beta 3 expression
DE4243729A1 (de) *	1992-12-23	1994-06-30	Behringwerke Ag	Verfahren zur Reaktivierung von gereinigten Membranproteinen
KR960700271A (ko) *	1993-01-08	1996-01-19	로렌스 티. 웰츠	인간 호흡계 합포체 바이러스 fg 당단백질의 정제 및 리폴딩 방법(process for the purification and refolding of human respiratory syncytial virus fg glycoprotein)
DE69429617T2 (de) *	1993-04-30	2002-08-22	Biognostik Gesellschaft Fuer Biomolekulare Diagnostik Mbh	Antisense-oligonukleotide zur behandlung des immunsuppressiven effektes des transformierenden wachstumsfaktor-beta1(tgf-beta1)
US5663304A (en) *	1993-08-20	1997-09-02	Genentech, Inc.	Refolding of misfolded insulin-like growth factor-I
US6291206B1 (en)	1993-09-17	2001-09-18	Genetics Institute, Inc.	BMP receptor proteins
JPH08503969A (ja) *	1993-09-29	1996-04-30	アルコンラボラトリーズ，インコーポレイテッド	増殖因子と組織形成抑制剤を含有する組成物
US5411940A (en) *	1993-09-29	1995-05-02	Alcon Laboratories, Inc.	Use of TGF-β3 to reduce the formation of scar tissue in response to corneal trauma
US6027919A (en)	1993-12-07	2000-02-22	Genetics Institute, Inc.	BMP-12 and BMP-13 proteins and DNA encoding them
US5399677A (en) *	1993-12-07	1995-03-21	Genetics Institute, Inc.	Mutants of bone morphogenetic proteins
WO1995016035A2 (en)	1993-12-07	1995-06-15	Genetics Institute, Inc.	Bmp-12, bmp-13 and tendon-inducing compositions thereof
TW517059B (en)	1994-07-25	2003-01-11	Ciba Geigy Ag	New process for the production of biologically active protein
WO1996003425A1 (en) *	1994-07-25	1996-02-08	Ciba-Geigy Ag	Process for folding of proteins like recombinant hirudin or epidermal growth factor
TW440566B (en) *	1994-07-25	2001-06-16	Novartis Ag	Novel process for the production of biologically active dimeric protein
UA46767C2 (uk) *	1995-04-19	2002-06-17	Біофарм Гезельшафт Цур Біотехнологішен Ентвіклунг Фон Фармака Мбх	Білок, фармацевтична композиція для лікування захворювань хрящів і кісток, спосіб отримання білка, спосіб отримання гомодимерного білка, спосіб лікування захворювань хрящів і кісток
US5714371A (en) *	1995-05-12	1998-02-03	Schering Corporation	Method for refolding insoluble aggregates of hepatitis C virus protease
US5800811A (en) *	1995-06-06	1998-09-01	Hall; Frederick L.	Artificial skin prepared from coclagen matrix containing transforming growth factor-β having a collagen binding site
US6352972B1 (en) *	1995-06-06	2002-03-05	Marcel E. Nimni	Bone morphogenetic proteins and their use in bone growth
US6040431A (en)	1995-06-07	2000-03-21	Stryker Corporation	Single chain analogs of the TGF-β superfamily (morphons)
CA2235223A1 (en)	1995-10-30	1997-05-09	Massachusetts Institute Of Technology	Rationally designed polysaccharide lyases derived from heparinase i
EP0943690B1 (en) *	1995-12-21	2006-11-29	Ajinomoto Co., Inc.	Method for refolding human activin a
DE69737809T2 (de) *	1996-01-22	2008-02-21	Curis, Inc., Cambridge	Methoden zur herstellung von op-1 morphogen analoge
US20030185792A1 (en) *	1996-01-22	2003-10-02	Curis, Inc.	Morphogen analogs of bone morphogenic proteins
US6664227B1 (en)	1996-03-01	2003-12-16	Genetics Institute, Llc	Treatment of fibrosis by antagonism of IL-13 and IL-13 receptor chains
US7811793B2 (en)	1996-12-25	2010-10-12	Biopharma Gesellschaft Zur Biotechnologischen Entwicklung Von Pharmaka Mbh	Process for preparing purified active monomer of bone-derived factor
US6500920B1 (en) *	1997-06-19	2002-12-31	St. Louis University	Inhibitor of transforming growth factor β and A method of inhibiting the biological effects of transforming growth factor
US7723473B2 (en)	1997-06-19	2010-05-25	St. Louis University	Peptide antagonists of TGF-beta family members and therapeutic uses thereof
ATE220564T1 (de)	1997-08-14	2002-08-15	Sulzer Innotec Ag	Zusammensetzung und vorrichtung zur reparatur von knorpelgewebe in vivo bestehend aus nanokapseln mit osteoinduktiven und/oder chondroinduktiven faktoren
US20020052026A1 (en)	1997-10-08	2002-05-02	Steven M. Vicik	Methods of refolding proteins
DE19749259A1 (de) *	1997-11-07	1999-05-12	Dade Behring Marburg Gmbh	Verfahren zur Herstellung von funktionalem rekombinantem Gewebsfaktor
PT1659179E (pt) *	1998-02-05	2011-09-16	Glaxosmithkline Biolog Sa	Derivados de antigénios associados a tumor da família mage e sequências de ácidos nucleicos codificando-os, utilizados para a preparação de proteínas de fusão e de composições para vacinação
US6057128A (en)	1998-03-17	2000-05-02	Genetics Institute, Inc.	MU-1, member of the cytokine receptor family
FR2776521B1 (fr) *	1998-03-27	2000-12-15	Pf Medicament	Utilisation de conjugues p40 actifs par voie nasale
CA2341412A1 (en)	1998-08-27	2000-03-09	Massachusetts Institute Of Technology	Rationally designed heparinases derived from heparinase i and ii
US7056504B1 (en)	1998-08-27	2006-06-06	Massachusetts Institute Of Technology	Rationally designed heparinases derived from heparinase I and II
US6933272B1 (en)	1998-09-22	2005-08-23	Erik Helmerhorst	Use of non-peptidyl compounds for the treatment of insulin related ailments
EP1117805A2 (en)	1998-10-07	2001-07-25	STRYKER CORPORATION (a Michigan corporation)	Modified tgf-beta superfamily proteins
US6846906B1 (en)	1998-10-07	2005-01-25	Stryker Corporation	Modified proteins of the TGF-β superfamily, including morphogenic proteins
US6677432B1 (en)	1998-10-07	2004-01-13	Stryker Corporation	Mutations of the C-terminal portion of TGF-β superfamily proteins
US7087577B2 (en)	1998-10-16	2006-08-08	Zimmer Orthobiologies, Inc.	Method of promoting natural bypass
US6992066B2 (en)	1998-10-16	2006-01-31	Zimmer Orthobiologics, Inc.	Povidone-containing carriers for polypeptide growth factors
ES2146552B1 (es) *	1998-11-24	2001-04-16	Inst Cientifico Tecnol Navarra	Peptidos inhibidores de tgf/31
EP1142908A4 (en) *	1999-01-07	2002-05-22	Takeda Chemical Industries Ltd	PROCESS FOR PRODUCING ACTIVATED PROTEINS
US6727224B1 (en)	1999-02-01	2004-04-27	Genetics Institute, Llc.	Methods and compositions for healing and repair of articular cartilage
DE19906096A1 (de)	1999-02-13	2000-08-17	Walter Sebald	Protein mit einem Heparin-bindenden Epitop
JP4824170B2 (ja)	1999-04-23	2011-11-30	マサチューセッツインスティテュートオブテクノロジー	ポリマーを表記するためのシステムおよび方法
DE19944626A1 (de) *	1999-09-17	2001-03-22	Knoell Hans Forschung Ev	Verfahren zur Herstellung von dimeren, biologisch aktiven knochenmorphogenetischen Proteinen
EP2286847A1 (en)	1999-10-15	2011-02-23	Genetics Institute, LLC	Formulations of hyaluronic acid for delivery of osteogenic proteins
CA2402160C (en)	2000-03-08	2012-02-14	Massachusetts Institute Of Technology	Heparinase iii and uses thereof
DE10026713A1 (de) *	2000-05-30	2001-12-06	Walter Sebald	Mutein einer Kette eines Proteins aus der Superfamilie des Wachstumsfaktors TGF-beta
US7081240B1 (en) *	2000-06-28	2006-07-25	Zimmer Orthobiologics, Inc.	Protein mixtures for wound healing
EP1319183B1 (en)	2000-09-12	2009-03-25	Massachusetts Institute Of Technology	Methods and products related to low molecular weight heparin
AU2002224408B2 (en)	2000-10-18	2007-08-23	Massachusetts Institute Of Technology	Methods and products related to pulmonary delivery of polysaccharides
US7442370B2 (en)	2001-02-01	2008-10-28	Biogen Idec Ma Inc.	Polymer conjugates of mutated neublastin
US7157557B2 (en)	2001-02-23	2007-01-02	Immunex Corporation	Increased recovery of active proteins
US7276580B2 (en)	2001-03-12	2007-10-02	Biogen Idec Ma Inc.	Neurotrophic factors
ES2305246T3 (es)	2001-06-01	2008-11-01	Wyeth	Composiciones para la administracion sistemica de secuencias que codifican proteinas oseas morfogeneticas.
TWI267378B (en)	2001-06-08	2006-12-01	Wyeth Corp	Calcium phosphate delivery vehicles for osteoinductive proteins
FI117667B (fi)	2001-07-05	2007-01-15	Univ Zuerich	Farmaseuttinen koostumus, joka soveltuu käytettäväksi ortopediassa ja hammaslääketieteessä
CA2460916A1 (en)	2001-10-04	2003-04-10	Laura Carter	Methods and compositions for modulating interleukin-21 receptor activity
US7232802B2 (en)	2001-12-21	2007-06-19	Zimmer Orthobiologics, Inc.	Compositions and methods for promoting myocardial and peripheral angiogenesis
RU2295535C2 (ru) *	2002-02-05	2007-03-20	Джимонат С.П.А.	Рекомбинантный плацентарный фактор роста и способ его получения
MXPA04007589A (es) *	2002-02-05	2005-06-08	Geymonat Spa	Proceso de produccion del factor de crecimiento placentario recombinante.
US7622562B2 (en)	2002-06-26	2009-11-24	Zimmer Orthobiologics, Inc.	Rapid isolation of osteoinductive protein mixtures from mammalian bone tissue
US7241740B2 (en) *	2002-08-13	2007-07-10	Wyeth	Peptides as solubilizing excipients for transforming growth factor beta proteins
JP4571776B2 (ja) *	2002-11-05	2010-10-27	Ｊｘ日鉱日石エネルギー株式会社	潤滑油組成物
US7074412B2 (en)	2003-01-30	2006-07-11	The University Of Zurich	Pharmaceutical composition
CA2864810A1 (en)	2003-04-18	2004-11-04	Biogen Idec Ma, Inc.	Polymer-conjugated glycosylated neublastin
EP1675608B1 (en)	2003-09-12	2007-03-21	Wyeth	Injectable calcium phosphate solid rods for delivery of osteogenic proteins
EP2338441B1 (en)	2003-12-11	2013-01-23	Isto Technologies Inc.	Particulate cartilage system
GEP20115196B (en) *	2004-08-19	2011-04-11	Biogen Idec Inc	Neublastin variants
ES2349043T3 (es)	2004-08-19	2010-12-22	Biogen Idec Ma Inc.	Variantes de neublastina.
WO2006081379A1 (en) *	2005-01-26	2006-08-03	Wyeth	Use of sfrps as markers of bmp activity
AU2006214384A1 (en)	2005-02-14	2006-08-24	University Of Pittsburgh Of The Commonwealth System Of Higher Education	Use of IL-17F in diagnosis and therapy of airway inflammation
PE20061391A1 (es)	2005-02-14	2007-01-09	Wyeth Corp	Anticuerpos para interleucina-17f y otros antagonistas de la senalizacion de il-17f
MX2007011591A (es) *	2005-03-30	2007-12-10	Wyeth Corp	Metodo para estimular el crecimiento de cabello administrando bmps.
GT200600148A (es)	2005-04-14	2006-11-22		Metodos para el tratamiento y la prevencion de fibrosis
GB0514262D0 (en) *	2005-07-12	2005-08-17	Renovo Ltd	Promotion of epithelial regeneration
EP1910415A4 (en) *	2005-07-25	2010-08-11	Trubion Pharmaceuticals Inc	COMPOSITIONS AND PROCESSES FOR PROTEIN DEGREGATION
GB0516204D0 (en) *	2005-08-06	2005-09-14	Riotech Pharmaceuticals Ltd	Methods
AU2006282754A1 (en)	2005-08-26	2007-03-01	Zimmer, Inc.	Implants and methods for repair, replacement and treatment of joint disease
TWI501774B (zh)	2006-02-27	2015-10-01	Biogen Idec Inc	神經性病症之治療
US7582609B2 (en) *	2006-03-01	2009-09-01	Digna Biotech, S.L.	Method for the treatment of skin fibrosis and suitable compositions for such treatment
ES2450065T3 (es) *	2006-03-01	2014-03-21	Biogen Idec Ma Inc.	Composiciones y métodos para la administración de proteínas de la familia de ligandos del GDNF
GB0604938D0 (en) *	2006-03-11	2006-04-19	Renovo Ltd	Proteins, nucleic acids and medicaments
GB0604964D0 (en) *	2006-03-11	2006-04-19	Renovo Ltd	Protein folding
GB0604966D0 (en) *	2006-03-11	2006-04-19	Renovo Ltd	Medicaments and proteins
SG162834A1 (en) *	2006-07-14	2010-07-29	Genentech Inc	Refolding of recombinant proteins
GB0617816D0 (en) *	2006-09-11	2006-10-18	Renovo Ltd	Nucleic acids and methods of protein expression
EP2078071B1 (en)	2006-11-08	2015-03-18	Wyeth LLC	Rationally designed media for cell culture
US8163549B2 (en)	2006-12-20	2012-04-24	Zimmer Orthobiologics, Inc.	Method of obtaining viable small tissue particles and use for tissue repair
CA2684040C (en)	2007-04-12	2016-12-06	Isto Technologies, Inc.	Method of forming an implant using a mold that mimics the shape of the tissue defect site and implant formed therefrom
TW200902708A (en)	2007-04-23	2009-01-16	Wyeth Corp	Methods of protein production using anti-senescence compounds
EP2142205B1 (en) *	2007-05-01	2014-04-02	Biogen Idec MA Inc.	Neublastin peptides for use in increasing vascularisation in tissue with impaired blood flow
US20110135648A1 (en) *	2007-08-08	2011-06-09	Biogen Idec Ma Inc.	Anti-neublastin antibodies and uses thereof
EP3327132A3 (en)	2007-08-09	2018-07-18	Wyeth LLC	Use of perfusion to enhance production of fed-batch cell culture in bioreactors
US8946201B2 (en)	2007-08-27	2015-02-03	Saint Louis University	Methods for inhibiting TGF-β
CN102159219B (zh)	2008-09-16	2015-06-24	圣路易斯大学	提高转化生长因子-β信号发送的方法
US8494140B2 (en) *	2008-10-30	2013-07-23	Centurylink Intellectual Property Llc	System and method for voice activated provisioning of telecommunication services
JP5793080B2 (ja)	2008-10-31	2015-10-14	ワイス・エルエルシー	セラミックヒドロキシアパタイトクロマトグラフィーを使用する酸性タンパク質の精製
WO2011005488A1 (en) *	2009-06-22	2011-01-13	Amgen Inc.	Refolding proteins using a chemically controlled redox state
FI3660032T3 (fi)	2009-06-25	2025-12-18	Amgen Inc	Ei-nisäkäsperäisessä järjestelmässä ekspressoitujen proteiinien sieppauspuhdistusmenetelmiä
KR100991203B1 (ko)	2010-05-10	2010-11-01	심영복	골형성 단백질의 정제 방법
WO2012029148A1 (ja)	2010-09-01	2012-03-08	株式会社オステオファーマ	組換えヒト骨形成タンパク質－２凍結乾燥製剤
IN2014DN07174A (fi) *	2012-02-10	2015-04-24	Japanic Corp
WO2014025771A2 (en) *	2012-08-06	2014-02-13	Biogen Idec Ma Inc.	Methods and compositions for inactivating enveloped viruses
US20140178343A1 (en)	2012-12-21	2014-06-26	Jian Q. Yao	Supports and methods for promoting integration of cartilage tissue explants
US9758786B2 (en)	2016-02-09	2017-09-12	Autotelic, Llc	Compositions and methods for treating pancreatic cancer
NZ754942A (en)	2016-12-30	2023-02-24	Biogend Therapeutics Co Ltd	Recombinant polypeptides, compositions, and methods thereof

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
RO81640B (ro) *	1980-03-27	1983-04-30	Eli Lilly And Company	Procedeu de preparare a insulinei
US4620948A (en) *	1982-12-22	1986-11-04	Genentech, Inc.	Purification and activity assurance of precipitated heterologous proteins
GR79124B (fi) *	1982-12-22	1984-10-02	Genentech Inc
WO1984004924A1 (en) *	1983-06-03	1984-12-20	Us Commerce	Purified transforming growth factor-beta derived from human platelets and placentas
DE3587022T2 (de) *	1984-02-17	1993-06-17	Genentech Inc	Menschlicher transformationswachstumsfaktor und vorlaeufer oder fragment hiervon, zellen, dna, vektoren und verfahren zu ihrer herstellung, zusammensetzungen und produkte, die diese enthalten, sowie davon abgeleitete antikoerper und diagnostizierverfahren.
US4572798A (en) *	1984-12-06	1986-02-25	Cetus Corporation	Method for promoting disulfide bond formation in recombinant proteins
US4731440A (en) *	1985-02-22	1988-03-15	Monsanto Company	Method of somatotropin solubilization using dimethylsulfone and naturation
IL78197A (en) *	1985-03-22	1991-07-18	Genentech Inc	Nucleic acid encoding tgf-beta and its uses
GB8508340D0 (en) *	1985-03-29	1985-05-09	Creighton T E	Production of protein
EP0208539A3 (en) *	1985-07-11	1988-08-03	Repligen Corporation	Folding disulfide-cross-linkable proteins
US5453363A (en) *	1985-10-23	1995-09-26	Boehringer Mannheim Gmbh	Process for the activation of t-PA or Ing after genetic expression in prokaryotes
NZ222168A (en) *	1986-10-20	1991-05-28	Oncogene Science Inc	Tumour growth inhibiting protein related to tgf-#b#1 and tgf-#b#2, preparation by genetic engineering methods, antibodies and pharmaceutical compositions
NZ222569A (en) *	1986-11-17	1990-08-28	Sandoz Ltd	Production of glioblastoma-derived t cell suppressor factor (g-tsf) using recombinant techniques
FI100106B (fi) *	1986-12-05	1997-09-30	Novartis Ag	Menetelmä plasminogeenin yksisäikeisen yhdistelmäaktivaattorin valmist amiseksi
US4931548A (en) *	1987-01-30	1990-06-05	Techne Corporation	Heterodimer form of transforming growth factor-beta
US5013653A (en) *	1987-03-20	1991-05-07	Creative Biomolecules, Inc.	Product and process for introduction of a hinge region into a fusion protein to facilitate cleavage
IL86090A (en) *	1987-04-16	1993-03-15	Cetus Oncology Corp	Production of purified, biologically active, bacterially produced recombinant human csf-1
EP0368857B1 (en) *	1987-05-11	1997-08-06	Chiron Corporation	Process for recovering purified, oxidized, renatured recombinant interleukin-2 from microorganisms
US5162507A (en) *	1987-05-11	1992-11-10	Cetus Corporation	Process for recovering purified, oxidized, renatured recombinant interleukin-2 from microorganisms
AU626524B2 (en) *	1987-05-29	1992-08-06	Bristol-Myers Squibb Company	Cloning and expression of simian transforming growth factor- beta 1
US4985544A (en) *	1987-08-04	1991-01-15	Kyowa Hakko Kogyo Co., Ltd.	Process for renaturing fish growth hormone
US5061786A (en) *	1989-05-25	1991-10-29	Genentech, Inc.	Biologically active polypeptides based on transforming growth factor-β
GB8927546D0 (en) *	1989-12-06	1990-02-07	Ciba Geigy	Process for the production of biologically active tgf-beta
US5144006A (en) *	1991-06-13	1992-09-01	The Rockefeller University	Oxidative folding of peptide and protein substrates using hydrocarbon sulfoxides
AU2738392A (en) *	1991-11-11	1993-05-13	Ciba-Geigy Ag	Novel hybrid transforming growth factors

1989
- 1989-12-06 GB GB898927546A patent/GB8927546D0/en active Pending
1990
- 1990-11-27 AU AU67018/90A patent/AU638075B2/en not_active Expired
- 1990-11-27 AT AT90810922T patent/ATE178616T1/de not_active IP Right Cessation
- 1990-11-27 ES ES90810922T patent/ES2132066T3/es not_active Expired - Lifetime
- 1990-11-27 DK DK90810922T patent/DK0433225T3/da active
- 1990-11-27 SG SG1996007909A patent/SG52690A1/en unknown
- 1990-11-27 EP EP98113487A patent/EP0891985A1/en not_active Withdrawn
- 1990-11-27 EP EP90810922A patent/EP0433225B1/en not_active Expired - Lifetime
- 1990-11-27 DE DE69033040T patent/DE69033040T2/de not_active Expired - Lifetime
- 1990-11-30 JP JP2330871A patent/JP3048061B2/ja not_active Expired - Lifetime
- 1990-12-03 FI FI905956A patent/FI103278B1/fi active IP Right Grant
- 1990-12-04 MX MX023579A patent/MX172600B/es unknown
- 1990-12-04 NZ NZ236333A patent/NZ236333A/en unknown
- 1990-12-04 PT PT96068A patent/PT96068B/pt not_active IP Right Cessation
- 1990-12-04 CA CA002031430A patent/CA2031430C/en not_active Expired - Lifetime
- 1990-12-05 IE IE438690A patent/IE904386A1/en not_active IP Right Cessation
- 1990-12-05 IL IL9654990A patent/IL96549A/xx not_active IP Right Cessation
- 1990-12-05 HU HU084/90A patent/HU218144B/hu unknown
- 1990-12-05 IE IE19990992A patent/IE990992A1/en not_active IP Right Cessation
- 1990-12-05 NO NO905264A patent/NO301768B1/no not_active IP Right Cessation
- 1990-12-05 KR KR1019900019881A patent/KR100203230B1/ko not_active Expired - Lifetime
- 1990-12-05 ZA ZA909762A patent/ZA909762B/xx unknown
1994
- 1994-03-25 PH PH8001A patent/PH31649A/en unknown
1995
- 1995-06-07 US US08/486,057 patent/US5650494A/en not_active Expired - Lifetime
1997
- 1997-01-24 US US08/789,588 patent/US5922846A/en not_active Expired - Fee Related
1999
- 1999-07-07 GR GR990401786T patent/GR3030703T3/el unknown

Also Published As

Publication number	Publication date
HU908084D0 (en)	1991-06-28
PH31649A (en)	1999-01-12
JPH03191791A (ja)	1991-08-21
US5650494A (en)	1997-07-22
GR3030703T3 (en)	1999-11-30
GB8927546D0 (en)	1990-02-07
NO905264L (no)	1991-06-07
IE990992A1 (en)	2000-12-13
FI103278B (fi)	1999-05-31
IL96549A0 (en)	1991-09-16
JP3048061B2 (ja)	2000-06-05
ZA909762B (en)	1991-08-28
DE69033040D1 (de)	1999-05-12
IL96549A (en)	2000-10-31
HUT56880A (en)	1991-10-28
ATE178616T1 (de)	1999-04-15
US5922846A (en)	1999-07-13
KR100203230B1 (ko)	1999-06-15
EP0433225A1 (en)	1991-06-19
FI103278B1 (fi)	1999-05-31
CA2031430A1 (en)	1991-06-07
ES2132066T3 (es)	1999-08-16
PT96068B (pt)	1998-02-27
DK0433225T3 (da)	1999-10-25
MX172600B (es)	1994-01-03
FI905956L (fi)	1991-06-07
NO301768B1 (no)	1997-12-08
NO905264D0 (no)	1990-12-05
DE69033040T2 (de)	1999-09-09
IE904386A1 (en)	1991-06-19
HU218144B (hu)	2000-06-28
SG52690A1 (en)	1998-09-28
PT96068A (pt)	1991-09-30
EP0891985A1 (en)	1999-01-20
KR910012240A (ko)	1991-08-07
EP0433225B1 (en)	1999-04-07
AU6701890A (en)	1991-06-13
CA2031430C (en)	2003-05-27
AU638075B2 (en)	1993-06-17
NZ236333A (en)	1992-03-26

Publication	Publication Date	Title
FI905956A0 (fi)	1990-12-03	Foerfarande foer producering av ett biologiskt aktivt protein.
ATE103914T1 (de)	1994-04-15	Neue thienylcarbonsaeureester von aminoalkoholen, ihre quaternierungsprodukte sowie die herstellung und verwendung dieser verbindungen.
ATE92929T1 (de)	1993-08-15	Komplexe verbindungen aus bioflavonoiden mit phospholipiden, ihre herstellung und verwendung und sie enthaltende pharmazeutische und kosmetische zusammensetzungen.
DK0409472T3 (da)	1995-01-16	Knoglemorfogenetisk protein
DK140996A (da)	1996-12-09	Fremgangsmåde til fremstilling af 2,3,4,5-tetraflour-6-alkyl-benzoesyreforbindelser
FR2680507B1 (fr)	1993-10-08	Nouvelles naphtylethylurees et naphtylethylthiourees, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
DK15589A (da)	1989-07-22	Kemiske forbindelser
ATE82857T1 (de)	1992-12-15	Interleukin-2-zusammensetzungen.
SE8404065D0 (sv)	1984-08-10	Novel biologically active compounds
DK0406745T3 (da)	1995-02-27	Antibiotiske GE 2270 faktorer A1, A2, A3 og H
JPS56138174A (en)	1981-10-28	Phenylpiperazine derivative of 1,3,4-oxadiazolylphenol, manufacture and medicine containing same
EP0318029A3 (en)	1990-09-26	Cyclic amine and pharmacological composition
DK0538690T3 (da)	1995-03-06	Arylquinolyl-substituerede 1,4-dihydropyridin-dicarboxylsyrederivater, fremgangsmåde til deres fremstilling af deres anvendelse i lægemidler
ATE85893T1 (de)	1993-03-15	Verwendung von somatostatin zur herstellung eines arzneimittels fuer die behandlung von rheumatoider arthritis.
DE69009765D1 (de)	1994-07-14	Kynurensäurederivate, deren herstellung und diese enthaltende pharmazeutische zusammensetzungen.
DK15088A (da)	1988-07-15	Antibakterielt lyofiliseret praeparat
SE8802323L (sv)	1988-12-24	8alfa-acylaminoergolin, dess framstaellning samt farmaceutiska kompositioner innehaallande detsamma
RU93034376A (ru)	1997-01-27	Лекарственное средство, стимулирующее эритроидный и гранулоцитарный ростки кроветворения при цитостатических миелодепрессиях
ATE53384T1 (de)	1990-06-15	3-mercapto-2-oxo-1-pyrrolidinessigsaeurederivate verfahren zur herstellung und pharmazeutische zusammensetzungen die sie enthalten.

Legal Events

Date	Code	Title	Description
1997-08-20	GB	Transfer or assigment of application	Owner name: NOVARTIS AG
2004-08-31	FG	Patent granted	Owner name: NOVARTIS AG