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FI871733L - N-(2'-aminofenyl)-benzamidderivat, deras framstaellningsfoerfarande och deras anvaendning vid bekaempande av neoplastiska sjukdomar. - Google Patents

N-(2'-aminofenyl)-benzamidderivat, deras framstaellningsfoerfarande och deras anvaendning vid bekaempande av neoplastiska sjukdomar. Download PDF

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Publication number
FI871733L
FI871733L FI871733A FI871733A FI871733L FI 871733 L FI871733 L FI 871733L FI 871733 A FI871733 A FI 871733A FI 871733 A FI871733 A FI 871733A FI 871733 L FI871733 L FI 871733L
Authority
FI
Finland
Prior art keywords
deras
neoplastiska
bekaempande
sjukdomar
aminophenyl
Prior art date
Application number
FI871733A
Other languages
English (en)
Other versions
FI87766C (fi
FI87766B (fi
FI871733A0 (fi
Inventor
Ute Weiershausen
Gerhard Satzinger
Karl-Otto Vollmer
Wolfgang Herrmann
Original Assignee
Goedecke Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19863613571 external-priority patent/DE3613571A1/de
Priority claimed from DE19863625359 external-priority patent/DE3625359A1/de
Application filed by Goedecke Ag filed Critical Goedecke Ag
Publication of FI871733A0 publication Critical patent/FI871733A0/fi
Publication of FI871733L publication Critical patent/FI871733L/fi
Application granted granted Critical
Publication of FI87766B publication Critical patent/FI87766B/fi
Publication of FI87766C publication Critical patent/FI87766C/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
FI871733A 1986-04-22 1987-04-21 Foerfarande foer framstaellning av terapeutiskt aktiva n-(2'-aminofenyl)bensamidderivat FI87766C (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE19863613571 DE3613571A1 (de) 1986-04-22 1986-04-22 N-(2'-aminophenyl)-benzamid-derivate, verfahren zu deren herstellung und deren verwendung bei der bekaempfung neoplastischer erkrankungen
DE3613571 1986-04-22
DE19863625359 DE3625359A1 (de) 1986-07-26 1986-07-26 N-(2'-aminophenyl)-benzamid-derivat, verfahren zu dessen herstellung und dessen verwendung bei der bekaempfung neoplastischer erkrankungen
DE3625359 1986-07-26

Publications (4)

Publication Number Publication Date
FI871733A0 FI871733A0 (fi) 1987-04-21
FI871733L true FI871733L (fi) 1987-10-23
FI87766B FI87766B (fi) 1992-11-13
FI87766C FI87766C (fi) 1993-02-25

Family

ID=25843119

Family Applications (1)

Application Number Title Priority Date Filing Date
FI871733A FI87766C (fi) 1986-04-22 1987-04-21 Foerfarande foer framstaellning av terapeutiskt aktiva n-(2'-aminofenyl)bensamidderivat

Country Status (19)

Country Link
US (1) US5137918A (fi)
EP (1) EP0242851B1 (fi)
JP (1) JPH0825977B2 (fi)
CN (1) CN1012498B (fi)
AT (1) AT388913B (fi)
CA (1) CA1334760C (fi)
CS (1) CS262448B2 (fi)
DE (1) DE3763191D1 (fi)
DK (1) DK170771B1 (fi)
ES (1) ES2095824T3 (fi)
FI (1) FI87766C (fi)
GR (1) GR3000562T3 (fi)
HU (1) HU197295B (fi)
IE (1) IE60332B1 (fi)
IL (1) IL82265A (fi)
NO (1) NO168353C (fi)
NZ (1) NZ219974A (fi)
PH (1) PH23928A (fi)
PT (1) PT84737B (fi)

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US5602277A (en) * 1995-03-30 1997-02-11 Biocryst Pharmaceuticals, Inc. Substituted benzene derivatives useful as neuraminidase inhibitors
WO1998047500A1 (en) * 1997-04-24 1998-10-29 Warner-Lambert Company Use of acetyldinaline for the manufacture of a medicament for the treatment of renal cell carcinoma
DK1115391T3 (da) * 1998-09-25 2003-02-10 Warner Lambert Co Kemoterapi af cancer med acetyldinalin i kombination med gemcitabin, capecitabin eller cisplatin
JP2003513912A (ja) * 1999-11-10 2003-04-15 ワーナー−ランバート・カンパニー 組合せ化学療法
CZ20022216A3 (cs) * 2001-07-02 2003-05-14 Warner-Lambert Company Kombinační chemoterapie
AR034897A1 (es) * 2001-08-07 2004-03-24 Hoffmann La Roche Derivados n-monoacilados de o-fenilendiaminas, sus analogos heterociclicos de seis miembros y su uso como agentes farmaceuticos
KR20100107509A (ko) * 2001-09-14 2010-10-05 9222-9129 퀘벡 인코포레이티드 히스톤 데아세틸라아제의 억제제
US7868204B2 (en) * 2001-09-14 2011-01-11 Methylgene Inc. Inhibitors of histone deacetylase
US6897220B2 (en) * 2001-09-14 2005-05-24 Methylgene, Inc. Inhibitors of histone deacetylase
GB0202873D0 (en) * 2002-02-07 2002-03-27 Novartis Ag Organic compounds
TW200426138A (en) * 2002-12-10 2004-12-01 Hoffmann La Roche Novel arylene-carboxylic acid (2-amino-phenyl)-amide derivatives, their manufacture and use as pharmaceutical agents
TW200424174A (en) 2003-02-06 2004-11-16 Hoffmann La Roche New TP diamide
US7208491B2 (en) * 2003-02-07 2007-04-24 Hoffmann-La Roche Inc. N-monoacylated o-phenylenediamines
TW200424187A (en) 2003-04-04 2004-11-16 Hoffmann La Roche New oxime derivatives and their use as pharmaceutically active agents
WO2005030705A1 (en) * 2003-09-24 2005-04-07 Methylgene, Inc. Inhibitors of histone deacetylase
EP1696898B1 (en) * 2003-12-02 2015-11-18 The Ohio State University Research Foundation Zn 2+ -chelating motif-tethered short-chain fatty acids as a novel class of histone deacetylase inhibitors
US7253204B2 (en) * 2004-03-26 2007-08-07 Methylgene Inc. Inhibitors of histone deacetylase
US8598168B2 (en) * 2006-04-07 2013-12-03 Methylgene Inc. Inhibitors of histone deacetylase
US7960434B2 (en) 2006-05-19 2011-06-14 University Of South Florida Small molecule inhibitors of STAT3 with anti-tumor activity
WO2009076234A2 (en) * 2007-12-07 2009-06-18 University Of Maryland, Baltimore Synthesis methods of histone deacetylase inhibitors (hdacis)
US9156792B2 (en) * 2008-05-09 2015-10-13 University Of Maryland, Baltimore Retinamide and uses thereof
US8173621B2 (en) 2008-06-11 2012-05-08 Gilead Pharmasset Llc Nucleoside cyclicphosphates
US8716263B2 (en) 2008-12-23 2014-05-06 Gilead Pharmasset Llc Synthesis of purine nucleosides
EA019341B1 (ru) 2008-12-23 2014-02-28 Джилид Фармассет, Ллс. Фосфорамидаты нуклеозидов
EA201100851A1 (ru) 2008-12-23 2012-04-30 Фармассет, Инк. Аналоги нуклеозидов
MX2012011171A (es) 2010-03-31 2013-02-01 Gilead Pharmasset Llc Fosforamidatos de nucleosido.
US8729130B2 (en) 2011-07-01 2014-05-20 The Broad Institute, Inc. Methods of using novel solid forms of tacedinaline
WO2012149540A1 (en) 2011-04-28 2012-11-01 The Broad Institute Inc Inhibitors of histone deacetylase
JP6337255B2 (ja) 2012-07-27 2018-06-06 ザ ブロード インスティテュート, インコーポレーテッドThe Broad Institute, Inc. ヒストンデアセチラーゼの阻害剤
US9914717B2 (en) 2012-12-20 2018-03-13 The Broad Institute, Inc. Cycloalkenyl hydroxamic acid derivatives and their use as histone deacetylase inhibitors
US9636298B2 (en) 2014-01-17 2017-05-02 Methylgene Inc. Prodrugs of compounds that enhance antifungal activity and compositions of said prodrugs
CN104058983B (zh) * 2014-07-02 2016-01-13 郑攀锋 一种医药原料酰胺类化合物的合成方法
US12128018B2 (en) 2018-01-12 2024-10-29 KDAc Therapeutics, Inc. Combination of a selective histone deacetylase 3 (HDAC3) inhibitor and an immunotherapy agent for the treatment of cancer

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1493783A1 (de) * 1965-07-12 1969-01-30 Goedecke Ag Verfahren zur Herstellung von 2-Amino-4'-(diaethylamino)-2'-methyl-benzanilid
DE1643264A1 (de) * 1967-12-20 1971-06-09 Basf Ag Verfahren zur Herstellung von Aminoaniliden
US4004029A (en) * 1974-05-13 1977-01-18 The Upjohn Company Compositions and method for treating epilepsy and convulsions
DE3305755A1 (de) * 1983-02-19 1984-08-23 Gödecke AG, 1000 Berlin N-phenyl-benzamid-derivate, verfahren zu deren herstellung und deren verwendung bei der bekaempfung von erkranungen des immunsystems
CH653670A5 (de) * 1983-03-03 1986-01-15 Hoffmann La Roche Benzamid-derivate.
US4642379A (en) * 1985-08-30 1987-02-10 Eli Lilly And Company Intermediates for anticonvulsant agents

Also Published As

Publication number Publication date
EP0242851B1 (de) 1990-06-13
NO168353C (no) 1992-02-12
DE3763191D1 (de) 1990-07-19
CS273687A2 (en) 1988-07-15
FI87766C (fi) 1993-02-25
NO168353B (no) 1991-11-04
FI87766B (fi) 1992-11-13
DK198487D0 (da) 1987-04-15
AT388913B (de) 1989-09-25
JPS63115852A (ja) 1988-05-20
IE60332B1 (en) 1994-06-29
PT84737B (pt) 1989-12-29
US5137918A (en) 1992-08-11
EP0242851A1 (de) 1987-10-28
HU197295B (en) 1989-03-28
NO871640D0 (no) 1987-04-21
IL82265A0 (en) 1987-10-30
JPH0825977B2 (ja) 1996-03-13
NZ219974A (en) 1989-08-29
IE871046L (en) 1987-10-22
IL82265A (en) 1991-01-31
CN1012498B (zh) 1991-05-01
CA1334760C (en) 1995-03-14
ES2095824T3 (es) 1997-03-01
ATA265187A (de) 1989-02-15
PT84737A (en) 1987-05-01
NO871640L (no) 1987-10-23
CN87103096A (zh) 1987-11-18
GR3000562T3 (en) 1991-07-31
DK198487A (da) 1987-10-23
FI871733A0 (fi) 1987-04-21
DK170771B1 (da) 1996-01-15
HUT43808A (en) 1987-12-28
PH23928A (en) 1990-01-23
CS262448B2 (en) 1989-03-14

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FG Patent granted

Owner name: GOEDECKE AKTIENGESELLSCHAFT

MA Patent expired