FI813178L - Spirokvaternaera ammoniumhalider och n-(2-pyrimidinyl)piperazinylalkylazaspiroalkandionprocess - Google Patents

Spirokvaternaera ammoniumhalider och n-(2-pyrimidinyl)piperazinylalkylazaspiroalkandionprocess

Info

Publication number: FI813178L
Authority: FI; Finland
Prior art keywords: spiroquaternaera; piperazinylalkylazaspiroalkandion; halider; pyrimidinyl; och
Prior art date: 1980-10-16

Application number

FI813178A

Other languages

English (en)

Other versions

FI75159C (fi

FI75159B (fi

Inventor

Jack C Simms

Original Assignee

Bristol Myers Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1980-10-16

Filing date

1981-10-13

Publication date

1982-04-17

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22729338&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=FI813178(L) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1981-10-13 Application filed by Bristol Myers Co filed Critical Bristol Myers Co

1981-10-13 Priority to FI872221A priority Critical patent/FI872221L/fi

1982-04-17 Publication of FI813178L publication Critical patent/FI813178L/fi

1988-01-29 Application granted granted Critical

1988-01-29 Publication of FI75159B publication Critical patent/FI75159B/fi

1988-05-09 Publication of FI75159C publication Critical patent/FI75159C/fi

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/10—Spiro-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Plural Heterocyclic Compounds (AREA)

FI813178A 1980-10-16 1981-10-13 Spirokvaternaera ammoniumhalogenider och n-(2-pyrimidinyl)piperazinylalkylazaspiroalkandionprocess. FI75159C (fi)

Priority Applications (1)

Application Number	Priority Date	Filing Date	Title
FI872221A FI872221L (fi)	1980-10-16	1981-10-13	Foerfarande foer framstaellning av spirokvaternaera halogenider.

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US19741680		1980-10-16
US06/197,416 US4351939A (en)	1980-10-16	1980-10-16	Spiro-quaternary ammonium halides and N-(2-pyrimidinyl)piperazinylalkylazaspiroalkanedione process

Publications (3)

Publication Number	Publication Date
FI813178L true FI813178L (fi)	1982-04-17
FI75159B FI75159B (fi)	1988-01-29
FI75159C FI75159C (fi)	1988-05-09

Family

ID=22729338

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
FI813178A FI75159C (fi)	1980-10-16	1981-10-13	Spirokvaternaera ammoniumhalogenider och n-(2-pyrimidinyl)piperazinylalkylazaspiroalkandionprocess.

Country Status (33)

Country	Link
US (1)	US4351939A (fi)
JP (2)	JPS5724384A (fi)
KR (2)	KR870000321B1 (fi)
AT (1)	AT382153B (fi)
AU (1)	AU524822B2 (fi)
BE (1)	BE890509A (fi)
CA (1)	CA1175832A (fi)
CH (1)	CH647778A5 (fi)
CY (1)	CY1325A (fi)
DE (1)	DE3141256C2 (fi)
DK (1)	DK148481C (fi)
ES (2)	ES8206516A1 (fi)
FI (1)	FI75159C (fi)
FR (1)	FR2492383A1 (fi)
GB (1)	GB2085436B (fi)
GR (1)	GR74687B (fi)
HK (1)	HK35386A (fi)
HU (2)	HU187999B (fi)
IE (1)	IE51646B1 (fi)
IL (1)	IL64047A (fi)
IT (1)	IT1143244B (fi)
KE (1)	KE3596A (fi)
LU (1)	LU83657A1 (fi)
MY (1)	MY8600475A (fi)
NL (2)	NL179055C (fi)
NZ (1)	NZ196974A (fi)
OA (1)	OA06920A (fi)
PT (1)	PT73824B (fi)
SE (2)	SE439167B (fi)
SG (1)	SG97885G (fi)
SU (1)	SU1342420A3 (fi)
YU (2)	YU42565B (fi)
ZA (1)	ZA812759B (fi)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AT387221B (de) *	1980-09-08	1988-12-27	Bristol Myers Co	Verfahren zur herstellung des neuen
US4507303A (en) *	1981-12-22	1985-03-26	Sumitomo Chemical Company, Limited	Succinimide derivatives, compositions and method of use
US4452799A (en) *	1981-12-23	1984-06-05	Mead Johnson & Company	Benzisothiazole and benzisoxazole piperazine derivatives
JPS5945380U (ja) *	1982-09-20	1984-03-26	いすゞ自動車株式会社	車両用帯状体の固定装置
US5066783A (en) *	1986-05-20	1991-11-19	Cohen Eric A	Antiviral peptides and means for treating herpes infections
US4810789A (en) *	1987-08-28	1989-03-07	Bristol-Myers Company	Process for buspirone hydrochloride polymorphic crystalline form conversion
US5015646A (en) *	1987-08-28	1991-05-14	Bristol-Myers Squibb Co.	Pharmaceutically useful polymorphic modification of buspirone
US5631017A (en) *	1993-03-26	1997-05-20	Beth Israel Deaconess Medical Center, Inc.	Topical application of buspirone for treatment of pathological conditions associated with immune responses
US5484788A (en) *	1993-03-26	1996-01-16	Beth Israel Hospital Association	Buspirone as a systemic immunosuppressant
FR2705098B1 (fr) *	1993-05-10	1995-08-04	Esteve Labor Dr	Procédé de préparation de 2-{4-[4-(chloro-1-pyrazolyl)butyl]1-pipérazinyl}pyrimidine (Lesopitron) .
CA2146593A1 (en) *	1994-05-05	1995-11-06	Jack Melton	Large-scale process for azapirone synthesis
US5521313A (en) *	1994-05-05	1996-05-28	Bristol-Myers Squibb Company	Process for preparing certain azapirones
US5637314A (en) *	1995-06-07	1997-06-10	Beth Israel Deaconess Medical Center, Inc.	Topical and systemic application of buspirone or derivatives thereof for treating atopic dermatitis
AR038368A1 (es) *	2002-02-01	2005-01-12	Novartis Ag	Compuestos n-pirimidin-2-il-aminas sustituidas como inhibidores de ige, una composicion farmaceutica y el uso de dichos compuestos para la preparacion de un medicamento
DE06790055T1 (de) *	2005-08-30	2008-09-25	Honeywell International Inc.	Verfahren zur synthese von quaternären ammoniumspirosystemen
CN101089000B (zh)	2006-06-16	2011-01-05	北京大学	螺环哌嗪季铵盐类化合物及其制备方法和应用
CN101362751B (zh) *	2007-08-10	2011-05-11	成都科瑞德医药投资有限责任公司	枸橼酸坦度螺酮及其制备方法、制剂和质量控制方法
ES2527545T3 (es) *	2010-04-26	2015-01-26	Sumitomo Dainippon Pharma Co., Ltd.	Un procedimiento de preparación de una sal de amonio cuaternario utilizando fosfato
JP5820821B2 (ja) *	2010-04-26	2015-11-24	大日本住友製薬株式会社	第四級アンモニウム塩の製造法
CN120463720A (zh)	2018-11-21	2025-08-12	卡斯西部储备大学	调节短链脱氢酶活性的组合物和方法
IT201900000657A1 (it)	2019-01-16	2020-07-16	Procos Spa	Processo per la sintesi di gepirone
CN117024414A (zh) *	2023-08-11	2023-11-10	浙江九洲药业股份有限公司	一种枸橼酸坦度螺酮的合成方法
CN119409681B (zh) *	2024-03-28	2025-12-16	北京华素制药股份有限公司	一种盐酸丁螺环酮的制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB948730A (en) *	1959-04-08	1964-02-05	Wellcome Found	Substituted cyclopropanes and related compounds
US3968216A (en) *	1969-10-29	1976-07-06	Smith Kline & French Laboratories Limited	Method of inhibiting histamine activity with guanidine compounds
BE759371A (fr) *	1969-11-24	1971-05-24	Bristol Myers Co	Azaspirodecanediones heterocycliques et procedes pour leur preparation

1980
- 1980-10-16 US US06/197,416 patent/US4351939A/en not_active Expired - Lifetime
1981
- 1981-04-27 ZA ZA00812759A patent/ZA812759B/xx unknown
- 1981-04-28 YU YU1103/81A patent/YU42565B/xx unknown
- 1981-04-30 NZ NZ196974A patent/NZ196974A/en unknown
- 1981-05-06 GR GR64860A patent/GR74687B/el unknown
- 1981-05-07 ES ES501994A patent/ES8206516A1/es not_active Expired
- 1981-05-08 AU AU70292/81A patent/AU524822B2/en not_active Expired
- 1981-05-27 JP JP7944381A patent/JPS5724384A/ja active Granted
- 1981-07-01 CY CY1325A patent/CY1325A/en unknown
- 1981-07-01 GB GB8120338A patent/GB2085436B/en not_active Expired
- 1981-08-11 CA CA000383588A patent/CA1175832A/en not_active Expired
- 1981-09-25 BE BE0/206077A patent/BE890509A/fr not_active IP Right Cessation
- 1981-09-28 LU LU83657A patent/LU83657A1/fr unknown
- 1981-09-30 DK DK433781A patent/DK148481C/da active
- 1981-10-12 OA OA57515A patent/OA06920A/xx unknown
- 1981-10-12 FR FR8119153A patent/FR2492383A1/fr active Granted
- 1981-10-13 IT IT49476/81A patent/IT1143244B/it active
- 1981-10-13 NL NLAANVRAGE8104660,A patent/NL179055C/xx not_active IP Right Cessation
- 1981-10-13 FI FI813178A patent/FI75159C/fi not_active IP Right Cessation
- 1981-10-13 SE SE8106060A patent/SE439167B/sv not_active IP Right Cessation
- 1981-10-14 IL IL64047A patent/IL64047A/xx not_active IP Right Cessation
- 1981-10-14 CH CH6580/81A patent/CH647778A5/de not_active IP Right Cessation
- 1981-10-15 PT PT73824A patent/PT73824B/pt unknown
- 1981-10-15 HU HU843458A patent/HU187999B/hu unknown
- 1981-10-15 IE IE2420/81A patent/IE51646B1/en not_active IP Right Cessation
- 1981-10-15 HU HU812982A patent/HU185967B/hu not_active IP Right Cessation
- 1981-10-16 AT AT0444681A patent/AT382153B/de not_active IP Right Cessation
- 1981-10-16 KR KR8103924A patent/KR870000321B1/ko not_active Expired
- 1981-10-16 DE DE3141256A patent/DE3141256C2/de not_active Expired
- 1981-10-16 KR KR1019810003924D patent/KR890000465B1/ko not_active Expired
1982
- 1982-04-01 ES ES511079A patent/ES8304967A1/es not_active Expired
1983
- 1983-03-09 SU SU833562184A patent/SU1342420A3/ru active
- 1983-06-21 YU YU1360/83A patent/YU43316B/xx unknown
1985
- 1985-05-17 NL NL8501430A patent/NL8501430A/nl active Search and Examination
- 1985-12-17 JP JP60282152A patent/JPS61178983A/ja active Granted
- 1985-12-23 SG SG978/85A patent/SG97885G/en unknown
1986
- 1986-01-13 KE KE3596A patent/KE3596A/xx unknown
- 1986-01-15 SE SE8600174A patent/SE447257B/sv not_active IP Right Cessation
- 1986-05-22 HK HK353/86A patent/HK35386A/xx not_active IP Right Cessation
- 1986-12-30 MY MY475/86A patent/MY8600475A/xx unknown

Also Published As

Publication number	Publication date
JPS5724384A (en)	1982-02-08
NL179055B (nl)	1986-02-03
CY1325A (en)	1986-06-27
MY8600475A (en)	1986-12-31
KR830007659A (ko)	1983-11-04
OA06920A (fr)	1983-05-31
KR890000465B1 (ko)	1989-03-18
SE8600174D0 (sv)	1986-01-15
SE8106060L (sv)	1982-04-17
KR870000321B1 (en)	1987-02-27
IE812420L (en)	1982-04-16
IL64047A0 (en)	1982-01-31
GR74687B (fi)	1984-07-03
JPS634828B2 (fi)	1988-02-01
KE3596A (en)	1986-02-07
NZ196974A (en)	1983-05-31
CH647778A5 (de)	1985-02-15
ES501994A0 (es)	1982-08-16
SE447257B (sv)	1986-11-03
HK35386A (en)	1986-05-30
YU136083A (en)	1986-02-28
CA1175832A (en)	1984-10-09
HU187999B (en)	1986-03-28
IT8149476A0 (it)	1981-10-13
YU43316B (en)	1989-06-30
IE51646B1 (en)	1987-01-21
LU83657A1 (fr)	1982-04-14
ZA812759B (en)	1982-05-26
BE890509A (fr)	1982-03-25
ES511079A0 (es)	1983-03-16
SG97885G (en)	1986-07-25
HU185967B (en)	1985-04-28
AU524822B2 (en)	1982-10-07
DK148481B (da)	1985-07-15
NL8501430A (nl)	1985-09-02
ES8206516A1 (es)	1982-08-16
US4351939A (en)	1982-09-28
IT1143244B (it)	1986-10-22
NL179055C (nl)	1986-07-01
IL64047A (en)	1984-12-31
FI75159C (fi)	1988-05-09
PT73824B (en)	1983-10-31
GB2085436B (en)	1984-01-18
FR2492383B1 (fi)	1985-01-25
SE8600174L (sv)	1986-01-15
ATA444681A (de)	1986-06-15
FR2492383A1 (fr)	1982-04-23
DK148481C (da)	1985-12-16
AU7029281A (en)	1982-04-22
JPS6153353B2 (fi)	1986-11-17
ES8304967A1 (es)	1983-03-16
DE3141256A1 (de)	1982-08-19
FI75159B (fi)	1988-01-29
NL8104660A (nl)	1982-05-17
AT382153B (de)	1987-01-26
PT73824A (en)	1981-11-01
SE439167B (sv)	1985-06-03
SU1342420A3 (ru)	1987-09-30
JPS61178983A (ja)	1986-08-11
DE3141256C2 (de)	1986-06-05
YU110381A (en)	1983-12-31
DK433781A (da)	1982-04-17
YU42565B (en)	1988-10-31
GB2085436A (en)	1982-04-28

Publication	Publication Date	Title
FI813178L (fi)	1982-04-17	Spirokvaternaera ammoniumhalider och n-(2-pyrimidinyl)piperazinylalkylazaspiroalkandionprocess
FI812067L (fi)	1982-01-02	Interferoner och process foer deras framstaellning
FI811085L (fi)	1981-10-12	Cementlimblandning och ur denna producerad cementprodukt
FI811547A7 (fi)	1981-11-23	Amiinijohdannaiset.
FI811762L (fi)	1981-12-07	Ml-236b-derivater och deras framstaellning
FI812652L (fi)	1982-03-01	Aminosyraderivat foerfarande foer deras framstaellning dessa innehaollande aemnen och deras anvaendning
FI813346L (fi)	1982-04-29	Foerpackningar och omslag foer multienheter
FI813408L (fi)	1982-05-01	Karbostyril-foereningar kompositioner innehaollande dessa och foerfarande foer deras framstaellning
FI813526L (fi)	1982-05-11	Bensoheterocykliska foereningar och foerfarande foer deras framstaellning
FI802279A7 (fi)	1982-01-19	Ytbelagt titandioxidpigment och foerfarande foer framstaellning daerav
FI812523L (fi)	1982-02-19	Anod med blybas och foerfarande foer framstaellning daerav
FI810712L (fi)	1981-09-09	Heterocykliska foereningar deras framstaellning och anvaendning
FI802351A7 (fi)	1981-01-26	Metallurgisk extraktionskomposition och process
FI820594L (fi)	1982-08-26	Substituerade n-(4-indolyl-piperidino-alkyl)-benzimidazoloner foerfarande foer deras framstaellning och deras anvaendning saosom farmaceutiska aemnen
BE877737A (fr)	1980-01-16	N-(diaminophosphinyl) arylcarboxamides
FI810718L (fi)	1981-09-14	Slitbana foer daeck och daeck innehaollande en dylik slitbana
FI813524L (fi)	1982-05-12	Maleinsyra-anhydridkopolymerater och deras framstaellning
FI812215L (fi)	1982-06-17	7-substituerade benzopyrander och foerfarande foer deras framstaellning
FI811189L (fi)	1981-10-24	Foerstaerkare med styrd foerstaerkning och med variabel belastningsimpedans
FI811208L (fi)	1981-10-19	Foderautomat foer mink
FI812504L (fi)	1982-02-15	Desinfekterande och steriliserande komposition
FI810960L (fi)	1981-09-30	Foerfarande foer framstaellning av mikrosfaerer av urea och mikrosfaerer framstaellda i enlighet med detta foerfarande
FI811532L (fi)	1981-11-23	Dioxidfoereningar foerfaranden foer deras framstaellning och deras anvaendning
FI813604L (fi)	1981-11-13	Sek -butylbifenylprodukt och foerfarande foer framstaellning daerav
DK73879A (da)	1979-08-25	Kvaternaere ammoniumforbindelser

Legal Events

Date	Code	Title	Description
2004-08-31	MA	Patent expired	Owner name: BRISTOL-MYERS CO