FI20050027L - Ei-terapeuttisesti käytettäviä trombiini-inhibiittoreita - Google Patents

Ei-terapeuttisesti käytettäviä trombiini-inhibiittoreita Download PDF

Info

Publication number: FI20050027L
Authority: FI; Finland
Prior art keywords: thrombin inhibitors; therapeutic; therapeutic thrombin; inhibitors; thrombin
Prior art date: 1991-02-08

Application number

FI20050027A

Other languages

English (en)

Swedish (sv)

Other versions

FI120690B (fi

Inventor

John M Maraganore

Jo-Ann M Jablonski

Paul R Bourdon

Original Assignee

Biogen Idec Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-02-08

Filing date

2005-01-11

Publication date

2005-01-11

2005-01-11 Application filed by Biogen Idec Inc filed Critical Biogen Idec Inc

2005-01-11 Publication of FI20050027L publication Critical patent/FI20050027L/fi

2010-01-29 Application granted granted Critical

2010-01-29 Publication of FI120690B publication Critical patent/FI120690B/fi

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/02—Linear peptides containing at least one abnormal peptide link
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/815—Protease inhibitors from leeches, e.g. hirudin, eglin
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1002—Tetrapeptides with the first amino acid being neutral
- C07K5/1016—Tetrapeptides with the first amino acid being neutral and aromatic or cycloaliphatic
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Biophysics (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biochemistry (AREA)
Tropical Medicine & Parasitology (AREA)
Gastroenterology & Hepatology (AREA)
Hematology (AREA)
Public Health (AREA)
Diabetes (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Materials For Medical Uses (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Pyrane Compounds (AREA)
Lighting Device Outwards From Vehicle And Optical Signal (AREA)
Manipulator (AREA)

FI20050027A 1991-02-08 2005-01-11 Ei-terapeuttisesti käytettäviä trombiini-inhibiittoreita FI120690B (fi)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
US07/652,929 US5240913A (en)	1989-08-18	1991-02-08	Inhibitors of thrombin
US65292991		1991-02-08
PCT/US1992/000836 WO1992013952A1 (en)	1991-02-08	1992-02-03	Improved inhibitors of thrombin
US9200836		1992-02-03

Publications (2)

Publication Number	Publication Date
FI20050027L true FI20050027L (fi)	2005-01-11
FI120690B FI120690B (fi)	2010-01-29

Family

ID=24618783

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
FI924503A FI120348B (fi)	1991-02-08	1992-10-06	Menetelmä terapeuttisesti käyttökelpoisen trombiini-inhibiittorin valmistamiseksi
FI20050027A FI120690B (fi)	1991-02-08	2005-01-11	Ei-terapeuttisesti käytettäviä trombiini-inhibiittoreita

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
FI924503A FI120348B (fi)	1991-02-08	1992-10-06	Menetelmä terapeuttisesti käyttökelpoisen trombiini-inhibiittorin valmistamiseksi

Country Status (18)

Country	Link
US (3)	US5240913A (fi)
EP (1)	EP0529031B9 (fi)
JP (1)	JPH05506252A (fi)
KR (1)	KR100259759B1 (fi)
AT (1)	ATE193325T1 (fi)
AU (1)	AU659828B2 (fi)
BG (1)	BG61243B2 (fi)
CA (1)	CA2079778C (fi)
DE (1)	DE69231081T2 (fi)
DK (1)	DK0529031T3 (fi)
ES (1)	ES2149170T3 (fi)
FI (2)	FI120348B (fi)
GR (1)	GR3034257T3 (fi)
HU (1)	HU218831B (fi)
NO (1)	NO315710B1 (fi)
NZ (1)	NZ241557A (fi)
TW (1)	TW222642B (fi)
WO (1)	WO1992013952A1 (fi)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5240913A (en) *	1989-08-18	1993-08-31	Biogen, Inc.	Inhibitors of thrombin
US6060451A (en) *	1990-06-15	2000-05-09	The National Research Council Of Canada	Thrombin inhibitors based on the amino acid sequence of hirudin
US5458568A (en) *	1991-05-24	1995-10-17	Cortrak Medical, Inc.	Porous balloon for selective dilatation and drug delivery
US5811447A (en)	1993-01-28	1998-09-22	Neorx Corporation	Therapeutic inhibitor of vascular smooth muscle cells
US6515009B1 (en) *	1991-09-27	2003-02-04	Neorx Corporation	Therapeutic inhibitor of vascular smooth muscle cells
US5656600A (en) *	1993-03-25	1997-08-12	Corvas International, Inc.	α-ketoamide derivatives as inhibitors of thrombosis
US5599307A (en) *	1993-07-26	1997-02-04	Loyola University Of Chicago	Catheter and method for the prevention and/or treatment of stenotic processes of vessels and cavities
CA2180140A1 (en) *	1993-12-27	1995-07-06	Jeffrey I. Weitz	Methods and compositions for inhibiting thrombogenesis
WO1995019359A1 (en) *	1994-01-12	1995-07-20	Massachusetts Institute Of Technology	Process for making xanthene or cubane based compounds, and protease inhibitors
US5510330A (en) *	1994-03-25	1996-04-23	Boehringer Mannheim Gmbh	Combinations of thrombolytically active proteins and non-heparin anticoagulants, and uses thereof.
US5849510A (en) *	1994-04-26	1998-12-15	Selectide Corporation	Factor Xa inhibitors
US6759384B1 (en)	1994-04-26	2004-07-06	Aventis Pharmaceuticals Inc.	Factor Xa inhibitors
DE4430205A1 (de)	1994-08-26	1996-02-29	Behringwerke Ag	Zusammensetzungen, die als Gegenmittel für Blut-Antikoagulanzien geeignet sind und deren Verwendung
DE4430204A1 (de)	1994-08-26	1996-02-29	Behringwerke Ag	Arzneimittel, welches als Gegenmittel für Blut-Antikoagulanzien geeignet ist und seine Verwendung
US5747453A (en)	1995-06-06	1998-05-05	Alza Corporation	Method for increasing the electrotransport flux of polypeptides
DE19549118C2 (de) *	1995-12-29	2000-07-13	Thomas W Stief	Hämostaseaktivierungs-Inhibitor und Verfahren zum Hemmen der Hämostaseaktivierung in Blut oder anderen biologischen Flüssigkeiten
US6333189B1 (en)	1996-06-06	2001-12-25	Alza Corporation	Method of making an electrotransport device
JPH1010784A (ja) *	1996-06-27	1998-01-16	Brother Ind Ltd	正帯電性一成分現像剤並びにその現像剤を用いた画像形成装置
GB9613719D0 (en) *	1996-06-29	1996-08-28	Thrombosis Res Inst	Serine protease inhibitors
GB9613718D0 (en) *	1996-06-29	1996-08-28	Thrombosis Res Inst	Thrombin inhibitors
US5840733A (en)	1996-07-01	1998-11-24	Redcell, Canada, Inc.	Methods and compositions for producing novel conjugates of thrombin inhibitors and endogenous carriers resulting in anti-thrombins with extended lifetimes
US5985833A (en) *	1996-09-17	1999-11-16	Wisconsin Alumni Research Foundation	Thrombin inhibitor
US20030077310A1 (en)	2001-10-22	2003-04-24	Chandrashekhar Pathak	Stent coatings containing HMG-CoA reductase inhibitors
DE10162521A1 (de) *	2001-12-19	2003-07-17	Goetz Nowak	Verwendung von molekulargewichtserweiterten Substanzen in der Tumortherapie
JP4903709B2 (ja)	2004-10-19	2012-03-28	ロンザアーゲー	固相ペプチド合成のための方法
US7598343B1 (en)	2008-07-27	2009-10-06	The Medicines Company	Pharmaceutical formulations of bivalirudin and processes of making the same
US7582727B1 (en)	2008-07-27	2009-09-01	The Medicinces Company	Pharmaceutical formulations of bivalirudin and processes of making the same
KR101634830B1 (ko)	2008-09-03	2016-06-29	시노팜 타이완 리미티드	비발리루딘의 제조방법
US7803762B1 (en)	2009-08-20	2010-09-28	The Medicines Company	Ready-to-use bivalirudin compositions
US7985733B1 (en)	2010-01-06	2011-07-26	The Medicines Company	Buffer-based method for preparing bivalirudin drug product
GB201121513D0 (en)	2011-12-14	2012-01-25	Cambridge Entpr Ltd	Thrombin-binding antibody molecules and uses thereof
US9518128B2 (en)	2011-12-14	2016-12-13	Janssen Pharmaceuticals, Inc.	Thrombin-binding antibody molecules
AU2017273857B2 (en)	2016-06-01	2021-08-19	Athira Pharma, Inc.	Compounds
WO2019030706A1 (en)	2017-08-10	2019-02-14	Janssen Pharmaceutica Nv	ANTI-THROMBIN ANTIBODY MOLECULES AND METHODS OF USE IN ORTHOPEDIC SURGERY
WO2019035055A1 (en)	2017-08-16	2019-02-21	Janssen Pharmaceutica Nv	ANTI-THROMBIN ANTIBODY MOLECULES AND METHODS OF USE WITH PLATELET ANTI-AGGREGATE AGENTS
US11992514B2 (en)	2019-05-20	2024-05-28	MAIA Pharmaceuticals, Inc.	Ready-to-use bivalirudin compositions

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA1161431A (en) *	1979-05-11	1984-01-31	Lars G. Svendsen	Tripeptide derivatives
GB8305985D0 (en) *	1983-03-04	1983-04-07	Szelke M	Enzyme inhibition
DE3501107A1 (de) *	1985-01-15	1986-07-17	Josef 8358 Vilshofen Paul	Nutzfahrzeug mit schieberahmenwechselaufbau
CA1341032C (en) *	1987-01-23	2000-06-20	John L. Krstenansky	Anticoagulant peptides
ZA883443B (en) *	1987-05-21	1988-11-16	Merrell Dow Pharmaceuticals Inc.	Cyclic anticoagulant peptides
ZA883444B (fi) *	1987-05-21	1988-11-16
EP0333356A3 (en) *	1988-03-04	1990-12-19	Biogen, Inc.	Hirudin peptides
US4971953A (en) *	1988-05-10	1990-11-20	Merrell Dow Pharmaceuticals	Anticoagulant peptide alcohols
NZ228995A (en) *	1988-05-10	1992-03-26	Merrell Dow Pharma	Hirudin peptide derivatives and pharmaceutical compositions
FI904330A7 (fi) *	1988-09-29	1990-09-03	Biogen Inc	Hirudiinipeptidejä
US5196404B1 (en) *	1989-08-18	1996-09-10	Biogen Inc	Inhibitors of thrombin
US5240913A (en) *	1989-08-18	1993-08-31	Biogen, Inc.	Inhibitors of thrombin
AU654820B2 (en) *	1990-06-15	1994-11-24	Majesty (Her) In Right Of Canada As Represented By The National Research Council Of Canada	Thrombin inhibitors based on the amino acid sequence of hirudin

1991
- 1991-02-08 US US07/652,929 patent/US5240913A/en not_active Expired - Lifetime
1992
- 1992-02-03 CA CA002079778A patent/CA2079778C/en not_active Expired - Lifetime
- 1992-02-03 KR KR1019920702485A patent/KR100259759B1/ko not_active Expired - Lifetime
- 1992-02-03 DE DE69231081T patent/DE69231081T2/de not_active Expired - Lifetime
- 1992-02-03 ES ES92905748T patent/ES2149170T3/es not_active Expired - Lifetime
- 1992-02-03 EP EP92905748A patent/EP0529031B9/en not_active Expired - Lifetime
- 1992-02-03 HU HU9203500A patent/HU218831B/hu unknown
- 1992-02-03 AT AT92905748T patent/ATE193325T1/de active
- 1992-02-03 JP JP92505745A patent/JPH05506252A/ja active Pending
- 1992-02-03 AU AU13621/92A patent/AU659828B2/en not_active Expired
- 1992-02-03 DK DK92905748T patent/DK0529031T3/da active
- 1992-02-03 WO PCT/US1992/000836 patent/WO1992013952A1/en not_active Ceased
- 1992-02-07 NZ NZ241557A patent/NZ241557A/en not_active IP Right Cessation
- 1992-02-13 TW TW081101012A patent/TW222642B/zh active
- 1992-07-31 US US07/924,549 patent/US5425936A/en not_active Expired - Lifetime
- 1992-10-06 FI FI924503A patent/FI120348B/fi not_active IP Right Cessation
- 1992-10-07 NO NO19923889A patent/NO315710B1/no not_active IP Right Cessation
1994
- 1994-02-24 BG BG098559A patent/BG61243B2/bg unknown
1995
- 1995-05-02 US US08/431,678 patent/US5514409A/en not_active Expired - Lifetime
2000
- 2000-08-24 GR GR20000401944T patent/GR3034257T3/el unknown
2005
- 2005-01-11 FI FI20050027A patent/FI120690B/fi not_active IP Right Cessation

Also Published As

Publication number	Publication date
GR3034257T3 (en)	2000-12-29
FI120348B (fi)	2009-09-30
ES2149170T3 (es)	2000-11-01
AU1362192A (en)	1992-09-07
AU659828B2 (en)	1995-06-01
US5425936A (en)	1995-06-20
NO923889L (no)	1992-12-08
NO315710B1 (no)	2003-10-13
FI924503A7 (fi)	1992-10-06
NO923889D0 (no)	1992-10-07
WO1992013952A1 (en)	1992-08-20
BG61243B2 (bg)	1997-03-31
EP0529031A1 (en)	1993-03-03
FI120690B (fi)	2010-01-29
US5240913A (en)	1993-08-31
NZ241557A (en)	1996-11-26
JPH05506252A (ja)	1993-09-16
FI924503A0 (fi)	1992-10-06
KR100259759B1 (ko)	2000-06-15
TW222642B (fi)	1994-04-21
ATE193325T1 (de)	2000-06-15
DK0529031T3 (da)	2000-10-09
DE69231081T2 (de)	2001-02-01
EP0529031B1 (en)	2000-05-24
HU9203500D0 (en)	1993-01-28
EP0529031B9 (en)	2007-11-21
HU218831B (hu)	2000-12-28
CA2079778C (en)	2002-09-03
HK1005995A1 (en)	1999-02-05
HUT65675A (en)	1994-07-28
CA2079778A1 (en)	1992-08-09
DE69231081D1 (de)	2000-06-29
US5514409A (en)	1996-05-07

Publication	Publication Date	Title
FI20050027L (fi)	2005-01-11	Ei-terapeuttisesti käytettäviä trombiini-inhibiittoreita
FI933303L (fi)	1993-08-31	Adenosinkinasinhibitorer
FI933277A7 (fi)	1994-01-21	Amiinidioli proteaasi-inhibiittorit
NO942064D0 (no)	1994-06-03	yminhibitorer
FI963597L (fi)	1996-11-14	Isoprenyylitransferaasi-inhibiittoreita
NO972930D0 (no)	1997-06-23	Fibronectin-adhesjonsinhibitorer
FI973282A0 (fi)	1997-08-08	Trombiinin inhibiittoreita
FI972160A0 (fi)	1997-05-21	Matriisimetalloproteaasi-inhibiittorit
ATE222240T1 (de)	2002-08-15	Hiv - protease inhibitoren
FI894748A7 (fi)	1990-04-08	Uusia peptidaasi-inhibiittoreita
DK0858464T3 (da)	2003-08-25	Thrombin-inhibitorer
DE59711714D1 (de)	2004-07-15	Thrombininhibitoren
BR8907457A (pt)	1991-04-02	Inibidores de interleucina-1
FI935644L (fi)	1994-06-17	Retrovirusten proteaasi-inhibiittoreita
FI895962A7 (fi)	1990-06-16	Proteaasi-inhibiittorit
IS3942A (is)	1993-05-07	Hálftilsniðinn hlutur
DE69210797D1 (de)	1996-06-20	Prolyl Endopeptidase Inhibitor
FI925696L (fi)	1992-12-15	Pao hirudinets aminosyrasekvens baserade trombininhibitorer
FI101796B1 (fi)	1998-08-31	Uusia -glukosidaasi-inhibiittoreita
FI952712L (fi)	1995-06-02	Protostomien syljestä saatu trombiini-inhibiittori
MX9100121A (es)	1992-02-28	Inhibidores de proteasas asparticas
DE69731664D1 (de)	2004-12-23	Thrombininhibitoren
DK174087D0 (da)	1987-04-06	Angiotensinkonverterende enzyminhibitor
DK69489D0 (da)	1989-02-15	Aspartattranscarbamylase-inhibitorer
NO922191L (no)	1993-12-06	Nye thrombininhibitorer

Legal Events

Date	Code	Title	Description
2010-01-29	FG	Patent granted	Ref document number: 120690 Country of ref document: FI
2012-03-29	MA	Patent expired

Date

Code

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2010-01-29

Patent granted

Ref document number: 120690

Country of ref document: FI

2012-03-29

Patent expired