FI119174B - Uusi oraalinen farmaseuttinen annostelumuoto - Google Patents

Uusi oraalinen farmaseuttinen annostelumuoto Download PDF

Info

Publication number: FI119174B
Authority: FI; Finland
Prior art keywords: administration; pellets; tableted; proton pump; coated
Prior art date: 1995-02-06

Application number

FI963984A

Other languages

English (en)

Finnish (fi)

Swedish (sv)

Other versions

FI963984A0 (fi

FI963984L (fi

Inventor

Adam Rosinski

Helene Depui

Original Assignee

Astrazeneca Ab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-02-06

Filing date

1996-10-04

Publication date

2008-08-29

1996-10-04 Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab

1996-10-04 Publication of FI963984A0 publication Critical patent/FI963984A0/fi

1996-10-04 Publication of FI963984L publication Critical patent/FI963984L/fi

2008-08-29 Application granted granted Critical

2008-08-29 Publication of FI119174B publication Critical patent/FI119174B/fi

Links

239000002552 dosage form Substances 0.000 title claims description 35
239000008188 pellet Substances 0.000 claims description 101
239000010410 layer Substances 0.000 claims description 100
229940126409 proton pump inhibitor Drugs 0.000 claims description 57
239000000612 proton pump inhibitor Substances 0.000 claims description 57
239000008187 granular material Substances 0.000 claims description 53
150000001875 compounds Chemical class 0.000 claims description 52
229960002626 clarithromycin Drugs 0.000 claims description 48
AGOYDEPGAOXOCK-KCBOHYOISA-N clarithromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@](C)([C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)OC)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 AGOYDEPGAOXOCK-KCBOHYOISA-N 0.000 claims description 48
230000000844 anti-bacterial effect Effects 0.000 claims description 46
238000000576 coating method Methods 0.000 claims description 42
239000011248 coating agent Substances 0.000 claims description 41
238000000926 separation method Methods 0.000 claims description 39
239000000203 mixture Substances 0.000 claims description 38
239000002253 acid Substances 0.000 claims description 35
239000011247 coating layer Substances 0.000 claims description 33
229960000282 metronidazole Drugs 0.000 claims description 31
VAOCPAMSLUNLGC-UHFFFAOYSA-N metronidazole Chemical compound CC1=NC=C([N+]([O-])=O)N1CCO VAOCPAMSLUNLGC-UHFFFAOYSA-N 0.000 claims description 31
SUBDBMMJDZJVOS-UHFFFAOYSA-N 5-methoxy-2-{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl}-1H-benzimidazole Chemical compound N=1C2=CC(OC)=CC=C2NC=1S(=O)CC1=NC=C(C)C(OC)=C1C SUBDBMMJDZJVOS-UHFFFAOYSA-N 0.000 claims description 21
238000005469 granulation Methods 0.000 claims description 20
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229960000381 omeprazole Drugs 0.000 claims description 20
238000000034 method Methods 0.000 claims description 18
239000013543 active substance Substances 0.000 claims description 16
-1 alkali metal salt Chemical class 0.000 claims description 14
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MJIHNNLFOKEZEW-UHFFFAOYSA-N lansoprazole Chemical compound CC1=C(OCC(F)(F)F)C=CN=C1CS(=O)C1=NC2=CC=CC=C2N1 MJIHNNLFOKEZEW-UHFFFAOYSA-N 0.000 claims description 12
239000000945 filler Substances 0.000 claims description 11
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FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical group [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 claims description 6
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LSQZJLSUYDQPKJ-NJBDSQKTSA-N amoxicillin Chemical compound C1([C@@H](N)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C(O)=O)(C)C)=CC=C(O)C=C1 LSQZJLSUYDQPKJ-NJBDSQKTSA-N 0.000 claims description 6
229910052749 magnesium Inorganic materials 0.000 claims description 6
LSQZJLSUYDQPKJ-UHFFFAOYSA-N p-Hydroxyampicillin Natural products O=C1N2C(C(O)=O)C(C)(C)SC2C1NC(=O)C(N)C1=CC=C(O)C=C1 LSQZJLSUYDQPKJ-UHFFFAOYSA-N 0.000 claims description 6
HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 claims description 5
210000001035 gastrointestinal tract Anatomy 0.000 claims description 4
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239000003814 drug Substances 0.000 claims description 3
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SUBDBMMJDZJVOS-DEOSSOPVSA-N esomeprazole Chemical compound C([S@](=O)C1=NC2=CC=C(C=C2N1)OC)C1=NC=C(C)C(OC)=C1C SUBDBMMJDZJVOS-DEOSSOPVSA-N 0.000 claims description 3
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KWORUUGOSLYAGD-UHFFFAOYSA-N magnesium 5-methoxy-2-[(4-methoxy-3,5-dimethyl-2-pyridinyl)methylsulfinyl]benzimidazol-1-ide Chemical compound [Mg+2].N=1C2=CC(OC)=CC=C2[N-]C=1S(=O)CC1=NC=C(C)C(OC)=C1C.N=1C2=CC(OC)=CC=C2[N-]C=1S(=O)CC1=NC=C(C)C(OC)=C1C KWORUUGOSLYAGD-UHFFFAOYSA-N 0.000 description 16
238000002360 preparation method Methods 0.000 description 16
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DOOTYTYQINUNNV-UHFFFAOYSA-N Triethyl citrate Chemical compound CCOC(=O)CC(O)(C(=O)OCC)CC(=O)OCC DOOTYTYQINUNNV-UHFFFAOYSA-N 0.000 description 14
239000011824 nuclear material Substances 0.000 description 14
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VMYFZRTXGLUXMZ-UHFFFAOYSA-N triethyl citrate Natural products CCOC(=O)C(O)(C(=O)OCC)C(=O)OCC VMYFZRTXGLUXMZ-UHFFFAOYSA-N 0.000 description 14
235000013769 triethyl citrate Nutrition 0.000 description 14
239000000843 powder Substances 0.000 description 13
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229910002012 Aerosil® Inorganic materials 0.000 description 11
VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 11
238000009472 formulation Methods 0.000 description 11
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 10
MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 10
150000003839 salts Chemical class 0.000 description 10
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239000011230 binding agent Substances 0.000 description 9
MVPICKVDHDWCJQ-UHFFFAOYSA-N ethyl 3-pyrrolidin-1-ylpropanoate Chemical compound CCOC(=O)CCN1CCCC1 MVPICKVDHDWCJQ-UHFFFAOYSA-N 0.000 description 9
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CPLXHLVBOLITMK-UHFFFAOYSA-N magnesium oxide Inorganic materials [Mg]=O CPLXHLVBOLITMK-UHFFFAOYSA-N 0.000 description 6
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DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 4
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IQPSEEYGBUAQFF-UHFFFAOYSA-N Pantoprazole Chemical compound COC1=CC=NC(CS(=O)C=2NC3=CC=C(OC(F)F)C=C3N=2)=C1OC IQPSEEYGBUAQFF-UHFFFAOYSA-N 0.000 description 2
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239000003485 histamine H2 receptor antagonist Substances 0.000 description 1
150000004677 hydrates Chemical class 0.000 description 1
BHEPBYXIRTUNPN-UHFFFAOYSA-N hydridophosphorus(.) (triplet) Chemical class [PH] BHEPBYXIRTUNPN-UHFFFAOYSA-N 0.000 description 1
XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical compound [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 description 1
125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 1
229940031704 hydroxypropyl methylcellulose phthalate Drugs 0.000 description 1
229920003132 hydroxypropyl methylcellulose phthalate Polymers 0.000 description 1
229960002182 imipenem Drugs 0.000 description 1
GSOSVVULSKVSLQ-JJVRHELESA-N imipenem hydrate Chemical compound O.C1C(SCCNC=N)=C(C(O)=O)N2C(=O)[C@H]([C@H](O)C)[C@H]21 GSOSVVULSKVSLQ-JJVRHELESA-N 0.000 description 1
239000012729 immediate-release (IR) formulation Substances 0.000 description 1
230000001771 impaired effect Effects 0.000 description 1
239000000543 intermediate Substances 0.000 description 1
239000002563 ionic surfactant Substances 0.000 description 1
239000008101 lactose Substances 0.000 description 1
239000007942 layered tablet Substances 0.000 description 1
229950007395 leminoprazole Drugs 0.000 description 1
229960005287 lincomycin Drugs 0.000 description 1
OJMMVQQUTAEWLP-KIDUDLJLSA-N lincomycin Chemical compound CN1C[C@H](CCC)C[C@H]1C(=O)N[C@H]([C@@H](C)O)[C@@H]1[C@H](O)[C@H](O)[C@@H](O)[C@@H](SC)O1 OJMMVQQUTAEWLP-KIDUDLJLSA-N 0.000 description 1
230000007774 longterm Effects 0.000 description 1
229940031703 low substituted hydroxypropyl cellulose Drugs 0.000 description 1
239000003120 macrolide antibiotic agent Substances 0.000 description 1
239000001095 magnesium carbonate Substances 0.000 description 1
229910000021 magnesium carbonate Inorganic materials 0.000 description 1
150000002681 magnesium compounds Chemical class 0.000 description 1
VTHJTEIRLNZDEV-UHFFFAOYSA-L magnesium dihydroxide Chemical class [OH-].[OH-].[Mg+2] VTHJTEIRLNZDEV-UHFFFAOYSA-L 0.000 description 1
239000000347 magnesium hydroxide Substances 0.000 description 1
235000012254 magnesium hydroxide Nutrition 0.000 description 1
229910001862 magnesium hydroxide Inorganic materials 0.000 description 1
159000000003 magnesium salts Chemical class 0.000 description 1
FYFFGSSZFBZTAH-UHFFFAOYSA-N methylaminomethanetriol Chemical compound CNC(O)(O)O FYFFGSSZFBZTAH-UHFFFAOYSA-N 0.000 description 1
229960003085 meticillin Drugs 0.000 description 1
125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 description 1
229960000210 nalidixic acid Drugs 0.000 description 1
MHWLWQUZZRMNGJ-UHFFFAOYSA-N nalidixic acid Chemical compound C1=C(C)N=C2N(CC)C=C(C(O)=O)C(=O)C2=C1 MHWLWQUZZRMNGJ-UHFFFAOYSA-N 0.000 description 1
YCWSUKQGVSGXJO-NTUHNPAUSA-N nifuroxazide Chemical compound C1=CC(O)=CC=C1C(=O)N\N=C\C1=CC=C([N+]([O-])=O)O1 YCWSUKQGVSGXJO-NTUHNPAUSA-N 0.000 description 1
229960003888 nifuroxazide Drugs 0.000 description 1
229960000564 nitrofurantoin Drugs 0.000 description 1
NXFQHRVNIOXGAQ-YCRREMRBSA-N nitrofurantoin Chemical compound O1C([N+](=O)[O-])=CC=C1\C=N\N1C(=O)NC(=O)C1 NXFQHRVNIOXGAQ-YCRREMRBSA-N 0.000 description 1
125000004433 nitrogen atom Chemical group N* 0.000 description 1
229960001180 norfloxacin Drugs 0.000 description 1
OGJPXUAPXNRGGI-UHFFFAOYSA-N norfloxacin Chemical compound C1=C2N(CC)C=C(C(O)=O)C(=O)C2=CC(F)=C1N1CCNCC1 OGJPXUAPXNRGGI-UHFFFAOYSA-N 0.000 description 1
229960001699 ofloxacin Drugs 0.000 description 1
239000006186 oral dosage form Substances 0.000 description 1
239000008183 oral pharmaceutical preparation Substances 0.000 description 1
150000007530 organic bases Chemical class 0.000 description 1
229920000620 organic polymer Polymers 0.000 description 1
125000002971 oxazolyl group Chemical group 0.000 description 1
229910052760 oxygen Inorganic materials 0.000 description 1
238000004806 packaging method and process Methods 0.000 description 1
229950005676 paldimycin Drugs 0.000 description 1
XJRJUPJOHBMXIC-DIOSQPHESA-N paldimycin Chemical compound C1[C@H](OC)[C@]([C@H](C)OC(=O)[C@@H](C)CC)(O)[C@H](C)O[C@H]1O[C@@H]1[C@H](OC(=O)C(CCSC[C@H](NC(C)=O)C(O)=O)NC(=S)SC[C@H](NC(C)=O)C(O)=O)[C@@H](COC(C)=O)OC([C@]2(O)C(C(C(O)=O)=C(N)C(=O)C2)=O)[C@@H]1O XJRJUPJOHBMXIC-DIOSQPHESA-N 0.000 description 1
229960001914 paromomycin Drugs 0.000 description 1
UOZODPSAJZTQNH-LSWIJEOBSA-N paromomycin Chemical compound N[C@@H]1[C@@H](O)[C@H](O)[C@H](CN)O[C@@H]1O[C@H]1[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](N)C[C@@H](N)[C@@H]2O)O[C@@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O2)N)O[C@@H]1CO UOZODPSAJZTQNH-LSWIJEOBSA-N 0.000 description 1
239000002245 particle Substances 0.000 description 1
230000000149 penetrating effect Effects 0.000 description 1
235000019371 penicillin G benzathine Nutrition 0.000 description 1
229940056360 penicillin g Drugs 0.000 description 1
229940056367 penicillin v Drugs 0.000 description 1
150000002960 penicillins Chemical class 0.000 description 1
PNJWIWWMYCMZRO-UHFFFAOYSA-N pent‐4‐en‐2‐one Natural products CC(=O)CC=C PNJWIWWMYCMZRO-UHFFFAOYSA-N 0.000 description 1
BPLBGHOLXOTWMN-MBNYWOFBSA-N phenoxymethylpenicillin Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)COC1=CC=CC=C1 BPLBGHOLXOTWMN-MBNYWOFBSA-N 0.000 description 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 1
125000002071 phenylalkoxy group Chemical group 0.000 description 1
150000003022 phthalic acids Chemical class 0.000 description 1
230000000704 physical effect Effects 0.000 description 1
229960003342 pivampicillin Drugs 0.000 description 1
ZEMIJUDPLILVNQ-ZXFNITATSA-N pivampicillin Chemical compound C1([C@@H](N)C(=O)N[C@H]2[C@@H]3N(C2=O)[C@H](C(S3)(C)C)C(=O)OCOC(=O)C(C)(C)C)=CC=CC=C1 ZEMIJUDPLILVNQ-ZXFNITATSA-N 0.000 description 1
229940068917 polyethylene glycols Drugs 0.000 description 1
239000013047 polymeric layer Substances 0.000 description 1
239000000047 product Substances 0.000 description 1
VMXUWOKSQNHOCA-LCYFTJDESA-N ranitidine Chemical compound [O-][N+](=O)/C=C(/NC)NCCSCC1=CC=C(CN(C)C)O1 VMXUWOKSQNHOCA-LCYFTJDESA-N 0.000 description 1
229960000620 ranitidine Drugs 0.000 description 1
239000000376 reactant Substances 0.000 description 1
229960001225 rifampicin Drugs 0.000 description 1
JQXXHWHPUNPDRT-WLSIYKJHSA-N rifampicin Chemical compound O([C@](C1=O)(C)O/C=C/[C@@H]([C@H]([C@@H](OC(C)=O)[C@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@@H](C)\C=C\C=C(C)/C(=O)NC=2C(O)=C3C([O-])=C4C)C)OC)C4=C1C3=C(O)C=2\C=N\N1CC[NH+](C)CC1 JQXXHWHPUNPDRT-WLSIYKJHSA-N 0.000 description 1
BTVYFIMKUHNOBZ-QXMMDKDBSA-N rifamycin s Chemical class O=C1C(C(O)=C2C)=C3C(=O)C=C1NC(=O)\C(C)=C/C=C\C(C)C(O)C(C)C(O)C(C)C(OC(C)=O)C(C)C(OC)\C=C/OC1(C)OC2=C3C1=O BTVYFIMKUHNOBZ-QXMMDKDBSA-N 0.000 description 1
229940081192 rifamycins Drugs 0.000 description 1
210000000813 small intestine Anatomy 0.000 description 1
239000011780 sodium chloride Substances 0.000 description 1
APSBXTVYXVQYAB-UHFFFAOYSA-M sodium docusate Chemical compound [Na+].CCCCC(CC)COC(=O)CC(S([O-])(=O)=O)C(=O)OCC(CC)CCCC APSBXTVYXVQYAB-UHFFFAOYSA-M 0.000 description 1
239000008279 sol Substances 0.000 description 1
239000007787 solid Substances 0.000 description 1
238000007711 solidification Methods 0.000 description 1
230000008023 solidification Effects 0.000 description 1
239000002904 solvent Substances 0.000 description 1
241000894007 species Species 0.000 description 1
229960000268 spectinomycin Drugs 0.000 description 1
UNFWWIHTNXNPBV-WXKVUWSESA-N spectinomycin Chemical compound O([C@@H]1[C@@H](NC)[C@@H](O)[C@H]([C@@H]([C@H]1O1)O)NC)[C@]2(O)[C@H]1O[C@H](C)CC2=O UNFWWIHTNXNPBV-WXKVUWSESA-N 0.000 description 1
239000007921 spray Substances 0.000 description 1
238000001694 spray drying Methods 0.000 description 1
229940032147 starch Drugs 0.000 description 1
239000008107 starch Substances 0.000 description 1
235000019698 starch Nutrition 0.000 description 1
230000003068 static effect Effects 0.000 description 1
238000003860 storage Methods 0.000 description 1
229960004306 sulfadiazine Drugs 0.000 description 1
SEEPANYCNGTZFQ-UHFFFAOYSA-N sulfadiazine Chemical compound C1=CC(N)=CC=C1S(=O)(=O)NC1=NC=CC=N1 SEEPANYCNGTZFQ-UHFFFAOYSA-N 0.000 description 1
229960005404 sulfamethoxazole Drugs 0.000 description 1
JLKIGFTWXXRPMT-UHFFFAOYSA-N sulphamethoxazole Chemical compound O1C(C)=CC(NS(=O)(=O)C=2C=CC(N)=CC=2)=N1 JLKIGFTWXXRPMT-UHFFFAOYSA-N 0.000 description 1
229960004576 temafloxacin Drugs 0.000 description 1
229940040944 tetracyclines Drugs 0.000 description 1
229960004659 ticarcillin Drugs 0.000 description 1
OHKOGUYZJXTSFX-KZFFXBSXSA-N ticarcillin Chemical compound C=1([C@@H](C(O)=O)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C(O)=O)(C)C)C=CSC=1 OHKOGUYZJXTSFX-KZFFXBSXSA-N 0.000 description 1
230000001256 tonic effect Effects 0.000 description 1
230000032258 transport Effects 0.000 description 1
125000004950 trifluoroalkyl group Chemical group 0.000 description 1
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 description 1
229960003165 vancomycin Drugs 0.000 description 1
MYPYJXKWCTUITO-LYRMYLQWSA-N vancomycin Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=C2C=C3C=C1OC1=CC=C(C=C1Cl)[C@@H](O)[C@H](C(N[C@@H](CC(N)=O)C(=O)N[C@H]3C(=O)N[C@H]1C(=O)N[C@H](C(N[C@@H](C3=CC(O)=CC(O)=C3C=3C(O)=CC=C1C=3)C(O)=O)=O)[C@H](O)C1=CC=C(C(=C1)Cl)O2)=O)NC(=O)[C@@H](CC(C)C)NC)[C@H]1C[C@](C)(N)[C@H](O)[C@H](C)O1 MYPYJXKWCTUITO-LYRMYLQWSA-N 0.000 description 1
MYPYJXKWCTUITO-UHFFFAOYSA-N vancomycin Natural products O1C(C(=C2)Cl)=CC=C2C(O)C(C(NC(C2=CC(O)=CC(O)=C2C=2C(O)=CC=C3C=2)C(O)=O)=O)NC(=O)C3NC(=O)C2NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(CC(C)C)NC)C(O)C(C=C3Cl)=CC=C3OC3=CC2=CC1=C3OC1OC(CO)C(O)C(O)C1OC1CC(C)(N)C(O)C(C)O1 MYPYJXKWCTUITO-UHFFFAOYSA-N 0.000 description 1
239000000080 wetting agent Substances 0.000 description 1
229910001845 yogo sapphire Inorganic materials 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2886—Dragees; Coated pills or tablets, e.g. with film or compression coating having two or more different drug-free coatings; Tablets of the type inert core-drug layer-inactive layer
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
- A61K9/2081—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets with microcapsules or coated microparticles according to A61K9/50
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
- A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5084—Mixtures of one or more drugs in different galenical forms, at least one of which being granules, microcapsules or (coated) microparticles according to A61K9/16 or A61K9/50, e.g. for obtaining a specific release pattern or for combining different drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents

Landscapes

Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
Epidemiology (AREA)
Organic Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Medicinal Preparation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

FI963984A 1995-02-06 1996-10-04 Uusi oraalinen farmaseuttinen annostelumuoto FI119174B (fi)

Applications Claiming Priority (6)

Application Number	Priority Date	Filing Date	Title
SE9500422		1995-02-06
SE9500422A SE9500422D0 (sv)	1995-02-06	1995-02-06	New oral pharmaceutical dosage forms
US46477595A	1995-06-07	1995-06-07
US46477595		1995-06-07
SE9600125		1996-02-02
PCT/SE1996/000125 WO1996024375A1 (fr)	1995-02-06	1996-02-02	Nouvelle forme galenique pharmaceutique orale

Publications (3)

Publication Number	Publication Date
FI963984A0 FI963984A0 (fi)	1996-10-04
FI963984L FI963984L (fi)	1996-10-04
FI119174B true FI119174B (fi)	2008-08-29

Family

ID=26662219

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
FI963984A FI119174B (fi)	1995-02-06	1996-10-04	Uusi oraalinen farmaseuttinen annostelumuoto

Country Status (31)

Country	Link
US (1)	US6136344A (fr)
EP (1)	EP0754061B1 (fr)
JP (1)	JP3699122B2 (fr)
CN (1)	CN1098104C (fr)
AR (1)	AR002275A1 (fr)
AT (1)	ATE219377T1 (fr)
AU (1)	AU689372B2 (fr)
BR (1)	BR9605111A (fr)
CA (1)	CA2186039C (fr)
CZ (1)	CZ293196A3 (fr)
DE (1)	DE69621885T2 (fr)
DK (1)	DK0754061T3 (fr)
EE (1)	EE9600118A (fr)
ES (1)	ES2176436T3 (fr)
FI (1)	FI119174B (fr)
HR (1)	HRP960032A2 (fr)
HU (1)	HUP9603064A2 (fr)
IL (1)	IL117041A (fr)
IS (1)	IS4360A (fr)
MA (1)	MA23801A1 (fr)
MX (1)	MX9604354A (fr)
NO (1)	NO316865B1 (fr)
NZ (1)	NZ301408A (fr)
PL (1)	PL316684A1 (fr)
PT (1)	PT754061E (fr)
SE (1)	SE9500422D0 (fr)
SK (1)	SK126096A3 (fr)
TR (1)	TR199600786T1 (fr)
TW (1)	TW474825B (fr)
WO (1)	WO1996024375A1 (fr)
ZA (1)	ZA96365B (fr)

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US6699885B2 (en)	1996-01-04	2004-03-02	The Curators Of The University Of Missouri	Substituted benzimidazole dosage forms and methods of using same
US6645988B2 (en)	1996-01-04	2003-11-11	Curators Of The University Of Missouri	Substituted benzimidazole dosage forms and method of using same
US6489346B1 (en)	1996-01-04	2002-12-03	The Curators Of The University Of Missouri	Substituted benzimidazole dosage forms and method of using same
US5840737A (en)	1996-01-04	1998-11-24	The Curators Of The University Of Missouri	Omeprazole solution and method for using same
SE9600070D0 (sv) *	1996-01-08	1996-01-08	Astra Ab	New oral pharmaceutical dosage forms
SE9702000D0 (sv) *	1997-05-28	1997-05-28	Astra Ab	New pharmaceutical formulation
SE510650C2 (sv)	1997-05-30	1999-06-14	Astra Ab	Ny förening
IL133800A0 (en)	1997-07-03	2001-04-30	Du Pont Pharm Co	Imidazopyrimidines and imidazopyridines for the treatment of neurological disorders
SI9700186B (sl) *	1997-07-14	2006-10-31	Lek, Tovarna Farmacevtskih In Kemicnih Izdelkov, D.D.	Nova farmacevtska oblika z nadzorovanim sproscanjem zdravilnih ucinkovin
WO1999010000A1 (fr) *	1997-08-25	1999-03-04	The Procter & Gamble Company	Preparations combinees pour le traitement des douleurs du tractus gastro-intestinal superieur
US6174548B1 (en)	1998-08-28	2001-01-16	Andrx Pharmaceuticals, Inc.	Omeprazole formulation
US6096340A (en) *	1997-11-14	2000-08-01	Andrx Pharmaceuticals, Inc.	Omeprazole formulation
SI1037607T1 (en) *	1997-12-08	2004-08-31	Altana Pharma Ag	Novel suppository form comprising an acid-labile active compound
SE9704870D0 (sv)	1997-12-22	1997-12-22	Astra Ab	New pharmaceutical formulation I
SE9704869D0 (sv) *	1997-12-22	1997-12-22	Astra Ab	New pharmaceutical formulaton II
PT1736144E (pt)	1998-05-18	2016-02-10	Takeda Pharmaceutical	Comprimidos de desintegração oral
US6365589B1 (en)	1998-07-02	2002-04-02	Bristol-Myers Squibb Pharma Company	Imidazo-pyridines, -pyridazines, and -triazines as corticotropin releasing factor antagonists
ATE291418T1 (de)	1998-07-28	2005-04-15	Takeda Pharmaceutical	Leicht zerfallende feste zubereitung
US6733778B1 (en)	1999-08-27	2004-05-11	Andrx Pharmaceuticals, Inc.	Omeprazole formulation
US6117868A (en) *	1998-09-16	2000-09-12	Ed. Geistlich Sohne Ag Fur Chemische Industrie	Treatment of gastrointestinal ulcers or gastritis caused by microbial infection
DE19850445A1 (de) *	1998-11-02	2000-05-04	Falk Pharma Gmbh	Arzneimittel zur topischen Behandlung entzündlicher Darmerkrankungen
EP1154771A4 (fr) *	1999-02-26	2005-04-20	Nitromed Inc	Inhibiteurs de la pompe a proton nitroses et nitrosyles, compositions et procedes d'utilisation
US6852739B1 (en)	1999-02-26	2005-02-08	Nitromed Inc.	Methods using proton pump inhibitors and nitric oxide donors
FR2793688B1 (fr) *	1999-05-21	2003-06-13	Ethypharm Lab Prod Ethiques	Microgranules gastroproteges, procede d'obtention et preparations pharmaceutiques
CA2413923A1 (fr) *	2000-03-09	2001-09-13	Andrew Ilchyshyn	Traitement de dermatoses inflammatoires a base d'erythromycine ou de clarithromycine ainsi que de metronidazole agissant comme inhibiteur du pompage d'hydrogene gastro-intestinal
EP1133987A1 (fr) *	2000-03-09	2001-09-19	Ian Whitcroft	Traitement de dermatoses inflammatoires avec une combinaison d'erythromycine ou clarithromycine, métronidazole et un inhibiteur des pompes à hydrogène
US20020064555A1 (en) *	2000-09-29	2002-05-30	Dan Cullen	Proton pump inhibitor formulation
SI20720A (sl) *	2000-11-20	2002-06-30	LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d.	Nov farmacevtski pripravek v obliki celuloznih kapsul uporaben za derivate benzimidazola
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1996
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- 1996-01-23 HR HR9500422-2A patent/HRP960032A2/hr not_active Application Discontinuation
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FI963984A0 (fi)	1996-10-04
ATE219377T1 (de)	2002-07-15
DE69621885T2 (de)	2003-01-02
SK126096A3 (en)	1997-05-07
IL117041A0 (en)	1996-06-18
JPH09511767A (ja)	1997-11-25
ZA96365B (en)	1996-08-06
CA2186039A1 (fr)	1996-08-15
NO316865B1 (no)	2004-06-07
MX9604354A (es)	1997-06-28
TR199600786T1 (tr)	1997-03-21
ES2176436T3 (es)	2002-12-01
CA2186039C (fr)	2005-06-07
CZ293196A3 (en)	1997-11-12
IL117041A (en)	2000-07-16
WO1996024375A1 (fr)	1996-08-15
DE69621885D1 (de)	2002-07-25
NO964212L (no)	1996-10-04
HRP960032A2 (en)	1997-10-31
EP0754061A1 (fr)	1997-01-22
JP3699122B2 (ja)	2005-09-28
SE9500422D0 (sv)	1995-02-06
PL316684A1 (en)	1997-02-03
NO964212D0 (no)	1996-10-04
IS4360A (is)	1996-09-17
CN1098104C (zh)	2003-01-08
MA23801A1 (fr)	1996-10-01
EE9600118A (et)	1997-04-15
DK0754061T3 (da)	2002-08-26
PT754061E (pt)	2002-11-29
EP0754061B1 (fr)	2002-06-19
HUP9603064A2 (en)	1997-08-28
CN1148344A (zh)	1997-04-23
TW474825B (en)	2002-02-01
US6136344A (en)	2000-10-24
AR002275A1 (es)	1998-03-11
AU689372B2 (en)	1998-03-26
NZ301408A (en)	1998-07-28
BR9605111A (pt)	1997-10-07
AU4682296A (en)	1996-08-27
FI963984L (fi)	1996-10-04

Publication	Publication Date	Title
FI119174B (fi)	2008-08-29	Uusi oraalinen farmaseuttinen annostelumuoto
EP0813424B1 (fr)	2002-11-20	Formes galeniques par voie orale comprenants un inhibiteur de la pompe a protons et un agent antacide ou un alginate
AU695966B2 (en)	1998-08-27	Multiple unit tableted dosage form I
EP0814839B1 (fr)	2003-06-04	Formes galeniques pharmaceutiques orales comprenant un inhibiteur de pompe a protons et un anti-inflammatoire non steroidien
MXPA96004354A (en)	1997-06-01	New form of pharmaceutical dosage or
SA99191077B1 (ar)	2006-07-11	صورة لجرعة صيدلانية طويلة المفعول تعطى عن طريق الفم
NZ505135A (en)	2002-06-28	Composition comprising a proton pump inhibitor (H+,K+-ATPase inhibitor) which provides two or more discrete release pulses in the small and/or large intestines
AU2005204014B2 (en)	2008-02-28	Pharmaceutical compositions comprising a proton pump inhibitor and a prokinetic agent
KR100399524B1 (ko)	2004-04-13	신규경구제약학상제형
HK1001763B (en)	2003-02-28	Oral pharmaceutical dosage forms comprising a proton pump inhibitor and an antacid agent or alginate
MXPA06007779A (en)	2006-12-13	Pharmaceutical compositions comprising a proton pump inhibitor and a prokinetic agent
HK1001761B (en)	2003-10-10	Oral pharmaceutical dosage forms comprising a proton pump inhibitor and a nsaid

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